Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 146 (16 Oct 2019)
Sequence version 3 (10 May 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

TBC1 domain family member 22B

Gene

TBC1D22B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a GTPase-activating protein for Rab family protein(s).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TBC1 domain family member 22B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TBC1D22B
Synonyms:C6orf197
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21602 TBC1D22B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616880 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NU19

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi58S → E: No effect on ACBD3-binding. 1 Publication1
Mutagenesisi88 – 90LNS → AAA: No effect on ACBD3-binding. 1 Publication3
Mutagenesisi91 – 92KV → AA: No effect on ACBD3-binding. 1 Publication2
Mutagenesisi94 – 96LAT → AAA: No effect on ACBD3-binding. 1 Publication3
Mutagenesisi99Q → A: No effect on ACBD3-binding. 1 Publication1
Mutagenesisi100 – 101VL → AA: Almost complete loss of ACBD3-binding. 1 Publication2
Mutagenesisi102 – 104ENH → AAA: No effect on ACBD3-binding. 1 Publication3
Mutagenesisi114S → E: No effect on ACBD3-binding. 1 Publication1
Mutagenesisi116 – 119STTS → EEEE: No effect on ACBD3-binding. 1 Publication4
Mutagenesisi140 – 141SS → EE: No effect on ACBD3-binding. 1 Publication2
Mutagenesisi143T → E: No effect on ACBD3-binding. 1 Publication1
Mutagenesisi168S → E: No effect on ACBD3-binding. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
55633

Open Targets

More...
OpenTargetsi
ENSG00000065491

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134867087

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NU19

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TBC1D22B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
47117913

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002080542 – 505TBC1 domain family member 22BAdd BLAST504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanine1 Publication1
Modified residuei58PhosphoserineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Modified residuei154PhosphoserineCombined sources1 Publication1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NU19

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NU19

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NU19

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NU19

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NU19

PeptideAtlas

More...
PeptideAtlasi
Q9NU19

PRoteomics IDEntifications database

More...
PRIDEi
Q9NU19

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82648

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NU19

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NU19

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000065491 Expressed in 165 organ(s), highest expression level in prostate gland

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NU19 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027908
HPA027909
HPA027910

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ACBD3 and ARFGEF1.

Interacts with YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120772, 120 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NU19, 150 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362590

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1505
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NU19

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9NU19

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini210 – 434Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST225

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1092 Eukaryota
ENOG410XQ68 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157472

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NU19

KEGG Orthology (KO)

More...
KOi
K20360

Identification of Orthologs from Complete Genome Data

More...
OMAi
SAKLPGX

Database of Orthologous Groups

More...
OrthoDBi
750722at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NU19

TreeFam database of animal gene trees

More...
TreeFami
TF314211

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00566 RabGAP-TBC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00164 TBC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47923 SSF47923, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50086 TBC_RABGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NU19-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAENSKQFW KRSAKLPGSI QPVYGAQHPP LDPRLTKNFI KERSKVNTVP
60 70 80 90 100
LKNKKASSFH EFARNTSDAW DIGDDEEEDF SSPSFQTLNS KVALATAAQV
110 120 130 140 150
LENHSKLRVK PERSQSTTSD VPANYKVIKS SSDAQLSRNS SDTCLRNPLH
160 170 180 190 200
KQQSLPLRPI IPLVARISDQ NASGAPPMTV REKTRLEKFR QLLSSQNTDL
210 220 230 240 250
DELRKCSWPG VPREVRPITW RLLSGYLPAN TERRKLTLQR KREEYFGFIE
260 270 280 290 300
QYYDSRNEEH HQDTYRQIHI DIPRTNPLIP LFQQPLVQEI FERILFIWAI
310 320 330 340 350
RHPASGYVQG INDLVTPFFV VFLSEYVEED VENFDVTNLS QDMLRSIEAD
360 370 380 390 400
SFWCMSKLLD GIQDNYTFAQ PGIQKKVKAL EELVSRIDEQ VHNHFRRYEV
410 420 430 440 450
EYLQFAFRWM NNLLMRELPL RCTIRLWDTY QSEPEGFSHF HLYVCAAFLI
460 470 480 490 500
KWRKEILDEE DFQGLLMLLQ NLPTIHWGNE EIGLLLAEAY RLKYMFADAP

NHYRR
Length:505
Mass (Da):59,081
Last modified:May 10, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC0093770BE04AA4D
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91099 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti376 – 378KVK → HEE in AAH00291 (PubMed:15489334).Curated3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB449909 mRNA Translation: BAH16652.1
AY313781 mRNA Translation: AAQ72548.1
AK000344 mRNA Translation: BAA91099.1 Different initiation.
AK292893 mRNA Translation: BAF85582.1
AL096712 Genomic DNA No translation available.
AL353579 Genomic DNA No translation available.
AL589667 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03939.1
BC000291 mRNA Translation: AAH00291.2
BC000743 mRNA Translation: AAH00743.2
BC001927 mRNA Translation: AAH01927.1
BC002720 mRNA Translation: AAH02720.2
BC063523 mRNA Translation: AAH63523.1
BC109026 mRNA Translation: AAI09027.1
BC109027 mRNA Translation: AAI09028.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4832.1

NCBI Reference Sequences

More...
RefSeqi
NP_060242.2, NM_017772.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000373491; ENSP00000362590; ENSG00000065491

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55633

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55633

UCSC genome browser

More...
UCSCi
uc003onn.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449909 mRNA Translation: BAH16652.1
AY313781 mRNA Translation: AAQ72548.1
AK000344 mRNA Translation: BAA91099.1 Different initiation.
AK292893 mRNA Translation: BAF85582.1
AL096712 Genomic DNA No translation available.
AL353579 Genomic DNA No translation available.
AL589667 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03939.1
BC000291 mRNA Translation: AAH00291.2
BC000743 mRNA Translation: AAH00743.2
BC001927 mRNA Translation: AAH01927.1
BC002720 mRNA Translation: AAH02720.2
BC063523 mRNA Translation: AAH63523.1
BC109026 mRNA Translation: AAI09027.1
BC109027 mRNA Translation: AAI09028.1
CCDSiCCDS4832.1
RefSeqiNP_060242.2, NM_017772.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6D0SX-ray2.30A178-505[»]
SMRiQ9NU19
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi120772, 120 interactors
IntActiQ9NU19, 150 interactors
STRINGi9606.ENSP00000362590

PTM databases

iPTMnetiQ9NU19
PhosphoSitePlusiQ9NU19

Polymorphism and mutation databases

BioMutaiTBC1D22B
DMDMi47117913

Proteomic databases

EPDiQ9NU19
jPOSTiQ9NU19
MassIVEiQ9NU19
MaxQBiQ9NU19
PaxDbiQ9NU19
PeptideAtlasiQ9NU19
PRIDEiQ9NU19
ProteomicsDBi82648

Genome annotation databases

EnsembliENST00000373491; ENSP00000362590; ENSG00000065491
GeneIDi55633
KEGGihsa:55633
UCSCiuc003onn.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55633
DisGeNETi55633

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TBC1D22B
HGNCiHGNC:21602 TBC1D22B
HPAiHPA027908
HPA027909
HPA027910
MIMi616880 gene
neXtProtiNX_Q9NU19
OpenTargetsiENSG00000065491
PharmGKBiPA134867087

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1092 Eukaryota
ENOG410XQ68 LUCA
GeneTreeiENSGT00940000157472
InParanoidiQ9NU19
KOiK20360
OMAiSAKLPGX
OrthoDBi750722at2759
PhylomeDBiQ9NU19
TreeFamiTF314211

Miscellaneous databases

EvolutionaryTraceiQ9NU19

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55633
PharosiQ9NU19

Protein Ontology

More...
PROi
PR:Q9NU19

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000065491 Expressed in 165 organ(s), highest expression level in prostate gland
GenevisibleiQ9NU19 HS

Family and domain databases

InterProiView protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTB22B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NU19
Secondary accession number(s): A8KA28
, Q32MQ8, Q5VUK9, Q6P4C3, Q7Z6P7, Q9BPV6, Q9BUT5, Q9NXB6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: May 10, 2004
Last modified: October 16, 2019
This is version 146 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again