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UniProtKB - Q9NUL5 (SHFL_HUMAN)

Entry version 126 (07 Oct 2020)
Sequence version 2 (26 Feb 2008)
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Protein

Shiftless antiviral inhibitor of ribosomal frameshifting protein

Gene

SHFL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses, such as HIV1, and cellular genes, such as PEG10. Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site (PubMed:30682371). Regulates HIV1 GAG-POL expression by inhibiting -1PRF (PubMed:30682371). Exhibits antiviral activity against dengue virus (DENV) and can inhibit the replication of all DENV serotypes. May block the protein translation of DENV RNA via its association with cellular mRNA-binding proteins and viral RNA. Can also limit the replication of hepatitis C virus (HCV), West Nile virus (WNV), Chikungunya virus (CHIKV), herpes simplex virus type 1 (HHV-1) and human adenovirus (PubMed:26735137, PubMed:27974568). Binds nucleic acids with a higher affinity for ssRNA and ssDNA than for dsDNA (PubMed:27974568).3 Publications
Isoform 4 does not inhibit programmed ribosomal frameshifting (-1PRF). Does not bind to ribosomes.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processAntiviral defense

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NUL5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Shiftless antiviral inhibitor of ribosomal frameshifting proteinCurated
Short name:
SFL1 Publication
Short name:
SHFLCurated
Alternative name(s):
Interferon-regulated antiviral protein1 Publication
Short name:
IRAV1 Publication
Repressor of yield of DENV protein1 Publication
Short name:
RyDEN1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SHFLImported
Synonyms:C19orf66, FLJ112861 Publication, IRAV1 Publication, RYDEN1 Publication, SFL1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000130813.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:25649, SHFL

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616808, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NUL5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi121 – 137RRVPQ…RKCRK → AAVPQAAEVSACAACAA: Decreased efficiency in the interaction with PABPC1 and reduced inhibitory activity against DENV replication. 1 PublicationAdd BLAST17

Organism-specific databases

DisGeNET

More...DisGeNETi		55337

Open Targets

More...OpenTargetsi		ENSG00000130813

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162378809

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NUL5, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		C19orf66

Domain mapping of disease mutations (DMDM)

More...DMDMi		172044675

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003187012 – 291Shiftless antiviral inhibitor of ribosomal frameshifting proteinAdd BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NUL5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NUL5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NUL5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NUL5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NUL5

PeptideAtlas

More...PeptideAtlasi		Q9NUL5

PRoteomics IDEntifications database

More...PRIDEi		Q9NUL5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82688 [Q9NUL5-1]
82689 [Q9NUL5-2]
82690 [Q9NUL5-3]
82691 [Q9NUL5-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NUL5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NUL5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by interferon (IFN) treatment (PubMed:26735137, PubMed:27974568, PubMed:30682371). Expression increases in response to DENV infection in an IFN-dependent manner (PubMed:27974568).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000130813, Expressed in right lobe of liver and 229 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NUL5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NUL5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000130813, Tissue enhanced (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PABPC1 (PubMed:26735137).

Found in a complex with PABPC1 and LARP1 (PubMed:26735137).

Interacts with ELAV1, MOV10 and UPF1; the interactions increase in presence of RNA (PubMed:27974568). Binds to ribosomes (PubMed:30682371).

Interacts with GSPT1 (PubMed:30682371).

3 Publications

(Microbial infection) Interacts with the human dengue virus DENV proteins NS3 and NS4A.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9NUL5
With#Exp.IntAct
ADAMTSL4 - isoform 3 [Q6UY14-3]3EBI-10313866,EBI-10173507
CADPS [A2RRN7]3EBI-10313866,EBI-10179719
CCDC136 - isoform 2 [Q96JN2-2]3EBI-10313866,EBI-10171416
DRICH1 [Q6PGQ1]3EBI-10313866,EBI-10253641
DTNBP1 [Q96EV8]3EBI-10313866,EBI-465804
IKZF1 [Q13422]3EBI-10313866,EBI-745305
KRT40 [Q6A162]3EBI-10313866,EBI-10171697
KRTAP10-5 [P60370]3EBI-10313866,EBI-10172150
KRTAP10-7 [P60409]3EBI-10313866,EBI-10172290
KRTAP10-8 [P60410]3EBI-10313866,EBI-10171774
KRTAP10-9 [P60411]3EBI-10313866,EBI-10172052
KRTAP2-3 [P0C7H8]3EBI-10313866,EBI-10196781
KRTAP4-12 [Q9BQ66]3EBI-10313866,EBI-739863
KRTAP4-2 [Q9BYR5]3EBI-10313866,EBI-10172511
KRTAP5-9 [P26371]3EBI-10313866,EBI-3958099
KRTAP9-2 [Q9BYQ4]3EBI-10313866,EBI-1044640
LZTS2 [Q9BRK4]3EBI-10313866,EBI-741037
MAGEA1 [P43355]3EBI-10313866,EBI-740978
MDFI [Q99750]3EBI-10313866,EBI-724076
MEOX2 [P50222]3EBI-10313866,EBI-748397
MID2 - isoform 2 [Q9UJV3-2]3EBI-10313866,EBI-10172526
MTUS2 [Q5JR59]3EBI-10313866,EBI-742948
NOTCH2NLA [Q7Z3S9]3EBI-10313866,EBI-945833
PDE4DIP [Q5VU43]3EBI-10313866,EBI-1105124
SPRY2 [O43597]3EBI-10313866,EBI-742487
SSX2IP [Q9Y2D8]3EBI-10313866,EBI-2212028
TCF4 [P15884]3EBI-10313866,EBI-533224
TERF1 [P54274]2EBI-10313866,EBI-710997
TNS2 [Q63HR2]4EBI-10313866,EBI-949753
TRAF1 [Q13077]3EBI-10313866,EBI-359224
SHFL - isoform 4 [Q9NUL5-4]
With#Exp.IntAct
ADAMTSL4 - isoform 3 [Q6UY14-3]3EBI-11955083,EBI-10173507
CCNDBP1 [O95273]3EBI-11955083,EBI-748961
CYSRT1 [A8MQ03]3EBI-11955083,EBI-3867333
DRICH1 [Q6PGQ1]3EBI-11955083,EBI-10253641
DVL3 [Q92997]3EBI-11955083,EBI-739789
FHL5 [Q5TD97]3EBI-11955083,EBI-750641
HSF2BP [O75031]3EBI-11955083,EBI-7116203
INCA1 [Q0VD86]3EBI-11955083,EBI-6509505
KLF15 [Q9UIH9]3EBI-11955083,EBI-2796400
KRT31 [Q15323]3EBI-11955083,EBI-948001
KRT40 [Q6A162]3EBI-11955083,EBI-10171697
KRTAP1-1 [Q07627]3EBI-11955083,EBI-11959885
KRTAP1-5 [Q9BYS1]3EBI-11955083,EBI-11741292
KRTAP10-5 [P60370]3EBI-11955083,EBI-10172150
KRTAP10-7 [P60409]3EBI-11955083,EBI-10172290
KRTAP10-8 [P60410]3EBI-11955083,EBI-10171774
KRTAP10-9 [P60411]3EBI-11955083,EBI-10172052
KRTAP12-3 [P60328]3EBI-11955083,EBI-11953334
KRTAP17-1 [Q9BYP8]3EBI-11955083,EBI-11988175
KRTAP2-4 [Q9BYR9]3EBI-11955083,EBI-14065470
KRTAP4-11 [Q9BYQ6]5EBI-11955083,EBI-10302392
KRTAP4-12 [Q9BQ66]3EBI-11955083,EBI-739863
KRTAP4-4 [Q9BYR3]3EBI-11955083,EBI-11958132
KRTAP4-5 [Q9BYR2]3EBI-11955083,EBI-11993254
KRTAP5-7 [Q6L8G8]3EBI-11955083,EBI-11987425
KRTAP5-9 [P26371]3EBI-11955083,EBI-3958099
KRTAP9-2 [Q9BYQ4]3EBI-11955083,EBI-1044640
KRTAP9-3 [Q9BYQ3]3EBI-11955083,EBI-1043191
LNX1 [Q8TBB1]3EBI-11955083,EBI-739832
LURAP1 [Q96LR2]3EBI-11955083,EBI-741355
MDFI [Q99750]3EBI-11955083,EBI-724076
MEOX2 [Q6FHY5]3EBI-11955083,EBI-16439278
MTUS2 - isoform 2 [Q5JR59-3]3EBI-11955083,EBI-11522433
NOTCH2NLC [P0DPK4]3EBI-11955083,EBI-22310682
PCSK5 - isoform PC6A [Q92824-2]3EBI-11955083,EBI-11956269
PICK1 [Q9NRD5]3EBI-11955083,EBI-79165
PPP2R5A [Q15172]3EBI-11955083,EBI-641666
itself3EBI-11955083,EBI-11955083
SSX2IP [Q9Y2D8]3EBI-11955083,EBI-2212028
TENM4 [Q6N022]3EBI-11955083,EBI-12827077
TLE5 - isoform 2 [Q08117-2]3EBI-11955083,EBI-11741437
TRAF1 [Q13077]3EBI-11955083,EBI-359224
TRIB3 [Q96RU7]3EBI-11955083,EBI-492476
TRIM42 [Q8IWZ5]3EBI-11955083,EBI-5235829
VWC2 [Q2TAL6]3EBI-11955083,EBI-11957238
ZNF835 [Q9Y2P0]3EBI-11955083,EBI-5667516

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120618, 75 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9NUL5

Protein interaction database and analysis system

More...IntActi		Q9NUL5, 64 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000253110

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NUL5, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni102 – 150Interaction with PABPC11 PublicationAdd BLAST49

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi121 – 137Nuclear localization signal1 PublicationAdd BLAST17
Motifi261 – 269Nuclear export signal1 Publication9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi262 – 291Asp/Glu-rich (acidic)Add BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SHFL family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QVND, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000005065

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_087318_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NUL5

Identification of Orthologs from Complete Genome Data

More...OMAi		HSCLAED

Database of Orthologous Groups

More...OrthoDBi		1485595at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NUL5

TreeFam database of animal gene trees

More...TreeFami		TF337433

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026795, SHFL

The PANTHER Classification System

More...PANTHERi		PTHR16135, PTHR16135, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15135, UPF0515, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NUL5-1) [UniParc]FASTAAdd to basket
Also known as: SFL1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQEGVELEK SVRRLREKFH GKVSSKKAGA LMRKFGSDHT GVGRSIVYGV 
        60         70         80         90        100
KQKDGQELSN DLDAQDPPED MKQDRDIQAV ATSLLPLTEA NLRMFQRAQD 
       110        120        130        140        150
DLIPAVDRQF ACSSCDHVWW RRVPQRKEVS RCRKCRKRYE PVPADKMWGL 
       160        170        180        190        200
AEFHCPKCRH NFRGWAQMGS PSPCYGCGFP VYPTRILPPR WDRDPDRRST 
       210        220        230        240        250
HTHSCSAADC YNRREPHVPG TSCAHPKSRK QNHLPKVLHP SNPHISSGST 
       260        270        280        290 
VATCLSQGGL LEDLDNLILE DLKEEEEEEE EVEDEEGGPR E
Length:291
Mass (Da):33,110
Last modified:February 26, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD6513814B96BDAF6
GO
Isoform 2 (identifier: Q9NUL5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-65: MSQEGVELEK...QELSNDLDAQ → MSQHQQACGICRQE

Show »
Length:240
Mass (Da):27,524
Checksum:iAF8580711EA1F41B
GO
Isoform 3 (identifier: Q9NUL5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     164-291: Missing.

Show »
Length:163
Mass (Da):18,871
Checksum:iBBB6A14F1DA8ECD7
GO
Isoform 4 (identifier: Q9NUL5-4) [UniParc]FASTAAdd to basket
Also known as: SFLS1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     164-199: Missing.

Show »
Length:255
Mass (Da):29,006
Checksum:i466D43FA57D26D25
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EML3K7EML3_HUMAN
Shiftless antiviral inhibitor of ri...
SHFL
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMS9K7EMS9_HUMAN
Shiftless antiviral inhibitor of ri...
SHFL
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EP02K7EP02_HUMAN
Shiftless antiviral inhibitor of ri...
SHFL
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELT7K7ELT7_HUMAN
Shiftless antiviral inhibitor of ri...
SHFL
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti191W → R in BAA92109 (PubMed:14702039).Curated1
Sequence conflicti249S → P in BAA92109 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0312721 – 65MSQEG…DLDAQ → MSQHQQACGICRQE in isoform 2. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_031273164 – 291Missing in isoform 3. 1 PublicationAdd BLAST128
Alternative sequenceiVSP_031274164 – 199Missing in isoform 4. 1 PublicationAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK002148 mRNA Translation: BAA92109.1
AK096142 mRNA Translation: BAC04710.1
AC020931 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84066.1
CH471106 Genomic DNA Translation: EAW84068.1
CH471106 Genomic DNA Translation: EAW84069.1
BC010847 mRNA Translation: AAH10847.1
BC026180 mRNA Translation: AAH26180.1
BC035817 mRNA Translation: AAH35817.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45957.1 [Q9NUL5-1]
CCDS77231.1 [Q9NUL5-4]

NCBI Reference Sequences

More...RefSeqi		NP_001295206.1, NM_001308277.1 [Q9NUL5-4]
NP_060851.2, NM_018381.3 [Q9NUL5-1]
XP_016882423.1, XM_017026934.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000253110; ENSP00000253110; ENSG00000130813 [Q9NUL5-1]
ENST00000397881; ENSP00000380978; ENSG00000130813 [Q9NUL5-2]
ENST00000591813; ENSP00000467182; ENSG00000130813 [Q9NUL5-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55337

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55337

UCSC genome browser

More...UCSCi		uc002mmu.5, human [Q9NUL5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002148 mRNA Translation: BAA92109.1
AK096142 mRNA Translation: BAC04710.1
AC020931 Genomic DNA No translation available.
CH471106 Genomic DNA Translation: EAW84066.1
CH471106 Genomic DNA Translation: EAW84068.1
CH471106 Genomic DNA Translation: EAW84069.1
BC010847 mRNA Translation: AAH10847.1
BC026180 mRNA Translation: AAH26180.1
BC035817 mRNA Translation: AAH35817.1
CCDSiCCDS45957.1 [Q9NUL5-1]
CCDS77231.1 [Q9NUL5-4]
RefSeqiNP_001295206.1, NM_001308277.1 [Q9NUL5-4]
NP_060851.2, NM_018381.3 [Q9NUL5-1]
XP_016882423.1, XM_017026934.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi120618, 75 interactors
CORUMiQ9NUL5
IntActiQ9NUL5, 64 interactors
STRINGi9606.ENSP00000253110

PTM databases

iPTMnetiQ9NUL5
PhosphoSitePlusiQ9NUL5

Polymorphism and mutation databases

BioMutaiC19orf66
DMDMi172044675

Proteomic databases

EPDiQ9NUL5
jPOSTiQ9NUL5
MassIVEiQ9NUL5
MaxQBiQ9NUL5
PaxDbiQ9NUL5
PeptideAtlasiQ9NUL5
PRIDEiQ9NUL5
ProteomicsDBi82688 [Q9NUL5-1]
82689 [Q9NUL5-2]
82690 [Q9NUL5-3]
82691 [Q9NUL5-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		51349, 34 antibodies

The DNASU plasmid repository

More...DNASUi		55337

Genome annotation databases

EnsembliENST00000253110; ENSP00000253110; ENSG00000130813 [Q9NUL5-1]
ENST00000397881; ENSP00000380978; ENSG00000130813 [Q9NUL5-2]
ENST00000591813; ENSP00000467182; ENSG00000130813 [Q9NUL5-4]
GeneIDi55337
KEGGihsa:55337
UCSCiuc002mmu.5, human [Q9NUL5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55337
DisGeNETi55337
EuPathDBiHostDB:ENSG00000130813.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		SHFL
HGNCiHGNC:25649, SHFL
HPAiENSG00000130813, Tissue enhanced (liver)
MIMi616808, gene
neXtProtiNX_Q9NUL5
OpenTargetsiENSG00000130813
PharmGKBiPA162378809

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QVND, Eukaryota
GeneTreeiENSGT00390000005065
HOGENOMiCLU_087318_0_0_1
InParanoidiQ9NUL5
OMAiHSCLAED
OrthoDBi1485595at2759
PhylomeDBiQ9NUL5
TreeFamiTF337433

Enzyme and pathway databases

PathwayCommonsiQ9NUL5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55337, 9 hits in 860 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		C19orf66, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55337
PharosiQ9NUL5, Tdark

Protein Ontology

More...PROi		PR:Q9NUL5
RNActiQ9NUL5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000130813, Expressed in right lobe of liver and 229 other tissues
ExpressionAtlasiQ9NUL5, baseline and differential
GenevisibleiQ9NUL5, HS

Family and domain databases

InterProiView protein in InterPro
IPR026795, SHFL
PANTHERiPTHR16135, PTHR16135, 1 hit
PfamiView protein in Pfam
PF15135, UPF0515, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSHFL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NUL5
Secondary accession number(s): A8MQT9
, Q4G188, Q8IYH6, Q8N8V1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: October 7, 2020
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
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