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UniProtKB - Q9NU23 (LYRM2_HUMAN)

Entry version 119 (02 Dec 2020)
Sequence version 1 (01 Oct 2000)
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Protein

LYR motif-containing protein 2

Gene

LYRM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NU23

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
LYR motif-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LYRM2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000083099.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:25229, LYRM2

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NU23

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		57226

Open Targets

More...OpenTargetsi		ENSG00000083099

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162394751

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NU23, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LYRM2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74734344

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002511751 – 88LYR motif-containing protein 2Add BLAST88

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NU23

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NU23

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NU23

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NU23

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NU23

PeptideAtlas

More...PeptideAtlasi		Q9NU23

PRoteomics IDEntifications database

More...PRIDEi		Q9NU23

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82650

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q9NU23

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NU23

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NU23

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000083099, Expressed in intestine and 231 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NU23, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NU23, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000083099, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121461, 17 interactors

Protein interaction database and analysis system

More...IntActi		Q9NU23, 15 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000430025

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NU23, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complex I LYR family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S8DG, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000002957

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_151409_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NU23

Identification of Orthologs from Complete Genome Data

More...OMAi		NQDAIRM

Database of Orthologous Groups

More...OrthoDBi		1575118at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NU23

TreeFam database of animal gene trees

More...TreeFami		TF323797

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR008011, Complex1_LYR

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05347, Complex1_LYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9NU23-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASRLPPAT LTLKQFVRRQ QVLLLYRRIL QTIRQVPNDS DRKYLKDWAR 
        60         70         80 
EEFRRNKSAT EEDTIRMMIT QGNMQLKELE KTLALAKS
Length:88
Mass (Da):10,449
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i33F3189D286A95A0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V136G3V136_HUMAN
LYR motif-containing protein 2
LYRM2 DJ122O8.2, hCG_2031500
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RG38E5RG38_HUMAN
LYR motif-containing protein 2
LYRM2
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJK7E5RJK7_HUMAN
LYR motif-containing protein 2
LYRM2
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05041734R → W. Corresponds to variant dbSNP:rs11553069Ensembl.1
Natural variantiVAR_03409946K → E1 PublicationCorresponds to variant dbSNP:rs34012596Ensembl.1
Natural variantiVAR_05041860T → P. Corresponds to variant dbSNP:rs1055889Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK311948 mRNA Translation: BAG34889.1
CH471051 Genomic DNA Translation: EAW48547.1
CH471051 Genomic DNA Translation: EAW48549.1
BC009782 mRNA Translation: AAH09782.1
BC104668 mRNA Translation: AAI04669.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5023.1

NCBI Reference Sequences

More...RefSeqi		NP_065199.1, NM_020466.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000523377; ENSP00000430025; ENSG00000083099

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57226

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57226

UCSC genome browser

More...UCSCi		uc003pnm.4, human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK311948 mRNA Translation: BAG34889.1
CH471051 Genomic DNA Translation: EAW48547.1
CH471051 Genomic DNA Translation: EAW48549.1
BC009782 mRNA Translation: AAH09782.1
BC104668 mRNA Translation: AAI04669.1
CCDSiCCDS5023.1
RefSeqiNP_065199.1, NM_020466.4

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi121461, 17 interactors
IntActiQ9NU23, 15 interactors
STRINGi9606.ENSP00000430025

PTM databases

iPTMnetiQ9NU23
PhosphoSitePlusiQ9NU23

Polymorphism and mutation databases

BioMutaiLYRM2
DMDMi74734344

Proteomic databases

EPDiQ9NU23
jPOSTiQ9NU23
MassIVEiQ9NU23
MaxQBiQ9NU23
PaxDbiQ9NU23
PeptideAtlasiQ9NU23
PRIDEiQ9NU23
ProteomicsDBi82650
TopDownProteomicsiQ9NU23

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		54908, 118 antibodies

The DNASU plasmid repository

More...DNASUi		57226

Genome annotation databases

EnsembliENST00000523377; ENSP00000430025; ENSG00000083099
GeneIDi57226
KEGGihsa:57226
UCSCiuc003pnm.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57226
DisGeNETi57226
EuPathDBiHostDB:ENSG00000083099.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		LYRM2
HGNCiHGNC:25229, LYRM2
HPAiENSG00000083099, Low tissue specificity
neXtProtiNX_Q9NU23
OpenTargetsiENSG00000083099
PharmGKBiPA162394751

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S8DG, Eukaryota
GeneTreeiENSGT00390000002957
HOGENOMiCLU_151409_1_1_1
InParanoidiQ9NU23
OMAiNQDAIRM
OrthoDBi1575118at2759
PhylomeDBiQ9NU23
TreeFamiTF323797

Enzyme and pathway databases

PathwayCommonsiQ9NU23

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57226, 65 hits in 845 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LYRM2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57226
PharosiQ9NU23, Tdark

Protein Ontology

More...PROi		PR:Q9NU23
RNActiQ9NU23, protein

Gene expression databases

BgeeiENSG00000083099, Expressed in intestine and 231 other tissues
ExpressionAtlasiQ9NU23, baseline and differential
GenevisibleiQ9NU23, HS

Family and domain databases

InterProiView protein in InterPro
IPR008011, Complex1_LYR
PfamiView protein in Pfam
PF05347, Complex1_LYR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLYRM2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NU23
Secondary accession number(s): B2R4U2, E1P517
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 1, 2000
Last modified: December 2, 2020
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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