UniProtKB - Q9NUU6 (OTULL_HUMAN)
Protein
Inactive ubiquitin thioesterase OTULINL
Gene
OTULINL
Organism
Homo sapiens (Human)
Status
Functioni
Lacks deubiquitinase activity.1 Publication
Caution
Although highly similar to the deubiquitinase OTULIN, lacks the conserved active site Cys at position 139 which is replaced by an Asp residue, and does not show deubiquitinase activity.1 Publication1 Publication
GO - Biological processi
- proteolysis Source: GOC
Enzyme and pathway databases
PathwayCommonsi | Q9NUU6 |
Names & Taxonomyi
Protein namesi | Recommended name: Inactive ubiquitin thioesterase OTULINL |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000145569.5 |
HGNCi | HGNC:25629, OTULINL |
neXtProti | NX_Q9NUU6 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Peripheral membrane protein 1 Publication
Nucleus
- Nucleus envelope 1 Publication
Other locations
- Cytoplasm 1 Publication
Endoplasmic reticulum
- extrinsic component of endoplasmic reticulum membrane Source: UniProtKB
Nucleus
- nuclear envelope Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulum, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 2 – 83 | Missing : Loss of membrane binding. 1 PublicationAdd BLAST | 82 | |
Mutagenesisi | 139 | D → C: Fails to confer catalytic activity; when associated with N-352. 1 Publication | 1 | |
Mutagenesisi | 352 | H → N: Fails to confer catalytic activity; when associated with C-139. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 54491 |
OpenTargetsi | ENSG00000145569 |
PharmGKBi | PA142671788 |
Miscellaneous databases
Pharosi | Q9NUU6, Tdark |
Polymorphism and mutation databases
BioMutai | FAM105A |
DMDMi | 74734394 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000274404 | 1 – 356 | Inactive ubiquitin thioesterase OTULINLAdd BLAST | 356 |
Proteomic databases
EPDi | Q9NUU6 |
jPOSTi | Q9NUU6 |
MassIVEi | Q9NUU6 |
MaxQBi | Q9NUU6 |
PaxDbi | Q9NUU6 |
PeptideAtlasi | Q9NUU6 |
PRIDEi | Q9NUU6 |
ProteomicsDBi | 82720 |
PTM databases
iPTMneti | Q9NUU6 |
PhosphoSitePlusi | Q9NUU6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000145569, Expressed in right lung and 183 other tissues |
Genevisiblei | Q9NUU6, HS |
Organism-specific databases
HPAi | ENSG00000145569, Tissue enhanced (bone) |
Interactioni
Subunit structurei
Does not bind ubiquitin or ubiquitin-like proteins.
1 PublicationBinary interactionsi
Hide detailsQ9NUU6
Protein-protein interaction databases
BioGRIDi | 119988, 401 interactors |
IntActi | Q9NUU6, 10 interactors |
STRINGi | 9606.ENSP00000274217 |
Miscellaneous databases
RNActi | Q9NUU6, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9NUU6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 128 – 356 | OTUPROSITE-ProRule annotationAdd BLAST | 229 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 83 | Required for membrane binding1 PublicationAdd BLAST | 83 |
Domaini
The N-terminal region that precedes the OTU domain mediates interaction with cellular membranes.1 Publication
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502QVY0, Eukaryota |
GeneTreei | ENSGT00390000009802 |
HOGENOMi | CLU_051856_0_0_1 |
InParanoidi | Q9NUU6 |
OMAi | EHKLYEA |
OrthoDBi | 1416236at2759 |
PhylomeDBi | Q9NUU6 |
TreeFami | TF328709 |
Family and domain databases
InterProi | View protein in InterPro IPR023235, FAM105 IPR023236, OTULINL |
PANTHERi | PTHR33662, PTHR33662, 1 hit |
Pfami | View protein in Pfam PF16218, Peptidase_C101, 1 hit |
PRINTSi | PR02055, PROTEINF105 PR02056, PROTEINF105A |
i Sequence
Sequence statusi: Complete.
Q9NUU6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAATRSPTRA RERERSGAPA AGSDQVHSWM LATSQALDTV WRMAKGFVML
60 70 80 90 100
AVSFLVAAIC YFRRLHLYSG HKLKWWIGYL QRKFKRNLSV EAEVDLLSYC
110 120 130 140 150
AREWKGETPR NKLMRKAYEE LFWRHHIKCV RQVRRDNYDA LRSVLFQIFS
160 170 180 190 200
QGISFPSWMK EKDIVKLPEK LLFSQGCNWI QQYSFGPEKY TGSNVFGKLR
210 220 230 240 250
KYVELLKTQW TEFNGIRDYH KRGSMCNTLF SDAILEYKLY EALKFIMLYQ
260 270 280 290 300
VTEVYEQMKT KKVIPSLFRL LFSRETSSDP LSFMMNHLNS VGDTCGLEQI
310 320 330 340 350
DMFILGYSLE VKIKVFRLFK FNSRDFEVCY PEEPLRDWPE ISLLTENDRH
YHIPVF
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 322 | N → I in BAD96451 (Ref. 2) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030281 | 319 | F → L. Corresponds to variant dbSNP:rs16903574Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001989 mRNA Translation: BAA92023.1 AK222731 mRNA Translation: BAD96451.1 BC011524 mRNA Translation: AAH11524.1 AL512750 mRNA Translation: CAC21673.1 |
CCDSi | CCDS3884.1 |
RefSeqi | NP_061891.1, NM_019018.2 |
Genome annotation databases
Ensembli | ENST00000274217; ENSP00000274217; ENSG00000145569 |
GeneIDi | 54491 |
KEGGi | hsa:54491 |
UCSCi | uc003jfj.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001989 mRNA Translation: BAA92023.1 AK222731 mRNA Translation: BAD96451.1 BC011524 mRNA Translation: AAH11524.1 AL512750 mRNA Translation: CAC21673.1 |
CCDSi | CCDS3884.1 |
RefSeqi | NP_061891.1, NM_019018.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6DRM | X-ray | 2.06 | A | 87-356 | [»] | |
SMRi | Q9NUU6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119988, 401 interactors |
IntActi | Q9NUU6, 10 interactors |
STRINGi | 9606.ENSP00000274217 |
PTM databases
iPTMneti | Q9NUU6 |
PhosphoSitePlusi | Q9NUU6 |
Polymorphism and mutation databases
BioMutai | FAM105A |
DMDMi | 74734394 |
Proteomic databases
EPDi | Q9NUU6 |
jPOSTi | Q9NUU6 |
MassIVEi | Q9NUU6 |
MaxQBi | Q9NUU6 |
PaxDbi | Q9NUU6 |
PeptideAtlasi | Q9NUU6 |
PRIDEi | Q9NUU6 |
ProteomicsDBi | 82720 |
Protocols and materials databases
Antibodypediai | 22546, 124 antibodies |
DNASUi | 54491 |
Genome annotation databases
Ensembli | ENST00000274217; ENSP00000274217; ENSG00000145569 |
GeneIDi | 54491 |
KEGGi | hsa:54491 |
UCSCi | uc003jfj.4, human |
Organism-specific databases
CTDi | 54491 |
DisGeNETi | 54491 |
EuPathDBi | HostDB:ENSG00000145569.5 |
GeneCardsi | OTULINL |
HGNCi | HGNC:25629, OTULINL |
HPAi | ENSG00000145569, Tissue enhanced (bone) |
neXtProti | NX_Q9NUU6 |
OpenTargetsi | ENSG00000145569 |
PharmGKBi | PA142671788 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QVY0, Eukaryota |
GeneTreei | ENSGT00390000009802 |
HOGENOMi | CLU_051856_0_0_1 |
InParanoidi | Q9NUU6 |
OMAi | EHKLYEA |
OrthoDBi | 1416236at2759 |
PhylomeDBi | Q9NUU6 |
TreeFami | TF328709 |
Enzyme and pathway databases
PathwayCommonsi | Q9NUU6 |
Miscellaneous databases
BioGRID-ORCSi | 54491, 3 hits in 848 CRISPR screens |
ChiTaRSi | FAM105A, human |
GenomeRNAii | 54491 |
Pharosi | Q9NUU6, Tdark |
PROi | PR:Q9NUU6 |
RNActi | Q9NUU6, protein |
Gene expression databases
Bgeei | ENSG00000145569, Expressed in right lung and 183 other tissues |
Genevisiblei | Q9NUU6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR023235, FAM105 IPR023236, OTULINL |
PANTHERi | PTHR33662, PTHR33662, 1 hit |
Pfami | View protein in Pfam PF16218, Peptidase_C101, 1 hit |
PRINTSi | PR02055, PROTEINF105 PR02056, PROTEINF105A |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | OTULL_HUMAN | |
Accessioni | Q9NUU6Primary (citable) accession number: Q9NUU6 Secondary accession number(s): Q53H50, Q9H037 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2007 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Peptidase families
Classification of peptidase families and list of entries