UniProtKB - Q9NUH8 (TM14B_HUMAN)
Transmembrane protein 14B
TMEM14B
Functioni
Primate-specific protein involved in cortical expansion and folding in the developing neocortex. May drive neural progenitor proliferation through nuclear translocation of IQGAP1, which in turn promotes G1/S cell cycle transitions.
1 PublicationMiscellaneous
GO - Molecular functioni
- identical protein binding Source: IntAct
GO - Biological processi
- cerebral cortex development Source: UniProtKB
- mitochondrial transport Source: GO_Central
- neural precursor cell proliferation Source: UniProtKB
- regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
Keywordsi
Molecular function | Developmental protein |
Biological process | Neurogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q9NUH8 |
SignaLinki | Q9NUH8 |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 14B |
Gene namesi | Name:TMEM14B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21384, TMEM14B |
neXtProti | NX_Q9NUH8 |
VEuPathDBi | HostDB:ENSG00000137210 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Sequence analysis
Mitochondrion
- mitochondrial inner membrane Source: GO_Central
- mitochondrial membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 8 – 28 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 34 – 54 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 60 – 80 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 83 – 103 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 81853 |
OpenTargetsi | ENSG00000137210 |
PharmGKBi | PA134964501 |
Miscellaneous databases
Pharosi | Q9NUH8, Tbio |
Genetic variation databases
BioMutai | TMEM14B |
DMDMi | 27734593 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000221172 | 1 – 114 | Transmembrane protein 14BAdd BLAST | 114 |
Proteomic databases
MassIVEi | Q9NUH8 |
MaxQBi | Q9NUH8 |
PaxDbi | Q9NUH8 |
PeptideAtlasi | Q9NUH8 |
PRIDEi | Q9NUH8 |
TopDownProteomicsi | Q9NUH8-1 [Q9NUH8-1] |
PTM databases
iPTMneti | Q9NUH8 |
PhosphoSitePlusi | Q9NUH8 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000137210, Expressed in oocyte and 223 other tissues |
ExpressionAtlasi | Q9NUH8, baseline and differential |
Genevisiblei | Q9NUH8, HS |
Organism-specific databases
HPAi | ENSG00000137210, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with IQGAP1; this interaction promotes phosphorylation and nuclear translocation of IQGAP1.
1 PublicationBinary interactionsi
Q9NUH8
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 123603, 274 interactors |
IntActi | Q9NUH8, 217 interactors |
MINTi | Q9NUH8 |
STRINGi | 9606.ENSP00000420658 |
Miscellaneous databases
RNActi | Q9NUH8, protein |
Structurei
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
GeneTreei | ENSGT00940000163914 |
HOGENOMi | CLU_096652_4_0_1 |
InParanoidi | Q9NUH8 |
OMAi | GANWLMV |
TreeFami | TF323345 |
Family and domain databases
Gene3Di | 1.10.10.1740, 1 hit |
InterProi | View protein in InterPro IPR005349, TMEM14 IPR044890, TMEM14_sf |
PANTHERi | PTHR12668, PTHR12668, 1 hit |
Pfami | View protein in Pfam PF03647, Tmemb_14, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEKPLFPLVP LHWFGFGYTA LVVSGGIVGY VKTGSVPSLA AGLLFGSLAG
60 70 80 90 100
LGAYQLYQDP RNVWGFLAAT SVTFVGVMGM RSYYYGKFMP VGLIAGASLL
110
MAAKVGVRML MTSD
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JCY4 | C9JCY4_HUMAN | Transmembrane protein 14B | TMEM14B | 151 | Annotation score: | ||
C9JQS0 | C9JQS0_HUMAN | Transmembrane protein 14B | TMEM14B | 117 | Annotation score: | ||
A0A087WU83 | A0A087WU83_HUMAN | Transmembrane protein 14B | TMEM14B hCG_1782975 | 103 | Annotation score: | ||
B4DFL6 | B4DFL6_HUMAN | Transmembrane protein 14B | TMEM14B | 135 | Annotation score: | ||
H7C541 | H7C541_HUMAN | Transmembrane protein 14B | TMEM14B | 47 | Annotation score: | ||
C9J786 | C9J786_HUMAN | Transmembrane protein 14B | TMEM14B | 101 | Annotation score: | ||
H7C5F1 | H7C5F1_HUMAN | Transmembrane protein 14B | TMEM14B | 59 | Annotation score: | ||
F2Z2F8 | F2Z2F8_HUMAN | Transmembrane protein 14B | TMEM14B | 35 | Annotation score: | ||
C9JDJ4 | C9JDJ4_HUMAN | Transmembrane protein 14B | TMEM14B | 53 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 37 | P → S in AAH07080 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 42 | G → W in AAH01033 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 83 | Y → C in AAH07080 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046899 | 34 – 67 | Missing in isoform 2. CuratedAdd BLAST | 34 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL024498 Genomic DNA No translation available. AL357497 Genomic DNA No translation available. CH471087 Genomic DNA Translation: EAW55279.1 CH471087 Genomic DNA Translation: EAW55281.1 BC001033 mRNA Translation: AAH01033.1 BC007080 mRNA Translation: AAH07080.1 BC013913 mRNA Translation: AAH13913.1 BC071660 mRNA Translation: AAH71660.1 |
CCDSi | CCDS4515.1 [Q9NUH8-1] CCDS47372.1 [Q9NUH8-2] |
RefSeqi | NP_001121183.1, NM_001127711.2 [Q9NUH8-2] NP_001273413.1, NM_001286484.1 NP_112231.3, NM_030969.4 [Q9NUH8-1] |
Genome annotation databases
Ensembli | ENST00000379530; ENSP00000368845; ENSG00000137210 [Q9NUH8-2] ENST00000379542; ENSP00000368858; ENSG00000137210 |
GeneIDi | 81853 |
KEGGi | hsa:81853 |
MANE-Selecti | ENST00000379542.10; ENSP00000368858.5; NM_030969.5; NP_112231.3 |
UCSCi | uc003mzk.5, human [Q9NUH8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL024498 Genomic DNA No translation available. AL357497 Genomic DNA No translation available. CH471087 Genomic DNA Translation: EAW55279.1 CH471087 Genomic DNA Translation: EAW55281.1 BC001033 mRNA Translation: AAH01033.1 BC007080 mRNA Translation: AAH07080.1 BC013913 mRNA Translation: AAH13913.1 BC071660 mRNA Translation: AAH71660.1 |
CCDSi | CCDS4515.1 [Q9NUH8-1] CCDS47372.1 [Q9NUH8-2] |
RefSeqi | NP_001121183.1, NM_001127711.2 [Q9NUH8-2] NP_001273413.1, NM_001286484.1 NP_112231.3, NM_030969.4 [Q9NUH8-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123603, 274 interactors |
IntActi | Q9NUH8, 217 interactors |
MINTi | Q9NUH8 |
STRINGi | 9606.ENSP00000420658 |
PTM databases
iPTMneti | Q9NUH8 |
PhosphoSitePlusi | Q9NUH8 |
Genetic variation databases
BioMutai | TMEM14B |
DMDMi | 27734593 |
Proteomic databases
MassIVEi | Q9NUH8 |
MaxQBi | Q9NUH8 |
PaxDbi | Q9NUH8 |
PeptideAtlasi | Q9NUH8 |
PRIDEi | Q9NUH8 |
TopDownProteomicsi | Q9NUH8-1 [Q9NUH8-1] |
Protocols and materials databases
Antibodypediai | 52852, 32 antibodies from 7 providers |
DNASUi | 81853 |
Genome annotation databases
Ensembli | ENST00000379530; ENSP00000368845; ENSG00000137210 [Q9NUH8-2] ENST00000379542; ENSP00000368858; ENSG00000137210 |
GeneIDi | 81853 |
KEGGi | hsa:81853 |
MANE-Selecti | ENST00000379542.10; ENSP00000368858.5; NM_030969.5; NP_112231.3 |
UCSCi | uc003mzk.5, human [Q9NUH8-1] |
Organism-specific databases
CTDi | 81853 |
DisGeNETi | 81853 |
GeneCardsi | TMEM14B |
HGNCi | HGNC:21384, TMEM14B |
HPAi | ENSG00000137210, Low tissue specificity |
neXtProti | NX_Q9NUH8 |
OpenTargetsi | ENSG00000137210 |
PharmGKBi | PA134964501 |
VEuPathDBi | HostDB:ENSG00000137210 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000163914 |
HOGENOMi | CLU_096652_4_0_1 |
InParanoidi | Q9NUH8 |
OMAi | GANWLMV |
TreeFami | TF323345 |
Enzyme and pathway databases
PathwayCommonsi | Q9NUH8 |
SignaLinki | Q9NUH8 |
Miscellaneous databases
BioGRID-ORCSi | 81853, 19 hits in 1035 CRISPR screens |
ChiTaRSi | TMEM14B, human |
GenomeRNAii | 81853 |
Pharosi | Q9NUH8, Tbio |
PROi | PR:Q9NUH8 |
RNActi | Q9NUH8, protein |
Gene expression databases
Bgeei | ENSG00000137210, Expressed in oocyte and 223 other tissues |
ExpressionAtlasi | Q9NUH8, baseline and differential |
Genevisiblei | Q9NUH8, HS |
Family and domain databases
Gene3Di | 1.10.10.1740, 1 hit |
InterProi | View protein in InterPro IPR005349, TMEM14 IPR044890, TMEM14_sf |
PANTHERi | PTHR12668, PTHR12668, 1 hit |
Pfami | View protein in Pfam PF03647, Tmemb_14, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TM14B_HUMAN | |
Accessioni | Q9NUH8Primary (citable) accession number: Q9NUH8 Secondary accession number(s): Q5THN7 Q9BVN8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2003 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families