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UniProtKB - Q9NUK0 (MBNL3_HUMAN)

Entry version 169 (10 Feb 2021)
Sequence version 2 (06 Dec 2002)
Previous versions | rss
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Protein

Muscleblind-like protein 3

Gene

MBNL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri14 – 42C3H1-type 1PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri48 – 74C3H1-type 2PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri174 – 202C3H1-type 3PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri210 – 236C3H1-type 4PROSITE-ProRule annotationAdd BLAST27

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processmRNA processing, mRNA splicing
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NUK0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Muscleblind-like protein 3
Alternative name(s):
Cys3His CCG1-required protein
Muscleblind-like X-linked protein
Protein HCHCR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MBNL3
Synonyms:CHCR, MBLX39, MBXL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20564, MBNL3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300413, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NUK0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000076770.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55796

Open Targets

More...OpenTargetsi		ENSG00000076770

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134992936

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NUK0, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MBNL3

Domain mapping of disease mutations (DMDM)

More...DMDMi		26396510

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000891801 – 354Muscleblind-like protein 3Add BLAST354

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NUK0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NUK0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NUK0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NUK0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NUK0

PeptideAtlas

More...PeptideAtlasi		Q9NUK0

PRoteomics IDEntifications database

More...PRIDEi		Q9NUK0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		70598
82679 [Q9NUK0-1]
82680 [Q9NUK0-2]
82681 [Q9NUK0-3]
82682 [Q9NUK0-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NUK0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NUK0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the placenta.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000076770, Expressed in placenta and 197 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NUK0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NUK0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000076770, Tissue enhanced (placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120909, 12 interactors

Protein interaction database and analysis system

More...IntActi		Q9NUK0, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000359890

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NUK0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NUK0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi118 – 169Pro-richAdd BLAST52

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the muscleblind family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri14 – 42C3H1-type 1PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri48 – 74C3H1-type 2PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri174 – 202C3H1-type 3PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri210 – 236C3H1-type 4PROSITE-ProRule annotationAdd BLAST27

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2494, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182897

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_053536_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NUK0

Identification of Orthologs from Complete Genome Data

More...OMAi		DIECKYA

Database of Orthologous Groups

More...OrthoDBi		1543798at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NUK0

TreeFam database of animal gene trees

More...TreeFami		TF321931

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000571, Znf_CCCH

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00642, zf-CCCH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00356, ZnF_C3H1, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50103, ZF_C3H1, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NUK0-1) [UniParc]FASTAAdd to basket
Also known as: HCHCR-G, G

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAVNVALIR DTKWLTLEVC REFQRGTCSR ADADCKFAHP PRVCHVENGR 
        60         70         80         90        100
VVACFDSLKG RCTRENCKYL HPPPHLKTQL EINGRNNLIQ QKTAAAMFAQ 
       110        120        130        140        150
QMQLMLQNAQ MSSLGSFPMT PSIPANPPMA FNPYIPHPGM GLVPAELVPN 
       160        170        180        190        200
TPVLIPGNPP LAMPGAVGPK LMRSDKLEVC REFQRGNCTR GENDCRYAHP 
       210        220        230        240        250
TDASMIEASD NTVTICMDYI KGRCSREKCK YFHPPAHLQA RLKAAHHQMN 
       260        270        280        290        300
HSAASAMALQ PGTLQLIPKR SALEKPNGAT PVFNPTVFHC QQALTNLQLP 
       310        320        330        340        350
QPAFIPAGPI LCMAPASNIV PMMHGATPTT VSAATTPATS VPFAAPTTGN 

QLKF
Length:354
Mass (Da):38,532
Last modified:December 6, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i145E1AF8CB3BEE27
GO
Isoform 2 (identifier: Q9NUK0-2) [UniParc]FASTAAdd to basket
Also known as: HCHCR-R, R

The sequence of this isoform differs from the canonical sequence as follows:
     258-292: Missing.
     352-354: LKF → IPQLSIDELNSSMFVSQM

Show »
Length:334
Mass (Da):36,380
Checksum:i9FB835135F474DCE
GO
Isoform 3 (identifier: Q9NUK0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.
     51-57: VVACFDS → MERASKN

Show »
Length:304
Mass (Da):32,942
Checksum:iACB92E93B3E5C097
GO
Isoform 4 (identifier: Q9NUK0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.
     51-57: VVACFDS → MERASKN
     308-319: Missing.

Show »
Length:292
Mass (Da):31,774
Checksum:iFB239634C3247296
GO
Isoform 5 (identifier: Q9NUK0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-96: Missing.

Show »
Length:258
Mass (Da):27,687
Checksum:i1DBE7A26DE8F5A4B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AKI6B1AKI6_HUMAN
Muscleblind-like protein 3
MBNL3
342Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AKI5B1AKI5_HUMAN
Muscleblind-like protein 3
MBNL3
223Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AKI4B1AKI4_HUMAN
Muscleblind-like protein 3
MBNL3
242Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AKI2B1AKI2_HUMAN
Muscleblind-like protein 3
MBNL3
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti113S → P in AAQ75759 (Ref. 3) Curated1
Sequence conflicti187N → I in AAQ75759 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0443091 – 96Missing in isoform 5. 2 PublicationsAdd BLAST96
Alternative sequenceiVSP_0064311 – 50Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST50
Alternative sequenceiVSP_00643251 – 57VVACFDS → MERASKN in isoform 3 and isoform 4. 2 Publications7
Alternative sequenceiVSP_006433258 – 292Missing in isoform 2. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_015935308 – 319Missing in isoform 4. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_006434352 – 354LKF → IPQLSIDELNSSMFVSQM in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY072692 mRNA Translation: AAL65661.1
AF467070 mRNA Translation: AAL87670.1
AB077698 mRNA Translation: BAB85648.1
AB077699 mRNA Translation: BAB85649.1
AJ427918 mRNA Translation: CAD20869.1
AJ427919 mRNA Translation: CAD20870.1
AF491305 mRNA Translation: AAM09533.1
AY372211 mRNA Translation: AAQ75759.1
AK002178 mRNA Translation: BAA92124.1
AK300248 mRNA Translation: BAG62014.1
AL161442 Genomic DNA No translation available.
AL050310 Genomic DNA No translation available.
BC042090 mRNA Translation: AAH42090.1
BC074775 mRNA Translation: AAH74775.1
BC074776 mRNA Translation: AAH74776.1
AL133625 mRNA Translation: CAB63751.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14633.1 [Q9NUK0-1]
CCDS14634.1 [Q9NUK0-2]
CCDS55492.1 [Q9NUK0-5]

Protein sequence database of the Protein Information Resource

More...PIRi		T43463

NCBI Reference Sequences

More...RefSeqi		NP_001164172.1, NM_001170701.1 [Q9NUK0-3]
NP_001164173.1, NM_001170702.1 [Q9NUK0-4]
NP_001164174.1, NM_001170703.1 [Q9NUK0-5]
NP_001164175.1, NM_001170704.1 [Q9NUK0-5]
NP_060858.2, NM_018388.3 [Q9NUK0-1]
NP_597846.1, NM_133486.2 [Q9NUK0-2]
XP_005262491.1, XM_005262434.3 [Q9NUK0-1]
XP_016885124.1, XM_017029635.1
XP_016885125.1, XM_017029636.1 [Q9NUK0-1]
XP_016885128.1, XM_017029639.1 [Q9NUK0-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000370839; ENSP00000359876; ENSG00000076770 [Q9NUK0-2]
ENST00000370844; ENSP00000359881; ENSG00000076770 [Q9NUK0-5]
ENST00000370849; ENSP00000359886; ENSG00000076770 [Q9NUK0-3]
ENST00000370853; ENSP00000359890; ENSG00000076770 [Q9NUK0-1]
ENST00000394311; ENSP00000377848; ENSG00000076770 [Q9NUK0-5]
ENST00000538204; ENSP00000439618; ENSG00000076770 [Q9NUK0-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55796

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55796

UCSC genome browser

More...UCSCi		uc004ewt.4, human [Q9NUK0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY072692 mRNA Translation: AAL65661.1
AF467070 mRNA Translation: AAL87670.1
AB077698 mRNA Translation: BAB85648.1
AB077699 mRNA Translation: BAB85649.1
AJ427918 mRNA Translation: CAD20869.1
AJ427919 mRNA Translation: CAD20870.1
AF491305 mRNA Translation: AAM09533.1
AY372211 mRNA Translation: AAQ75759.1
AK002178 mRNA Translation: BAA92124.1
AK300248 mRNA Translation: BAG62014.1
AL161442 Genomic DNA No translation available.
AL050310 Genomic DNA No translation available.
BC042090 mRNA Translation: AAH42090.1
BC074775 mRNA Translation: AAH74775.1
BC074776 mRNA Translation: AAH74776.1
AL133625 mRNA Translation: CAB63751.1
CCDSiCCDS14633.1 [Q9NUK0-1]
CCDS14634.1 [Q9NUK0-2]
CCDS55492.1 [Q9NUK0-5]
PIRiT43463
RefSeqiNP_001164172.1, NM_001170701.1 [Q9NUK0-3]
NP_001164173.1, NM_001170702.1 [Q9NUK0-4]
NP_001164174.1, NM_001170703.1 [Q9NUK0-5]
NP_001164175.1, NM_001170704.1 [Q9NUK0-5]
NP_060858.2, NM_018388.3 [Q9NUK0-1]
NP_597846.1, NM_133486.2 [Q9NUK0-2]
XP_005262491.1, XM_005262434.3 [Q9NUK0-1]
XP_016885124.1, XM_017029635.1
XP_016885125.1, XM_017029636.1 [Q9NUK0-1]
XP_016885128.1, XM_017029639.1 [Q9NUK0-5]

3D structure databases

SMRiQ9NUK0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120909, 12 interactors
IntActiQ9NUK0, 5 interactors
STRINGi9606.ENSP00000359890

PTM databases

iPTMnetiQ9NUK0
PhosphoSitePlusiQ9NUK0

Genetic variation databases

BioMutaiMBNL3
DMDMi26396510

Proteomic databases

EPDiQ9NUK0
jPOSTiQ9NUK0
MassIVEiQ9NUK0
MaxQBiQ9NUK0
PaxDbiQ9NUK0
PeptideAtlasiQ9NUK0
PRIDEiQ9NUK0
ProteomicsDBi70598
82679 [Q9NUK0-1]
82680 [Q9NUK0-2]
82681 [Q9NUK0-3]
82682 [Q9NUK0-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		446, 141 antibodies

The DNASU plasmid repository

More...DNASUi		55796

Genome annotation databases

EnsembliENST00000370839; ENSP00000359876; ENSG00000076770 [Q9NUK0-2]
ENST00000370844; ENSP00000359881; ENSG00000076770 [Q9NUK0-5]
ENST00000370849; ENSP00000359886; ENSG00000076770 [Q9NUK0-3]
ENST00000370853; ENSP00000359890; ENSG00000076770 [Q9NUK0-1]
ENST00000394311; ENSP00000377848; ENSG00000076770 [Q9NUK0-5]
ENST00000538204; ENSP00000439618; ENSG00000076770 [Q9NUK0-4]
GeneIDi55796
KEGGihsa:55796
UCSCiuc004ewt.4, human [Q9NUK0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55796
DisGeNETi55796

GeneCards: human genes, protein and diseases

More...GeneCardsi		MBNL3
HGNCiHGNC:20564, MBNL3
HPAiENSG00000076770, Tissue enhanced (placenta)
MIMi300413, gene
neXtProtiNX_Q9NUK0
OpenTargetsiENSG00000076770
PharmGKBiPA134992936
VEuPathDBiHostDB:ENSG00000076770.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2494, Eukaryota
GeneTreeiENSGT00950000182897
HOGENOMiCLU_053536_0_0_1
InParanoidiQ9NUK0
OMAiDIECKYA
OrthoDBi1543798at2759
PhylomeDBiQ9NUK0
TreeFamiTF321931

Enzyme and pathway databases

PathwayCommonsiQ9NUK0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55796, 5 hits in 503 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MBNL3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MBNL3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55796
PharosiQ9NUK0, Tbio

Protein Ontology

More...PROi		PR:Q9NUK0
RNActiQ9NUK0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000076770, Expressed in placenta and 197 other tissues
ExpressionAtlasiQ9NUK0, baseline and differential
GenevisibleiQ9NUK0, HS

Family and domain databases

InterProiView protein in InterPro
IPR000571, Znf_CCCH
PfamiView protein in Pfam
PF00642, zf-CCCH, 1 hit
SMARTiView protein in SMART
SM00356, ZnF_C3H1, 4 hits
PROSITEiView protein in PROSITE
PS50103, ZF_C3H1, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMBNL3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NUK0
Secondary accession number(s): Q5JXN8
, Q5JXN9, Q5JXP4, Q6UDQ1, Q8IUR4, Q8TAD9, Q8TAF4, Q9H0Z7, Q9UF37
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: December 6, 2002
Last modified: February 10, 2021
This is version 169 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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