UniProtKB - Q9NUZ1 (ACOXL_HUMAN)
Protein
Acyl-coenzyme A oxidase-like protein
Gene
ACOXL
Organism
Homo sapiens (Human)
Status
Functioni
Cofactori
FADBy similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 350 – 355 | FADBy similarity | 6 |
GO - Molecular functioni
- acyl-CoA oxidase activity Source: GO_Central
- fatty acid binding Source: GO_Central
- flavin adenine dinucleotide binding Source: GO_Central
GO - Biological processi
- fatty acid beta-oxidation using acyl-CoA oxidase Source: GO_Central
- lipid homeostasis Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Ligand | FAD, Flavoprotein |
Enzyme and pathway databases
PathwayCommonsi | Q9NUZ1 |
Reactomei | R-HSA-389887, Beta-oxidation of pristanoyl-CoA |
Names & Taxonomyi
Protein namesi | Recommended name: Acyl-coenzyme A oxidase-like protein (EC:1.3.3.-)Short name: Acyl-CoA oxidase-like protein |
Gene namesi | Name:ACOXL |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25621, ACOXL |
neXtProti | NX_Q9NUZ1 |
VEuPathDBi | HostDB:ENSG00000153093.18 |
Subcellular locationi
Peroxisome
- peroxisomal matrix Source: Reactome
- peroxisome Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 55289 |
OpenTargetsi | ENSG00000153093 |
PharmGKBi | PA134932567 |
Miscellaneous databases
Pharosi | Q9NUZ1, Tdark |
Genetic variation databases
BioMutai | ACOXL |
DMDMi | 205371797 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000305100 | 1 – 547 | Acyl-coenzyme A oxidase-like proteinAdd BLAST | 547 |
Proteomic databases
MassIVEi | Q9NUZ1 |
PeptideAtlasi | Q9NUZ1 |
PRIDEi | Q9NUZ1 |
ProteomicsDBi | 19125 82730 [Q9NUZ1-1] 82731 [Q9NUZ1-2] 82732 [Q9NUZ1-3] |
PTM databases
iPTMneti | Q9NUZ1 |
PhosphoSitePlusi | Q9NUZ1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000153093, Expressed in lung and 108 other tissues |
ExpressionAtlasi | Q9NUZ1, baseline and differential |
Genevisiblei | Q9NUZ1, HS |
Organism-specific databases
HPAi | ENSG00000153093, Tissue enhanced (epididymis, lung, placenta) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 120577, 2 interactors |
IntActi | Q9NUZ1, 1 interactor |
STRINGi | 9606.ENSP00000407761 |
Miscellaneous databases
RNActi | Q9NUZ1, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the acyl-CoA oxidase family.Curated
Phylogenomic databases
eggNOGi | KOG0135, Eukaryota |
GeneTreei | ENSGT00940000161693 |
HOGENOMi | CLU_014629_4_1_1 |
InParanoidi | Q9NUZ1 |
OMAi | YVTRAPI |
OrthoDBi | 226134at2759 |
PhylomeDBi | Q9NUZ1 |
TreeFami | TF354292 |
Family and domain databases
InterProi | View protein in InterPro IPR006091, Acyl-CoA_Oxase/DH_cen-dom IPR002655, Acyl-CoA_oxidase_C IPR036250, AcylCo_DH-like_C IPR009075, AcylCo_DH/oxidase_C IPR009100, AcylCoA_DH/oxidase_NM_dom |
Pfami | View protein in Pfam PF01756, ACOX, 1 hit PF00441, Acyl-CoA_dh_1, 1 hit PF02770, Acyl-CoA_dh_M, 1 hit |
SUPFAMi | SSF47203, SSF47203, 2 hits SSF56645, SSF56645, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NUZ1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRALTVQRVK FAMDLPLLKR AGQDLAEKTK NFVSRSLVIG EVLSMADMAT
60 70 80 90 100
GVKCGIIYWL FGGAIRNLGS PEHVTKWFQP LQEQKYTGMF AMTERGHGSN
110 120 130 140 150
ARGIQTEATF DLSAQEFVID TPCENAEKMY IGNAMYGNYA AVFAQLIIDG
160 170 180 190 200
RSQGPHCFIV PVRDENGSLY PGVTAIDMMY KEGLHGVDNG ILIFDKVRIP
210 220 230 240 250
RENLLDKFGS VAPDGQYHSP IRNKSARFNA MLAALTPSRL AVAFQAMGAM
260 270 280 290 300
KLGLTIAIRY SHSRRQFGPK TKEEVKIIEH QTQTLRLMPH LATALALTFV
310 320 330 340 350
SRYAGALLDE DVFQGKELVN SRSLQALVAG LKAYSTWENI RCLQDCRECT
360 370 380 390 400
GGMGYMMENR ISGLKCDTDV FATFEGDDVV MLQVVGRELL AQYTKQYEEK
410 420 430 440 450
PLFGLLQNWA ESVGDKLRTS FLAFNMDTVD DLAFLLKAVK FRERVLQRGL
460 470 480 490 500
VARIYYKVKT KKEDFFHAWN SCLHHVASLS LAHTHRVTLE QFSLAVKSCP
510 520 530 540
DQEDQTLLMK FCLLYGTKLV FQERAWYLEH KYLTPMASTR IRNQERC
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0C4DG10 | A0A0C4DG10_HUMAN | Acyl-coenzyme A oxidase-like protei... | ACOXL | 355 | Annotation score: | ||
H7C2M3 | H7C2M3_HUMAN | Acyl-coenzyme A oxidase-like protei... | ACOXL | 161 | Annotation score: | ||
H7C0A6 | H7C0A6_HUMAN | Acyl-coenzyme A oxidase-like protei... | ACOXL | 93 | Annotation score: | ||
H7C345 | H7C345_HUMAN | Acyl-coenzyme A oxidase-like protei... | ACOXL | 106 | Annotation score: | ||
C9JQI3 | C9JQI3_HUMAN | Acyl-coenzyme A oxidase-like protei... | ACOXL | 70 | Annotation score: |
Sequence cautioni
The sequence AAH22268 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence BAA91970 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 219 | S → L in AAH22268 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 512 | C → R in BAA91970 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035164 | 255 | T → M. Corresponds to variant dbSNP:rs1554005Ensembl. | 1 | |
Natural variantiVAR_035165 | 535 | P → L. Corresponds to variant dbSNP:rs17041850Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028237 | 263 – 279 | SRRQF…VKIIE → RSRIISQNCCSAPAGLY in isoform 3. 1 PublicationAdd BLAST | 17 | |
Alternative sequenceiVSP_028238 | 280 – 547 | Missing in isoform 3. 1 PublicationAdd BLAST | 268 | |
Alternative sequenceiVSP_028239 | 354 – 383 | Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST | 30 | |
Alternative sequenceiVSP_046900 | 544 – 547 | QERC → QLLDLCDSVKDDARRVISTF NIPHTYLHAPIAGISNPRAA WAFYPAPLQPRPREEARSRR PKLGAKL in isoform 4. Curated | 4 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC096670 Genomic DNA Translation: AAY14796.1 AC023131 Genomic DNA Translation: AAY14838.1 AC096591 Genomic DNA Translation: AAY24074.1 AC114776 Genomic DNA No translation available. CH471237 Genomic DNA Translation: EAW50357.1 BC022268 mRNA Translation: AAH22268.1 Sequence problems. BC131514 mRNA Translation: AAI31515.2 AK001904 mRNA Translation: BAA91970.1 Different initiation. |
CCDSi | CCDS46389.1 [Q9NUZ1-4] |
RefSeqi | NP_001136279.1, NM_001142807.1 [Q9NUZ1-4] XP_011509718.1, XM_011511416.2 XP_011509721.1, XM_011511419.2 [Q9NUZ1-2] |
Genome annotation databases
Ensembli | ENST00000340561; ENSP00000343717; ENSG00000153093 [Q9NUZ1-3] ENST00000389811; ENSP00000374461; ENSG00000153093 [Q9NUZ1-1] ENST00000439055; ENSP00000407761; ENSG00000153093 [Q9NUZ1-4] |
GeneIDi | 55289 |
KEGGi | hsa:55289 |
UCSCi | uc010yxk.1, human [Q9NUZ1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC096670 Genomic DNA Translation: AAY14796.1 AC023131 Genomic DNA Translation: AAY14838.1 AC096591 Genomic DNA Translation: AAY24074.1 AC114776 Genomic DNA No translation available. CH471237 Genomic DNA Translation: EAW50357.1 BC022268 mRNA Translation: AAH22268.1 Sequence problems. BC131514 mRNA Translation: AAI31515.2 AK001904 mRNA Translation: BAA91970.1 Different initiation. |
CCDSi | CCDS46389.1 [Q9NUZ1-4] |
RefSeqi | NP_001136279.1, NM_001142807.1 [Q9NUZ1-4] XP_011509718.1, XM_011511416.2 XP_011509721.1, XM_011511419.2 [Q9NUZ1-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120577, 2 interactors |
IntActi | Q9NUZ1, 1 interactor |
STRINGi | 9606.ENSP00000407761 |
PTM databases
iPTMneti | Q9NUZ1 |
PhosphoSitePlusi | Q9NUZ1 |
Genetic variation databases
BioMutai | ACOXL |
DMDMi | 205371797 |
Proteomic databases
MassIVEi | Q9NUZ1 |
PeptideAtlasi | Q9NUZ1 |
PRIDEi | Q9NUZ1 |
ProteomicsDBi | 19125 82730 [Q9NUZ1-1] 82731 [Q9NUZ1-2] 82732 [Q9NUZ1-3] |
Protocols and materials databases
Antibodypediai | 55058, 36 antibodies |
Genome annotation databases
Ensembli | ENST00000340561; ENSP00000343717; ENSG00000153093 [Q9NUZ1-3] ENST00000389811; ENSP00000374461; ENSG00000153093 [Q9NUZ1-1] ENST00000439055; ENSP00000407761; ENSG00000153093 [Q9NUZ1-4] |
GeneIDi | 55289 |
KEGGi | hsa:55289 |
UCSCi | uc010yxk.1, human [Q9NUZ1-1] |
Organism-specific databases
CTDi | 55289 |
DisGeNETi | 55289 |
GeneCardsi | ACOXL |
HGNCi | HGNC:25621, ACOXL |
HPAi | ENSG00000153093, Tissue enhanced (epididymis, lung, placenta) |
neXtProti | NX_Q9NUZ1 |
OpenTargetsi | ENSG00000153093 |
PharmGKBi | PA134932567 |
VEuPathDBi | HostDB:ENSG00000153093.18 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0135, Eukaryota |
GeneTreei | ENSGT00940000161693 |
HOGENOMi | CLU_014629_4_1_1 |
InParanoidi | Q9NUZ1 |
OMAi | YVTRAPI |
OrthoDBi | 226134at2759 |
PhylomeDBi | Q9NUZ1 |
TreeFami | TF354292 |
Enzyme and pathway databases
PathwayCommonsi | Q9NUZ1 |
Reactomei | R-HSA-389887, Beta-oxidation of pristanoyl-CoA |
Miscellaneous databases
BioGRID-ORCSi | 55289, 5 hits in 872 CRISPR screens |
ChiTaRSi | ACOXL, human |
GenomeRNAii | 55289 |
Pharosi | Q9NUZ1, Tdark |
PROi | PR:Q9NUZ1 |
RNActi | Q9NUZ1, protein |
Gene expression databases
Bgeei | ENSG00000153093, Expressed in lung and 108 other tissues |
ExpressionAtlasi | Q9NUZ1, baseline and differential |
Genevisiblei | Q9NUZ1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006091, Acyl-CoA_Oxase/DH_cen-dom IPR002655, Acyl-CoA_oxidase_C IPR036250, AcylCo_DH-like_C IPR009075, AcylCo_DH/oxidase_C IPR009100, AcylCoA_DH/oxidase_NM_dom |
Pfami | View protein in Pfam PF01756, ACOX, 1 hit PF00441, Acyl-CoA_dh_1, 1 hit PF02770, Acyl-CoA_dh_M, 1 hit |
SUPFAMi | SSF47203, SSF47203, 2 hits SSF56645, SSF56645, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACOXL_HUMAN | |
Accessioni | Q9NUZ1Primary (citable) accession number: Q9NUZ1 Secondary accession number(s): A2RRB7 Q8TCE7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | September 2, 2008 | |
Last modified: | February 10, 2021 | |
This is version 156 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families