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Entry version 165 (16 Oct 2019)
Sequence version 4 (05 Jul 2005)
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Protein

Zinc finger and BTB domain-containing protein 40

Gene

ZBTB40

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri807 – 830C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri836 – 858C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri864 – 887C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri893 – 915C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri921 – 944C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri950 – 973C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri978 – 1000C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1006 – 1029C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1046 – 1069C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1075 – 1098C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1104 – 1127C2H2-type 11; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1135 – 1158C2H2-type 12PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 40
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZBTB40
Synonyms:KIAA0478
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29045 ZBTB40

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612106 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NUA8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9923

Open Targets

More...
OpenTargetsi
ENSG00000184677

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670544

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NUA8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZBTB40

Domain mapping of disease mutations (DMDM)

More...
DMDMi
68847213

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000477451 – 1239Zinc finger and BTB domain-containing protein 40Add BLAST1239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei190PhosphoserineCombined sources1
Modified residuei703PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1066Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NUA8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NUA8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NUA8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NUA8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NUA8

PeptideAtlas

More...
PeptideAtlasi
Q9NUA8

PRoteomics IDEntifications database

More...
PRIDEi
Q9NUA8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82658 [Q9NUA8-1]
82659 [Q9NUA8-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9NUA8-2 [Q9NUA8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NUA8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NUA8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184677 Expressed in 226 organ(s), highest expression level in epithelium of mammary gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NUA8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NUA8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042386

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115251, 7 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NUA8, 9 interactors

Molecular INTeraction database

More...
MINTi
Q9NUA8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000384527

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NUA8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 87BTBPROSITE-ProRule annotationAdd BLAST64

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri807 – 830C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri836 – 858C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri864 – 887C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri893 – 915C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri921 – 944C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri950 – 973C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri978 – 1000C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1006 – 1029C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1046 – 1069C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1075 – 1098C2H2-type 10PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1104 – 1127C2H2-type 11; atypicalPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1135 – 1158C2H2-type 12PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00930000151052

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000143421

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NUA8

KEGG Orthology (KO)

More...
KOi
K10512

Identification of Orthologs from Complete Genome Data

More...
OMAi
FHECDKC

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NUA8

TreeFam database of animal gene trees

More...
TreeFami
TF350897

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR030404 ZBTB40
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

The PANTHER Classification System

More...
PANTHERi
PTHR24394:SF0 PTHR24394:SF0, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 14 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NUA8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELPNYSRQL LQQLYTLCKE QQFCDCTISI GTIYFRAHKL VLAAASLLFK
60 70 80 90 100
TLLDNTDTIS IDASVVSPEE FALLLEMMYT GKLPVGKHNF SKIISLADSL
110 120 130 140 150
QMFDVAVSCK NLLTSLVNCS VQGQVVRDVS APSSETFRKE PEKPQVEILS
160 170 180 190 200
SEGAGEPHSS PELAATPGGP VKAETEEAAH SVSQEMSVNS PTAQESQRNA
210 220 230 240 250
ETPAETPTTA EACSPSPAVQ TFSEAKKTST EPGCERKHYQ LNFLLENEGV
260 270 280 290 300
FSDALMVTQD VLKKLEMCSE IKGPQKEMIV KCFEGEGGHS AFQRILGKVR
310 320 330 340 350
EESLDVQTVV SLLRLYQYSN PAVKTALLDR KPEDVDTVQP KGSTEEGKTL
360 370 380 390 400
SVLLLEHKED LIQCVTQLRP IMESLETAKE EFLTGTEKRV ILNCCEGRTP
410 420 430 440 450
KETIENLLHR MTEEKTLTAE GLVKLLQAVK TTFPNLGLLL EKLQKSATLP
460 470 480 490 500
STTVQPSPDD YGTELLRRYH ENLSEIFTDN QILLKMISHM TSLAPGEREV
510 520 530 540 550
MEKLVKRDSG SGGFNSLISA VLEKQTLSAT AIWQLLLVVQ ETKTCPLDLL
560 570 580 590 600
MEEIRREPGA DAFFRAVTTP EHATLETILR HNQLILEAIQ QKIEYKLFTS
610 620 630 640 650
EEEHLAETVK EILSIPSETA SPEASLRAVL SRAMEKSVPA IEICHLLCSV
660 670 680 690 700
HKSFPGLQPV MQELAYIGVL TKEDGEKETW KVSNKFHLEA NNKEDEKAAK
710 720 730 740 750
EDSQPGEQND QGETGSLPGQ QEKEASASPD PAKKSFICKA CDKSFHFYCR
760 770 780 790 800
LKVHMKRCRV AKSKQVQCKE CSETKDSKKE LDKHQLEAHG AGGEPDAPKK
810 820 830 840 850
KKKRLPVTCD LCGREFAHAS GMQYHKLTEH FDEKPFSCEE CGAKFAANST
860 870 880 890 900
LKNHLRLHTG DRPFMCKHCL MTFTQASALA YHTKKKHSEG KMYACQYCDA
910 920 930 940 950
VFAQSIELSR HVRTHTGDKP YVCRDCGKGF RQANGLSIHL HTFHNIEDPY
960 970 980 990 1000
DCKKCRMSFP TLQDHRKHIH EVHSKEYHPC PTCGKIFSAP SMLERHVVTH
1010 1020 1030 1040 1050
VGGKPFSCGI CNKAYQQLSG LWYHNRTHHP DVFAAQNHRS SKFSSLQCSS
1060 1070 1080 1090 1100
CDKTFPNTIE HKKHIKAEHA DMKFHECDQC KELFPTPALL QVHVKCQHSG
1110 1120 1130 1140 1150
SQPFRCLYCA ATFRFPGALQ HHVTTEHFKQ SETTFPCELC GELFTSQAQL
1160 1170 1180 1190 1200
DSHLESEHPK VMSTETQAAA SQMAQVIQTP EPVAPTEQVI TLEETQLAGS
1210 1220 1230
QVFVTLPDSQ ASQASSELVA VTVEDLLDGT VTLICGEAK
Length:1,239
Mass (Da):138,118
Last modified:July 5, 2005 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1B35528EB104052C
GO
Isoform 2 (identifier: Q9NUA8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-162: Missing.
     270-281: EIKGPQKEMIVK → NCCVPVEAVPIF
     282-1239: Missing.

Note: No experimental confirmation available.
Show »
Length:234
Mass (Da):25,555
Checksum:iB6ADF1CB81075860
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WAI8F8WAI8_HUMAN
Zinc finger and BTB domain-containi...
ZBTB40
1,127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AKC8B1AKC8_HUMAN
Zinc finger and BTB domain-containi...
ZBTB40
453Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRZ6A0A3B3IRZ6_HUMAN
Zinc finger and BTB domain-containi...
ZBTB40
584Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA32323 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti218A → P in BAA32323 (PubMed:9455484).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052920225A → T. Corresponds to variant dbSNP:rs6659222Ensembl.1
Natural variantiVAR_052921267M → I. Corresponds to variant dbSNP:rs36115661Ensembl.1
Natural variantiVAR_052922595Y → C1 PublicationCorresponds to variant dbSNP:rs209729Ensembl.1
Natural variantiVAR_052923997V → M1 PublicationCorresponds to variant dbSNP:rs209720Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_007757116 – 162Missing in isoform 2. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_007758270 – 281EIKGP…EMIVK → NCCVPVEAVPIF in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_007759282 – 1239Missing in isoform 2. 1 PublicationAdd BLAST958

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB007947 mRNA Translation: BAA32323.2 Different initiation.
AK095273 mRNA Translation: BAC04518.1
AL035703 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS224.1 [Q9NUA8-1]

NCBI Reference Sequences

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RefSeqi
NP_001077090.1, NM_001083621.1 [Q9NUA8-1]
NP_055685.3, NM_014870.3 [Q9NUA8-1]
XP_011540801.1, XM_011542499.2 [Q9NUA8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000375647; ENSP00000364798; ENSG00000184677 [Q9NUA8-1]
ENST00000404138; ENSP00000384527; ENSG00000184677 [Q9NUA8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9923

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9923

UCSC genome browser

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UCSCi
uc001bft.2 human [Q9NUA8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007947 mRNA Translation: BAA32323.2 Different initiation.
AK095273 mRNA Translation: BAC04518.1
AL035703 Genomic DNA No translation available.
CCDSiCCDS224.1 [Q9NUA8-1]
RefSeqiNP_001077090.1, NM_001083621.1 [Q9NUA8-1]
NP_055685.3, NM_014870.3 [Q9NUA8-1]
XP_011540801.1, XM_011542499.2 [Q9NUA8-1]

3D structure databases

SMRiQ9NUA8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115251, 7 interactors
IntActiQ9NUA8, 9 interactors
MINTiQ9NUA8
STRINGi9606.ENSP00000384527

PTM databases

iPTMnetiQ9NUA8
PhosphoSitePlusiQ9NUA8

Polymorphism and mutation databases

BioMutaiZBTB40
DMDMi68847213

Proteomic databases

EPDiQ9NUA8
jPOSTiQ9NUA8
MassIVEiQ9NUA8
MaxQBiQ9NUA8
PaxDbiQ9NUA8
PeptideAtlasiQ9NUA8
PRIDEiQ9NUA8
ProteomicsDBi82658 [Q9NUA8-1]
82659 [Q9NUA8-2]
TopDownProteomicsiQ9NUA8-2 [Q9NUA8-2]

Genome annotation databases

EnsembliENST00000375647; ENSP00000364798; ENSG00000184677 [Q9NUA8-1]
ENST00000404138; ENSP00000384527; ENSG00000184677 [Q9NUA8-1]
GeneIDi9923
KEGGihsa:9923
UCSCiuc001bft.2 human [Q9NUA8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9923
DisGeNETi9923

GeneCards: human genes, protein and diseases

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GeneCardsi
ZBTB40
HGNCiHGNC:29045 ZBTB40
HPAiHPA042386
MIMi612106 gene
neXtProtiNX_Q9NUA8
OpenTargetsiENSG00000184677
PharmGKBiPA142670544

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000151052
HOGENOMiHOG000143421
InParanoidiQ9NUA8
KOiK10512
OMAiFHECDKC
OrthoDBi1318335at2759
PhylomeDBiQ9NUA8
TreeFamiTF350897

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZBTB40 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ZBTB40

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9923
PharosiQ9NUA8

Protein Ontology

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PROi
PR:Q9NUA8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000184677 Expressed in 226 organ(s), highest expression level in epithelium of mammary gland
ExpressionAtlasiQ9NUA8 baseline and differential
GenevisibleiQ9NUA8 HS

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR030404 ZBTB40
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR24394:SF0 PTHR24394:SF0, 3 hits
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZBT40_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NUA8
Secondary accession number(s): O75066, Q5TFU5, Q8N1R1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: July 5, 2005
Last modified: October 16, 2019
This is version 165 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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