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Protein

Gamma-taxilin

Gene

TXLNG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression.2 Publications

Miscellaneous

Depletion of TXLNG by siRNA decreases the percentage of Hep-G2 cells arrested in G1 phase.

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB
  • syntaxin binding Source: InterPro

GO - Biological processi

Keywordsi

Biological processCell cycle, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-taxilin
Alternative name(s):
Environmental lipopolysaccharide-responding gene protein
Factor inhibiting ATF4-mediated transcription
Short name:
FIAT
Lipopolysaccharide-specific response protein 5
Gene namesi
Name:TXLNG
Synonyms:CXorf15, ELRG, LSR5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000086712.12
HGNCiHGNC:18578 TXLNG
MIMi300677 gene
neXtProtiNX_Q9NUQ3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55787
OpenTargetsiENSG00000086712
PharmGKBiPA38588

Polymorphism and mutation databases

BioMutaiTXLNG
DMDMi212276476

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001894261 – 528Gamma-taxilinAdd BLAST528

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12Omega-N-methylarginineCombined sources1
Modified residuei24Omega-N-methylarginineCombined sources1
Modified residuei79PhosphoserineBy similarity1
Modified residuei86PhosphoserineCombined sources1
Modified residuei97PhosphoserineCombined sources1
Modified residuei105PhosphoserineCombined sources1
Modified residuei283PhosphotyrosineCombined sources1
Modified residuei517PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9NUQ3
MaxQBiQ9NUQ3
PaxDbiQ9NUQ3
PeptideAtlasiQ9NUQ3
PRIDEiQ9NUQ3
ProteomicsDBi82707
82708 [Q9NUQ3-2]

PTM databases

iPTMnetiQ9NUQ3
PhosphoSitePlusiQ9NUQ3

Expressioni

Tissue specificityi

Ubiquitously expressed. Expressed at high level in heart and skeletal muscle. Expressed in brain, placenta, lung, liver, kidney and pancreas.1 Publication

Inductioni

By bacterial lipopolysaccharides (LPS) in Hep-G2 cells.1 Publication

Gene expression databases

BgeeiENSG00000086712
CleanExiHS_CXorf15
GenevisibleiQ9NUQ3 HS

Organism-specific databases

HPAiHPA000297
HPA000841

Interactioni

Subunit structurei

Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A. Forms a heterodimer with ATF4 in osteoblasts.1 Publication

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB
  • syntaxin binding Source: InterPro

Protein-protein interaction databases

BioGridi120901, 51 interactors
IntActiQ9NUQ3, 18 interactors
STRINGi9606.ENSP00000369465

Structurei

3D structure databases

ProteinModelPortaliQ9NUQ3
SMRiQ9NUQ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili153 – 464Sequence analysisAdd BLAST312

Sequence similaritiesi

Belongs to the taxilin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1850 Eukaryota
ENOG410XQH1 LUCA
GeneTreeiENSGT00390000001482
HOGENOMiHOG000231384
HOVERGENiHBG104385
InParanoidiQ9NUQ3
OMAiWRKKSHH
OrthoDBiEOG091G0GVB
PhylomeDBiQ9NUQ3
TreeFamiTF318595

Family and domain databases

InterProiView protein in InterPro
IPR026183 Taxilin_fam
PANTHERiPTHR16127 PTHR16127, 1 hit
PfamiView protein in Pfam
PF09728 Taxilin, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NUQ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATRVEEAAR GRGGGAEEAT EAGRGGRRRS PRQKFEIGTM EEAGICGLGV
60 70 80 90 100
KADMLCNSQS NDILQHQGSN CGGTSNKHSL EEDEGSDFIT ENRNLVSPAY
110 120 130 140 150
CTQESREEIP GGEARTDPPD GQQDSECNRN KEKTLGKEVL LLMQALNTLS
160 170 180 190 200
TPEEKLAALC KKYADLLEES RSVQKQMKIL QKKQAQIVKE KVHLQSEHSK
210 220 230 240 250
AILARSKLES LCRELQRHNK TLKEENMQQA REEEERRKEA TAHFQITLNE
260 270 280 290 300
IQAQLEQHDI HNAKLRQENI ELGEKLKKLI EQYALREEHI DKVFKHKELQ
310 320 330 340 350
QQLVDAKLQQ TTQLIKEADE KHQREREFLL KEATESRHKY EQMKQQEVQL
360 370 380 390 400
KQQLSLYMDK FEEFQTTMAK SNELFTTFRQ EMEKMTKKIK KLEKETIIWR
410 420 430 440 450
TKWENNNKAL LQMAEEKTVR DKEYKALQIK LERLEKLCRA LQTERNELNE
460 470 480 490 500
KVEVLKEQVS IKAAIKAANR DLATPVMQPC TALDSHKELN TSSKRALGAH
510 520
LEAEPKSQRS AVQKPPSTGS APAIESVD
Length:528
Mass (Da):60,586
Last modified:November 4, 2008 - v2
Checksum:i4EAC314330CE4490
GO
Isoform 2 (identifier: Q9NUQ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-166: Missing.

Show »
Length:396
Mass (Da):46,252
Checksum:iE05B3ED888BEE3A6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti249N → D in BAA92068 (PubMed:14702039).Curated1
Sequence conflicti296H → R in BAA92068 (PubMed:14702039).Curated1
Sequence conflicti402K → I in AAF70546 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019809246I → V. Corresponds to variant dbSNP:rs5969783Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03939135 – 166Missing in isoform 2. 1 PublicationAdd BLAST132

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY739713 mRNA Translation: AAW65982.1
AK002071 mRNA Translation: BAA92068.1
AL929302 Genomic DNA No translation available.
BX004861 Genomic DNA No translation available.
CH471074 Genomic DNA Translation: EAW98918.1
BC101572 mRNA Translation: AAI01573.1
BC101576 mRNA Translation: AAI01577.1
AF143740 mRNA Translation: AAF70546.2
CCDSiCCDS14178.1 [Q9NUQ3-1]
CCDS55373.1 [Q9NUQ3-2]
RefSeqiNP_001162154.1, NM_001168683.1 [Q9NUQ3-2]
NP_060830.2, NM_018360.2 [Q9NUQ3-1]
UniGeneiHs.555961

Genome annotation databases

EnsembliENST00000380122; ENSP00000369465; ENSG00000086712 [Q9NUQ3-1]
ENST00000398155; ENSP00000381222; ENSG00000086712 [Q9NUQ3-2]
GeneIDi55787
KEGGihsa:55787
UCSCiuc004cxq.3 human [Q9NUQ3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTXLNG_HUMAN
AccessioniPrimary (citable) accession number: Q9NUQ3
Secondary accession number(s): Q2KQ75, Q5JNZ7, Q9P0X1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 4, 2008
Last modified: July 18, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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