Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alkaline ceramidase 3

Gene

ACER3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity.

Activity regulationi

Activated by Ca2+ and inhibited by Zn2+.

GO - Molecular functioni

  • phytoceramidase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BRENDAi3.5.1.23 2681
ReactomeiR-HSA-1660661 Sphingolipid de novo biosynthesis

Chemistry databases

SwissLipidsiSLP:000000680

Names & Taxonomyi

Protein namesi
Recommended name:
Alkaline ceramidase 3 (EC:3.5.1.-)
Short name:
AlkCDase 3
Short name:
Alkaline CDase 3
Alternative name(s):
Alkaline dihydroceramidase SB89
Alkaline phytoceramidase
Short name:
aPHC
Gene namesi
Name:ACER3
Synonyms:APHC, PHCA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000078124.11
HGNCiHGNC:16066 ACER3
neXtProtiNX_Q9NUN7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 51HelicalSequence analysisAdd BLAST23
Transmembranei63 – 84HelicalSequence analysisAdd BLAST22
Transmembranei94 – 111HelicalSequence analysisAdd BLAST18
Transmembranei118 – 137HelicalSequence analysisAdd BLAST20
Transmembranei147 – 169HelicalSequence analysisAdd BLAST23
Transmembranei174 – 196HelicalSequence analysisAdd BLAST23
Transmembranei216 – 238HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55331
MalaCardsiACER3
OpenTargetsiENSG00000078124
PharmGKBiPA33256

Polymorphism and mutation databases

BioMutaiACER3
DMDMi296439452

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002124631 – 267Alkaline ceramidase 3Add BLAST267

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NUN7
PeptideAtlasiQ9NUN7
PRIDEiQ9NUN7
ProteomicsDBi82700
82701 [Q9NUN7-2]
TopDownProteomicsiQ9NUN7-1 [Q9NUN7-1]

PTM databases

iPTMnetiQ9NUN7
PhosphoSitePlusiQ9NUN7

Expressioni

Tissue specificityi

Ubiquitously expressed. Highest expression in placenta.

Gene expression databases

BgeeiENSG00000078124 Expressed in 204 organ(s), highest expression level in placenta
CleanExiHS_ACER3
ExpressionAtlasiQ9NUN7 baseline and differential
GenevisibleiQ9NUN7 HS

Organism-specific databases

HPAiHPA070087

Interactioni

Protein-protein interaction databases

BioGridi120612, 2 interactors
IntActiQ9NUN7, 1 interactor
STRINGi9606.ENSP00000434480

Structurei

3D structure databases

ProteinModelPortaliQ9NUN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alkaline ceramidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2329 Eukaryota
ENOG4111RPN LUCA
GeneTreeiENSGT00730000111189
HOGENOMiHOG000192011
InParanoidiQ9NUN7
KOiK04711
OMAiVFHQVMY
OrthoDBiEOG091G0DCZ
PhylomeDBiQ9NUN7
TreeFamiTF313019

Family and domain databases

InterProiView protein in InterPro
IPR008901 Ceramidase
PfamiView protein in Pfam
PF05875 Ceramidase, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q9NUN7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPAADREGY WGPTTSTLDW CEENYSVTWY IAEFWNTVSN LIMIIPPMFG
60 70 80 90 100
AVQSVRDGLE KRYIASYLAL TVVGMGSWCF HMTLKYEMQL LDELPMIYSC
110 120 130 140 150
CIFVYCMFEC FKIKNSVNYH LLFTLVLFSL IVTTVYLKVK EPIFHQVMYG
160 170 180 190 200
MLVFTLVLRS IYIVTWVYPW LRGLGYTSLG IFLLGFLFWN IDNIFCESLR
210 220 230 240 250
NFRKKVPPII GITTQFHAWW HILTGLGSYL HILFSLYTRT LYLRYRPKVK
260
FLFGIWPVIL FEPLRKH
Length:267
Mass (Da):31,552
Last modified:May 18, 2010 - v3
Checksum:iCFD2A901F12A5918
GO
Isoform 2 (identifier: Q9NUN7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-133: Missing.
     134-145: TVYLKVKEPIFH → MAQSRLIGTSTS

Note: No experimental confirmation available.
Show »
Length:134
Mass (Da):15,895
Checksum:i8333C599D48A5525
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z2V2B7Z2V2_HUMAN
Alkaline ceramidase 3
ACER3
172Annotation score:
B7Z2Q2B7Z2Q2_HUMAN
Alkaline ceramidase 3
ACER3
230Annotation score:
E9PIN9E9PIN9_HUMAN
Alkaline ceramidase 3
ACER3
205Annotation score:
E9PL35E9PL35_HUMAN
Alkaline ceramidase 3
ACER3
74Annotation score:
E9PLZ9E9PLZ9_HUMAN
Alkaline ceramidase 3
ACER3
71Annotation score:
E9PR08E9PR08_HUMAN
Alkaline ceramidase 3
ACER3
80Annotation score:
J3KN85J3KN85_HUMAN
Alkaline ceramidase 3
ACER3
76Annotation score:
E9PKR3E9PKR3_HUMAN
Alkaline ceramidase 3
ACER3
51Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52V → I in AAK71923 (PubMed:11356846).Curated1
Sequence conflicti52V → I in AAL56013 (Ref. 2) Curated1
Sequence conflicti52V → I in BAG37496 (PubMed:14702039).Curated1
Sequence conflicti52V → I in EAW75010 (Ref. 5) Curated1
Sequence conflicti52V → I in AAH73853 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0391621 – 133Missing in isoform 2. 1 PublicationAdd BLAST133
Alternative sequenceiVSP_039163134 – 145TVYLK…EPIFH → MAQSRLIGTSTS in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214454 mRNA Translation: AAK71923.1
AF327353 mRNA Translation: AAL56013.1
AK002100 mRNA Translation: BAA92085.1
AK315000 mRNA Translation: BAG37496.1
AP000752 Genomic DNA No translation available.
AP002498 Genomic DNA No translation available.
AP003119 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW75010.1
BC073853 mRNA Translation: AAH73853.1
CCDSiCCDS8247.1 [Q9NUN7-1]
RefSeqiNP_060837.3, NM_018367.6 [Q9NUN7-1]
UniGeneiHs.23862
Hs.720248

Genome annotation databases

EnsembliENST00000532485; ENSP00000434480; ENSG00000078124 [Q9NUN7-1]
GeneIDi55331
KEGGihsa:55331
UCSCiuc009yum.2 human [Q9NUN7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiACER3_HUMAN
AccessioniPrimary (citable) accession number: Q9NUN7
Secondary accession number(s): B2RC99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 139 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again