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Protein

DDB1- and CUL4-associated factor 13

Gene

DCAF13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.By similarity1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • estrogen receptor binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein
Biological processRibosome biogenesis, rRNA processing, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-8951664 Neddylation
SignaLinkiQ9NV06
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 13
Alternative name(s):
WD repeat and SOF domain-containing protein 1
Gene namesi
Name:DCAF13
Synonyms:WDSOF1
ORF Names:HSPC064
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000164934.13
HGNCiHGNC:24535 DCAF13
MIMi616196 gene
neXtProtiNX_Q9NV06

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi25879
OpenTargetsiENSG00000164934
PharmGKBiPA165585440

Polymorphism and mutation databases

BioMutaiDCAF13
DMDMi160358731

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003104281 – 445DDB1- and CUL4-associated factor 13Add BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9NV06
MaxQBiQ9NV06
PaxDbiQ9NV06
PeptideAtlasiQ9NV06
PRIDEiQ9NV06
ProteomicsDBi82733
82734 [Q9NV06-2]

PTM databases

iPTMnetiQ9NV06
PhosphoSitePlusiQ9NV06

Expressioni

Gene expression databases

BgeeiENSG00000164934 Expressed in 194 organ(s), highest expression level in secondary oocyte
CleanExiHS_WDSOF1
ExpressionAtlasiQ9NV06 baseline and differential
GenevisibleiQ9NV06 HS

Organism-specific databases

HPAiHPA044504

Interactioni

Subunit structurei

Interacts with DDB1 (PubMed:16949367). Interacts with ESR1 and LATS1 (PubMed:28068668).2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117393, 38 interactors
IntActiQ9NV06, 10 interactors
MINTiQ9NV06
STRINGi9606.ENSP00000297579

Structurei

3D structure databases

ProteinModelPortaliQ9NV06
SMRiQ9NV06
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati64 – 104WD 1Add BLAST41
Repeati107 – 146WD 2Add BLAST40
Repeati149 – 191WD 3Add BLAST43
Repeati194 – 234WD 4Add BLAST41
Repeati236 – 276WD 5Add BLAST41
Repeati280 – 319WD 6Add BLAST40
Repeati323 – 362WD 7Add BLAST40

Sequence similaritiesi

Belongs to the WD repeat DCAF13/WDSOF1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0268 Eukaryota
ENOG410XNX6 LUCA
GeneTreeiENSGT00390000005711
HOGENOMiHOG000210082
HOVERGENiHBG056998
InParanoidiQ9NV06
KOiK11806
PhylomeDBiQ9NV06
TreeFamiTF300844

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR007287 Sof1
IPR013979 TIF_beta_prop-like
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08662 eIF2A, 1 hit
PF04158 Sof1, 1 hit
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NV06-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKVKMLSRNP DNYVRETKLD LQRVPRNYDP ALHPFEVPRE YIRALNATKL
60 70 80 90 100
ERVFAKPFLA SLDGHRDGVN CLAKHPEKLA TVLSGACDGE VRIWNLTQRN
110 120 130 140 150
CIRTIQAHEG FVRGICTRFC GTSFFTVGDD KTVKQWKMDG PGYGDEEEPL
160 170 180 190 200
HTILGKTVYT GIDHHWKEAV FATCGQQVDI WDEQRTNPIC SMTWGFDSIS
210 220 230 240 250
SVKFNPIETF LLGSCASDRN IVLYDMRQAT PLKKVILDMR TNTICWNPME
260 270 280 290 300
AFIFTAANED YNLYTFDMRA LDTPVMVHMD HVSAVLDVDY SPTGKEFVSA
310 320 330 340 350
SFDKSIRIFP VDKSRSREVY HTKRMQHVIC VKWTSDSKYI MCGSDEMNIR
360 370 380 390 400
LWKANASEKL GVLTSREKAA KDYNQKLKEK FQHYPHIKRI ARHRHLPKSI
410 420 430 440
YSQIQEQRIM KEARRRKEVN RIKHSKPGSV PLVSEKKKHV VAVVK
Length:445
Mass (Da):51,402
Last modified:November 13, 2007 - v2
Checksum:i33F6079364A0F0A3
GO
Isoform 2 (identifier: Q9NV06-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     91-96: VRIWNL → LVMTKL
     97-445: Missing.

Note: No experimental confirmation available.
Show »
Length:96
Mass (Da):10,919
Checksum:i5E6BC46DEA1832DF
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WT20A0A087WT20_HUMAN
DDB1- and CUL4-associated factor 13
DCAF13
597Annotation score:
B3KME9B3KME9_HUMAN
DDB1- and CUL4-associated factor 13
DCAF13
221Annotation score:
E5RHM4E5RHM4_HUMAN
DDB1- and CUL4-associated factor 13
DCAF13
185Annotation score:
A0A087X1F8A0A087X1F8_HUMAN
DDB1- and CUL4-associated factor 13
DCAF13
204Annotation score:

Sequence cautioni

The sequence AAH26067 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAI01811 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAI12043 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB55377 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC11163 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38P → S in BAC11163 (PubMed:14702039).Curated1
Sequence conflicti86A → S in AAH26067 (PubMed:15489334).Curated1
Sequence conflicti304K → E in BAC11163 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03703542I → V2 PublicationsCorresponds to variant dbSNP:rs3134253Ensembl.1
Natural variantiVAR_03703670N → S. Corresponds to variant dbSNP:rs13272825Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02928391 – 96VRIWNL → LVMTKL in isoform 2. 1 Publication6
Alternative sequenceiVSP_02928497 – 445Missing in isoform 2. 1 PublicationAdd BLAST349

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161549 mRNA Translation: AAF29036.1
AK001874 mRNA Translation: BAA91955.1
AK027799 mRNA Translation: BAB55377.1 Different initiation.
AK074725 mRNA Translation: BAC11163.1 Different initiation.
BC026067 mRNA Translation: AAH26067.2 Different initiation.
BC101810 mRNA Translation: AAI01811.1 Different initiation.
BC112042 mRNA Translation: AAI12043.1 Different initiation.
CCDSiCCDS34934.1 [Q9NV06-1]
RefSeqiNP_056235.4, NM_015420.6 [Q9NV06-1]
UniGeneiHs.532265

Genome annotation databases

EnsembliENST00000612750; ENSP00000484962; ENSG00000164934 [Q9NV06-1]
ENST00000618975; ENSP00000480810; ENSG00000164934 [Q9NV06-2]
GeneIDi25879
KEGGihsa:25879
UCSCiuc064pix.1 human [Q9NV06-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161549 mRNA Translation: AAF29036.1
AK001874 mRNA Translation: BAA91955.1
AK027799 mRNA Translation: BAB55377.1 Different initiation.
AK074725 mRNA Translation: BAC11163.1 Different initiation.
BC026067 mRNA Translation: AAH26067.2 Different initiation.
BC101810 mRNA Translation: AAI01811.1 Different initiation.
BC112042 mRNA Translation: AAI12043.1 Different initiation.
CCDSiCCDS34934.1 [Q9NV06-1]
RefSeqiNP_056235.4, NM_015420.6 [Q9NV06-1]
UniGeneiHs.532265

3D structure databases

ProteinModelPortaliQ9NV06
SMRiQ9NV06
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117393, 38 interactors
IntActiQ9NV06, 10 interactors
MINTiQ9NV06
STRINGi9606.ENSP00000297579

PTM databases

iPTMnetiQ9NV06
PhosphoSitePlusiQ9NV06

Polymorphism and mutation databases

BioMutaiDCAF13
DMDMi160358731

Proteomic databases

EPDiQ9NV06
MaxQBiQ9NV06
PaxDbiQ9NV06
PeptideAtlasiQ9NV06
PRIDEiQ9NV06
ProteomicsDBi82733
82734 [Q9NV06-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000612750; ENSP00000484962; ENSG00000164934 [Q9NV06-1]
ENST00000618975; ENSP00000480810; ENSG00000164934 [Q9NV06-2]
GeneIDi25879
KEGGihsa:25879
UCSCiuc064pix.1 human [Q9NV06-1]

Organism-specific databases

CTDi25879
DisGeNETi25879
EuPathDBiHostDB:ENSG00000164934.13
GeneCardsiDCAF13
H-InvDBiHIX0201273
HGNCiHGNC:24535 DCAF13
HPAiHPA044504
MIMi616196 gene
neXtProtiNX_Q9NV06
OpenTargetsiENSG00000164934
PharmGKBiPA165585440
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0268 Eukaryota
ENOG410XNX6 LUCA
GeneTreeiENSGT00390000005711
HOGENOMiHOG000210082
HOVERGENiHBG056998
InParanoidiQ9NV06
KOiK11806
PhylomeDBiQ9NV06
TreeFamiTF300844

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-8951664 Neddylation
SignaLinkiQ9NV06

Miscellaneous databases

ChiTaRSiDCAF13 human
GenomeRNAii25879
PROiPR:Q9NV06
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164934 Expressed in 194 organ(s), highest expression level in secondary oocyte
CleanExiHS_WDSOF1
ExpressionAtlasiQ9NV06 baseline and differential
GenevisibleiQ9NV06 HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR007287 Sof1
IPR013979 TIF_beta_prop-like
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08662 eIF2A, 1 hit
PF04158 Sof1, 1 hit
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDCA13_HUMAN
AccessioniPrimary (citable) accession number: Q9NV06
Secondary accession number(s): Q3MII9
, Q8NCH8, Q8TC51, Q96JY7, Q9NZX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 7, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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