UniProtKB - Q9NUJ7 (PLCX1_HUMAN)
Protein
PI-PLC X domain-containing protein 1
Gene
PLCXD1
Organism
Homo sapiens (Human)
Status
Functioni
Miscellaneous
The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.
GO - Molecular functioni
- phosphoric diester hydrolase activity Source: InterPro
GO - Biological processi
- lipid metabolic process Source: InterPro
Enzyme and pathway databases
PathwayCommonsi | Q9NUJ7 |
Names & Taxonomyi
Protein namesi | Recommended name: PI-PLC X domain-containing protein 1 |
Gene namesi | Name:PLCXD1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000182378.13 |
HGNCi | HGNC:23148, PLCXD1 |
MIMi | 300974, gene 400046, gene |
neXtProti | NX_Q9NUJ7 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000182378 |
PharmGKBi | PA134878642 |
Miscellaneous databases
Pharosi | Q9NUJ7, Tdark |
Polymorphism and mutation databases
BioMutai | PLCXD1 |
DMDMi | 74752980 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000304804 | 1 – 323 | PI-PLC X domain-containing protein 1Add BLAST | 323 |
Proteomic databases
EPDi | Q9NUJ7 |
MassIVEi | Q9NUJ7 |
MaxQBi | Q9NUJ7 |
PaxDbi | Q9NUJ7 |
PeptideAtlasi | Q9NUJ7 |
PRIDEi | Q9NUJ7 |
ProteomicsDBi | 82678 |
PTM databases
iPTMneti | Q9NUJ7 |
PhosphoSitePlusi | Q9NUJ7 |
Expressioni
Tissue specificityi
Widely expressed.1 Publication
Gene expression databases
Bgeei | ENSG00000182378, Expressed in cerebellum and 222 other tissues |
ExpressionAtlasi | Q9NUJ7, baseline and differential |
Genevisiblei | Q9NUJ7, HS |
Organism-specific databases
HPAi | ENSG00000182378, Tissue enhanced (brain) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 120625, 6 interactors |
STRINGi | 9606.ENSP00000371073 |
Miscellaneous databases
RNActi | Q9NUJ7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 206 | PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST | 177 |
Phylogenomic databases
eggNOGi | KOG4306, Eukaryota |
GeneTreei | ENSGT00940000161625 |
HOGENOMi | CLU_051926_1_0_1 |
InParanoidi | Q9NUJ7 |
OMAi | KYICTHP |
OrthoDBi | 477702at2759 |
PhylomeDBi | Q9NUJ7 |
TreeFami | TF314457 |
Family and domain databases
CDDi | cd08616, PI-PLCXD1c, 1 hit |
Gene3Di | 3.20.20.190, 1 hit |
InterProi | View protein in InterPro IPR017946, PLC-like_Pdiesterase_TIM-brl IPR042158, PLCXD1/2/3 IPR000909, PLipase_C_PInositol-sp_X_dom |
Pfami | View protein in Pfam PF00388, PI-PLC-X, 1 hit |
SMARTi | View protein in SMART SM00148, PLCXc, 1 hit |
SUPFAMi | SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS50007, PIPLC_X_DOMAIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
Q9NUJ7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGGQVSASNS FSRLHCRNAN EDWMSALCPR LWDVPLHHLS IPGSHDTMTY
60 70 80 90 100
CLNKKSPISH EESRLLQLLN KALPCITRPV VLKWSVTQAL DVTEQLDAGV
110 120 130 140 150
RYLDLRIAHM LEGSEKNLHF VHMVYTTALV EDTLTEISEW LERHPREVVI
160 170 180 190 200
LACRNFEGLS EDLHEYLVAC IKNIFGDMLC PRGEVPTLRQ LWSRGQQVIV
210 220 230 240 250
SYEDESSLRR HHELWPGVPY WWGNRVKTEA LIRYLETMKS CGRPGGLFVA
260 270 280 290 300
GINLTENLQY VLAHPSESLE KMTLPNLPRL SAWVREQCPG PGSRCTNIIA
310 320
GDFIGADGFV SDVIALNQKL LWC
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MT29 | A0A0A0MT29_HUMAN | PI-PLC X domain-containing protein ... | PLCXD1 | 88 | Annotation score: | ||
A0A0A0MT41 | A0A0A0MT41_HUMAN | PI-PLC X domain-containing protein ... | PLCXD1 | 124 | Annotation score: | ||
C9JP92 | C9JP92_HUMAN | PI-PLC X domain-containing protein ... | PLCXD1 | 174 | Annotation score: | ||
K7EIC3 | K7EIC3_HUMAN | PI-PLC X domain-containing protein ... | PLCXD1 | 60 | Annotation score: | ||
X6RFG1 | X6RFG1_HUMAN | PI-PLC X domain-containing protein ... | PLCXD1 | 178 | Annotation score: | ||
A0A0A0MSZ3 | A0A0A0MSZ3_HUMAN | PI-PLC X domain-containing protein ... | PLCXD1 | 74 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002185 mRNA Translation: BAA92127.1 BX537334 Genomic DNA No translation available. CH471225 Genomic DNA Translation: EAW66822.1 BC005028 mRNA Translation: AAH05028.1 |
CCDSi | CCDS14103.1 |
RefSeqi | NP_060860.1, NM_018390.3 XP_006724507.1, XM_006724444.2 XP_006724508.1, XM_006724445.2 XP_006724509.1, XM_006724446.2 XP_006724928.1, XM_006724865.2 XP_006724929.1, XM_006724866.2 XP_006724930.1, XM_006724867.2 XP_011543935.1, XM_011545633.2 XP_011544482.1, XM_011546180.2 |
Genome annotation databases
Ensembli | ENST00000381657; ENSP00000371073; ENSG00000182378 ENST00000381663; ENSP00000371079; ENSG00000182378 ENST00000399012; ENSP00000381976; ENSG00000182378 |
GeneIDi | 55344 |
KEGGi | hsa:55344 |
UCSCi | uc004cpc.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002185 mRNA Translation: BAA92127.1 BX537334 Genomic DNA No translation available. CH471225 Genomic DNA Translation: EAW66822.1 BC005028 mRNA Translation: AAH05028.1 |
CCDSi | CCDS14103.1 |
RefSeqi | NP_060860.1, NM_018390.3 XP_006724507.1, XM_006724444.2 XP_006724508.1, XM_006724445.2 XP_006724509.1, XM_006724446.2 XP_006724928.1, XM_006724865.2 XP_006724929.1, XM_006724866.2 XP_006724930.1, XM_006724867.2 XP_011543935.1, XM_011545633.2 XP_011544482.1, XM_011546180.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120625, 6 interactors |
STRINGi | 9606.ENSP00000371073 |
PTM databases
iPTMneti | Q9NUJ7 |
PhosphoSitePlusi | Q9NUJ7 |
Polymorphism and mutation databases
BioMutai | PLCXD1 |
DMDMi | 74752980 |
Proteomic databases
EPDi | Q9NUJ7 |
MassIVEi | Q9NUJ7 |
MaxQBi | Q9NUJ7 |
PaxDbi | Q9NUJ7 |
PeptideAtlasi | Q9NUJ7 |
PRIDEi | Q9NUJ7 |
ProteomicsDBi | 82678 |
Protocols and materials databases
Antibodypediai | 557, 172 antibodies |
DNASUi | 55344 |
Genome annotation databases
Ensembli | ENST00000381657; ENSP00000371073; ENSG00000182378 ENST00000381663; ENSP00000371079; ENSG00000182378 ENST00000399012; ENSP00000381976; ENSG00000182378 |
GeneIDi | 55344 |
KEGGi | hsa:55344 |
UCSCi | uc004cpc.4, human |
Organism-specific databases
CTDi | 55344 |
EuPathDBi | HostDB:ENSG00000182378.13 |
GeneCardsi | PLCXD1 |
HGNCi | HGNC:23148, PLCXD1 |
HPAi | ENSG00000182378, Tissue enhanced (brain) |
MIMi | 300974, gene 400046, gene |
neXtProti | NX_Q9NUJ7 |
OpenTargetsi | ENSG00000182378 |
PharmGKBi | PA134878642 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4306, Eukaryota |
GeneTreei | ENSGT00940000161625 |
HOGENOMi | CLU_051926_1_0_1 |
InParanoidi | Q9NUJ7 |
OMAi | KYICTHP |
OrthoDBi | 477702at2759 |
PhylomeDBi | Q9NUJ7 |
TreeFami | TF314457 |
Enzyme and pathway databases
PathwayCommonsi | Q9NUJ7 |
Miscellaneous databases
BioGRID-ORCSi | 55344, 5 hits in 421 CRISPR screens |
ChiTaRSi | PLCXD1, human |
GeneWikii | PLCXD1 |
GenomeRNAii | 55344 |
Pharosi | Q9NUJ7, Tdark |
PROi | PR:Q9NUJ7 |
RNActi | Q9NUJ7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000182378, Expressed in cerebellum and 222 other tissues |
ExpressionAtlasi | Q9NUJ7, baseline and differential |
Genevisiblei | Q9NUJ7, HS |
Family and domain databases
CDDi | cd08616, PI-PLCXD1c, 1 hit |
Gene3Di | 3.20.20.190, 1 hit |
InterProi | View protein in InterPro IPR017946, PLC-like_Pdiesterase_TIM-brl IPR042158, PLCXD1/2/3 IPR000909, PLipase_C_PInositol-sp_X_dom |
Pfami | View protein in Pfam PF00388, PI-PLC-X, 1 hit |
SMARTi | View protein in SMART SM00148, PLCXc, 1 hit |
SUPFAMi | SSF51695, SSF51695, 1 hit |
PROSITEi | View protein in PROSITE PS50007, PIPLC_X_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PLCX1_HUMAN | |
Accessioni | Q9NUJ7Primary (citable) accession number: Q9NUJ7 Secondary accession number(s): A2BH51, A2BH52 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | October 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM