UniProtKB - Q9NUU7 (DD19A_HUMAN)

BLAST

>sp|Q9NUU7|DD19A_HUMAN ATP-dependent RNA helicase DDX19A OS=Homo sapiens OX=9606 GN=DDX19A PE=1 SV=1
MATDSWALAVDEQEAAVKSMTNLQIKEEKVKADTNGIIKTSTTAEKTDEEEKEDRAAQSL
LNKLIRSNLVDNTNQVEVLQRDPNSPLYSVKSFEELRLKPQLLQGVYAMGFNRPSKIQEN
ALPMMLAEPPQNLIAQSQSGTGKTAAFVLAMLSRVEPSDRYPQCLCLSPTYELALQTGKV
IEQMGKFYPELKLAYAVRGNKLERGQKISEQIVIGTPGTVLDWCSKLKFIDPKKIKVFVL
DEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIKLKREE
ETLDTIKQYYVLCSSRDEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSKEGHQVA
LLSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKDGNPDNE
TYLHRIGRTGRFGKRGLAVNMVDSKHSMNILNRIQEHFNKKIERLDTDDLDEIEKIAN

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History
Entry version 161 (07 Nov 2018)
Sequence version 1 (01 Oct 2000)
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Protein

ATP-dependent RNA helicase DDX19A

Gene

DDX19A

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (By similarity).By similarity

Catalytic activityⁱ

ATP + H₂O = ADP + phosphate.

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	118	ATPBy similarity	1
Binding siteⁱ	428	ATPBy similarity	1
Binding siteⁱ	431	ATPBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	137 – 144	ATPPROSITE-ProRule annotation		8

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
helicase activity Source: UniProtKB-KW
RNA binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA transport Source: UniProtKB-KW
protein transport Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Helicase, Hydrolase, RNA-binding
Biological process	mRNA transport, Protein transport, Translocation, Transport
Ligand	ATP-binding, Nucleotide-binding

Protein family/group databases

TCDBⁱ	1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

TCDBⁱ

1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ATP-dependent RNA helicase DDX19A (EC:3.6.4.13) Alternative name(s): DDX19-like protein DEAD box protein 19A
Gene namesⁱ	Name:DDX19A Synonyms:DDX19L
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168872.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25628 DDX19A
neXtProtⁱ	NX_Q9NUU7

Keywords - Cellular componentⁱ

Cytoplasm, Membrane, Nuclear pore complex, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55308
Open Targets More...OpenTargetsⁱ	ENSG00000168872
PharmGKBⁱ	PA134894996

Polymorphism and mutation databases

BioMutaⁱ	DDX19A
DMDMⁱ	73919226

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000055021	2 – 478	ATP-dependent RNA helicase DDX19AAdd BLAST		477

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Cross-linkⁱ	26	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linkⁱ	26	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	42	PhosphothreonineBy similarity	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9NUU7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9NUU7
PaxDbⁱ	Q9NUU7
PeptideAtlas More...PeptideAtlasⁱ	Q9NUU7
PRIDEⁱ	Q9NUU7
ProteomicsDBⁱ	82721

PTM databases

iPTMnetⁱ	Q9NUU7
PhosphoSitePlusⁱ	Q9NUU7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000168872 Expressed in 108 organ(s), highest expression level in gastrocnemius
CleanExⁱ	HS_DDX19A
ExpressionAtlasⁱ	Q9NUU7 baseline and differential
Genevisibleⁱ	Q9NUU7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA045252 HPA066668

HPAⁱ

HPA045252
HPA066668

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
MIF4GD	A9UHW6	5	EBI-740301,EBI-373498

With

Entry

#Exp.

IntAct

Notes

MIF4GD

A9UHW6

EBI-740301,EBI-373498

Protein-protein interaction databases

BioGridⁱ	120592, 30 interactors
IntActⁱ	Q9NUU7, 17 interactors
Molecular INTeraction database More...MINTⁱ	Q9NUU7
STRINGⁱ	9606.ENSP00000306117

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NUU7
SMRⁱ	Q9NUU7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	124 – 294	Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST		171
Domainⁱ	305 – 473	Helicase C-terminalPROSITE-ProRule annotationAdd BLAST		169

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	2 – 299	N-terminal lobeBy similarityAdd BLAST	298
Regionⁱ	54 – 67	N-terminal helixBy similarityAdd BLAST	14
Regionⁱ	300 – 478	C-terminal lobeBy similarityAdd BLAST	179

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	91 – 119	Q motifAdd BLAST		29
Motifⁱ	241 – 244	DEAD box		4

Domainⁱ

The N-terminal extension helix acts as an autoinhibitory domain, preventing ATP hydrolysis, unless the N-terminus of the protein is displaced by RNA binding, allowing cleft closure to bring key side chains into position for catalysis.By similarity

Sequence similaritiesⁱ

Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0332 Eukaryota ENOG410XRGX LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063236
HOGENOMⁱ	HOG000268797
HOVERGENⁱ	HBG107989
InParanoidⁱ	Q9NUU7
KEGG Orthology (KO) More...KOⁱ	K18655
OMAⁱ	IGAKENA
PhylomeDBⁱ	Q9NUU7
TreeFamⁱ	TF314957

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00079 HELICc, 1 hit
InterProⁱ	View protein in InterPro IPR011545 DEAD/DEAH_box_helicase_dom IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR027417 P-loop_NTPase IPR014014 RNA_helicase_DEAD_Q_motif
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00270 DEAD, 1 hit PF00271 Helicase_C, 1 hit
SMARTⁱ	View protein in SMART SM00487 DEXDc, 1 hit SM00490 HELICc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit PS51195 Q_MOTIF, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9NUU7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATDSWALAV DEQEAAVKSM TNLQIKEEKV KADTNGIIKT STTAEKTDEE 
        60         70         80         90        100
EKEDRAAQSL LNKLIRSNLV DNTNQVEVLQ RDPNSPLYSV KSFEELRLKP 
       110        120        130        140        150
QLLQGVYAMG FNRPSKIQEN ALPMMLAEPP QNLIAQSQSG TGKTAAFVLA 
       160        170        180        190        200
MLSRVEPSDR YPQCLCLSPT YELALQTGKV IEQMGKFYPE LKLAYAVRGN 
       210        220        230        240        250
KLERGQKISE QIVIGTPGTV LDWCSKLKFI DPKKIKVFVL DEADVMIATQ 
       260        270        280        290        300
GHQDQSIRIQ RMLPRNCQML LFSATFEDSV WKFAQKVVPD PNVIKLKREE 
       310        320        330        340        350
ETLDTIKQYY VLCSSRDEKF QALCNLYGAI TIAQAMIFCH TRKTASWLAA 
       360        370        380        390        400
ELSKEGHQVA LLSGEMMVEQ RAAVIERFRE GKEKVLVTTN VCARGIDVEQ 
       410        420        430        440        450
VSVVINFDLP VDKDGNPDNE TYLHRIGRTG RFGKRGLAVN MVDSKHSMNI 
       460        470 
LNRIQEHFNK KIERLDTDDL DEIEKIAN

Length:478

Mass (Da):53,975

Last modified:October 1, 2000 - v1

Checksum:ⁱC51F9E1D7B8584D0

Isoform 2 (identifier: Q9NUU7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-98: MATDSWALAV...SVKSFEELRL → MSGTFLIR

« Hide

        10         20         30         40         50
MSGTFLIRKP QLLQGVYAMG FNRPSKIQEN ALPMMLAEPP QNLIAQSQSG 
        60         70         80         90        100
TGKTAAFVLA MLSRVEPSDR YPQCLCLSPT YELALQTGKV IEQMGKFYPE 
       110        120        130        140        150
LKLAYAVRGN KLERGQKISE QIVIGTPGTV LDWCSKLKFI DPKKIKVFVL 
       160        170        180        190        200
DEADVMIATQ GHQDQSIRIQ RMLPRNCQML LFSATFEDSV WKFAQKVVPD 
       210        220        230        240        250
PNVIKLKREE ETLDTIKQYY VLCSSRDEKF QALCNLYGAI TIAQAMIFCH 
       260        270        280        290        300
TRKTASWLAA ELSKEGHQVA LLSGEMMVEQ RAAVIERFRE GKEKVLVTTN 
       310        320        330        340        350
VCARGIDVEQ VSVVINFDLP VDKDGNPDNE TYLHRIGRTG RFGKRGLAVN 
       360        370        380 
MVDSKHSMNI LNRIQEHFNK KIERLDTDDL DEIEKIAN

Note: No experimental confirmation available.

Show »

Length:388

Mass (Da):43,875

Checksum:ⁱ71A5EA464F65A911

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

I3L352	I3L352_HUMAN	ATP-dependent RNA helicase DDX19A ATP-dependent RNA helicase DDX19A	DDX19A	396	Annotation score:
I3L0H8	I3L0H8_HUMAN	ATP-dependent RNA helicase DDX19A ATP-dependent RNA helicase DDX19A	DDX19A	447	Annotation score:
H3BTB3	H3BTB3_HUMAN	ATP-dependent RNA helicase DDX19A ATP-dependent RNA helicase DDX19A	DDX19A	129	Annotation score:
H3BSL8	H3BSL8_HUMAN	ATP-dependent RNA helicase DDX19A ATP-dependent RNA helicase DDX19A	DDX19A	78	Annotation score:
J3QRH0	J3QRH0_HUMAN	ATP-dependent RNA helicase DDX19A ATP-dependent RNA helicase DDX19A	DDX19A	64	Annotation score:
H3BP50	H3BP50_HUMAN	ATP-dependent RNA helicase DDX19A ATP-dependent RNA helicase DDX19A	DDX19A	51	Annotation score:
H3BP36	H3BP36_HUMAN	ATP-dependent RNA helicase DDX19A ATP-dependent RNA helicase DDX19A	DDX19A	47	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	463	E → G in BAD96982 (Ref. 2) Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056954	1 – 98	MATDS…EELRL → MSGTFLIR in isoform 2. 1 PublicationAdd BLAST		98

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK001988 mRNA Translation: BAA92022.1 AK299504 mRNA Translation: BAG61459.1 AK223262 mRNA Translation: BAD96982.1 AL832970 mRNA Translation: CAH10622.1 AC012184 Genomic DNA No translation available. CH471241 Genomic DNA Translation: EAW51826.1 BC005162 mRNA Translation: AAH05162.1 BC006544 mRNA Translation: AAH06544.1 BC137496 mRNA Translation: AAI37497.1 BC137497 mRNA Translation: AAI37498.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10889.1 [Q9NUU7-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001307451.1, NM_001320522.1 NP_001307454.1, NM_001320525.1 [Q9NUU7-2] NP_001307455.1, NM_001320526.1 NP_001307456.1, NM_001320527.1 NP_060802.1, NM_018332.4 [Q9NUU7-1]
UniGeneⁱ	Hs.656037

Genome annotation databases

Ensemblⁱ	ENST00000302243; ENSP00000306117; ENSG00000168872 [Q9NUU7-1]
GeneIDⁱ	55308
KEGGⁱ	hsa:55308
UCSC genome browser More...UCSCⁱ	uc002eyv.4 human [Q9NUU7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NUU7	DDX19A isoform 1		PANTR		478	UniRef100_Q9NUU7
Uncharacterized protein		PANPA		478
DEAD-box helicase 19A		GORGO		478
Q9NUU7-2	ATP-dependent RNA helicase DDX19A (Fragment)		HUMAN		396	UniRef100_Q9NUU7-2
DDX19A isoform 5 (Fragment)		PANTR		395

Protein	Similar proteins		Species	Score	Length	Source
Q9NUU7	ATP-dependent RNA helicase DDX19A		BOVIN		478	UniRef90_Q9NUU7
ATP-dependent RNA helicase DDX19A		MOUSE		478
DDX19A isoform 1		PANTR		478
Uncharacterized protein		PANPA		478
DEAD-box helicase 19A		GORGO		478
+233
Q9NUU7-2	ATP-dependent RNA helicase DDX19A (Fragment)		HUMAN		396	UniRef90_Q9NUU7-2
DDX19A isoform 5 (Fragment)		PANTR		395
Uncharacterized protein		ANAPL		494
ATP-dependent RNA helicase DDX19B-like (Fragment)		Asian bonytongue		443
Uncharacterized protein		LATCH		396
+6

Protein	Similar proteins		Species	Score	Length	Source
Q9NUU7	Isoform 4 of ATP-dependent RNA helicase DDX19B		HUMAN		453	UniRef50_Q9UMR2-4
ATP-dependent RNA helicase DDX19A		MOUSE		478
ATP-dependent RNA helicase DDX19A		BOVIN		478
ATP-dependent RNA helicase DDX25		XENLA		483
ATP-dependent RNA helicase DDX19B isoform X2		LEPWE		487
+674
Q9NUU7-2	ATP-dependent RNA helicase DDX19A (Fragment)		HUMAN		396	UniRef50_Q9NUU7-2
DDX19A isoform 5 (Fragment)		PANTR		395
Uncharacterized protein		ANAPL		494
ATP-dependent RNA helicase DDX19B-like (Fragment)		Asian bonytongue		443
Uncharacterized protein		LATCH		396
+119

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK001988 mRNA Translation: BAA92022.1 AK299504 mRNA Translation: BAG61459.1 AK223262 mRNA Translation: BAD96982.1 AL832970 mRNA Translation: CAH10622.1 AC012184 Genomic DNA No translation available. CH471241 Genomic DNA Translation: EAW51826.1 BC005162 mRNA Translation: AAH05162.1 BC006544 mRNA Translation: AAH06544.1 BC137496 mRNA Translation: AAI37497.1 BC137497 mRNA Translation: AAI37498.1
CCDSⁱ	CCDS10889.1 [Q9NUU7-1]
RefSeqⁱ	NP_001307451.1, NM_001320522.1 NP_001307454.1, NM_001320525.1 [Q9NUU7-2] NP_001307455.1, NM_001320526.1 NP_001307456.1, NM_001320527.1 NP_060802.1, NM_018332.4 [Q9NUU7-1]
UniGeneⁱ	Hs.656037

3D structure databases

ProteinModelPortalⁱ	Q9NUU7
SMRⁱ	Q9NUU7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120592, 30 interactors
IntActⁱ	Q9NUU7, 17 interactors
MINTⁱ	Q9NUU7
STRINGⁱ	9606.ENSP00000306117

Protein family/group databases

TCDBⁱ	1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

TCDBⁱ

1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetⁱ	Q9NUU7
PhosphoSitePlusⁱ	Q9NUU7

Polymorphism and mutation databases

BioMutaⁱ	DDX19A
DMDMⁱ	73919226

Proteomic databases

EPDⁱ	Q9NUU7
MaxQBⁱ	Q9NUU7
PaxDbⁱ	Q9NUU7
PeptideAtlasⁱ	Q9NUU7
PRIDEⁱ	Q9NUU7
ProteomicsDBⁱ	82721

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	55308
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000302243; ENSP00000306117; ENSG00000168872 [Q9NUU7-1]
GeneIDⁱ	55308
KEGGⁱ	hsa:55308
UCSCⁱ	uc002eyv.4 human [Q9NUU7-1]

Organism-specific databases

CTDⁱ	55308
DisGeNETⁱ	55308
EuPathDBⁱ	HostDB:ENSG00000168872.16
GeneCardsⁱ	DDX19A
H-InvDBⁱ	HIX0038837
HGNCⁱ	HGNC:25628 DDX19A
HPAⁱ	HPA045252 HPA066668
neXtProtⁱ	NX_Q9NUU7
OpenTargetsⁱ	ENSG00000168872
PharmGKBⁱ	PA134894996
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0332 Eukaryota ENOG410XRGX LUCA
GeneTreeⁱ	ENSGT00530000063236
HOGENOMⁱ	HOG000268797
HOVERGENⁱ	HBG107989
InParanoidⁱ	Q9NUU7
KOⁱ	K18655
OMAⁱ	IGAKENA
PhylomeDBⁱ	Q9NUU7
TreeFamⁱ	TF314957

Miscellaneous databases

GenomeRNAiⁱ	55308
Protein Ontology More...PROⁱ	PR:Q9NUU7

Gene expression databases

Bgeeⁱ	ENSG00000168872 Expressed in 108 organ(s), highest expression level in gastrocnemius
CleanExⁱ	HS_DDX19A
ExpressionAtlasⁱ	Q9NUU7 baseline and differential
Genevisibleⁱ	Q9NUU7 HS

Family and domain databases

CDDⁱ	cd00079 HELICc, 1 hit
InterProⁱ	View protein in InterPro IPR011545 DEAD/DEAH_box_helicase_dom IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR027417 P-loop_NTPase IPR014014 RNA_helicase_DEAD_Q_motif
Pfamⁱ	View protein in Pfam PF00270 DEAD, 1 hit PF00271 Helicase_C, 1 hit
SMARTⁱ	View protein in SMART SM00487 DEXDc, 1 hit SM00490 HELICc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit PS51195 Q_MOTIF, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DD19A_HUMAN
Accessionⁱ	Q9NUU7Primary (citable) accession number: Q9NUU7 Secondary accession number(s): B2RPL0, B4DRZ7, Q53FM0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
	Last sequence update:	October 1, 2000
	Last modified:	November 7, 2018
	This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NUU7 (DD19A_HUMAN)

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ATP-dependent RNA helicase DDX19A

DDX19A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ