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Protein

ATP-dependent RNA helicase DDX19A

Gene

DDX19A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei118ATPBy similarity1
Binding sitei428ATPBy similarity1
Binding sitei431ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi137 – 144ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processmRNA transport, Protein transport, Translocation, Transport
LigandATP-binding, Nucleotide-binding

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DDX19A (EC:3.6.4.13)
Alternative name(s):
DDX19-like protein
DEAD box protein 19A
Gene namesi
Name:DDX19A
Synonyms:DDX19L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000168872.16
HGNCiHGNC:25628 DDX19A
neXtProtiNX_Q9NUU7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55308
OpenTargetsiENSG00000168872
PharmGKBiPA134894996

Polymorphism and mutation databases

BioMutaiDDX19A
DMDMi73919226

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000550212 – 478ATP-dependent RNA helicase DDX19AAdd BLAST477

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Cross-linki26Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki26Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei42PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9NUU7
MaxQBiQ9NUU7
PaxDbiQ9NUU7
PeptideAtlasiQ9NUU7
PRIDEiQ9NUU7
ProteomicsDBi82721

PTM databases

iPTMnetiQ9NUU7
PhosphoSitePlusiQ9NUU7

Expressioni

Gene expression databases

BgeeiENSG00000168872 Expressed in 108 organ(s), highest expression level in gastrocnemius
CleanExiHS_DDX19A
ExpressionAtlasiQ9NUU7 baseline and differential
GenevisibleiQ9NUU7 HS

Organism-specific databases

HPAiHPA045252
HPA066668

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MIF4GDA9UHW65EBI-740301,EBI-373498

Protein-protein interaction databases

BioGridi120592, 30 interactors
IntActiQ9NUU7, 17 interactors
MINTiQ9NUU7
STRINGi9606.ENSP00000306117

Structurei

3D structure databases

ProteinModelPortaliQ9NUU7
SMRiQ9NUU7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 294Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST171
Domaini305 – 473Helicase C-terminalPROSITE-ProRule annotationAdd BLAST169

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 299N-terminal lobeBy similarityAdd BLAST298
Regioni54 – 67N-terminal helixBy similarityAdd BLAST14
Regioni300 – 478C-terminal lobeBy similarityAdd BLAST179

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi91 – 119Q motifAdd BLAST29
Motifi241 – 244DEAD box4

Domaini

The N-terminal extension helix acts as an autoinhibitory domain, preventing ATP hydrolysis, unless the N-terminus of the protein is displaced by RNA binding, allowing cleft closure to bring key side chains into position for catalysis.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0332 Eukaryota
ENOG410XRGX LUCA
GeneTreeiENSGT00530000063236
HOGENOMiHOG000268797
HOVERGENiHBG107989
InParanoidiQ9NUU7
KOiK18655
OMAiIGAKENA
PhylomeDBiQ9NUU7
TreeFamiTF314957

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NUU7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATDSWALAV DEQEAAVKSM TNLQIKEEKV KADTNGIIKT STTAEKTDEE
60 70 80 90 100
EKEDRAAQSL LNKLIRSNLV DNTNQVEVLQ RDPNSPLYSV KSFEELRLKP
110 120 130 140 150
QLLQGVYAMG FNRPSKIQEN ALPMMLAEPP QNLIAQSQSG TGKTAAFVLA
160 170 180 190 200
MLSRVEPSDR YPQCLCLSPT YELALQTGKV IEQMGKFYPE LKLAYAVRGN
210 220 230 240 250
KLERGQKISE QIVIGTPGTV LDWCSKLKFI DPKKIKVFVL DEADVMIATQ
260 270 280 290 300
GHQDQSIRIQ RMLPRNCQML LFSATFEDSV WKFAQKVVPD PNVIKLKREE
310 320 330 340 350
ETLDTIKQYY VLCSSRDEKF QALCNLYGAI TIAQAMIFCH TRKTASWLAA
360 370 380 390 400
ELSKEGHQVA LLSGEMMVEQ RAAVIERFRE GKEKVLVTTN VCARGIDVEQ
410 420 430 440 450
VSVVINFDLP VDKDGNPDNE TYLHRIGRTG RFGKRGLAVN MVDSKHSMNI
460 470
LNRIQEHFNK KIERLDTDDL DEIEKIAN
Length:478
Mass (Da):53,975
Last modified:October 1, 2000 - v1
Checksum:iC51F9E1D7B8584D0
GO
Isoform 2 (identifier: Q9NUU7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: MATDSWALAV...SVKSFEELRL → MSGTFLIR

Note: No experimental confirmation available.
Show »
Length:388
Mass (Da):43,875
Checksum:i71A5EA464F65A911
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L352I3L352_HUMAN
ATP-dependent RNA helicase DDX19A
DDX19A
396Annotation score:
I3L0H8I3L0H8_HUMAN
ATP-dependent RNA helicase DDX19A
DDX19A
447Annotation score:
H3BTB3H3BTB3_HUMAN
ATP-dependent RNA helicase DDX19A
DDX19A
129Annotation score:
H3BSL8H3BSL8_HUMAN
ATP-dependent RNA helicase DDX19A
DDX19A
78Annotation score:
J3QRH0J3QRH0_HUMAN
ATP-dependent RNA helicase DDX19A
DDX19A
64Annotation score:
H3BP50H3BP50_HUMAN
ATP-dependent RNA helicase DDX19A
DDX19A
51Annotation score:
H3BP36H3BP36_HUMAN
ATP-dependent RNA helicase DDX19A
DDX19A
47Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti463E → G in BAD96982 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0569541 – 98MATDS…EELRL → MSGTFLIR in isoform 2. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001988 mRNA Translation: BAA92022.1
AK299504 mRNA Translation: BAG61459.1
AK223262 mRNA Translation: BAD96982.1
AL832970 mRNA Translation: CAH10622.1
AC012184 Genomic DNA No translation available.
CH471241 Genomic DNA Translation: EAW51826.1
BC005162 mRNA Translation: AAH05162.1
BC006544 mRNA Translation: AAH06544.1
BC137496 mRNA Translation: AAI37497.1
BC137497 mRNA Translation: AAI37498.1
CCDSiCCDS10889.1 [Q9NUU7-1]
RefSeqiNP_001307451.1, NM_001320522.1
NP_001307454.1, NM_001320525.1 [Q9NUU7-2]
NP_001307455.1, NM_001320526.1
NP_001307456.1, NM_001320527.1
NP_060802.1, NM_018332.4 [Q9NUU7-1]
UniGeneiHs.656037

Genome annotation databases

EnsembliENST00000302243; ENSP00000306117; ENSG00000168872 [Q9NUU7-1]
GeneIDi55308
KEGGihsa:55308
UCSCiuc002eyv.4 human [Q9NUU7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001988 mRNA Translation: BAA92022.1
AK299504 mRNA Translation: BAG61459.1
AK223262 mRNA Translation: BAD96982.1
AL832970 mRNA Translation: CAH10622.1
AC012184 Genomic DNA No translation available.
CH471241 Genomic DNA Translation: EAW51826.1
BC005162 mRNA Translation: AAH05162.1
BC006544 mRNA Translation: AAH06544.1
BC137496 mRNA Translation: AAI37497.1
BC137497 mRNA Translation: AAI37498.1
CCDSiCCDS10889.1 [Q9NUU7-1]
RefSeqiNP_001307451.1, NM_001320522.1
NP_001307454.1, NM_001320525.1 [Q9NUU7-2]
NP_001307455.1, NM_001320526.1
NP_001307456.1, NM_001320527.1
NP_060802.1, NM_018332.4 [Q9NUU7-1]
UniGeneiHs.656037

3D structure databases

ProteinModelPortaliQ9NUU7
SMRiQ9NUU7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120592, 30 interactors
IntActiQ9NUU7, 17 interactors
MINTiQ9NUU7
STRINGi9606.ENSP00000306117

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetiQ9NUU7
PhosphoSitePlusiQ9NUU7

Polymorphism and mutation databases

BioMutaiDDX19A
DMDMi73919226

Proteomic databases

EPDiQ9NUU7
MaxQBiQ9NUU7
PaxDbiQ9NUU7
PeptideAtlasiQ9NUU7
PRIDEiQ9NUU7
ProteomicsDBi82721

Protocols and materials databases

DNASUi55308
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302243; ENSP00000306117; ENSG00000168872 [Q9NUU7-1]
GeneIDi55308
KEGGihsa:55308
UCSCiuc002eyv.4 human [Q9NUU7-1]

Organism-specific databases

CTDi55308
DisGeNETi55308
EuPathDBiHostDB:ENSG00000168872.16
GeneCardsiDDX19A
H-InvDBiHIX0038837
HGNCiHGNC:25628 DDX19A
HPAiHPA045252
HPA066668
neXtProtiNX_Q9NUU7
OpenTargetsiENSG00000168872
PharmGKBiPA134894996
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0332 Eukaryota
ENOG410XRGX LUCA
GeneTreeiENSGT00530000063236
HOGENOMiHOG000268797
HOVERGENiHBG107989
InParanoidiQ9NUU7
KOiK18655
OMAiIGAKENA
PhylomeDBiQ9NUU7
TreeFamiTF314957

Miscellaneous databases

GenomeRNAii55308
PROiPR:Q9NUU7

Gene expression databases

BgeeiENSG00000168872 Expressed in 108 organ(s), highest expression level in gastrocnemius
CleanExiHS_DDX19A
ExpressionAtlasiQ9NUU7 baseline and differential
GenevisibleiQ9NUU7 HS

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDD19A_HUMAN
AccessioniPrimary (citable) accession number: Q9NUU7
Secondary accession number(s): B2RPL0, B4DRZ7, Q53FM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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