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Protein

Mycophenolic acid acyl-glucuronide esterase, mitochondrial

Gene

ABHD10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate.1 Publication

Catalytic activityi

Mycophenolic acid O-acyl-glucuronide + H2O = mycophenolate + D-glucuronate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei152Charge relay systemBy similarity1
Active sitei249Charge relay systemBy similarity1
Active sitei279Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular glucuronidation Source: Reactome
  • glucuronoside catabolic process Source: BHF-UCL

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000144827-MONOMER
BRENDAi3.1.1.93 2681
ReactomeiR-HSA-156588 Glucuronidation

Protein family/group databases

ESTHERihuman-ABHD10 AlphaBeta_hydrolase
MEROPSiS09.062

Names & Taxonomyi

Protein namesi
Recommended name:
Mycophenolic acid acyl-glucuronide esterase, mitochondrial (EC:3.1.1.93)
Alternative name(s):
Alpha/beta hydrolase domain-containing protein 10
Short name:
Abhydrolase domain-containing protein 10
Gene namesi
Name:ABHD10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000144827.8
HGNCiHGNC:25656 ABHD10
neXtProtiNX_Q9NUJ1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi55347
OpenTargetsiENSG00000144827
PharmGKBiPA134978569

Polymorphism and mutation databases

DMDMi74734347

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 52MitochondrionSequence analysisAdd BLAST52
ChainiPRO_000028073353 – 306Mycophenolic acid acyl-glucuronide esterase, mitochondrialAdd BLAST254

Proteomic databases

EPDiQ9NUJ1
MaxQBiQ9NUJ1
PaxDbiQ9NUJ1
PeptideAtlasiQ9NUJ1
PRIDEiQ9NUJ1
ProteomicsDBi82676

PTM databases

iPTMnetiQ9NUJ1
PhosphoSitePlusiQ9NUJ1
SwissPalmiQ9NUJ1

Expressioni

Gene expression databases

BgeeiENSG00000144827
CleanExiHS_ABHD10
ExpressionAtlasiQ9NUJ1 baseline and differential
GenevisibleiQ9NUJ1 HS

Organism-specific databases

HPAiHPA036991
HPA036992
HPA066081

Interactioni

Protein-protein interaction databases

BioGridi120628, 15 interactors
DIPiDIP-56934N
IntActiQ9NUJ1, 12 interactors
MINTiQ9NUJ1
STRINGi9606.ENSP00000273359

Structurei

3D structure databases

ProteinModelPortaliQ9NUJ1
SMRiQ9NUJ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 178AB hydrolase-1Sequence analysisAdd BLAST101

Sequence similaritiesi

Belongs to the AB hydrolase superfamily.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IHI0 Eukaryota
COG0596 LUCA
GeneTreeiENSGT00390000017765
HOGENOMiHOG000139902
HOVERGENiHBG080562
InParanoidiQ9NUJ1
KOiK13702
OMAiTISRWLE
OrthoDBiEOG091G0DZV
PhylomeDBiQ9NUJ1
TreeFamiTF329757

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
PfamiView protein in Pfam
PF00561 Abhydrolase_1, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NUJ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVARLAAVA AWVPCRSWGW AAVPFGPHRG LSVLLARIPQ RAPRWLPACR
60 70 80 90 100
QKTSLSFLNR PDLPNLAYKK LKGKSPGIIF IPGYLSYMNG TKALAIEEFC
110 120 130 140 150
KSLGHACIRF DYSGVGSSDG NSEESTLGKW RKDVLSIIDD LADGPQILVG
160 170 180 190 200
SSLGGWLMLH AAIARPEKVV ALIGVATAAD TLVTKFNQLP VELKKEVEMK
210 220 230 240 250
GVWSMPSKYS EEGVYNVQYS FIKEAEHHCL LHSPIPVNCP IRLLHGMKDD
260 270 280 290 300
IVPWHTSMQV ADRVLSTDVD VILRKHSDHR MREKADIQLL VYTIDDLIDK

LSTIVN
Length:306
Mass (Da):33,933
Last modified:October 1, 2000 - v1
Checksum:iE41139D5C22A83FE
GO
Isoform 2 (identifier: Q9NUJ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-157: Missing.

Note: No experimental confirmation available.
Show »
Length:149
Mass (Da):16,910
Checksum:iBB6B75027A2FD486
GO
Isoform 3 (identifier: Q9NUJ1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     193-205: LKKEVEMKGVWSM → DSGRKNYISLHSA
     206-306: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:205
Mass (Da):22,141
Checksum:i8EDC2A7F6446189B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031194251I → V. Corresponds to variant dbSNP:rs17429033Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0560931 – 157Missing in isoform 2. 1 PublicationAdd BLAST157
Alternative sequenceiVSP_056742193 – 205LKKEV…GVWSM → DSGRKNYISLHSA in isoform 3. CuratedAdd BLAST13
Alternative sequenceiVSP_056743206 – 306Missing in isoform 3. CuratedAdd BLAST101

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002204 mRNA Translation: BAA92133.1
AK300018 mRNA Translation: BAH13194.1
AC060225 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79688.1
CH471052 Genomic DNA Translation: EAW79689.1
BC014516 mRNA Translation: AAH14516.1
AL713726 mRNA Translation: CAD28516.2
CCDSiCCDS2963.1 [Q9NUJ1-1]
CCDS63718.1 [Q9NUJ1-3]
RefSeqiNP_001258998.1, NM_001272069.1 [Q9NUJ1-3]
NP_060864.1, NM_018394.3 [Q9NUJ1-1]
XP_011511262.1, XM_011512960.2 [Q9NUJ1-3]
UniGeneiHs.477115

Genome annotation databases

EnsembliENST00000273359; ENSP00000273359; ENSG00000144827 [Q9NUJ1-1]
ENST00000494817; ENSP00000418973; ENSG00000144827 [Q9NUJ1-3]
GeneIDi55347
KEGGihsa:55347
UCSCiuc003dyk.6 human [Q9NUJ1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiABHDA_HUMAN
AccessioniPrimary (citable) accession number: Q9NUJ1
Secondary accession number(s): B7Z6A8
, C9IZX5, D3DN63, Q8TCF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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