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UniProtKB - Q9NUZ1 (ACOXL_HUMAN)

Entry version 159 (29 Sep 2021)
Sequence version 3 (02 Sep 2008)
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Protein

Acyl-coenzyme A oxidase-like protein

Gene

ACOXL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADBy similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi350 – 355FADBy similarity6

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NUZ1

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-389887, Beta-oxidation of pristanoyl-CoA

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Acyl-coenzyme A oxidase-like protein (EC:1.3.3.-)
Short name:
Acyl-CoA oxidase-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACOXL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25621, ACOXL

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NUZ1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000153093

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55289

Open Targets

More...OpenTargetsi		ENSG00000153093

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134932567

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NUZ1, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ACOXL

Domain mapping of disease mutations (DMDM)

More...DMDMi		205371797

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003051001 – 547Acyl-coenzyme A oxidase-like proteinAdd BLAST547

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NUZ1

PeptideAtlas

More...PeptideAtlasi		Q9NUZ1

PRoteomics IDEntifications database

More...PRIDEi		Q9NUZ1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		19125
82730 [Q9NUZ1-1]
82731 [Q9NUZ1-2]
82732 [Q9NUZ1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NUZ1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NUZ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000153093, Expressed in lung and 109 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NUZ1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NUZ1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000153093, Tissue enhanced (epididymis, lung, placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120577, 2 interactors

Protein interaction database and analysis system

More...IntActi		Q9NUZ1, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000407761

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NUZ1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NUZ1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0135, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161693

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014629_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NUZ1

Database of Orthologous Groups

More...OrthoDBi		226134at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NUZ1

TreeFam database of animal gene trees

More...TreeFami		TF354292

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006091, Acyl-CoA_Oxase/DH_cen-dom
IPR012258, Acyl-CoA_oxidase
IPR002655, Acyl-CoA_oxidase_C
IPR036250, AcylCo_DH-like_C
IPR009075, AcylCo_DH/oxidase_C
IPR009100, AcylCoA_DH/oxidase_NM_dom

The PANTHER Classification System

More...PANTHERi		PTHR10909, PTHR10909, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01756, ACOX, 1 hit
PF00441, Acyl-CoA_dh_1, 1 hit
PF02770, Acyl-CoA_dh_M, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47203, SSF47203, 2 hits
SSF56645, SSF56645, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NUZ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRALTVQRVK FAMDLPLLKR AGQDLAEKTK NFVSRSLVIG EVLSMADMAT 
        60         70         80         90        100
GVKCGIIYWL FGGAIRNLGS PEHVTKWFQP LQEQKYTGMF AMTERGHGSN 
       110        120        130        140        150
ARGIQTEATF DLSAQEFVID TPCENAEKMY IGNAMYGNYA AVFAQLIIDG 
       160        170        180        190        200
RSQGPHCFIV PVRDENGSLY PGVTAIDMMY KEGLHGVDNG ILIFDKVRIP 
       210        220        230        240        250
RENLLDKFGS VAPDGQYHSP IRNKSARFNA MLAALTPSRL AVAFQAMGAM 
       260        270        280        290        300
KLGLTIAIRY SHSRRQFGPK TKEEVKIIEH QTQTLRLMPH LATALALTFV 
       310        320        330        340        350
SRYAGALLDE DVFQGKELVN SRSLQALVAG LKAYSTWENI RCLQDCRECT 
       360        370        380        390        400
GGMGYMMENR ISGLKCDTDV FATFEGDDVV MLQVVGRELL AQYTKQYEEK 
       410        420        430        440        450
PLFGLLQNWA ESVGDKLRTS FLAFNMDTVD DLAFLLKAVK FRERVLQRGL 
       460        470        480        490        500
VARIYYKVKT KKEDFFHAWN SCLHHVASLS LAHTHRVTLE QFSLAVKSCP 
       510        520        530        540 
DQEDQTLLMK FCLLYGTKLV FQERAWYLEH KYLTPMASTR IRNQERC
Length:547
Mass (Da):61,795
Last modified:September 2, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7F2B9B961AAE2F08
GO
Isoform 2 (identifier: Q9NUZ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     354-383: Missing.

Show »
Length:517
Mass (Da):58,428
Checksum:iB5754E07F073B6C9
GO
Isoform 3 (identifier: Q9NUZ1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     263-279: SRRQFGPKTKEEVKIIE → RSRIISQNCCSAPAGLY
     280-547: Missing.

Show »
Length:279
Mass (Da):30,737
Checksum:iB1E0B26AAEA56D45
GO
Isoform 4 (identifier: Q9NUZ1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     354-383: Missing.
     544-547: QERC → QLLDLCDSVKDDARRVISTFNIPHTYLHAPIAGISNPRAAWAFYPAPLQPRPREEARSRRPKLGAKL

Show »
Length:580
Mass (Da):65,457
Checksum:i9DE724781D7ED1AA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A7I2V3X2A0A7I2V3X2_HUMAN
Acyl-coenzyme A oxidase
ACOXL
610Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DG10A0A0C4DG10_HUMAN
Acyl-coenzyme A oxidase-like protei...
ACOXL
355Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2M3H7C2M3_HUMAN
Acyl-coenzyme A oxidase-like protei...
ACOXL
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0A6H7C0A6_HUMAN
Acyl-coenzyme A oxidase-like protei...
ACOXL
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C345H7C345_HUMAN
Acyl-coenzyme A oxidase-like protei...
ACOXL
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQI3C9JQI3_HUMAN
Acyl-coenzyme A oxidase-like protei...
ACOXL
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH22268 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence BAA91970 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti219S → L in AAH22268 (PubMed:15489334).Curated1
Sequence conflicti512C → R in BAA91970 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035164255T → M. Corresponds to variant dbSNP:rs1554005Ensembl.1
Natural variantiVAR_035165535P → L. Corresponds to variant dbSNP:rs17041850Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_028237263 – 279SRRQF…VKIIE → RSRIISQNCCSAPAGLY in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_028238280 – 547Missing in isoform 3. 1 PublicationAdd BLAST268
Alternative sequenceiVSP_028239354 – 383Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_046900544 – 547QERC → QLLDLCDSVKDDARRVISTF NIPHTYLHAPIAGISNPRAA WAFYPAPLQPRPREEARSRR PKLGAKL in isoform 4. Curated4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC096670 Genomic DNA Translation: AAY14796.1
AC023131 Genomic DNA Translation: AAY14838.1
AC096591 Genomic DNA Translation: AAY24074.1
AC114776 Genomic DNA No translation available.
CH471237 Genomic DNA Translation: EAW50357.1
BC022268 mRNA Translation: AAH22268.1 Sequence problems.
BC131514 mRNA Translation: AAI31515.2
AK001904 mRNA Translation: BAA91970.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46389.1 [Q9NUZ1-4]

NCBI Reference Sequences

More...RefSeqi		NP_001136279.1, NM_001142807.1 [Q9NUZ1-4]
XP_011509718.1, XM_011511416.2
XP_011509721.1, XM_011511419.2 [Q9NUZ1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000340561; ENSP00000343717; ENSG00000153093 [Q9NUZ1-3]
ENST00000389811; ENSP00000374461; ENSG00000153093 [Q9NUZ1-1]
ENST00000439055; ENSP00000407761; ENSG00000153093 [Q9NUZ1-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55289

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55289

UCSC genome browser

More...UCSCi		uc010yxk.1, human [Q9NUZ1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC096670 Genomic DNA Translation: AAY14796.1
AC023131 Genomic DNA Translation: AAY14838.1
AC096591 Genomic DNA Translation: AAY24074.1
AC114776 Genomic DNA No translation available.
CH471237 Genomic DNA Translation: EAW50357.1
BC022268 mRNA Translation: AAH22268.1 Sequence problems.
BC131514 mRNA Translation: AAI31515.2
AK001904 mRNA Translation: BAA91970.1 Different initiation.
CCDSiCCDS46389.1 [Q9NUZ1-4]
RefSeqiNP_001136279.1, NM_001142807.1 [Q9NUZ1-4]
XP_011509718.1, XM_011511416.2
XP_011509721.1, XM_011511419.2 [Q9NUZ1-2]

3D structure databases

SMRiQ9NUZ1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120577, 2 interactors
IntActiQ9NUZ1, 1 interactor
STRINGi9606.ENSP00000407761

PTM databases

iPTMnetiQ9NUZ1
PhosphoSitePlusiQ9NUZ1

Genetic variation databases

BioMutaiACOXL
DMDMi205371797

Proteomic databases

MassIVEiQ9NUZ1
PeptideAtlasiQ9NUZ1
PRIDEiQ9NUZ1
ProteomicsDBi19125
82730 [Q9NUZ1-1]
82731 [Q9NUZ1-2]
82732 [Q9NUZ1-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		55058, 36 antibodies

The DNASU plasmid repository

More...DNASUi		55289

Genome annotation databases

EnsembliENST00000340561; ENSP00000343717; ENSG00000153093 [Q9NUZ1-3]
ENST00000389811; ENSP00000374461; ENSG00000153093 [Q9NUZ1-1]
ENST00000439055; ENSP00000407761; ENSG00000153093 [Q9NUZ1-4]
GeneIDi55289
KEGGihsa:55289
UCSCiuc010yxk.1, human [Q9NUZ1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55289
DisGeNETi55289

GeneCards: human genes, protein and diseases

More...GeneCardsi		ACOXL
HGNCiHGNC:25621, ACOXL
HPAiENSG00000153093, Tissue enhanced (epididymis, lung, placenta)
neXtProtiNX_Q9NUZ1
OpenTargetsiENSG00000153093
PharmGKBiPA134932567
VEuPathDBiHostDB:ENSG00000153093

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0135, Eukaryota
GeneTreeiENSGT00940000161693
HOGENOMiCLU_014629_4_1_1
InParanoidiQ9NUZ1
OrthoDBi226134at2759
PhylomeDBiQ9NUZ1
TreeFamiTF354292

Enzyme and pathway databases

PathwayCommonsiQ9NUZ1
ReactomeiR-HSA-389887, Beta-oxidation of pristanoyl-CoA

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55289, 6 hits in 1006 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ACOXL, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55289
PharosiQ9NUZ1, Tdark

Protein Ontology

More...PROi		PR:Q9NUZ1
RNActiQ9NUZ1, protein

Gene expression databases

BgeeiENSG00000153093, Expressed in lung and 109 other tissues
ExpressionAtlasiQ9NUZ1, baseline and differential
GenevisibleiQ9NUZ1, HS

Family and domain databases

InterProiView protein in InterPro
IPR006091, Acyl-CoA_Oxase/DH_cen-dom
IPR012258, Acyl-CoA_oxidase
IPR002655, Acyl-CoA_oxidase_C
IPR036250, AcylCo_DH-like_C
IPR009075, AcylCo_DH/oxidase_C
IPR009100, AcylCoA_DH/oxidase_NM_dom
PANTHERiPTHR10909, PTHR10909, 1 hit
PfamiView protein in Pfam
PF01756, ACOX, 1 hit
PF00441, Acyl-CoA_dh_1, 1 hit
PF02770, Acyl-CoA_dh_M, 1 hit
SUPFAMiSSF47203, SSF47203, 2 hits
SSF56645, SSF56645, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACOXL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NUZ1
Secondary accession number(s): A2RRB7
, B7WPB3, B7WPP7, E9PB20, Q53R27, Q53R31, Q53SC6, Q8TCE7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: September 2, 2008
Last modified: September 29, 2021
This is version 159 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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