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Protein

Palmitoyltransferase ZDHHC18

Gene

ZDHHC18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has palmitoyltransferase activity towards HRAS and LCK.By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei222S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC18 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 18
Short name:
DHHC-18
Gene namesi
Name:ZDHHC18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000204160.11
HGNCiHGNC:20712 ZDHHC18
neXtProtiNX_Q9NUE0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204160
PharmGKBiPA134968241

Polymorphism and mutation databases

BioMutaiZDHHC18
DMDMi34395910

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002129021 – 388Palmitoyltransferase ZDHHC18Add BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphoserineCombined sources1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiQ9NUE0
PaxDbiQ9NUE0
PeptideAtlasiQ9NUE0
PRIDEiQ9NUE0
ProteomicsDBi82667

PTM databases

iPTMnetiQ9NUE0
PhosphoSitePlusiQ9NUE0
SwissPalmiQ9NUE0

Expressioni

Gene expression databases

BgeeiENSG00000204160 Expressed in 190 organ(s), highest expression level in blood
CleanExiHS_ZDHHC18
ExpressionAtlasiQ9NUE0 baseline and differential
GenevisibleiQ9NUE0 HS

Organism-specific databases

HPAiHPA040234

Interactioni

Protein-protein interaction databases

BioGridi123972, 23 interactors
STRINGi9606.ENSP00000363257

Structurei

3D structure databases

ProteinModelPortaliQ9NUE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini192 – 242DHHCPROSITE-ProRule annotationAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi11 – 46Pro-richAdd BLAST36

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00550000074293
HOGENOMiHOG000242943
HOVERGENiHBG056239
InParanoidiQ9NUE0
KOiK16675
OMAiVPWDEPR
OrthoDBiEOG091G0BOW
PhylomeDBiQ9NUE0
TreeFamiTF312923

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q9NUE0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKDCEYQQIS PGAAPLPASP GARRPGPAAS PTPGPGPAPP AAPAPPRWSS
60 70 80 90 100
SGSGSGSGSG SLGRRPRRKW EVFPGRNRFY CGGRLMLAGH GGVFALTLLL
110 120 130 140 150
ILTTTGLFFV FDCPYLARKL TLAIPIIAAI LFFFVMSCLL QTSFTDPGIL
160 170 180 190 200
PRATVCEAAA LEKQIDNTGS STYRPPPRTR EVLINGQMVK LKYCFTCKMF
210 220 230 240 250
RPPRTSHCSV CDNCVERFDH HCPWVGNCVG RRNYRFFYAF ILSLSFLTAF
260 270 280 290 300
IFACVVTHLT LRAQGSNFLS TLKETPASVL ELVICFFSIW SILGLSGFHT
310 320 330 340 350
YLVASNLTTN EDIKGSWSSK RGGEASVNPY SHKSIITNCC AVLCGPLPPS
360 370 380
LIDRRGFVQS DTVLPSPIRS DEPACRAKPD ASMVGGHP
Length:388
Mass (Da):42,031
Last modified:August 29, 2003 - v2
Checksum:i446114704C461C6E
GO
Isoform 2 (identifier: Q9NUE0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: Missing.

Note: No experimental confirmation available.
Show »
Length:253
Mass (Da):27,940
Checksum:iF830CB10F25997D6
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PJS3E9PJS3_HUMAN
Palmitoyltransferase
ZDHHC18
158Annotation score:
H0YEN1H0YEN1_HUMAN
Palmitoyltransferase ZDHHC18
ZDHHC18
161Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0560001 – 135Missing in isoform 2. 1 PublicationAdd BLAST135

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298683 mRNA Translation: BAG60846.1
AL034380 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07788.1
BC066776 mRNA Translation: AAH66776.1
AL512765 mRNA Translation: CAC21682.1
CCDSiCCDS30650.1 [Q9NUE0-1]
RefSeqiNP_115659.1, NM_032283.2 [Q9NUE0-1]
UniGeneiHs.523710

Genome annotation databases

EnsembliENST00000374141; ENSP00000363256; ENSG00000204160 [Q9NUE0-2]
ENST00000374142; ENSP00000363257; ENSG00000204160 [Q9NUE0-1]
GeneIDi84243
KEGGihsa:84243
UCSCiuc001bnb.4 human [Q9NUE0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298683 mRNA Translation: BAG60846.1
AL034380 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07788.1
BC066776 mRNA Translation: AAH66776.1
AL512765 mRNA Translation: CAC21682.1
CCDSiCCDS30650.1 [Q9NUE0-1]
RefSeqiNP_115659.1, NM_032283.2 [Q9NUE0-1]
UniGeneiHs.523710

3D structure databases

ProteinModelPortaliQ9NUE0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123972, 23 interactors
STRINGi9606.ENSP00000363257

PTM databases

iPTMnetiQ9NUE0
PhosphoSitePlusiQ9NUE0
SwissPalmiQ9NUE0

Polymorphism and mutation databases

BioMutaiZDHHC18
DMDMi34395910

Proteomic databases

EPDiQ9NUE0
PaxDbiQ9NUE0
PeptideAtlasiQ9NUE0
PRIDEiQ9NUE0
ProteomicsDBi82667

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374141; ENSP00000363256; ENSG00000204160 [Q9NUE0-2]
ENST00000374142; ENSP00000363257; ENSG00000204160 [Q9NUE0-1]
GeneIDi84243
KEGGihsa:84243
UCSCiuc001bnb.4 human [Q9NUE0-1]

Organism-specific databases

CTDi84243
EuPathDBiHostDB:ENSG00000204160.11
GeneCardsiZDHHC18
H-InvDBiHIX0199867
HGNCiHGNC:20712 ZDHHC18
HPAiHPA040234
neXtProtiNX_Q9NUE0
OpenTargetsiENSG00000204160
PharmGKBiPA134968241
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1311 Eukaryota
COG5273 LUCA
GeneTreeiENSGT00550000074293
HOGENOMiHOG000242943
HOVERGENiHBG056239
InParanoidiQ9NUE0
KOiK16675
OMAiVPWDEPR
OrthoDBiEOG091G0BOW
PhylomeDBiQ9NUE0
TreeFamiTF312923

Miscellaneous databases

ChiTaRSiZDHHC18 human
GenomeRNAii84243
PROiPR:Q9NUE0

Gene expression databases

BgeeiENSG00000204160 Expressed in 190 organ(s), highest expression level in blood
CleanExiHS_ZDHHC18
ExpressionAtlasiQ9NUE0 baseline and differential
GenevisibleiQ9NUE0 HS

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZDH18_HUMAN
AccessioniPrimary (citable) accession number: Q9NUE0
Secondary accession number(s): A6NHY9
, B4DQ84, Q5JYH0, Q9H020
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 29, 2003
Last modified: September 12, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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