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Protein

Protein lin-7 homolog C

Gene

LIN7C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

GO - Molecular functioni

  • cytoskeletal protein binding Source: UniProtKB
  • L27 domain binding Source: UniProtKB
  • PDZ domain binding Source: Ensembl
  • protein domain specific binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-212676 Dopamine Neurotransmitter Release Cycle
R-HSA-6794361 Neurexins and neuroligins
SIGNORiQ9NUP9

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lin-7 homolog C
Short name:
Lin-7C
Alternative name(s):
Mammalian lin-seven protein 3
Short name:
MALS-3
Vertebrate lin-7 homolog 3
Short name:
Veli-3
Gene namesi
Name:LIN7C
Synonyms:MALS3, VELI3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000148943.11
HGNCiHGNC:17789 LIN7C
MIMi612332 gene
neXtProtiNX_Q9NUP9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi55327
OpenTargetsiENSG00000148943
PharmGKBiPA134891786

Polymorphism and mutation databases

BioMutaiLIN7C
DMDMi59798474

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001896292 – 197Protein lin-7 homolog CAdd BLAST196

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9NUP9
MaxQBiQ9NUP9
PaxDbiQ9NUP9
PeptideAtlasiQ9NUP9
PRIDEiQ9NUP9
ProteomicsDBi82705

PTM databases

iPTMnetiQ9NUP9
PhosphoSitePlusiQ9NUP9

Expressioni

Gene expression databases

BgeeiENSG00000148943 Expressed in 230 organ(s), highest expression level in forebrain
CleanExiHS_LIN7C
ExpressionAtlasiQ9NUP9 baseline and differential
GenevisibleiQ9NUP9 HS

Organism-specific databases

HPAiHPA051118

Interactioni

Subunit structurei

Forms two exclusive ternary complexes with CASK and APBA1 or CASKIN1 (By similarity). Can also interact with other modular proteins containing protein-protein interaction domains like MPP5, MPP6, MPP7, DLG1, DLG2 and DLG3 through its L27 domain. Interacts with DLG4 and GRIN2B as well as CDH1 and CTNNB1, the channels KCNJ12/Kir2.2, KCNJ4/Kir2.3 and probably KCNJ2/Kir2.1 and SLC6A12/BGT-1 via its PDZ domain. The association of LIN7A with cadherin and beta-catenin is calcium-dependent, occurs at synaptic junctions and requires the actin cytoskeleton. Interacts with EGFR, ERBB2, ERBB3 and ERBB4 with both PDZ and KID domains. Associates with KIF17 via APBA1. Interacts with HTR4 (By similarity). Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C). Interacts with MAPK12 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120608, 44 interactors
CORUMiQ9NUP9
IntActiQ9NUP9, 29 interactors
STRINGi9606.ENSP00000278193

Structurei

Secondary structure

1197
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NUP9
SMRiQ9NUP9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NUP9

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 65L27PROSITE-ProRule annotationAdd BLAST56
Domaini93 – 175PDZPROSITE-ProRule annotationAdd BLAST83

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi2 – 13Kinase interacting siteBy similarityAdd BLAST12

Domaini

The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane.By similarity
The PDZ domain regulates endocytosis and recycling of the receptor at the membrane.By similarity
The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes.By similarity

Sequence similaritiesi

Belongs to the lin-7 family.Curated

Phylogenomic databases

eggNOGiKOG3550 Eukaryota
ENOG410XP5T LUCA
GeneTreeiENSGT00550000074581
HOGENOMiHOG000285929
HOVERGENiHBG052329
InParanoidiQ9NUP9
KOiK19931
OMAiRRQQNNF
OrthoDBiEOG091G0PR4
PhylomeDBiQ9NUP9
TreeFamiTF316850

Family and domain databases

InterProiView protein in InterPro
IPR014775 L27_C
IPR004172 L27_dom
IPR036892 L27_dom_sf
IPR017365 LIN7
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF02828 L27, 1 hit
PF00595 PDZ, 1 hit
PIRSFiPIRSF038039 Lin-7_homologue, 1 hit
SMARTiView protein in SMART
SM00569 L27, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF101288 SSF101288, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51022 L27, 1 hit
PS50106 PDZ, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q9NUP9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAALGEPVRL ERDICRAIEL LEKLQRSGEV PPQKLQALQR VLQSEFCNAV
60 70 80 90 100
REVYEHVYET VDISSSPEVR ANATAKATVA AFAASEGHSH PRVVELPKTE
110 120 130 140 150
EGLGFNIMGG KEQNSPIYIS RIIPGGIADR HGGLKRGDQL LSVNGVSVEG
160 170 180 190
EHHEKAVELL KAAQGKVKLV VRYTPKVLEE MESRFEKMRS AKRRQQT
Length:197
Mass (Da):21,834
Last modified:October 1, 2000 - v1
Checksum:i7410FBFA3BD24F45
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V1D4G3V1D4_HUMAN
Lin-7 homolog C (C. elegans), isofo...
LIN7C hCG_27394
173Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002077 mRNA Translation: BAA92072.1
BC053907 mRNA Translation: AAH53907.1
CCDSiCCDS7864.1
RefSeqiNP_060832.1, NM_018362.3
UniGeneiHs.91393

Genome annotation databases

EnsembliENST00000278193; ENSP00000278193; ENSG00000148943
GeneIDi55327
KEGGihsa:55327
UCSCiuc001mrl.4 human

Similar proteinsi

Entry informationi

Entry nameiLIN7C_HUMAN
AccessioniPrimary (citable) accession number: Q9NUP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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