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UniProtKB - Q9NU19 (TB22B_HUMAN)
Protein
TBC1 domain family member 22B
Gene
TBC1D22B
Organism
Homo sapiens (Human)
Status
Functioni
May act as a GTPase-activating protein for Rab family protein(s).
By similarityGO - Molecular functioni
- 14-3-3 protein binding Source: UniProtKB
- GTPase activator activity Source: GO_Central
GO - Biological processi
- activation of GTPase activity Source: GO_Central
- intracellular protein transport Source: GO_Central
Keywordsi
Molecular function | GTPase activation |
Enzyme and pathway databases
PathwayCommonsi | Q9NU19 |
SignaLinki | Q9NU19 |
Names & Taxonomyi
Protein namesi | Recommended name: TBC1 domain family member 22B |
Gene namesi | Name:TBC1D22B Synonyms:C6orf197 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21602, TBC1D22B |
MIMi | 616880, gene |
neXtProti | NX_Q9NU19 |
VEuPathDBi | HostDB:ENSG00000065491 |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 58 | S → E: No effect on ACBD3-binding. 1 Publication | 1 | |
Mutagenesisi | 88 – 90 | LNS → AAA: No effect on ACBD3-binding. 1 Publication | 3 | |
Mutagenesisi | 91 – 92 | KV → AA: No effect on ACBD3-binding. 1 Publication | 2 | |
Mutagenesisi | 94 – 96 | LAT → AAA: No effect on ACBD3-binding. 1 Publication | 3 | |
Mutagenesisi | 99 | Q → A: No effect on ACBD3-binding. 1 Publication | 1 | |
Mutagenesisi | 100 – 101 | VL → AA: Almost complete loss of ACBD3-binding. 1 Publication | 2 | |
Mutagenesisi | 102 – 104 | ENH → AAA: No effect on ACBD3-binding. 1 Publication | 3 | |
Mutagenesisi | 114 | S → E: No effect on ACBD3-binding. 1 Publication | 1 | |
Mutagenesisi | 116 – 119 | STTS → EEEE: No effect on ACBD3-binding. 1 Publication | 4 | |
Mutagenesisi | 140 – 141 | SS → EE: No effect on ACBD3-binding. 1 Publication | 2 | |
Mutagenesisi | 143 | T → E: No effect on ACBD3-binding. 1 Publication | 1 | |
Mutagenesisi | 168 | S → E: No effect on ACBD3-binding. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 55633 |
OpenTargetsi | ENSG00000065491 |
PharmGKBi | PA134867087 |
Miscellaneous databases
Pharosi | Q9NU19, Tbio |
Genetic variation databases
BioMutai | TBC1D22B |
DMDMi | 47117913 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000208054 | 2 – 505 | TBC1 domain family member 22BAdd BLAST | 504 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanine1 Publication | 1 | |
Modified residuei | 58 | PhosphoserineCombined sources | 1 | |
Modified residuei | 116 | PhosphoserineCombined sources | 1 | |
Modified residuei | 154 | PhosphoserineCombined sources1 Publication | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9NU19 |
jPOSTi | Q9NU19 |
MassIVEi | Q9NU19 |
MaxQBi | Q9NU19 |
PaxDbi | Q9NU19 |
PeptideAtlasi | Q9NU19 |
PRIDEi | Q9NU19 |
ProteomicsDBi | 82648 |
PTM databases
GlyGeni | Q9NU19, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9NU19 |
MetOSitei | Q9NU19 |
PhosphoSitePlusi | Q9NU19 |
Expressioni
Gene expression databases
Bgeei | ENSG00000065491, Expressed in prostate gland and 182 other tissues |
Genevisiblei | Q9NU19, HS |
Organism-specific databases
HPAi | ENSG00000065491, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with ACBD3 and ARFGEF1.
Interacts with YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ.
1 PublicationBinary interactionsi
Q9NU19
GO - Molecular functioni
- 14-3-3 protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 120772, 186 interactors |
IntActi | Q9NU19, 152 interactors |
STRINGi | 9606.ENSP00000362590 |
Miscellaneous databases
RNActi | Q9NU19, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9NU19 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9NU19 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 210 – 434 | Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST | 225 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 105 – 146 | DisorderedSequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 114 – 146 | Polar residuesSequence analysisAdd BLAST | 33 |
Phylogenomic databases
eggNOGi | KOG1092, Eukaryota |
GeneTreei | ENSGT00940000157472 |
HOGENOMi | CLU_018687_6_0_1 |
InParanoidi | Q9NU19 |
OMAi | SAKLPGX |
OrthoDBi | 750722at2759 |
PhylomeDBi | Q9NU19 |
TreeFami | TF314211 |
Family and domain databases
InterProi | View protein in InterPro IPR000195, Rab-GTPase-TBC_dom IPR035969, Rab-GTPase_TBC_sf |
Pfami | View protein in Pfam PF00566, RabGAP-TBC, 1 hit |
SMARTi | View protein in SMART SM00164, TBC, 1 hit |
SUPFAMi | SSF47923, SSF47923, 2 hits |
PROSITEi | View protein in PROSITE PS50086, TBC_RABGAP, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9NU19-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAENSKQFW KRSAKLPGSI QPVYGAQHPP LDPRLTKNFI KERSKVNTVP
60 70 80 90 100
LKNKKASSFH EFARNTSDAW DIGDDEEEDF SSPSFQTLNS KVALATAAQV
110 120 130 140 150
LENHSKLRVK PERSQSTTSD VPANYKVIKS SSDAQLSRNS SDTCLRNPLH
160 170 180 190 200
KQQSLPLRPI IPLVARISDQ NASGAPPMTV REKTRLEKFR QLLSSQNTDL
210 220 230 240 250
DELRKCSWPG VPREVRPITW RLLSGYLPAN TERRKLTLQR KREEYFGFIE
260 270 280 290 300
QYYDSRNEEH HQDTYRQIHI DIPRTNPLIP LFQQPLVQEI FERILFIWAI
310 320 330 340 350
RHPASGYVQG INDLVTPFFV VFLSEYVEED VENFDVTNLS QDMLRSIEAD
360 370 380 390 400
SFWCMSKLLD GIQDNYTFAQ PGIQKKVKAL EELVSRIDEQ VHNHFRRYEV
410 420 430 440 450
EYLQFAFRWM NNLLMRELPL RCTIRLWDTY QSEPEGFSHF HLYVCAAFLI
460 470 480 490 500
KWRKEILDEE DFQGLLMLLQ NLPTIHWGNE EIGLLLAEAY RLKYMFADAP
NHYRR
Sequence cautioni
The sequence BAA91099 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 376 – 378 | KVK → HEE in AAH00291 (PubMed:15489334).Curated | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB449909 mRNA Translation: BAH16652.1 AY313781 mRNA Translation: AAQ72548.1 AK000344 mRNA Translation: BAA91099.1 Different initiation. AK292893 mRNA Translation: BAF85582.1 AL096712 Genomic DNA No translation available. AL353579 Genomic DNA No translation available. AL589667 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03939.1 BC000291 mRNA Translation: AAH00291.2 BC000743 mRNA Translation: AAH00743.2 BC001927 mRNA Translation: AAH01927.1 BC002720 mRNA Translation: AAH02720.2 BC063523 mRNA Translation: AAH63523.1 BC109026 mRNA Translation: AAI09027.1 BC109027 mRNA Translation: AAI09028.1 |
CCDSi | CCDS4832.1 |
RefSeqi | NP_060242.2, NM_017772.3 |
Genome annotation databases
Ensembli | ENST00000373491; ENSP00000362590; ENSG00000065491 |
GeneIDi | 55633 |
KEGGi | hsa:55633 |
MANE-Selecti | ENST00000373491.3; ENSP00000362590.3; NM_017772.4; NP_060242.2 |
UCSCi | uc003onn.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB449909 mRNA Translation: BAH16652.1 AY313781 mRNA Translation: AAQ72548.1 AK000344 mRNA Translation: BAA91099.1 Different initiation. AK292893 mRNA Translation: BAF85582.1 AL096712 Genomic DNA No translation available. AL353579 Genomic DNA No translation available. AL589667 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03939.1 BC000291 mRNA Translation: AAH00291.2 BC000743 mRNA Translation: AAH00743.2 BC001927 mRNA Translation: AAH01927.1 BC002720 mRNA Translation: AAH02720.2 BC063523 mRNA Translation: AAH63523.1 BC109026 mRNA Translation: AAI09027.1 BC109027 mRNA Translation: AAI09028.1 |
CCDSi | CCDS4832.1 |
RefSeqi | NP_060242.2, NM_017772.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6D0S | X-ray | 2.30 | A | 178-505 | [»] | |
SMRi | Q9NU19 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120772, 186 interactors |
IntActi | Q9NU19, 152 interactors |
STRINGi | 9606.ENSP00000362590 |
PTM databases
GlyGeni | Q9NU19, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9NU19 |
MetOSitei | Q9NU19 |
PhosphoSitePlusi | Q9NU19 |
Genetic variation databases
BioMutai | TBC1D22B |
DMDMi | 47117913 |
Proteomic databases
EPDi | Q9NU19 |
jPOSTi | Q9NU19 |
MassIVEi | Q9NU19 |
MaxQBi | Q9NU19 |
PaxDbi | Q9NU19 |
PeptideAtlasi | Q9NU19 |
PRIDEi | Q9NU19 |
ProteomicsDBi | 82648 |
Protocols and materials databases
Antibodypediai | 29804, 24 antibodies from 9 providers |
DNASUi | 55633 |
Genome annotation databases
Ensembli | ENST00000373491; ENSP00000362590; ENSG00000065491 |
GeneIDi | 55633 |
KEGGi | hsa:55633 |
MANE-Selecti | ENST00000373491.3; ENSP00000362590.3; NM_017772.4; NP_060242.2 |
UCSCi | uc003onn.3, human |
Organism-specific databases
CTDi | 55633 |
DisGeNETi | 55633 |
GeneCardsi | TBC1D22B |
HGNCi | HGNC:21602, TBC1D22B |
HPAi | ENSG00000065491, Low tissue specificity |
MIMi | 616880, gene |
neXtProti | NX_Q9NU19 |
OpenTargetsi | ENSG00000065491 |
PharmGKBi | PA134867087 |
VEuPathDBi | HostDB:ENSG00000065491 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1092, Eukaryota |
GeneTreei | ENSGT00940000157472 |
HOGENOMi | CLU_018687_6_0_1 |
InParanoidi | Q9NU19 |
OMAi | SAKLPGX |
OrthoDBi | 750722at2759 |
PhylomeDBi | Q9NU19 |
TreeFami | TF314211 |
Enzyme and pathway databases
PathwayCommonsi | Q9NU19 |
SignaLinki | Q9NU19 |
Miscellaneous databases
BioGRID-ORCSi | 55633, 16 hits in 1045 CRISPR screens |
EvolutionaryTracei | Q9NU19 |
GenomeRNAii | 55633 |
Pharosi | Q9NU19, Tbio |
PROi | PR:Q9NU19 |
RNActi | Q9NU19, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000065491, Expressed in prostate gland and 182 other tissues |
Genevisiblei | Q9NU19, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000195, Rab-GTPase-TBC_dom IPR035969, Rab-GTPase_TBC_sf |
Pfami | View protein in Pfam PF00566, RabGAP-TBC, 1 hit |
SMARTi | View protein in SMART SM00164, TBC, 1 hit |
SUPFAMi | SSF47923, SSF47923, 2 hits |
PROSITEi | View protein in PROSITE PS50086, TBC_RABGAP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TB22B_HUMAN | |
Accessioni | Q9NU19Primary (citable) accession number: Q9NU19 Secondary accession number(s): A8KA28 Q9NXB6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2002 |
Last sequence update: | May 10, 2004 | |
Last modified: | February 23, 2022 | |
This is version 159 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references