UniProtKB - Q9NUN7 (ACER3_HUMAN)

BLAST

>sp|Q9NUN7|ACER3_HUMAN Alkaline ceramidase 3 OS=Homo sapiens OX=9606 GN=ACER3 PE=1 SV=3
MAPAADREGYWGPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMIIPPMFGAVQSVRDGLE
KRYIASYLALTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFECFKIKNSVNYH
LLFTLVLFSLIVTTVYLKVKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLG
IFLLGFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHAWWHILTGLGSYLHILFSLYTRT
LYLRYRPKVKFLFGIWPVILFEPLRKH

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History
Entry version 139 (12 Sep 2018)
Sequence version 3 (18 May 2010)
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Protein

Alkaline ceramidase 3

Gene

ACER3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity.

Activity regulationⁱ

Activated by Ca²⁺ and inhibited by Zn²⁺.

GO - Molecular functionⁱ

phytoceramidase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11356846
- 20068046

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ceramide metabolic process Source: InterPro
phytosphingosine biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 11356846
- 20068046
positive regulation of cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20068046
sphingolipid biosynthetic process Source: Reactome
sphingosine biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 20068046

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase

Molecular function

Hydrolase

Enzyme and pathway databases

BRENDAⁱ	3.5.1.23 2681
Reactomeⁱ	R-HSA-1660661 Sphingolipid de novo biosynthesis

Chemistry databases

SwissLipidsⁱ	SLP:000000680

SwissLipidsⁱ

SLP:000000680

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alkaline ceramidase 3 (EC:3.5.1.-) Short name: AlkCDase 3 Short name: Alkaline CDase 3 Alternative name(s): Alkaline dihydroceramidase SB89 Alkaline phytoceramidase Short name: aPHC
Gene namesⁱ	Name:ACER3 Synonyms:APHC, PHCA
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000078124.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16066 ACER3
neXtProtⁱ	NX_Q9NUN7

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	29 – 51	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	63 – 84	HelicalSequence analysisAdd BLAST	22
Transmembraneⁱ	94 – 111	HelicalSequence analysisAdd BLAST	18
Transmembraneⁱ	118 – 137	HelicalSequence analysisAdd BLAST	20
Transmembraneⁱ	147 – 169	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	174 – 196	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	216 – 238	HelicalSequence analysisAdd BLAST	23

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55331
MalaCards human disease database More...MalaCardsⁱ	ACER3
Open Targets More...OpenTargetsⁱ	ENSG00000078124
PharmGKBⁱ	PA33256

Polymorphism and mutation databases

BioMutaⁱ	ACER3
DMDMⁱ	296439452

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000212463	1 – 267	Alkaline ceramidase 3Add BLAST		267

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	24	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q9NUN7
PeptideAtlas More...PeptideAtlasⁱ	Q9NUN7
PRIDEⁱ	Q9NUN7
ProteomicsDBⁱ	82700 82701 [Q9NUN7-2]
TopDownProteomicsⁱ	Q9NUN7-1 [Q9NUN7-1]

PTM databases

iPTMnetⁱ	Q9NUN7
PhosphoSitePlusⁱ	Q9NUN7

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed. Highest expression in placenta.

Gene expression databases

Bgeeⁱ	ENSG00000078124 Expressed in 204 organ(s), highest expression level in placenta
CleanExⁱ	HS_ACER3
ExpressionAtlasⁱ	Q9NUN7 baseline and differential
Genevisibleⁱ	Q9NUN7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA070087

HPAⁱ

HPA070087

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	120612, 2 interactors
IntActⁱ	Q9NUN7, 1 interactor
STRINGⁱ	9606.ENSP00000434480

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NUN7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the alkaline ceramidase family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2329 Eukaryota ENOG4111RPN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111189
HOGENOMⁱ	HOG000192011
InParanoidⁱ	Q9NUN7
KEGG Orthology (KO) More...KOⁱ	K04711
OMAⁱ	VFHQVMY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0DCZ
PhylomeDBⁱ	Q9NUN7
TreeFamⁱ	TF313019

Family and domain databases

InterProⁱ	View protein in InterPro IPR008901 Ceramidase
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05875 Ceramidase, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q9NUN7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPAADREGY WGPTTSTLDW CEENYSVTWY IAEFWNTVSN LIMIIPPMFG 
        60         70         80         90        100
AVQSVRDGLE KRYIASYLAL TVVGMGSWCF HMTLKYEMQL LDELPMIYSC 
       110        120        130        140        150
CIFVYCMFEC FKIKNSVNYH LLFTLVLFSL IVTTVYLKVK EPIFHQVMYG 
       160        170        180        190        200
MLVFTLVLRS IYIVTWVYPW LRGLGYTSLG IFLLGFLFWN IDNIFCESLR 
       210        220        230        240        250
NFRKKVPPII GITTQFHAWW HILTGLGSYL HILFSLYTRT LYLRYRPKVK 
       260 
FLFGIWPVIL FEPLRKH

Length:267

Mass (Da):31,552

Last modified:May 18, 2010 - v3

Checksum:ⁱCFD2A901F12A5918

Isoform 2 (identifier: Q9NUN7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-133: Missing.
134-145: TVYLKVKEPIFH → MAQSRLIGTSTS

« Hide

        10         20         30         40         50
MAQSRLIGTS TSQVMYGMLV FTLVLRSIYI VTWVYPWLRG LGYTSLGIFL 
        60         70         80         90        100
LGFLFWNIDN IFCESLRNFR KKVPPIIGIT TQFHAWWHIL TGLGSYLHIL 
       110        120        130 
FSLYTRTLYL RYRPKVKFLF GIWPVILFEP LRKH

Note: No experimental confirmation available.

Show »

Length:134

Mass (Da):15,895

Checksum:ⁱ8333C599D48A5525

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
B7Z2V2	B7Z2V2_HUMAN	Alkaline ceramidase 3 Alkaline ceramidase 3 (cDNA FLJ57303, highly similar to Alkaline phytoceramidase) (cDNA, FLJ79019, highly similar to Alkaline phytoceramidase)	ACER3	172	Annotation score:
B7Z2Q2	B7Z2Q2_HUMAN	Alkaline ceramidase 3 Alkaline ceramidase 3 (cDNA FLJ50957, highly similar to Alkaline phytoceramidase)	ACER3	230	Annotation score:
E9PIN9	E9PIN9_HUMAN	Alkaline ceramidase 3 Alkaline ceramidase 3	ACER3	205	Annotation score:
E9PL35	E9PL35_HUMAN	Alkaline ceramidase 3 Alkaline ceramidase 3	ACER3	74	Annotation score:
E9PLZ9	E9PLZ9_HUMAN	Alkaline ceramidase 3 Alkaline ceramidase 3	ACER3	71	Annotation score:
E9PR08	E9PR08_HUMAN	Alkaline ceramidase 3 Alkaline ceramidase 3	ACER3	80	Annotation score:
J3KN85	J3KN85_HUMAN	Alkaline ceramidase 3 Alkaline ceramidase 3	ACER3	76	Annotation score:
E9PKR3	E9PKR3_HUMAN	Alkaline ceramidase 3 Alkaline ceramidase 3	ACER3	51	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	52	V → I in AAK71923 (PubMed:11356846).Curated	1
Sequence conflictⁱ	52	V → I in AAL56013 (Ref. 2) Curated	1
Sequence conflictⁱ	52	V → I in BAG37496 (PubMed:14702039).Curated	1
Sequence conflictⁱ	52	V → I in EAW75010 (Ref. 5) Curated	1
Sequence conflictⁱ	52	V → I in AAH73853 (PubMed:15489334).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_039162	1 – 133	Missing in isoform 2. 1 PublicationAdd BLAST		133
Alternative sequenceⁱVSP_039163	134 – 145	TVYLK…EPIFH → MAQSRLIGTSTS in isoform 2. 1 PublicationAdd BLAST		12

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF214454 mRNA Translation: AAK71923.1 AF327353 mRNA Translation: AAL56013.1 AK002100 mRNA Translation: BAA92085.1 AK315000 mRNA Translation: BAG37496.1 AP000752 Genomic DNA No translation available. AP002498 Genomic DNA No translation available. AP003119 Genomic DNA No translation available. CH471076 Genomic DNA Translation: EAW75010.1 BC073853 mRNA Translation: AAH73853.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8247.1 [Q9NUN7-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_060837.3, NM_018367.6 [Q9NUN7-1]
UniGeneⁱ	Hs.23862 Hs.720248

Genome annotation databases

Ensemblⁱ	ENST00000532485; ENSP00000434480; ENSG00000078124 [Q9NUN7-1]
GeneIDⁱ	55331
KEGGⁱ	hsa:55331
UCSC genome browser More...UCSCⁱ	uc009yum.2 human [Q9NUN7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NUN7	Alkaline ceramidase 3		HUMAN		172	UniRef100_Q9NUN7
Alkaline ceramidase		PONAB		172
Alkaline ceramidase		PANTR		172
Alkaline ceramidase 3 (Fragment)		HUMAN		205
UPI000387BA43		HUMAN		165
+1

Protein	Similar proteins		Species	Score	Length	Source
Q9NUN7	Alkaline ceramidase 3		HUMAN		172	UniRef90_Q9NUN7
Alkaline ceramidase		PONAB		172
Alkaline ceramidase		PANTR		172
Alkaline ceramidase 3		MACMU		267
Alkaline ceramidase 3		MACFA		267
+84

Protein	Similar proteins		Species	Score	Length	Source
Q9NUN7	Alkaline ceramidase 3		MOUSE		267	UniRef50_Q9NUN7
Alkaline ceramidase 3		HUMAN		172
Alkaline ceramidase		PONAB		172
Alkaline ceramidase		PANTR		172
Alkaline ceramidase 3		RHIRO		267
+329
Q9NUN7-2	Alkaline ceramidase		HUMAN		134	UniRef50_A0A024R5J3
Alkaline ceramidase		blackstripe livebearer		152
UPI0005150E14		PHACA		138
UPI000528C30D		ANTCR		123
UPI0004F0F331		rifleman		121

Entry informationⁱ

Entry nameⁱ	ACER3_HUMAN
Accessionⁱ	Q9NUN7Primary (citable) accession number: Q9NUN7 Secondary accession number(s): B2RC99
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 14, 2001
	Last sequence update:	May 18, 2010
	Last modified:	September 12, 2018
	This is version 139 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NUN7 (ACER3_HUMAN)

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Alkaline ceramidase 3

ACER3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Endoplasmic reticulum

Endoplasmic reticulum

Golgi apparatus

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ