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UniProtKB - Q9NU19 (TB22B_HUMAN)

Entry version 153 (07 Oct 2020)
Sequence version 3 (10 May 2004)
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Protein

TBC1 domain family member 22B

Gene

TBC1D22B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a GTPase-activating protein for Rab family protein(s).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NU19

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TBC1 domain family member 22B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TBC1D22B
Synonyms:C6orf197
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000065491.8

Human Gene Nomenclature Database

More...HGNCi		HGNC:21602, TBC1D22B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		616880, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NU19

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi58S → E: No effect on ACBD3-binding. 1 Publication1
Mutagenesisi88 – 90LNS → AAA: No effect on ACBD3-binding. 1 Publication3
Mutagenesisi91 – 92KV → AA: No effect on ACBD3-binding. 1 Publication2
Mutagenesisi94 – 96LAT → AAA: No effect on ACBD3-binding. 1 Publication3
Mutagenesisi99Q → A: No effect on ACBD3-binding. 1 Publication1
Mutagenesisi100 – 101VL → AA: Almost complete loss of ACBD3-binding. 1 Publication2
Mutagenesisi102 – 104ENH → AAA: No effect on ACBD3-binding. 1 Publication3
Mutagenesisi114S → E: No effect on ACBD3-binding. 1 Publication1
Mutagenesisi116 – 119STTS → EEEE: No effect on ACBD3-binding. 1 Publication4
Mutagenesisi140 – 141SS → EE: No effect on ACBD3-binding. 1 Publication2
Mutagenesisi143T → E: No effect on ACBD3-binding. 1 Publication1
Mutagenesisi168S → E: No effect on ACBD3-binding. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		55633

Open Targets

More...OpenTargetsi		ENSG00000065491

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134867087

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NU19, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TBC1D22B

Domain mapping of disease mutations (DMDM)

More...DMDMi		47117913

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002080542 – 505TBC1 domain family member 22BAdd BLAST504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanine1 Publication1
Modified residuei58PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Modified residuei154PhosphoserineCombined sources1 Publication1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NU19

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NU19

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NU19

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NU19

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NU19

PeptideAtlas

More...PeptideAtlasi		Q9NU19

PRoteomics IDEntifications database

More...PRIDEi		Q9NU19

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82648

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NU19

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9NU19

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NU19

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000065491, Expressed in prostate gland and 182 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NU19, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000065491, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ACBD3 and ARFGEF1.

Interacts with YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9NU19
With#Exp.IntAct
ACBD3 [Q9H3P7]6EBI-8787464,EBI-1791792
AP1B1 - isoform C [Q10567-3]3EBI-8787464,EBI-11978055
ARHGEF9 [O43307]3EBI-8787464,EBI-3447299
BLZF1 [Q9H2G9]3EBI-8787464,EBI-2548012
CALCOCO2 [Q13137]3EBI-8787464,EBI-739580
CARD10 [Q9BWT7]3EBI-8787464,EBI-3866279
CCDC57 [Q2TAC2]3EBI-8787464,EBI-2808286
CCDC88B [A6NC98]3EBI-8787464,EBI-347573
CDR2 [Q01850]4EBI-8787464,EBI-1181367
CEP63 - isoform 3 [Q96MT8-3]3EBI-8787464,EBI-11522539
CEP70 [Q8NHQ1]3EBI-8787464,EBI-739624
COG6 [Q9Y2V7]3EBI-8787464,EBI-3866319
DDIT4L [Q96D03]3EBI-8787464,EBI-742054
DEUP1 [Q05D60]4EBI-8787464,EBI-748597
EFHC2 [Q5JST6]3EBI-8787464,EBI-2349927
EXOC8 [Q8IYI6]3EBI-8787464,EBI-742102
FHL3 [Q13643]3EBI-8787464,EBI-741101
FXR1 - isoform 2 [P51114-2]3EBI-8787464,EBI-11022345
FXR2 [P51116]5EBI-8787464,EBI-740459
GFAP [P14136]3EBI-8787464,EBI-744302
GOLGA2 [Q08379]5EBI-8787464,EBI-618309
HMG20A [Q9NP66]3EBI-8787464,EBI-740641
HOMER3 [Q9NSC5]3EBI-8787464,EBI-748420
HOOK2 - isoform 2 [Q96ED9-2]3EBI-8787464,EBI-10961706
HSD17B14 [Q9BPX1]7EBI-8787464,EBI-742664
IKZF3 [Q9UKT9]9EBI-8787464,EBI-747204
KIFC3 - isoform 4 [Q9BVG8-5]3EBI-8787464,EBI-14069005
KRT34 [O76011]3EBI-8787464,EBI-1047093
KRT40 [Q6A162]4EBI-8787464,EBI-10171697
LHX8 [Q68G74]3EBI-8787464,EBI-8474075
LIMS1 - isoform 3 [P48059-3]3EBI-8787464,EBI-12864460
MID2 - isoform 2 [Q9UJV3-2]3EBI-8787464,EBI-10172526
MTUS2 - isoform 2 [Q5JR59-3]4EBI-8787464,EBI-11522433
PICK1 [Q9NRD5]3EBI-8787464,EBI-79165
PLEKHG4 [Q58EX7]3EBI-8787464,EBI-949255
PNMA5 [Q96PV4]4EBI-8787464,EBI-10171633
RBM10 [P98175]3EBI-8787464,EBI-721525
RBM48 [Q5RL73]3EBI-8787464,EBI-473821
REL - isoform 2 [Q04864-2]3EBI-8787464,EBI-10829018
SIAH1 [Q8IUQ4]3EBI-8787464,EBI-747107
SLAIN1 [Q8ND83]3EBI-8787464,EBI-10269374
SORBS3 [O60504]4EBI-8787464,EBI-741237
SPATA2 [Q9UM82]3EBI-8787464,EBI-744066
TACC3 [Q9Y6A5]7EBI-8787464,EBI-2554984
TEPSIN [Q96N21]3EBI-8787464,EBI-11139477
TEX11 [Q8IYF3]3EBI-8787464,EBI-742397
TP53BP2 - isoform 3 [Q13625-3]3EBI-8787464,EBI-10175039
TRIM23 [P36406]8EBI-8787464,EBI-740098
TRIM27 [P14373]4EBI-8787464,EBI-719493
TRIM54 [Q9BYV2]5EBI-8787464,EBI-2130429
TRIP6 [Q15654]3EBI-8787464,EBI-742327
VPS52 [Q8N1B4]7EBI-8787464,EBI-2799833
ZFP90 [Q8TF47]3EBI-8787464,EBI-11419867
ZNF438 [Q7Z4V0]3EBI-8787464,EBI-11962468
ZNF76 [P36508]3EBI-8787464,EBI-7254550
ZSCAN4 [Q8NAM6]3EBI-8787464,EBI-7252920

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120772, 156 interactors

Protein interaction database and analysis system

More...IntActi		Q9NU19, 150 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362590

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NU19, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1505
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NU19

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9NU19

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini210 – 434Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST225

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1092, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157472

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_018687_6_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NU19

KEGG Orthology (KO)

More...KOi		K20360

Identification of Orthologs from Complete Genome Data

More...OMAi		SAKLPGX

Database of Orthologous Groups

More...OrthoDBi		750722at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NU19

TreeFam database of animal gene trees

More...TreeFami		TF314211

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000195, Rab-GTPase-TBC_dom
IPR035969, Rab-GTPase_TBC_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00566, RabGAP-TBC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00164, TBC, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47923, SSF47923, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50086, TBC_RABGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NU19-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAENSKQFW KRSAKLPGSI QPVYGAQHPP LDPRLTKNFI KERSKVNTVP 
        60         70         80         90        100
LKNKKASSFH EFARNTSDAW DIGDDEEEDF SSPSFQTLNS KVALATAAQV 
       110        120        130        140        150
LENHSKLRVK PERSQSTTSD VPANYKVIKS SSDAQLSRNS SDTCLRNPLH 
       160        170        180        190        200
KQQSLPLRPI IPLVARISDQ NASGAPPMTV REKTRLEKFR QLLSSQNTDL 
       210        220        230        240        250
DELRKCSWPG VPREVRPITW RLLSGYLPAN TERRKLTLQR KREEYFGFIE 
       260        270        280        290        300
QYYDSRNEEH HQDTYRQIHI DIPRTNPLIP LFQQPLVQEI FERILFIWAI 
       310        320        330        340        350
RHPASGYVQG INDLVTPFFV VFLSEYVEED VENFDVTNLS QDMLRSIEAD 
       360        370        380        390        400
SFWCMSKLLD GIQDNYTFAQ PGIQKKVKAL EELVSRIDEQ VHNHFRRYEV 
       410        420        430        440        450
EYLQFAFRWM NNLLMRELPL RCTIRLWDTY QSEPEGFSHF HLYVCAAFLI 
       460        470        480        490        500
KWRKEILDEE DFQGLLMLLQ NLPTIHWGNE EIGLLLAEAY RLKYMFADAP 

NHYRR
Length:505
Mass (Da):59,081
Last modified:May 10, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC0093770BE04AA4D
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91099 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti376 – 378KVK → HEE in AAH00291 (PubMed:15489334).Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB449909 mRNA Translation: BAH16652.1
AY313781 mRNA Translation: AAQ72548.1
AK000344 mRNA Translation: BAA91099.1 Different initiation.
AK292893 mRNA Translation: BAF85582.1
AL096712 Genomic DNA No translation available.
AL353579 Genomic DNA No translation available.
AL589667 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03939.1
BC000291 mRNA Translation: AAH00291.2
BC000743 mRNA Translation: AAH00743.2
BC001927 mRNA Translation: AAH01927.1
BC002720 mRNA Translation: AAH02720.2
BC063523 mRNA Translation: AAH63523.1
BC109026 mRNA Translation: AAI09027.1
BC109027 mRNA Translation: AAI09028.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4832.1

NCBI Reference Sequences

More...RefSeqi		NP_060242.2, NM_017772.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000373491; ENSP00000362590; ENSG00000065491

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55633

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55633

UCSC genome browser

More...UCSCi		uc003onn.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449909 mRNA Translation: BAH16652.1
AY313781 mRNA Translation: AAQ72548.1
AK000344 mRNA Translation: BAA91099.1 Different initiation.
AK292893 mRNA Translation: BAF85582.1
AL096712 Genomic DNA No translation available.
AL353579 Genomic DNA No translation available.
AL589667 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03939.1
BC000291 mRNA Translation: AAH00291.2
BC000743 mRNA Translation: AAH00743.2
BC001927 mRNA Translation: AAH01927.1
BC002720 mRNA Translation: AAH02720.2
BC063523 mRNA Translation: AAH63523.1
BC109026 mRNA Translation: AAI09027.1
BC109027 mRNA Translation: AAI09028.1
CCDSiCCDS4832.1
RefSeqiNP_060242.2, NM_017772.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6D0SX-ray2.30A178-505[»]
SMRiQ9NU19
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120772, 156 interactors
IntActiQ9NU19, 150 interactors
STRINGi9606.ENSP00000362590

PTM databases

iPTMnetiQ9NU19
MetOSiteiQ9NU19
PhosphoSitePlusiQ9NU19

Polymorphism and mutation databases

BioMutaiTBC1D22B
DMDMi47117913

Proteomic databases

EPDiQ9NU19
jPOSTiQ9NU19
MassIVEiQ9NU19
MaxQBiQ9NU19
PaxDbiQ9NU19
PeptideAtlasiQ9NU19
PRIDEiQ9NU19
ProteomicsDBi82648

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		29804, 24 antibodies

Genome annotation databases

EnsembliENST00000373491; ENSP00000362590; ENSG00000065491
GeneIDi55633
KEGGihsa:55633
UCSCiuc003onn.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55633
DisGeNETi55633
EuPathDBiHostDB:ENSG00000065491.8

GeneCards: human genes, protein and diseases

More...GeneCardsi		TBC1D22B
HGNCiHGNC:21602, TBC1D22B
HPAiENSG00000065491, Low tissue specificity
MIMi616880, gene
neXtProtiNX_Q9NU19
OpenTargetsiENSG00000065491
PharmGKBiPA134867087

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1092, Eukaryota
GeneTreeiENSGT00940000157472
HOGENOMiCLU_018687_6_0_1
InParanoidiQ9NU19
KOiK20360
OMAiSAKLPGX
OrthoDBi750722at2759
PhylomeDBiQ9NU19
TreeFamiTF314211

Enzyme and pathway databases

PathwayCommonsiQ9NU19

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55633, 15 hits in 870 CRISPR screens
EvolutionaryTraceiQ9NU19

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55633
PharosiQ9NU19, Tbio

Protein Ontology

More...PROi		PR:Q9NU19
RNActiQ9NU19, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000065491, Expressed in prostate gland and 182 other tissues
GenevisibleiQ9NU19, HS

Family and domain databases

InterProiView protein in InterPro
IPR000195, Rab-GTPase-TBC_dom
IPR035969, Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF00566, RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164, TBC, 1 hit
SUPFAMiSSF47923, SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086, TBC_RABGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTB22B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NU19
Secondary accession number(s): A8KA28
, Q32MQ8, Q5VUK9, Q6P4C3, Q7Z6P7, Q9BPV6, Q9BUT5, Q9NXB6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: May 10, 2004
Last modified: October 7, 2020
This is version 153 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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