Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 139 (18 Sep 2019)
Sequence version 1 (01 Oct 2000)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Protein FAM49B

Gene

FAM49B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-114608 Platelet degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM49B
Alternative name(s):
L1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM49B
ORF Names:BM-009
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25216 FAM49B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617978 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NUQ9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51571

Open Targets

More...
OpenTargetsi
ENSG00000153310

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134990565

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM49B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
52782794

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001870602 – 324Protein FAM49BAdd BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine1 Publication1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NUQ9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NUQ9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NUQ9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NUQ9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NUQ9

PeptideAtlas

More...
PeptideAtlasi
Q9NUQ9

PRoteomics IDEntifications database

More...
PRIDEi
Q9NUQ9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82714 [Q9NUQ9-1]
82891

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NUQ9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NUQ9

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9NUQ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000153310 Expressed in 224 organ(s), highest expression level in caudate nucleus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NUQ9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NUQ9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA009076

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
NIF3L1Q9GZT83EBI-1055930,EBI-740897

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119617, 21 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NUQ9, 11 interactors

Molecular INTeraction database

More...
MINTi
Q9NUQ9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000429150

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NUQ9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM49 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3951 Eukaryota
ENOG410XQDW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015159

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007560

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NUQ9

Identification of Orthologs from Complete Genome Data

More...
OMAi
VHPQGAF

Database of Orthologous Groups

More...
OrthoDBi
1129868at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NUQ9

TreeFam database of animal gene trees

More...
TreeFami
TF314541

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009828 DUF1394
IPR039789 FAM49

The PANTHER Classification System

More...
PANTHERi
PTHR12422 PTHR12422, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07159 DUF1394, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NUQ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNLLKVLTC TDLEQGPNFF LDFENAQPTE SEKEIYNQVN VVLKDAEGIL
60 70 80 90 100
EDLQSYRGAG HEIREAIQHP ADEKLQEKAW GAVVPLVGKL KKFYEFSQRL
110 120 130 140 150
EAALRGLLGA LTSTPYSPTQ HLEREQALAK QFAEILHFTL RFDELKMTNP
160 170 180 190 200
AIQNDFSYYR RTLSRMRINN VPAEGENEVN NELANRMSLF YAEATPMLKT
210 220 230 240 250
LSDATTKFVS ENKNLPIENT TDCLSTMASV CRVMLETPEY RSRFTNEETV
260 270 280 290 300
SFCLRVMVGV IILYDHVHPV GAFAKTSKID MKGCIKVLKD QPPNSVEGLL
310 320
NALRYTTKHL NDETTSKQIK SMLQ
Length:324
Mass (Da):36,748
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE370E3D170A6E38
GO
Isoform 2 (identifier: Q9NUQ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-146: Missing.

Note: No experimental confirmation available.
Show »
Length:178
Mass (Da):20,193
Checksum:i6B1EB5EC8FC79566
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RFS4E5RFS4_HUMAN
Protein FAM49B
FAM49B
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHU5E5RHU5_HUMAN
Protein FAM49B
FAM49B
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RI16E5RI16_HUMAN
Protein FAM49B
FAM49B
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIR8E5RIR8_HUMAN
Protein FAM49B
FAM49B
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJE1E5RJE1_HUMAN
Protein FAM49B
FAM49B
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJL8E5RJL8_HUMAN
Protein FAM49B
FAM49B
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RK61E5RK61_HUMAN
Protein FAM49B
FAM49B
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGI7E5RGI7_HUMAN
Protein FAM49B
FAM49B
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RH75E5RH75_HUMAN
Protein FAM49B
FAM49B
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RK81E5RK81_HUMAN
Protein FAM49B
FAM49B
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF64265 differs from that shown. Reason: Frameshift at positions 65, 90, 126, 169, 172, 252 and 292.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019704169N → K2 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0565031 – 146Missing in isoform 2. 1 PublicationAdd BLAST146

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF208851 mRNA Translation: AAF64265.1 Frameshift.
AY598320 mRNA Translation: AAT06731.1
AK001226 mRNA Translation: BAA91566.1
AK002059 mRNA Translation: BAA92062.1
AC022973 Genomic DNA No translation available.
AC131568 Genomic DNA No translation available.
BC003599 mRNA Translation: AAH03599.1
BC016345 mRNA Translation: AAH16345.1
BC017297 mRNA Translation: AAH17297.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6361.1 [Q9NUQ9-1]
CCDS83327.1 [Q9NUQ9-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001243692.1, NM_001256763.1 [Q9NUQ9-1]
NP_001317541.1, NM_001330612.1 [Q9NUQ9-2]
NP_057707.3, NM_016623.4 [Q9NUQ9-1]
XP_011515410.1, XM_011517108.2
XP_011515411.1, XM_011517109.2
XP_011515412.1, XM_011517110.2
XP_011515413.1, XM_011517111.2
XP_011515414.1, XM_011517112.2 [Q9NUQ9-1]
XP_011515415.1, XM_011517113.2
XP_011515416.1, XM_011517114.2
XP_011515417.1, XM_011517115.2
XP_011515423.1, XM_011517121.2 [Q9NUQ9-1]
XP_011515424.1, XM_011517122.2
XP_011515425.1, XM_011517123.2
XP_011515426.1, XM_011517124.2
XP_011515427.1, XM_011517125.2
XP_016869028.1, XM_017013539.1
XP_016869029.1, XM_017013540.1
XP_016869030.1, XM_017013541.1
XP_016869031.1, XM_017013542.1
XP_016869032.1, XM_017013543.1
XP_016869033.1, XM_017013544.1
XP_016869034.1, XM_017013545.1 [Q9NUQ9-1]
XP_016869035.1, XM_017013546.1
XP_016869036.1, XM_017013547.1
XP_016869037.1, XM_017013548.1 [Q9NUQ9-1]
XP_016869038.1, XM_017013549.1
XP_016869039.1, XM_017013550.1
XP_016869040.1, XM_017013551.1 [Q9NUQ9-1]
XP_016869047.1, XM_017013558.1
XP_016869048.1, XM_017013559.1
XP_016869049.1, XM_017013560.1
XP_016869050.1, XM_017013561.1
XP_016869051.1, XM_017013562.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000401979; ENSP00000384880; ENSG00000153310 [Q9NUQ9-1]
ENST00000517654; ENSP00000430674; ENSG00000153310 [Q9NUQ9-1]
ENST00000519110; ENSP00000429078; ENSG00000153310 [Q9NUQ9-1]
ENST00000519540; ENSP00000429499; ENSG00000153310 [Q9NUQ9-1]
ENST00000519824; ENSP00000429150; ENSG00000153310 [Q9NUQ9-1]
ENST00000522250; ENSP00000429978; ENSG00000153310 [Q9NUQ9-2]
ENST00000522746; ENSP00000428117; ENSG00000153310 [Q9NUQ9-1]
ENST00000522941; ENSP00000430433; ENSG00000153310 [Q9NUQ9-2]
ENST00000523509; ENSP00000429802; ENSG00000153310 [Q9NUQ9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51571

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51571

UCSC genome browser

More...
UCSCi
uc003yss.5 human [Q9NUQ9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208851 mRNA Translation: AAF64265.1 Frameshift.
AY598320 mRNA Translation: AAT06731.1
AK001226 mRNA Translation: BAA91566.1
AK002059 mRNA Translation: BAA92062.1
AC022973 Genomic DNA No translation available.
AC131568 Genomic DNA No translation available.
BC003599 mRNA Translation: AAH03599.1
BC016345 mRNA Translation: AAH16345.1
BC017297 mRNA Translation: AAH17297.1
CCDSiCCDS6361.1 [Q9NUQ9-1]
CCDS83327.1 [Q9NUQ9-2]
RefSeqiNP_001243692.1, NM_001256763.1 [Q9NUQ9-1]
NP_001317541.1, NM_001330612.1 [Q9NUQ9-2]
NP_057707.3, NM_016623.4 [Q9NUQ9-1]
XP_011515410.1, XM_011517108.2
XP_011515411.1, XM_011517109.2
XP_011515412.1, XM_011517110.2
XP_011515413.1, XM_011517111.2
XP_011515414.1, XM_011517112.2 [Q9NUQ9-1]
XP_011515415.1, XM_011517113.2
XP_011515416.1, XM_011517114.2
XP_011515417.1, XM_011517115.2
XP_011515423.1, XM_011517121.2 [Q9NUQ9-1]
XP_011515424.1, XM_011517122.2
XP_011515425.1, XM_011517123.2
XP_011515426.1, XM_011517124.2
XP_011515427.1, XM_011517125.2
XP_016869028.1, XM_017013539.1
XP_016869029.1, XM_017013540.1
XP_016869030.1, XM_017013541.1
XP_016869031.1, XM_017013542.1
XP_016869032.1, XM_017013543.1
XP_016869033.1, XM_017013544.1
XP_016869034.1, XM_017013545.1 [Q9NUQ9-1]
XP_016869035.1, XM_017013546.1
XP_016869036.1, XM_017013547.1
XP_016869037.1, XM_017013548.1 [Q9NUQ9-1]
XP_016869038.1, XM_017013549.1
XP_016869039.1, XM_017013550.1
XP_016869040.1, XM_017013551.1 [Q9NUQ9-1]
XP_016869047.1, XM_017013558.1
XP_016869048.1, XM_017013559.1
XP_016869049.1, XM_017013560.1
XP_016869050.1, XM_017013561.1
XP_016869051.1, XM_017013562.1

3D structure databases

SMRiQ9NUQ9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi119617, 21 interactors
IntActiQ9NUQ9, 11 interactors
MINTiQ9NUQ9
STRINGi9606.ENSP00000429150

PTM databases

iPTMnetiQ9NUQ9
PhosphoSitePlusiQ9NUQ9
SwissPalmiQ9NUQ9

Polymorphism and mutation databases

BioMutaiFAM49B
DMDMi52782794

Proteomic databases

EPDiQ9NUQ9
jPOSTiQ9NUQ9
MassIVEiQ9NUQ9
MaxQBiQ9NUQ9
PaxDbiQ9NUQ9
PeptideAtlasiQ9NUQ9
PRIDEiQ9NUQ9
ProteomicsDBi82714 [Q9NUQ9-1]
82891

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51571
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000401979; ENSP00000384880; ENSG00000153310 [Q9NUQ9-1]
ENST00000517654; ENSP00000430674; ENSG00000153310 [Q9NUQ9-1]
ENST00000519110; ENSP00000429078; ENSG00000153310 [Q9NUQ9-1]
ENST00000519540; ENSP00000429499; ENSG00000153310 [Q9NUQ9-1]
ENST00000519824; ENSP00000429150; ENSG00000153310 [Q9NUQ9-1]
ENST00000522250; ENSP00000429978; ENSG00000153310 [Q9NUQ9-2]
ENST00000522746; ENSP00000428117; ENSG00000153310 [Q9NUQ9-1]
ENST00000522941; ENSP00000430433; ENSG00000153310 [Q9NUQ9-2]
ENST00000523509; ENSP00000429802; ENSG00000153310 [Q9NUQ9-1]
GeneIDi51571
KEGGihsa:51571
UCSCiuc003yss.5 human [Q9NUQ9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51571
DisGeNETi51571

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM49B
HGNCiHGNC:25216 FAM49B
HPAiHPA009076
MIMi617978 gene
neXtProtiNX_Q9NUQ9
OpenTargetsiENSG00000153310
PharmGKBiPA134990565

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3951 Eukaryota
ENOG410XQDW LUCA
GeneTreeiENSGT00390000015159
HOGENOMiHOG000007560
InParanoidiQ9NUQ9
OMAiVHPQGAF
OrthoDBi1129868at2759
PhylomeDBiQ9NUQ9
TreeFamiTF314541

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAM49B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51571

Pharos

More...
Pharosi
Q9NUQ9

Protein Ontology

More...
PROi
PR:Q9NUQ9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000153310 Expressed in 224 organ(s), highest expression level in caudate nucleus
ExpressionAtlasiQ9NUQ9 baseline and differential
GenevisibleiQ9NUQ9 HS

Family and domain databases

InterProiView protein in InterPro
IPR009828 DUF1394
IPR039789 FAM49
PANTHERiPTHR12422 PTHR12422, 1 hit
PfamiView protein in Pfam
PF07159 DUF1394, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFA49B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NUQ9
Secondary accession number(s): Q96AZ5, Q9NW21, Q9NZE7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: October 1, 2000
Last modified: September 18, 2019
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again