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Protein

Protein FAM217B

Gene

FAM217B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM217B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM217B
Synonyms:C20orf177
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000196227.10

Human Gene Nomenclature Database

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HGNCi
HGNC:16170 FAM217B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NTX9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000196227

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25720

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM217B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
27734258

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000794851 – 383Protein FAM217BAdd BLAST383

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9NTX9

PeptideAtlas

More...
PeptideAtlasi
Q9NTX9

PRoteomics IDEntifications database

More...
PRIDEi
Q9NTX9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82644

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NTX9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NTX9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196227 Expressed in 194 organ(s), highest expression level in dorsolateral prefrontal cortex

CleanEx database of gene expression profiles

More...
CleanExi
HS_C20orf177

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NTX9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NTX9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041021
HPA056698

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122004, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NTX9, 14 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000351040

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9NTX9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi293 – 296Poly-Lys4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM217 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IVFB Eukaryota
ENOG4112055 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154543

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231581

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051210

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NTX9

Identification of Orthologs from Complete Genome Data

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OMAi
PFNSWDL

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0EJ7

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NTX9

TreeFam database of animal gene trees

More...
TreeFami
TF337855

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029266 FAM217

The PANTHER Classification System

More...
PANTHERi
PTHR22145 PTHR22145, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15344 FAM217, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9NTX9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNAGPSWNKV QHSKNSSGKR QSKSQVPHAS SQPRSSLTAV TQPTEEKLKE
60 70 80 90 100
SISPEARRKR NPLGSRCQGA SGNKLFLDFQ SMKIIKENAD EDSASDLSDS
110 120 130 140 150
ERIPIPPSPL TPPDLNLRAE EIDPVYFDLH PGQGHTKPEY YYPNFLPSPF
160 170 180 190 200
SSWDLRDMAL LLNAENKTEA VPRVGGLLGK YIDRLIQLEW LQVQTVQCEK
210 220 230 240 250
AKGGKARPPT APGTSGALKS PGRSKLIASA LSKPLPHQEG ASKSGPSRKK
260 270 280 290 300
AFHHEEIHPS HYAFETSPRP IDVLGGTRFC SQRQTLEMRT EEKKKKSSKS
310 320 330 340 350
TKLQRWDLSG SGSSSKVETS GHIRVPKQAA VILDSADSCK ASKTQAHAHP
360 370 380
RKKGKAESCG HATVSSEKKL KTNGVKQNTY KLK
Length:383
Mass (Da):42,052
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i56E1DB8E27CD544F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A2M7A2A2M7_HUMAN
Protein FAM217B
FAM217B
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti68Q → G (PubMed:17974005).Curated1
Sequence conflicti120E → G in CAB70739 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03569195S → G in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1180582304Ensembl.1
Natural variantiVAR_050922380Y → C. Corresponds to variant dbSNP:rs6027210Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK125073 mRNA Translation: BAG54133.1
AL109928 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75424.1
BC054002 mRNA Translation: AAH54002.1
AL137442 mRNA Translation: CAB70739.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13484.1

Protein sequence database of the Protein Information Resource

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PIRi
T46282

NCBI Reference Sequences

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RefSeqi
NP_001177755.1, NM_001190826.1
NP_001177756.1, NM_001190827.1
NP_071389.1, NM_022106.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.54973
Hs.596058

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000358293; ENSP00000351040; ENSG00000196227
ENST00000360816; ENSP00000354056; ENSG00000196227

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
63939

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:63939

UCSC genome browser

More...
UCSCi
uc002yba.4 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125073 mRNA Translation: BAG54133.1
AL109928 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75424.1
BC054002 mRNA Translation: AAH54002.1
AL137442 mRNA Translation: CAB70739.2
CCDSiCCDS13484.1
PIRiT46282
RefSeqiNP_001177755.1, NM_001190826.1
NP_001177756.1, NM_001190827.1
NP_071389.1, NM_022106.2
UniGeneiHs.54973
Hs.596058

3D structure databases

ProteinModelPortaliQ9NTX9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122004, 11 interactors
IntActiQ9NTX9, 14 interactors
STRINGi9606.ENSP00000351040

PTM databases

iPTMnetiQ9NTX9
PhosphoSitePlusiQ9NTX9

Polymorphism and mutation databases

BioMutaiFAM217B
DMDMi27734258

Proteomic databases

PaxDbiQ9NTX9
PeptideAtlasiQ9NTX9
PRIDEiQ9NTX9
ProteomicsDBi82644

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
63939
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358293; ENSP00000351040; ENSG00000196227
ENST00000360816; ENSP00000354056; ENSG00000196227
GeneIDi63939
KEGGihsa:63939
UCSCiuc002yba.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
63939
EuPathDBiHostDB:ENSG00000196227.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM217B

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0203045
HGNCiHGNC:16170 FAM217B
HPAiHPA041021
HPA056698
neXtProtiNX_Q9NTX9
OpenTargetsiENSG00000196227
PharmGKBiPA25720

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IVFB Eukaryota
ENOG4112055 LUCA
GeneTreeiENSGT00940000154543
HOGENOMiHOG000231581
HOVERGENiHBG051210
InParanoidiQ9NTX9
OMAiPFNSWDL
OrthoDBiEOG091G0EJ7
PhylomeDBiQ9NTX9
TreeFamiTF337855

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAM217B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
63939

Protein Ontology

More...
PROi
PR:Q9NTX9

Gene expression databases

BgeeiENSG00000196227 Expressed in 194 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_C20orf177
ExpressionAtlasiQ9NTX9 baseline and differential
GenevisibleiQ9NTX9 HS

Family and domain databases

InterProiView protein in InterPro
IPR029266 FAM217
PANTHERiPTHR22145 PTHR22145, 1 hit
PfamiView protein in Pfam
PF15344 FAM217, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF217B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NTX9
Secondary accession number(s): B3KWH1, Q9NTA3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 1, 2000
Last modified: December 5, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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