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UniProtKB - Q9NUM3 (S39A9_HUMAN)
Protein
Zinc transporter ZIP9
Gene
SLC39A9
Organism
Homo sapiens (Human)
Status
Functioni
May act as a zinc-influx transporter.
By similarityGO - Molecular functioni
- metal ion transmembrane transporter activity Source: InterPro
GO - Biological processi
- zinc ion transport Source: UniProtKB-KW
Keywordsi
Biological process | Ion transport, Transport, Zinc transport |
Ligand | Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9NUM3 |
SignaLinki | Q9NUM3 |
Protein family/group databases
TCDBi | 2.A.5.6.1, the zinc (zn(2+))-iron (fe(2+)) permease (zip) family |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc transporter ZIP9Alternative name(s): Solute carrier family 39 member 9 Zrt- and Irt-like protein 9 Short name: ZIP-9 |
Gene namesi | Name:SLC39A9 Synonyms:ZIP9 ORF Names:UNQ714/PRO1377 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20182, SLC39A9 |
MIMi | 619116, gene |
neXtProti | NX_Q9NUM3 |
VEuPathDBi | HostDB:ENSG00000029364 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 4 – 24 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 35 – 55 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 106 – 126 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 146 – 166 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 176 – 196 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 210 – 230 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 244 – 264 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 286 – 306 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 55334 |
OpenTargetsi | ENSG00000029364 |
PharmGKBi | PA134889179 |
Miscellaneous databases
Pharosi | Q9NUM3, Tbio |
Chemistry databases
DrugBanki | DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
Genetic variation databases
BioMutai | SLC39A9 |
DMDMi | 156633628 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000297597 | 1 – 307 | Zinc transporter ZIP9Add BLAST | 307 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 29 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 241 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q9NUM3 |
jPOSTi | Q9NUM3 |
MassIVEi | Q9NUM3 |
MaxQBi | Q9NUM3 |
PaxDbi | Q9NUM3 |
PeptideAtlasi | Q9NUM3 |
PRIDEi | Q9NUM3 |
ProteomicsDBi | 33545 82693 [Q9NUM3-1] 82694 [Q9NUM3-2] |
TopDownProteomicsi | Q9NUM3-2 [Q9NUM3-2] |
PTM databases
GlyGeni | Q9NUM3, 2 sites |
iPTMneti | Q9NUM3 |
PhosphoSitePlusi | Q9NUM3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000029364, Expressed in testis and 222 other tissues |
ExpressionAtlasi | Q9NUM3, baseline and differential |
Genevisiblei | Q9NUM3, HS |
Organism-specific databases
HPAi | ENSG00000029364, Low tissue specificity |
Interactioni
Binary interactionsi
Q9NUM3
Protein-protein interaction databases
BioGRIDi | 120615, 132 interactors |
IntActi | Q9NUM3, 82 interactors |
MINTi | Q9NUM3 |
STRINGi | 9606.ENSP00000336887 |
Miscellaneous databases
RNActi | Q9NUM3, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3907, Eukaryota |
GeneTreei | ENSGT00390000010094 |
InParanoidi | Q9NUM3 |
OMAi | HWWTGML |
PhylomeDBi | Q9NUM3 |
TreeFami | TF315051 |
Family and domain databases
InterProi | View protein in InterPro IPR003689, ZIP IPR045891, ZIP9 |
PANTHERi | PTHR16133, PTHR16133, 1 hit |
Pfami | View protein in Pfam PF02535, Zip, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NUM3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDDFISISLL SLAMLVGCYV AGIIPLAVNF SEERLKLVTV LGAGLLCGTA
60 70 80 90 100
LAVIVPEGVH ALYEDILEGK HHQASETHNV IASDKAAEKS VVHEHEHSHD
110 120 130 140 150
HTQLHAYIGV SLVLGFVFML LVDQIGNSHV HSTDDPEAAR SSNSKITTTL
160 170 180 190 200
GLVVHAAADG VALGAAASTS QTSVQLIVFV AIMLHKAPAA FGLVSFLMHA
210 220 230 240 250
GLERNRIRKH LLVFALAAPV MSMVTYLGLS KSSKEALSEV NATGVAMLFS
260 270 280 290 300
AGTFLYVATV HVLPEVGGIG HSHKPDATGG RGLSRLEVAA LVLGCLIPLI
LSVGHQH
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QX28 | M0QX28_HUMAN | Solute carrier family 39 member 9 | SLC39A9 | 241 | Annotation score: | ||
A0A0D9SFA2 | A0A0D9SFA2_HUMAN | Zinc transporter ZIP9 | SLC39A9 | 92 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 122 | V → M in BAD96267 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034648 | 64 | E → D. Corresponds to variant dbSNP:rs2296723Ensembl. | 1 | |
Natural variantiVAR_034649 | 221 | M → T1 PublicationCorresponds to variant dbSNP:rs2232059Ensembl. | 1 | |
Natural variantiVAR_034650 | 285 | R → C1 PublicationCorresponds to variant dbSNP:rs17855898Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027302 | 135 – 157 | Missing in isoform 2. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_054057 | 232 | S → D in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_054058 | 233 – 307 | Missing in isoform 3. 1 PublicationAdd BLAST | 75 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358687 mRNA Translation: AAQ89050.1 AK002136 mRNA Translation: BAA92100.1 AK222547 mRNA Translation: BAD96267.1 AY780789 mRNA Translation: AAV98359.1 AL157996 Genomic DNA No translation available. BC047682 mRNA Translation: AAH47682.1 BC064383 mRNA Translation: AAH64383.1 |
CCDSi | CCDS58327.1 [Q9NUM3-3] CCDS58328.1 [Q9NUM3-2] CCDS9795.1 [Q9NUM3-1] |
RefSeqi | NP_001239077.1, NM_001252148.1 [Q9NUM3-2] NP_001239079.1, NM_001252150.1 [Q9NUM3-3] NP_001239080.1, NM_001252151.1 NP_001239081.1, NM_001252152.1 NP_060845.2, NM_018375.4 [Q9NUM3-1] |
Genome annotation databases
Ensembli | ENST00000336643; ENSP00000336887; ENSG00000029364 ENST00000555840; ENSP00000450639; ENSG00000029364 ENST00000556605; ENSP00000452385; ENSG00000029364 [Q9NUM3-3] ENST00000557046; ENSP00000451833; ENSG00000029364 [Q9NUM3-2] |
GeneIDi | 55334 |
KEGGi | hsa:55334 |
MANE-Selecti | ENST00000336643.10; ENSP00000336887.5; NM_018375.5; NP_060845.2 |
UCSCi | uc001xle.5, human [Q9NUM3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358687 mRNA Translation: AAQ89050.1 AK002136 mRNA Translation: BAA92100.1 AK222547 mRNA Translation: BAD96267.1 AY780789 mRNA Translation: AAV98359.1 AL157996 Genomic DNA No translation available. BC047682 mRNA Translation: AAH47682.1 BC064383 mRNA Translation: AAH64383.1 |
CCDSi | CCDS58327.1 [Q9NUM3-3] CCDS58328.1 [Q9NUM3-2] CCDS9795.1 [Q9NUM3-1] |
RefSeqi | NP_001239077.1, NM_001252148.1 [Q9NUM3-2] NP_001239079.1, NM_001252150.1 [Q9NUM3-3] NP_001239080.1, NM_001252151.1 NP_001239081.1, NM_001252152.1 NP_060845.2, NM_018375.4 [Q9NUM3-1] |
3D structure databases
SMRi | Q9NUM3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120615, 132 interactors |
IntActi | Q9NUM3, 82 interactors |
MINTi | Q9NUM3 |
STRINGi | 9606.ENSP00000336887 |
Chemistry databases
DrugBanki | DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
Protein family/group databases
TCDBi | 2.A.5.6.1, the zinc (zn(2+))-iron (fe(2+)) permease (zip) family |
PTM databases
GlyGeni | Q9NUM3, 2 sites |
iPTMneti | Q9NUM3 |
PhosphoSitePlusi | Q9NUM3 |
Genetic variation databases
BioMutai | SLC39A9 |
DMDMi | 156633628 |
Proteomic databases
EPDi | Q9NUM3 |
jPOSTi | Q9NUM3 |
MassIVEi | Q9NUM3 |
MaxQBi | Q9NUM3 |
PaxDbi | Q9NUM3 |
PeptideAtlasi | Q9NUM3 |
PRIDEi | Q9NUM3 |
ProteomicsDBi | 33545 82693 [Q9NUM3-1] 82694 [Q9NUM3-2] |
TopDownProteomicsi | Q9NUM3-2 [Q9NUM3-2] |
Protocols and materials databases
Antibodypediai | 107, 135 antibodies from 28 providers |
DNASUi | 55334 |
Genome annotation databases
Ensembli | ENST00000336643; ENSP00000336887; ENSG00000029364 ENST00000555840; ENSP00000450639; ENSG00000029364 ENST00000556605; ENSP00000452385; ENSG00000029364 [Q9NUM3-3] ENST00000557046; ENSP00000451833; ENSG00000029364 [Q9NUM3-2] |
GeneIDi | 55334 |
KEGGi | hsa:55334 |
MANE-Selecti | ENST00000336643.10; ENSP00000336887.5; NM_018375.5; NP_060845.2 |
UCSCi | uc001xle.5, human [Q9NUM3-1] |
Organism-specific databases
CTDi | 55334 |
DisGeNETi | 55334 |
GeneCardsi | SLC39A9 |
HGNCi | HGNC:20182, SLC39A9 |
HPAi | ENSG00000029364, Low tissue specificity |
MIMi | 619116, gene |
neXtProti | NX_Q9NUM3 |
OpenTargetsi | ENSG00000029364 |
PharmGKBi | PA134889179 |
VEuPathDBi | HostDB:ENSG00000029364 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3907, Eukaryota |
GeneTreei | ENSGT00390000010094 |
InParanoidi | Q9NUM3 |
OMAi | HWWTGML |
PhylomeDBi | Q9NUM3 |
TreeFami | TF315051 |
Enzyme and pathway databases
PathwayCommonsi | Q9NUM3 |
SignaLinki | Q9NUM3 |
Miscellaneous databases
BioGRID-ORCSi | 55334, 40 hits in 1049 CRISPR screens |
ChiTaRSi | SLC39A9, human |
GenomeRNAii | 55334 |
Pharosi | Q9NUM3, Tbio |
PROi | PR:Q9NUM3 |
RNActi | Q9NUM3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000029364, Expressed in testis and 222 other tissues |
ExpressionAtlasi | Q9NUM3, baseline and differential |
Genevisiblei | Q9NUM3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR003689, ZIP IPR045891, ZIP9 |
PANTHERi | PTHR16133, PTHR16133, 1 hit |
Pfami | View protein in Pfam PF02535, Zip, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S39A9_HUMAN | |
Accessioni | Q9NUM3Primary (citable) accession number: Q9NUM3 Secondary accession number(s): G3V5J8 Q86WY2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 21, 2007 |
Last sequence update: | August 21, 2007 | |
Last modified: | February 23, 2022 | |
This is version 137 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families