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Protein

Transmembrane protein 74B

Gene

TMEM74B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 74B
Gene namesi
Name:TMEM74B
Synonyms:C20orf46
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125895.5
HGNCiHGNC:15893 TMEM74B
neXtProtiNX_Q9NUR3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000125895
PharmGKBiPA25759

Polymorphism and mutation databases

BioMutaiTMEM74B
DMDMi27734260

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000794311 – 256Transmembrane protein 74BAdd BLAST256

Proteomic databases

PaxDbiQ9NUR3
PeptideAtlasiQ9NUR3
PRIDEiQ9NUR3
ProteomicsDBi82715

PTM databases

iPTMnetiQ9NUR3
PhosphoSitePlusiQ9NUR3

Expressioni

Gene expression databases

BgeeiENSG00000125895 Expressed in 122 organ(s), highest expression level in right lung
CleanExiHS_C20orf46
ExpressionAtlasiQ9NUR3 baseline and differential
GenevisibleiQ9NUR3 HS

Organism-specific databases

HPAiHPA045213

Interactioni

Protein-protein interaction databases

IntActiQ9NUR3, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ9NUR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM74 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW2S Eukaryota
ENOG4111X0T LUCA
GeneTreeiENSGT00530000063880
HOGENOMiHOG000112021
HOVERGENiHBG051165
InParanoidiQ9NUR3
OMAiEEHETHF
OrthoDBiEOG091G0NPC
PhylomeDBiQ9NUR3
TreeFamiTF335735

Family and domain databases

InterProiView protein in InterPro
IPR029695 TMEM74-like
PANTHERiPTHR16125 PTHR16125, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q9NUR3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPAQGYEFA AAKGPRDELG PSFPMASPPG LELKTLSNGP QAPRRSAPLG
60 70 80 90 100
PVAPTREGVE NACFSSEEHE THFQNPGNTR LGSSPSPPGG VSSLPRSQRD
110 120 130 140 150
DLSLHSEEGP ALEPVSRPVD YGFVSALVFL VSGILLVVTA YAIPREARVN
160 170 180 190 200
PDTVTAREME RLEMYYARLG SHLDRCIIAG LGLLTVGGML LSVLLMVSLC
210 220 230 240 250
KGELYRRRTF VPGKGSRKTY GSINLRMRQL NGDGGQALVE NEVVQVSETS

HTLQRS
Length:256
Mass (Da):27,551
Last modified:October 1, 2000 - v1
Checksum:i0824103831C4668A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5QPM3Q5QPM3_HUMAN
Transmembrane protein 74B
TMEM74B
154Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03375733L → M. Corresponds to variant dbSNP:rs35393697Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002052 mRNA Translation: BAA92058.1
AL031665 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10647.1
CH471133 Genomic DNA Translation: EAX10648.1
CCDSiCCDS13011.1
RefSeqiNP_001291677.1, NM_001304748.1
NP_001291678.1, NM_001304749.1
NP_060824.1, NM_018354.2
XP_011527584.1, XM_011529282.2
XP_011527585.1, XM_011529283.2
XP_011527586.1, XM_011529284.2
XP_016883413.1, XM_017027924.1
UniGeneiHs.516834
Hs.744640

Genome annotation databases

EnsembliENST00000381894; ENSP00000371318; ENSG00000125895
GeneIDi55321
KEGGihsa:55321
UCSCiuc002weq.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTM74B_HUMAN
AccessioniPrimary (citable) accession number: Q9NUR3
Secondary accession number(s): D3DVW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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