UniProtKB - Q9NUP9 (LIN7C_HUMAN)
Protein lin-7 homolog C
LIN7C
Functioni
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity).
This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
By similarityGO - Molecular functioni
- cytoskeletal protein binding Source: UniProtKB
- L27 domain binding Source: UniProtKB
- protein domain specific binding Source: BHF-UCL
GO - Biological processi
- exocytosis Source: UniProtKB-KW
- maintenance of epithelial cell apical/basal polarity Source: GO_Central
- morphogenesis of an epithelial sheet Source: UniProtKB
- neurotransmitter secretion Source: GO_Central
- protein localization to basolateral plasma membrane Source: GO_Central
- protein transport Source: UniProtKB-KW
Keywordsi
Biological process | Exocytosis, Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9NUP9 |
Reactomei | R-HSA-212676, Dopamine Neurotransmitter Release Cycle R-HSA-6794361, Neurexins and neuroligins R-HSA-9609736, Assembly and cell surface presentation of NMDA receptors |
SignaLinki | Q9NUP9 |
SIGNORi | Q9NUP9 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein lin-7 homolog CShort name: Lin-7C Alternative name(s): Mammalian lin-seven protein 3 Short name: MALS-3 Vertebrate lin-7 homolog 3 Short name: Veli-3 |
Gene namesi | Name:LIN7C Synonyms:MALS3, VELI3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17789, LIN7C |
MIMi | 612332, gene |
neXtProti | NX_Q9NUP9 |
VEuPathDBi | HostDB:ENSG00000148943 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Peripheral membrane protein 1 Publication
- Basolateral cell membrane 1 Publication; Peripheral membrane protein 1 Publication
- postsynaptic density membrane By similarity; Peripheral membrane protein By similarity
Other locations
- Cell junction By similarity
- tight junction By similarity
Note: Mainly basolateral in renal epithelial cells.By similarity
Plasma Membrane
- basolateral plasma membrane Source: GO_Central
- MPP7-DLG1-LIN7 complex Source: UniProtKB
- plasma membrane Source: UniProtKB
- postsynaptic density membrane Source: UniProtKB-SubCell
Other locations
- bicellular tight junction Source: UniProtKB-SubCell
- cell-cell junction Source: UniProtKB
- cytoplasm Source: UniProtKB
- presynapse Source: GOC
- synapse Source: GO_Central
Keywords - Cellular componenti
Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse, Tight junctionPathology & Biotechi
Organism-specific databases
DisGeNETi | 55327 |
OpenTargetsi | ENSG00000148943 |
PharmGKBi | PA134891786 |
Miscellaneous databases
Pharosi | Q9NUP9, Tbio |
Genetic variation databases
BioMutai | LIN7C |
DMDMi | 59798474 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000189629 | 2 – 197 | Protein lin-7 homolog CAdd BLAST | 196 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q9NUP9 |
jPOSTi | Q9NUP9 |
MassIVEi | Q9NUP9 |
MaxQBi | Q9NUP9 |
PaxDbi | Q9NUP9 |
PeptideAtlasi | Q9NUP9 |
PRIDEi | Q9NUP9 |
ProteomicsDBi | 82705 |
PTM databases
GlyGeni | Q9NUP9, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9NUP9 |
MetOSitei | Q9NUP9 |
PhosphoSitePlusi | Q9NUP9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000148943, Expressed in forebrain and 242 other tissues |
ExpressionAtlasi | Q9NUP9, baseline and differential |
Genevisiblei | Q9NUP9, HS |
Organism-specific databases
HPAi | ENSG00000148943, Low tissue specificity |
Interactioni
Subunit structurei
Forms a complex with CASK and APBA1 or CASKIN1 (By similarity).
Component of the brain-specific heterotrimeric complex (LIN-10-LIN-2-LIN-7 complex) composed of at least APBA1, CASK, and LIN7, which associates with the motor protein KIF17 to transport vesicles along microtubules (By similarity). Can also interact with other modular proteins containing protein-protein interaction domains like PALS1, PALS2, MPP7, DLG1, DLG2 and DLG3 through its L27 domain.
Interacts with DLG4 and GRIN2B as well as CDH1 and CTNNB1, the channels KCNJ12/Kir2.2, KCNJ4/Kir2.3 and probably KCNJ2/Kir2.1 and SLC6A12/BGT-1 via its PDZ domain. The association of LIN7A with cadherin and beta-catenin is calcium-dependent, occurs at synaptic junctions and requires the actin cytoskeleton.
Interacts with EGFR, ERBB2, ERBB3 and ERBB4 with both PDZ and KID domains. Associates with KIF17 via APBA1.
Interacts with HTR4 (By similarity).
Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C).
Interacts with MAPK12 (By similarity).
By similarityBinary interactionsi
Q9NUP9
GO - Molecular functioni
- cytoskeletal protein binding Source: UniProtKB
- L27 domain binding Source: UniProtKB
- protein domain specific binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 120608, 85 interactors |
CORUMi | Q9NUP9 |
IntActi | Q9NUP9, 55 interactors |
MINTi | Q9NUP9 |
STRINGi | 9606.ENSP00000278193 |
Miscellaneous databases
RNActi | Q9NUP9, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9NUP9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9NUP9 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 10 – 65 | L27PROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 93 – 175 | PDZPROSITE-ProRule annotationAdd BLAST | 83 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 2 – 13 | Kinase interacting siteBy similarityAdd BLAST | 12 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3550, Eukaryota |
GeneTreei | ENSGT00940000153222 |
InParanoidi | Q9NUP9 |
OMAi | MENRFER |
OrthoDBi | 1335138at2759 |
PhylomeDBi | Q9NUP9 |
TreeFami | TF316850 |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit |
IDEALi | IID00521 |
InterProi | View protein in InterPro IPR014775, L27_C IPR004172, L27_dom IPR036892, L27_dom_sf IPR017365, LIN7 IPR001478, PDZ IPR036034, PDZ_sf |
Pfami | View protein in Pfam PF02828, L27, 1 hit PF00595, PDZ, 1 hit |
PIRSFi | PIRSF038039, Lin-7_homologue, 1 hit |
SMARTi | View protein in SMART SM00569, L27, 1 hit SM00228, PDZ, 1 hit |
SUPFAMi | SSF101288, SSF101288, 1 hit SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS51022, L27, 1 hit PS50106, PDZ, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MAALGEPVRL ERDICRAIEL LEKLQRSGEV PPQKLQALQR VLQSEFCNAV
60 70 80 90 100
REVYEHVYET VDISSSPEVR ANATAKATVA AFAASEGHSH PRVVELPKTE
110 120 130 140 150
EGLGFNIMGG KEQNSPIYIS RIIPGGIADR HGGLKRGDQL LSVNGVSVEG
160 170 180 190
EHHEKAVELL KAAQGKVKLV VRYTPKVLEE MESRFEKMRS AKRRQQT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V1D4 | G3V1D4_HUMAN | Lin-7 homolog C (C. elegans), isofo... | LIN7C hCG_27394 | 173 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002077 mRNA Translation: BAA92072.1 BC053907 mRNA Translation: AAH53907.1 |
CCDSi | CCDS7864.1 |
RefSeqi | NP_060832.1, NM_018362.3 |
Genome annotation databases
Ensembli | ENST00000278193; ENSP00000278193; ENSG00000148943 |
GeneIDi | 55327 |
KEGGi | hsa:55327 |
MANE-Selecti | ENST00000278193.7; ENSP00000278193.2; NM_018362.4; NP_060832.1 |
UCSCi | uc001mrl.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002077 mRNA Translation: BAA92072.1 BC053907 mRNA Translation: AAH53907.1 |
CCDSi | CCDS7864.1 |
RefSeqi | NP_060832.1, NM_018362.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3LRA | X-ray | 2.95 | A | 3-64 | [»] | |
SMRi | Q9NUP9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120608, 85 interactors |
CORUMi | Q9NUP9 |
IntActi | Q9NUP9, 55 interactors |
MINTi | Q9NUP9 |
STRINGi | 9606.ENSP00000278193 |
PTM databases
GlyGeni | Q9NUP9, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9NUP9 |
MetOSitei | Q9NUP9 |
PhosphoSitePlusi | Q9NUP9 |
Genetic variation databases
BioMutai | LIN7C |
DMDMi | 59798474 |
Proteomic databases
EPDi | Q9NUP9 |
jPOSTi | Q9NUP9 |
MassIVEi | Q9NUP9 |
MaxQBi | Q9NUP9 |
PaxDbi | Q9NUP9 |
PeptideAtlasi | Q9NUP9 |
PRIDEi | Q9NUP9 |
ProteomicsDBi | 82705 |
Protocols and materials databases
Antibodypediai | 25423, 141 antibodies from 27 providers |
DNASUi | 55327 |
Genome annotation databases
Ensembli | ENST00000278193; ENSP00000278193; ENSG00000148943 |
GeneIDi | 55327 |
KEGGi | hsa:55327 |
MANE-Selecti | ENST00000278193.7; ENSP00000278193.2; NM_018362.4; NP_060832.1 |
UCSCi | uc001mrl.4, human |
Organism-specific databases
CTDi | 55327 |
DisGeNETi | 55327 |
GeneCardsi | LIN7C |
HGNCi | HGNC:17789, LIN7C |
HPAi | ENSG00000148943, Low tissue specificity |
MIMi | 612332, gene |
neXtProti | NX_Q9NUP9 |
OpenTargetsi | ENSG00000148943 |
PharmGKBi | PA134891786 |
VEuPathDBi | HostDB:ENSG00000148943 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3550, Eukaryota |
GeneTreei | ENSGT00940000153222 |
InParanoidi | Q9NUP9 |
OMAi | MENRFER |
OrthoDBi | 1335138at2759 |
PhylomeDBi | Q9NUP9 |
TreeFami | TF316850 |
Enzyme and pathway databases
PathwayCommonsi | Q9NUP9 |
Reactomei | R-HSA-212676, Dopamine Neurotransmitter Release Cycle R-HSA-6794361, Neurexins and neuroligins R-HSA-9609736, Assembly and cell surface presentation of NMDA receptors |
SignaLinki | Q9NUP9 |
SIGNORi | Q9NUP9 |
Miscellaneous databases
BioGRID-ORCSi | 55327, 38 hits in 1045 CRISPR screens |
ChiTaRSi | LIN7C, human |
EvolutionaryTracei | Q9NUP9 |
GeneWikii | LIN7C |
GenomeRNAii | 55327 |
Pharosi | Q9NUP9, Tbio |
PROi | PR:Q9NUP9 |
RNActi | Q9NUP9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000148943, Expressed in forebrain and 242 other tissues |
ExpressionAtlasi | Q9NUP9, baseline and differential |
Genevisiblei | Q9NUP9, HS |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit |
IDEALi | IID00521 |
InterProi | View protein in InterPro IPR014775, L27_C IPR004172, L27_dom IPR036892, L27_dom_sf IPR017365, LIN7 IPR001478, PDZ IPR036034, PDZ_sf |
Pfami | View protein in Pfam PF02828, L27, 1 hit PF00595, PDZ, 1 hit |
PIRSFi | PIRSF038039, Lin-7_homologue, 1 hit |
SMARTi | View protein in SMART SM00569, L27, 1 hit SM00228, PDZ, 1 hit |
SUPFAMi | SSF101288, SSF101288, 1 hit SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS51022, L27, 1 hit PS50106, PDZ, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LIN7C_HUMAN | |
Accessioni | Q9NUP9Primary (citable) accession number: Q9NUP9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 15, 2005 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 180 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families