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UniProtKB - Q9NUU6 (OTULL_HUMAN)

Entry version 118 (02 Dec 2020)
Sequence version 1 (01 Oct 2000)
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Protein

Inactive ubiquitin thioesterase OTULINL

Gene

OTULINL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Lacks deubiquitinase activity.1 Publication

Caution

Although highly similar to the deubiquitinase OTULIN, lacks the conserved active site Cys at position 139 which is replaced by an Asp residue, and does not show deubiquitinase activity.1 Publication1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NUU6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inactive ubiquitin thioesterase OTULINL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OTULINL1 PublicationImported
Synonyms:FAM105A1 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000145569.5

Human Gene Nomenclature Database

More...HGNCi		HGNC:25629, OTULINL

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NUU6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2 – 83Missing : Loss of membrane binding. 1 PublicationAdd BLAST82
Mutagenesisi139D → C: Fails to confer catalytic activity; when associated with N-352. 1 Publication1
Mutagenesisi352H → N: Fails to confer catalytic activity; when associated with C-139. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		54491

Open Targets

More...OpenTargetsi		ENSG00000145569

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671788

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NUU6, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FAM105A

Domain mapping of disease mutations (DMDM)

More...DMDMi		74734394

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002744041 – 356Inactive ubiquitin thioesterase OTULINLAdd BLAST356

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NUU6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NUU6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NUU6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NUU6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NUU6

PeptideAtlas

More...PeptideAtlasi		Q9NUU6

PRoteomics IDEntifications database

More...PRIDEi		Q9NUU6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82720

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NUU6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NUU6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000145569, Expressed in right lung and 183 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NUU6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000145569, Tissue enhanced (bone)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Does not bind ubiquitin or ubiquitin-like proteins.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119988, 401 interactors

Protein interaction database and analysis system

More...IntActi		Q9NUU6, 10 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000274217

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NUU6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1356
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NUU6

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini128 – 356OTUPROSITE-ProRule annotationAdd BLAST229

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 83Required for membrane binding1 PublicationAdd BLAST83

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal region that precedes the OTU domain mediates interaction with cellular membranes.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C65 family. Otulin subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QVY0, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000009802

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_051856_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NUU6

Identification of Orthologs from Complete Genome Data

More...OMAi		EHKLYEA

Database of Orthologous Groups

More...OrthoDBi		1416236at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NUU6

TreeFam database of animal gene trees

More...TreeFami		TF328709

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR023235, FAM105
IPR023236, OTULINL

The PANTHER Classification System

More...PANTHERi		PTHR33662, PTHR33662, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16218, Peptidase_C101, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR02055, PROTEINF105
PR02056, PROTEINF105A

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9NUU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAATRSPTRA RERERSGAPA AGSDQVHSWM LATSQALDTV WRMAKGFVML 
        60         70         80         90        100
AVSFLVAAIC YFRRLHLYSG HKLKWWIGYL QRKFKRNLSV EAEVDLLSYC 
       110        120        130        140        150
AREWKGETPR NKLMRKAYEE LFWRHHIKCV RQVRRDNYDA LRSVLFQIFS 
       160        170        180        190        200
QGISFPSWMK EKDIVKLPEK LLFSQGCNWI QQYSFGPEKY TGSNVFGKLR 
       210        220        230        240        250
KYVELLKTQW TEFNGIRDYH KRGSMCNTLF SDAILEYKLY EALKFIMLYQ 
       260        270        280        290        300
VTEVYEQMKT KKVIPSLFRL LFSRETSSDP LSFMMNHLNS VGDTCGLEQI 
       310        320        330        340        350
DMFILGYSLE VKIKVFRLFK FNSRDFEVCY PEEPLRDWPE ISLLTENDRH 

YHIPVF
Length:356
Mass (Da):42,196
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i91EEC6C877D5315B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti322N → I in BAD96451 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030281319F → L. Corresponds to variant dbSNP:rs16903574Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK001989 mRNA Translation: BAA92023.1
AK222731 mRNA Translation: BAD96451.1
BC011524 mRNA Translation: AAH11524.1
AL512750 mRNA Translation: CAC21673.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3884.1

NCBI Reference Sequences

More...RefSeqi		NP_061891.1, NM_019018.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000274217; ENSP00000274217; ENSG00000145569

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54491

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54491

UCSC genome browser

More...UCSCi		uc003jfj.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001989 mRNA Translation: BAA92023.1
AK222731 mRNA Translation: BAD96451.1
BC011524 mRNA Translation: AAH11524.1
AL512750 mRNA Translation: CAC21673.1
CCDSiCCDS3884.1
RefSeqiNP_061891.1, NM_019018.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6DRMX-ray2.06A87-356[»]
SMRiQ9NUU6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119988, 401 interactors
IntActiQ9NUU6, 10 interactors
STRINGi9606.ENSP00000274217

PTM databases

iPTMnetiQ9NUU6
PhosphoSitePlusiQ9NUU6

Polymorphism and mutation databases

BioMutaiFAM105A
DMDMi74734394

Proteomic databases

EPDiQ9NUU6
jPOSTiQ9NUU6
MassIVEiQ9NUU6
MaxQBiQ9NUU6
PaxDbiQ9NUU6
PeptideAtlasiQ9NUU6
PRIDEiQ9NUU6
ProteomicsDBi82720

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		22546, 124 antibodies

The DNASU plasmid repository

More...DNASUi		54491

Genome annotation databases

EnsembliENST00000274217; ENSP00000274217; ENSG00000145569
GeneIDi54491
KEGGihsa:54491
UCSCiuc003jfj.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54491
DisGeNETi54491
EuPathDBiHostDB:ENSG00000145569.5

GeneCards: human genes, protein and diseases

More...GeneCardsi		OTULINL
HGNCiHGNC:25629, OTULINL
HPAiENSG00000145569, Tissue enhanced (bone)
neXtProtiNX_Q9NUU6
OpenTargetsiENSG00000145569
PharmGKBiPA142671788

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QVY0, Eukaryota
GeneTreeiENSGT00390000009802
HOGENOMiCLU_051856_0_0_1
InParanoidiQ9NUU6
OMAiEHKLYEA
OrthoDBi1416236at2759
PhylomeDBiQ9NUU6
TreeFamiTF328709

Enzyme and pathway databases

PathwayCommonsiQ9NUU6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54491, 3 hits in 848 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FAM105A, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54491
PharosiQ9NUU6, Tdark

Protein Ontology

More...PROi		PR:Q9NUU6
RNActiQ9NUU6, protein

Gene expression databases

BgeeiENSG00000145569, Expressed in right lung and 183 other tissues
GenevisibleiQ9NUU6, HS

Family and domain databases

InterProiView protein in InterPro
IPR023235, FAM105
IPR023236, OTULINL
PANTHERiPTHR33662, PTHR33662, 1 hit
PfamiView protein in Pfam
PF16218, Peptidase_C101, 1 hit
PRINTSiPR02055, PROTEINF105
PR02056, PROTEINF105A

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOTULL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NUU6
Secondary accession number(s): Q53H50, Q9H037
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 1, 2000
Last modified: December 2, 2020
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Peptidase families
    Classification of peptidase families and list of entries
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