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Entry version 143 (12 Aug 2020)
Sequence version 1 (01 Oct 2000)
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Protein

Transmembrane protein 14B

Gene

TMEM14B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Primate-specific protein involved in cortical expansion and folding in the developing neocortex. May drive neural progenitor proliferation through nuclear translocation of IQGAP1, which in turn promotes G1/S cell cycle transitions.1 Publication

Miscellaneous

When expressed in embryonic mouse neocortex, induces intermediate progenitor cells and outer radial glia expansion, cortical thickening and induces gyrification (PubMed:29033352).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processNeurogenesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9NUH8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 14B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM14B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000137210.13

Human Gene Nomenclature Database

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HGNCi
HGNC:21384, TMEM14B

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9NUH8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
81853

Open Targets

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OpenTargetsi
ENSG00000137210

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134964501

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q9NUH8, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TMEM14B

Domain mapping of disease mutations (DMDM)

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DMDMi
27734593

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002211721 – 114Transmembrane protein 14BAdd BLAST114

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NUH8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9NUH8

PeptideAtlas

More...
PeptideAtlasi
Q9NUH8

PRoteomics IDEntifications database

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PRIDEi
Q9NUH8

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
65158
82672 [Q9NUH8-1]

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q9NUH8-1 [Q9NUH8-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9NUH8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NUH8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mainly expressed in the outer subventricular zone (OSVZ) of the fetal brains.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137210, Expressed in oocyte and 223 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NUH8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NUH8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000137210, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with IQGAP1; this interaction promotes phosphorylation and nuclear translocation of IQGAP1.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9NUH8
With#Exp.IntAct
ABHD16A [O95870]3EBI-8638294,EBI-348517
ABHD5 [Q8WTS1]3EBI-8638294,EBI-2813554
ACSL5 [Q9ULC5]3EBI-8638294,EBI-2876927
ADAM33 [Q08AM2]3EBI-8638294,EBI-10225815
AGPAT3 [Q9NRZ7]3EBI-8638294,EBI-2803601
AGPAT4 [Q9NRZ5]3EBI-8638294,EBI-1754287
AGR3 [Q8TD06]3EBI-8638294,EBI-3925742
APOC4 [P55056]3EBI-8638294,EBI-18302142
ARL6IP1 [Q15041]3EBI-8638294,EBI-714543
ARL8B [Q9NVJ2]3EBI-8638294,EBI-718376
ARV1 [Q9H2C2]3EBI-8638294,EBI-11724186
ATP13A1 - isoform C [Q9HD20-3]3EBI-8638294,EBI-12069500
B4GALT7 [Q9UBV7]3EBI-8638294,EBI-10319970
BIK [Q13323]3EBI-8638294,EBI-700794
BLCAP [P62952]3EBI-8638294,EBI-3895726
BMP10 [O95393]3EBI-8638294,EBI-3922513
BTN2A2 [Q8WVV5]3EBI-8638294,EBI-8648738
C10orf67 - isoform 2 [Q8IYJ2-2]3EBI-8638294,EBI-13381098
C2CD2L [O14523]3EBI-8638294,EBI-12822627
CCL4 [P13236]3EBI-8638294,EBI-2873970
CD79A [P11912]3EBI-8638294,EBI-7797864
CEPT1 [Q9Y6K0]3EBI-8638294,EBI-1237183
CFHR5 [Q9BXR6]3EBI-8638294,EBI-11579371
CIDEB [Q9UHD4]3EBI-8638294,EBI-7062247
CLDN10 [P78369]3EBI-8638294,EBI-13372810
CLDND2 [Q8NHS1]3EBI-8638294,EBI-11959453
CMTM5 - isoform 2 [Q96DZ9-2]3EBI-8638294,EBI-11522780
CMTM8 [Q8IZV2]3EBI-8638294,EBI-7868911
CNIH2 [Q6PI25]3EBI-8638294,EBI-12815321
CNIH3 [Q8TBE1]3EBI-8638294,EBI-12208021
CNIH4 [Q9P003]3EBI-8638294,EBI-1044341
COMT [P21964]3EBI-8638294,EBI-372265
CPLX4 [Q7Z7G2]3EBI-8638294,EBI-18013275
CREB3L1 [Q96BA8]3EBI-8638294,EBI-6942903
CYB561 [P49447]3EBI-8638294,EBI-8646596
CYB5R3 [P00387]3EBI-8638294,EBI-1046040
DEFB103B [P81534]3EBI-8638294,EBI-12074168
DGAT2L6 [Q6ZPD8]3EBI-8638294,EBI-12831978
DHRSX [Q8N5I4]3EBI-8638294,EBI-3923585
EBP [Q15125]3EBI-8638294,EBI-3915253
EI24 [O14681]3EBI-8638294,EBI-2339413
EMC6 [Q9BV81]3EBI-8638294,EBI-2820492
EPHX4 [Q8IUS5]3EBI-8638294,EBI-17962164
ERGIC3 [Q9Y282]3EBI-8638294,EBI-781551
EXTL1 [Q92935]3EBI-8638294,EBI-1760167
FA2H [Q7L5A8]3EBI-8638294,EBI-11337888
FADS6 [Q8N9I5]3EBI-8638294,EBI-3943864
FAM209A [Q5JX71]3EBI-8638294,EBI-18304435
FIS1 [Q9Y3D6]3EBI-8638294,EBI-3385283
FKBP8 [Q14318]3EBI-8638294,EBI-724839
GDAP1 [Q8TB36]3EBI-8638294,EBI-11110431
GIMAP1 [Q8WWP7]3EBI-8638294,EBI-11991950
GPR152 [Q8TDT2]3EBI-8638294,EBI-13345167
GPX8 [Q8TED1]3EBI-8638294,EBI-11721746
GYPA [P02724]3EBI-8638294,EBI-702665
GYPC [P04921]3EBI-8638294,EBI-7797098
HEXB [P07686]3EBI-8638294,EBI-7133736
HIBADH [P31937]3EBI-8638294,EBI-11427100
HIGD1C [A8MV81]3EBI-8638294,EBI-12809676
HMOX1 [P09601]3EBI-8638294,EBI-2806151
HMOX2 [P30519]3EBI-8638294,EBI-712096
HSD17B11 [Q8NBQ5]3EBI-8638294,EBI-1052304
HSD3B1 [P14060]3EBI-8638294,EBI-17426018
IER3IP1 [Q9Y5U9]3EBI-8638294,EBI-725665
IFITM3 [Q01628]3EBI-8638294,EBI-7932862
INSIG2 [Q9Y5U4]3EBI-8638294,EBI-8503746
ITGAM [P11215]3EBI-8638294,EBI-2568251
JAGN1 [Q8N5M9]3EBI-8638294,EBI-10266796
KCNA1 [Q09470]3EBI-8638294,EBI-8286599
KCNK1 [O00180]3EBI-8638294,EBI-3914675
LEPROTL1 [O95214]3EBI-8638294,EBI-750776
LPAR3 [Q9UBY5]3EBI-8638294,EBI-12033434
LRCH1 - isoform 3 [Q9Y2L9-3]3EBI-8638294,EBI-12082218
MAL2 [Q969L2]3EBI-8638294,EBI-944295
MARCHF5 [Q9NX47]3EBI-8638294,EBI-2341610
MEOX2 [Q6FHY5]3EBI-8638294,EBI-16439278
MFSD12 - isoform 2 [Q6NUT3-2]3EBI-8638294,EBI-17295698
MFSD5 [Q6N075]3EBI-8638294,EBI-3920969
MGAM [O43451]3EBI-8638294,EBI-2829774
MMD2 - isoform 2 [Q8IY49-2]3EBI-8638294,EBI-13349813
MS4A13 [Q5J8X5]3EBI-8638294,EBI-12070086
MS4A4A [Q96JQ5]3EBI-8638294,EBI-12820341
NAT8 [Q9UHE5]3EBI-8638294,EBI-2863634
NDUFA3 [O95167]3EBI-8638294,EBI-1246131
NEU1 [Q99519]3EBI-8638294,EBI-721517
NINJ1 [Q92982]3EBI-8638294,EBI-2802124
NINJ2 [Q9NZG7]3EBI-8638294,EBI-10317425
NIPAL3 [Q6P499]3EBI-8638294,EBI-10252783
NRAC [Q8N912]3EBI-8638294,EBI-12051377
ORMDL1 [Q9P0S3]3EBI-8638294,EBI-1054848
OTULINL [Q9NUU6]3EBI-8638294,EBI-6916492
PAGE1 [O75459]3EBI-8638294,EBI-2559100
PDPN [Q86YL7]3EBI-8638294,EBI-723160
PDZK1IP1 [Q13113]3EBI-8638294,EBI-716063
PEX11G [Q96HA9]3EBI-8638294,EBI-17284886
PIGF [Q07326]3EBI-8638294,EBI-17180304
PLLP [Q9Y342]3EBI-8638294,EBI-3919291
PLP1 - isoform DM-20 [P60201-2]3EBI-8638294,EBI-12188331
PLP2 [Q04941]3EBI-8638294,EBI-608347
PMP22 [Q01453]3EBI-8638294,EBI-2845982
PNLIPRP1 [P54315]3EBI-8638294,EBI-8652812
PRAF2 [O60831]3EBI-8638294,EBI-2506064
PTPMT1 [Q8WUK0]3EBI-8638294,EBI-7199479
RABAC1 [Q9UI14]3EBI-8638294,EBI-712367
RHD - isoform 2 [Q02161-2]3EBI-8638294,EBI-17249212
RHOT2 [Q8IXI1]3EBI-8638294,EBI-1396563
SAR1B [Q9Y6B6]3EBI-8638294,EBI-4290665
SCAMP5 [Q8TAC9]3EBI-8638294,EBI-2695784
SCN3B [Q9NY72]3EBI-8638294,EBI-17247926
SCRG1 [O75711]3EBI-8638294,EBI-10189029
SERF1B [O75920]3EBI-8638294,EBI-2115181
SERP1 [Q9Y6X1]3EBI-8638294,EBI-10329948
SERP2 [Q8N6R1]3EBI-8638294,EBI-749270
SFT2D1 [Q8WV19]3EBI-8638294,EBI-2854842
SFT2D2 [O95562]3EBI-8638294,EBI-4402330
SFXN1 [Q9H9B4]3EBI-8638294,EBI-355861
SFXN2 [Q96NB2]3EBI-8638294,EBI-6381136
SFXN3 [A0A1P0AYU5]3EBI-8638294,EBI-14193895
SLC16A10 [Q8TF71]3EBI-8638294,EBI-17858931
SLC16A13 [Q7RTY0]3EBI-8638294,EBI-12243266
SLC18A1 - isoform 3 [P54219-3]3EBI-8638294,EBI-17595455
SLC19A3 [Q9BZV2]3EBI-8638294,EBI-3923779
SLC2A6 [Q9UGQ3]3EBI-8638294,EBI-18004831
SLC30A3 [Q99726]3EBI-8638294,EBI-10294651
SLC30A8 [Q8IWU4]3EBI-8638294,EBI-10262251
SLC35A4 [Q96G79]3EBI-8638294,EBI-12363689
SLC35C2 - isoform 3 [Q9NQQ7-3]3EBI-8638294,EBI-17295964
SLC35E3 [Q7Z769]3EBI-8638294,EBI-13389236
SLC35E4 [Q6ICL7]3EBI-8638294,EBI-12867720
SLC35F1 [Q5T1Q4]3EBI-8638294,EBI-13365456
SLC35F6 [Q8N357]3EBI-8638294,EBI-713484
SLC35G1 [Q2M3R5]3EBI-8638294,EBI-13311257
SLC39A2 [Q9NP94]3EBI-8638294,EBI-12898013
SLC39A7 [Q92504]3EBI-8638294,EBI-1051105
SLC48A1 [Q6P1K1]3EBI-8638294,EBI-1222191
SLC7A8 [Q9UHI5]3EBI-8638294,EBI-13292283
SMAGP [Q0VAQ4]3EBI-8638294,EBI-10226799
SMPD2 [O60906]3EBI-8638294,EBI-12828299
SQLE [Q14534]3EBI-8638294,EBI-3905171
ST6GAL2 - isoform 2 [Q96JF0-2]3EBI-8638294,EBI-12908338
STOM [P27105]3EBI-8638294,EBI-1211440
STX12 [Q86Y82]3EBI-8638294,EBI-2691717
STX3 [Q13277]3EBI-8638294,EBI-1394295
STX6 [O43752]3EBI-8638294,EBI-2695795
STX8 [Q9UNK0]3EBI-8638294,EBI-727240
SUCNR1 [Q9BXA5]3EBI-8638294,EBI-17962797
SYNGR1 - isoform 1B [O43759-2]3EBI-8638294,EBI-12187159
SYNJ2BP [P57105]3EBI-8638294,EBI-1049004
TAP1 [Q03518]3EBI-8638294,EBI-747259
TAS2R19 [P59542]3EBI-8638294,EBI-12847034
TBC1D20 [Q96BZ9]3EBI-8638294,EBI-9254454
TEX44 [Q53QW1]3EBI-8638294,EBI-10278496
THBD [P07204]3EBI-8638294,EBI-941422
TIMM22 [Q9Y584]3EBI-8638294,EBI-1200494
TIMM23 [O14925]3EBI-8638294,EBI-1047996
TIMMDC1 [Q9NPL8]3EBI-8638294,EBI-6268651
TLCD1 [Q96CP7]3EBI-8638294,EBI-11337932
TM4SF4 [P48230]3EBI-8638294,EBI-8650934
TMEM11 [P17152]3EBI-8638294,EBI-723946
TMEM120A [Q9BXJ8]3EBI-8638294,EBI-727322
TMEM120B [A0PK00]3EBI-8638294,EBI-10171534
TMEM121 [Q9BTD3]3EBI-8638294,EBI-12155101
TMEM147 [Q9BVK8]3EBI-8638294,EBI-348587
TMEM14A [Q9Y6G1]3EBI-8638294,EBI-2800360
itself3EBI-8638294,EBI-8638294
TMEM14C [Q9P0S9]3EBI-8638294,EBI-2339195
TMEM187 [Q14656]3EBI-8638294,EBI-13046724
TMEM19 [Q96HH6]3EBI-8638294,EBI-741829
TMEM199 [Q8N511]3EBI-8638294,EBI-10265825
TMEM203 [Q969S6]3EBI-8638294,EBI-12274070
TMEM220 [Q6QAJ8]3EBI-8638294,EBI-17963211
TMEM222 [Q9H0R3]3EBI-8638294,EBI-347385
TMEM229B [Q8NBD8]3EBI-8638294,EBI-12195227
TMEM243 [Q9BU79]3EBI-8638294,EBI-12887458
TMEM254 [Q8TBM7]3EBI-8638294,EBI-11956809
TMEM255B [Q8WV15]3EBI-8638294,EBI-2870087
TMEM267 [Q0VDI3]3EBI-8638294,EBI-17555467
TMEM42 [Q69YG0]3EBI-8638294,EBI-12038591
TMEM50A [O95807]3EBI-8638294,EBI-12903814
TMEM50B [P56557]3EBI-8638294,EBI-12366453
TMEM51 [Q9NW97]3EBI-8638294,EBI-726044
TMEM60 [Q9H2L4]3EBI-8638294,EBI-2852148
TMEM69 [Q5SWH9]3EBI-8638294,EBI-17963363
TMEM97 [Q5BJF2]3EBI-8638294,EBI-12111910
TMUB1 [Q9BVT8]3EBI-8638294,EBI-11425701
TMX2 [Q9Y320]3EBI-8638294,EBI-6447886
TOMM6 [Q96B49]3EBI-8638294,EBI-10826510
TSPAN2 [O60636]3EBI-8638294,EBI-3914288
TSPO [P30536]3EBI-8638294,EBI-6623146
TVP23B [Q9NYZ1]3EBI-8638294,EBI-11343401
UBE2J1 [Q9Y385]3EBI-8638294,EBI-988826
UBE2J2 [Q8N2K1]3EBI-8638294,EBI-2340110
UBE3A - isoform III [Q05086-3]3EBI-8638294,EBI-11026619
UBIAD1 [Q9Y5Z9]3EBI-8638294,EBI-2819725
UBXN8 [O00124]3EBI-8638294,EBI-1993850
UNC50 [Q53HI1]3EBI-8638294,EBI-7601760
UNC93A - isoform 2 [Q86WB7-2]3EBI-8638294,EBI-13356252
VAMP1 - isoform 2 [P23763-3]3EBI-8638294,EBI-12097582
VAMP5 [O95183]3EBI-8638294,EBI-10191195
VRK2 [Q86Y07]3EBI-8638294,EBI-1207615
VTI1B [Q9UEU0]3EBI-8638294,EBI-723716
YIF1A [O95070]3EBI-8638294,EBI-2799703
YIPF1 [Q9Y548]3EBI-8638294,EBI-7850136
YIPF2 [Q9BWQ6]3EBI-8638294,EBI-751204
YIPF4 [Q9BSR8]3EBI-8638294,EBI-751253
YIPF6 [Q96EC8]3EBI-8638294,EBI-751210
ZDHHC11 [Q9H8X9]3EBI-8638294,EBI-17961574
ZDHHC22 [Q8N966]3EBI-8638294,EBI-10268111
ZDHHC24 [Q6UX98]3EBI-8638294,EBI-10254561
ZFPL1 [O95159]3EBI-8638294,EBI-718439
A0A087WZY13EBI-8638294,EBI-13387614

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123603, 18 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NUH8, 216 interactors

Molecular INTeraction database

More...
MINTi
Q9NUH8

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NUH8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NUH8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM14 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163914

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_096652_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NUH8

Identification of Orthologs from Complete Genome Data

More...
OMAi
VGIMGMR

TreeFam database of animal gene trees

More...
TreeFami
TF323345

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005349, TMEM14

The PANTHER Classification System

More...
PANTHERi
PTHR12668, PTHR12668, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03647, Tmemb_14, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NUH8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEKPLFPLVP LHWFGFGYTA LVVSGGIVGY VKTGSVPSLA AGLLFGSLAG
60 70 80 90 100
LGAYQLYQDP RNVWGFLAAT SVTFVGVMGM RSYYYGKFMP VGLIAGASLL
110
MAAKVGVRML MTSD
Length:114
Mass (Da):12,078
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAA2251A59C53BCB7
GO
Isoform 2 (identifier: Q9NUH8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-67: Missing.

Show »
Length:80
Mass (Da):8,557
Checksum:iB28BCFD1A57908D3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JCY4C9JCY4_HUMAN
Transmembrane protein 14B
TMEM14B
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WU83A0A087WU83_HUMAN
Transmembrane protein 14B
TMEM14B hCG_1782975
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQS0C9JQS0_HUMAN
Transmembrane protein 14B
TMEM14B
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C541H7C541_HUMAN
Transmembrane protein 14B
TMEM14B
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DFL6B4DFL6_HUMAN
Transmembrane protein 14B
TMEM14B
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J786C9J786_HUMAN
Transmembrane protein 14B
TMEM14B
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5F1H7C5F1_HUMAN
Transmembrane protein 14B
TMEM14B
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2F8F2Z2F8_HUMAN
Transmembrane protein 14B
TMEM14B
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JDJ4C9JDJ4_HUMAN
Transmembrane protein 14B
TMEM14B
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti37P → S in AAH07080 (PubMed:15489334).Curated1
Sequence conflicti42G → W in AAH01033 (PubMed:15489334).Curated1
Sequence conflicti83Y → C in AAH07080 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04689934 – 67Missing in isoform 2. CuratedAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL024498 Genomic DNA No translation available.
AL357497 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55279.1
CH471087 Genomic DNA Translation: EAW55281.1
BC001033 mRNA Translation: AAH01033.1
BC007080 mRNA Translation: AAH07080.1
BC013913 mRNA Translation: AAH13913.1
BC071660 mRNA Translation: AAH71660.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4515.1 [Q9NUH8-1]
CCDS47372.1 [Q9NUH8-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001121183.1, NM_001127711.2 [Q9NUH8-2]
NP_001273413.1, NM_001286484.1
NP_112231.3, NM_030969.4 [Q9NUH8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000379530; ENSP00000368845; ENSG00000137210 [Q9NUH8-2]
ENST00000379542; ENSP00000368858; ENSG00000137210 [Q9NUH8-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
81853

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:81853

UCSC genome browser

More...
UCSCi
uc003mzk.5, human [Q9NUH8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL024498 Genomic DNA No translation available.
AL357497 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55279.1
CH471087 Genomic DNA Translation: EAW55281.1
BC001033 mRNA Translation: AAH01033.1
BC007080 mRNA Translation: AAH07080.1
BC013913 mRNA Translation: AAH13913.1
BC071660 mRNA Translation: AAH71660.1
CCDSiCCDS4515.1 [Q9NUH8-1]
CCDS47372.1 [Q9NUH8-2]
RefSeqiNP_001121183.1, NM_001127711.2 [Q9NUH8-2]
NP_001273413.1, NM_001286484.1
NP_112231.3, NM_030969.4 [Q9NUH8-1]

3D structure databases

SMRiQ9NUH8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123603, 18 interactors
IntActiQ9NUH8, 216 interactors
MINTiQ9NUH8

PTM databases

iPTMnetiQ9NUH8
PhosphoSitePlusiQ9NUH8

Polymorphism and mutation databases

BioMutaiTMEM14B
DMDMi27734593

Proteomic databases

MaxQBiQ9NUH8
PaxDbiQ9NUH8
PeptideAtlasiQ9NUH8
PRIDEiQ9NUH8
ProteomicsDBi65158
82672 [Q9NUH8-1]
TopDownProteomicsiQ9NUH8-1 [Q9NUH8-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
52852, 26 antibodies

The DNASU plasmid repository

More...
DNASUi
81853

Genome annotation databases

EnsembliENST00000379530; ENSP00000368845; ENSG00000137210 [Q9NUH8-2]
ENST00000379542; ENSP00000368858; ENSG00000137210 [Q9NUH8-1]
GeneIDi81853
KEGGihsa:81853
UCSCiuc003mzk.5, human [Q9NUH8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
81853
DisGeNETi81853
EuPathDBiHostDB:ENSG00000137210.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM14B
HGNCiHGNC:21384, TMEM14B
HPAiENSG00000137210, Low tissue specificity
neXtProtiNX_Q9NUH8
OpenTargetsiENSG00000137210
PharmGKBiPA134964501

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000163914
HOGENOMiCLU_096652_4_0_1
InParanoidiQ9NUH8
OMAiVGIMGMR
TreeFamiTF323345

Enzyme and pathway databases

PathwayCommonsiQ9NUH8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
81853, 17 hits in 866 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TMEM14B, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
81853
PharosiQ9NUH8, Tdark

Protein Ontology

More...
PROi
PR:Q9NUH8
RNActiQ9NUH8, protein

Gene expression databases

BgeeiENSG00000137210, Expressed in oocyte and 223 other tissues
ExpressionAtlasiQ9NUH8, baseline and differential
GenevisibleiQ9NUH8, HS

Family and domain databases

InterProiView protein in InterPro
IPR005349, TMEM14
PANTHERiPTHR12668, PTHR12668, 1 hit
PfamiView protein in Pfam
PF03647, Tmemb_14, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM14B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NUH8
Secondary accession number(s): Q5THN7
, Q5THN8, Q96IX7, Q9BVN8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 1, 2000
Last modified: August 12, 2020
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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