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Protein

p53 and DNA damage-regulated protein 1

Gene

PDRG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in chaperone-mediated protein folding.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
p53 and DNA damage-regulated protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDRG1
Synonyms:C20orf126, PDRG
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000088356.5

Human Gene Nomenclature Database

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HGNCi
HGNC:16119 PDRG1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610789 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NUG6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
81572

Open Targets

More...
OpenTargetsi
ENSG00000088356

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25667

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PDRG1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
24211602

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000582771 – 133p53 and DNA damage-regulated protein 1Add BLAST133

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NUG6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NUG6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NUG6

PeptideAtlas

More...
PeptideAtlasi
Q9NUG6

PRoteomics IDEntifications database

More...
PRIDEi
Q9NUG6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82671

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9NUG6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NUG6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NUG6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in normal testis and exhibits reduced but detectable expression in other organs.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By UV irradiation and repressed by p53/TP53.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000088356 Expressed in 194 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_PDRG1

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NUG6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047084
HPA063542

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123533, 47 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9NUG6

Database of interacting proteins

More...
DIPi
DIP-27568N

Protein interaction database and analysis system

More...
IntActi
Q9NUG6, 22 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000202017

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9NUG6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NUG6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the prefoldin subunit beta family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IYXP Eukaryota
ENOG41127ER LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013253

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007729

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053553

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NUG6

Identification of Orthologs from Complete Genome Data

More...
OMAi
KVWITIG

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0USB

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NUG6

TreeFam database of animal gene trees

More...
TreeFami
TF329240

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030482 PDRG1
IPR002777 PFD_beta-like

The PANTHER Classification System

More...
PANTHERi
PTHR21162 PTHR21162, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01920 Prefoldin_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9NUG6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSPEAERVL RYLVEVEELA EEVLADKRQI VDLDTKRNQN REGLRALQKD
60 70 80 90 100
LSLSEDVMVC FGNMFIKMPH PETKEMIEKD QDHLDKEIEK LRKQLKVKVN
110 120 130
RLFEAQGKPE LKGFNLNPLN QDELKALKVI LKG
Length:133
Mass (Da):15,511
Last modified:October 19, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i13D3293D9724B46A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY286301 mRNA Translation: AAP45329.1
AK312021 mRNA Translation: BAG34958.1
AL031658 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76399.1
BC001856 mRNA Translation: AAH01856.2
BC009334 mRNA Translation: AAH09334.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13194.1

NCBI Reference Sequences

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RefSeqi
NP_110442.1, NM_030815.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.435755

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000202017; ENSP00000202017; ENSG00000088356

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
81572

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:81572

UCSC genome browser

More...
UCSCi
uc002wxd.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY286301 mRNA Translation: AAP45329.1
AK312021 mRNA Translation: BAG34958.1
AL031658 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76399.1
BC001856 mRNA Translation: AAH01856.2
BC009334 mRNA Translation: AAH09334.1
CCDSiCCDS13194.1
RefSeqiNP_110442.1, NM_030815.2
UniGeneiHs.435755

3D structure databases

ProteinModelPortaliQ9NUG6
SMRiQ9NUG6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123533, 47 interactors
CORUMiQ9NUG6
DIPiDIP-27568N
IntActiQ9NUG6, 22 interactors
STRINGi9606.ENSP00000202017

PTM databases

iPTMnetiQ9NUG6
PhosphoSitePlusiQ9NUG6

Polymorphism and mutation databases

BioMutaiPDRG1
DMDMi24211602

Proteomic databases

EPDiQ9NUG6
MaxQBiQ9NUG6
PaxDbiQ9NUG6
PeptideAtlasiQ9NUG6
PRIDEiQ9NUG6
ProteomicsDBi82671
TopDownProteomicsiQ9NUG6

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
81572
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000202017; ENSP00000202017; ENSG00000088356
GeneIDi81572
KEGGihsa:81572
UCSCiuc002wxd.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
81572
DisGeNETi81572
EuPathDBiHostDB:ENSG00000088356.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PDRG1
HGNCiHGNC:16119 PDRG1
HPAiHPA047084
HPA063542
MIMi610789 gene
neXtProtiNX_Q9NUG6
OpenTargetsiENSG00000088356
PharmGKBiPA25667

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IYXP Eukaryota
ENOG41127ER LUCA
GeneTreeiENSGT00390000013253
HOGENOMiHOG000007729
HOVERGENiHBG053553
InParanoidiQ9NUG6
OMAiKVWITIG
OrthoDBiEOG091G0USB
PhylomeDBiQ9NUG6
TreeFamiTF329240

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
81572

Protein Ontology

More...
PROi
PR:Q9NUG6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000088356 Expressed in 194 organ(s), highest expression level in testis
CleanExiHS_PDRG1
GenevisibleiQ9NUG6 HS

Family and domain databases

InterProiView protein in InterPro
IPR030482 PDRG1
IPR002777 PFD_beta-like
PANTHERiPTHR21162 PTHR21162, 1 hit
PfamiView protein in Pfam
PF01920 Prefoldin_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDRG1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NUG6
Secondary accession number(s): B2R511, Q96GP3, Q9BUW8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: November 7, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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