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Protein

ATP-binding cassette sub-family F member 3

Gene

ABCF3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B.By similarity

Caution

Lacks transmembrane domains and is probably not involved in transport.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi210 – 217ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi525 – 532ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAntiviral defense
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family F member 3
Gene namesi
Name:ABCF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000161204.11
HGNCiHGNC:72 ABCF3
neXtProtiNX_Q9NUQ8

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000161204
PharmGKBiPA24407

Polymorphism and mutation databases

BioMutaiABCF3
DMDMi114149223

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002480422 – 709ATP-binding cassette sub-family F member 3Add BLAST708

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei83PhosphoserineCombined sources1
Modified residuei155PhosphoserineCombined sources1
Modified residuei157PhosphoserineCombined sources1
Modified residuei161PhosphoserineCombined sources1
Modified residuei283PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NUQ8
MaxQBiQ9NUQ8
PaxDbiQ9NUQ8
PeptideAtlasiQ9NUQ8
PRIDEiQ9NUQ8
ProteomicsDBi82712
82713 [Q9NUQ8-2]

PTM databases

iPTMnetiQ9NUQ8
PhosphoSitePlusiQ9NUQ8

Expressioni

Gene expression databases

BgeeiENSG00000161204 Expressed in 201 organ(s), highest expression level in right adrenal gland
CleanExiHS_ABCF3
ExpressionAtlasiQ9NUQ8 baseline and differential
GenevisibleiQ9NUQ8 HS

Organism-specific databases

HPAiHPA036332

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120605, 31 interactors
IntActiQ9NUQ8, 20 interactors
MINTiQ9NUQ8
STRINGi9606.ENSP00000411471

Structurei

3D structure databases

ProteinModelPortaliQ9NUQ8
SMRiQ9NUQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini178 – 424ABC transporter 1PROSITE-ProRule annotationAdd BLAST247
Domaini492 – 707ABC transporter 2PROSITE-ProRule annotationAdd BLAST216

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0927 Eukaryota
COG0488 LUCA
GeneTreeiENSGT00630000089843
HOGENOMiHOG000271637
HOVERGENiHBG050440
InParanoidiQ9NUQ8
KOiK06158
OMAiEHEWAGD
OrthoDBiEOG091G031N
PhylomeDBiQ9NUQ8
TreeFamiTF105209

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR032781 ABC_tran_Xtn
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00005 ABC_tran, 2 hits
PF12848 ABC_tran_Xtn, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 3 hits
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: Q9NUQ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATCAEILRS EFPEIDGQVF DYVTGVLHSG SADFESVDDL VEAVGELLQE
60 70 80 90 100
VSGDSKDDAG IRAVCQRMYN TLRLAEPQSQ GNSQVLLDAP IQLSKITENY
110 120 130 140 150
DCGTKLPGLL KREQSSTVNA KKLEKAEARL KAKQEKRSEK DTLKTSNPLV
160 170 180 190 200
LEEASASQAG SRKESRLESS GKNKSYDVRI ENFDVSFGDR VLLAGADVNL
210 220 230 240 250
AWGRRYGLVG RNGLGKTTLL KMLATRSLRV PAHISLLHVE QEVAGDDTPA
260 270 280 290 300
LQSVLESDSV REDLLRRERE LTAQIAAGRA EGSEAAELAE IYAKLEEIEA
310 320 330 340 350
DKAPARASVI LAGLGFTPKM QQQPTREFSG GWRMRLALAR ALFARPDLLL
360 370 380 390 400
LDEPTNMLDV RAILWLENYL QTWPSTILVV SHDRNFLNAI ATDIIHLHSQ
410 420 430 440 450
RLDGYRGDFE TFIKSKQERL LNQQREYEAQ QQYRQHIQVF IDRFRYNANR
460 470 480 490 500
ASQVQSKLKM LEKLPELKPV DKESEVVMKF PDGFEKFSPP ILQLDEVDFY
510 520 530 540 550
YDPKHVIFSR LSVSADLESR ICVVGENGAG KSTMLKLLLG DLAPVRGIRH
560 570 580 590 600
AHRNLKIGYF SQHHVEQLDL NVSAVELLAR KFPGRPEEEY RHQLGRYGIS
610 620 630 640 650
GELAMRPLAS LSGGQKSRVA FAQMTMPCPN FYILDEPTNH LDMETIEALG
660 670 680 690 700
RALNNFRGGV ILVSHDERFI RLVCRELWVC EGGGVTRVEG GFDQYRALLQ

EQFRREGFL
Length:709
Mass (Da):79,745
Last modified:September 5, 2006 - v2
Checksum:iE7E0FDB6426F3F60
GO
Isoform 2 (identifier: Q9NUQ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-74: Missing.

Show »
Length:703
Mass (Da):78,984
Checksum:iF952B10FD525CEB7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WCU6F8WCU6_HUMAN
ATP-binding cassette sub-family F m...
ABCF3
103Annotation score:

Sequence cautioni

The sequence BAB14989 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti231P → S in BAC03881 (PubMed:14702039).Curated1
Sequence conflicti289A → G in BAB14989 (PubMed:14702039).Curated1
Sequence conflicti468K → R in BAA92063 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027247503P → L1 PublicationCorresponds to variant dbSNP:rs11706273Ensembl.1
Natural variantiVAR_027248510R → H. Corresponds to variant dbSNP:rs9811715Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02014269 – 74Missing in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002060 mRNA Translation: BAA92063.1
AK024758 mRNA Translation: BAB14989.1 Different initiation.
AK092415 mRNA Translation: BAC03881.1
AK290106 mRNA Translation: BAF82795.1
BC009253 mRNA Translation: AAH09253.1
BC051754 mRNA Translation: AAH51754.1
BC051884 mRNA Translation: AAH51884.2
CCDSiCCDS3254.1 [Q9NUQ8-1]
CCDS87173.1 [Q9NUQ8-2]
RefSeqiNP_060828.2, NM_018358.2 [Q9NUQ8-1]
UniGeneiHs.361323

Genome annotation databases

EnsembliENST00000292808; ENSP00000292808; ENSG00000161204 [Q9NUQ8-2]
ENST00000429586; ENSP00000411471; ENSG00000161204 [Q9NUQ8-1]
GeneIDi55324
KEGGihsa:55324
UCSCiuc003fmz.3 human [Q9NUQ8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiABCF3_HUMAN
AccessioniPrimary (citable) accession number: Q9NUQ8
Secondary accession number(s): A8K241
, Q86UA2, Q8NAN1, Q96GS8, Q9H7A8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: September 12, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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