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UniProtKB - Q9NTX7 (RN146_HUMAN)

Entry version 166 (17 Jun 2020)
Sequence version 1 (01 Oct 2000)
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Protein

E3 ubiquitin-protein ligase RNF146

Gene

RNF146

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'. May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective protein. Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos. Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner. Does not affect PARP1 activation (By similarity). Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest. Promotes cell survival after gamma-irradiation. Facilitates DNA repair.By similarity5 Publications

Miscellaneous

Was named dactylidin after the Greek term 'daktylidi' for ring, 'the thing around the finger' (PubMed:15813938). Was named Iduna after the Norse goddess of protection and eternal youth (PubMed:21602803).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei108iso-ADP-ribose adenine ring group1 Publication1
Binding sitei111iso-ADP-ribose 5'-phosphate group1 Publication1
Binding sitei115iso-ADP-ribose 5'-phosphate group1 Publication1
Binding sitei145iso-ADP-ribose 1'-phosphate group1 Publication1
Binding sitei154iso-ADP-ribose adenine ring group1 Publication1
Binding sitei164iso-ADP-ribose 1'-phosphate group1 Publication1
Binding sitei176iso-ADP-ribose 5'-phosphate group1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri37 – 75RING-typePROSITE-ProRule annotationAdd BLAST39

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway, Wnt signaling pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-4641257 Degradation of AXIN
R-HSA-5689880 Ub-specific processing proteases
R-HSA-8948751 Regulation of PTEN stability and activity

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9NTX7

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF146 (EC:2.3.2.27)
Alternative name(s):
Dactylidin
Iduna
RING finger protein 146
RING-type E3 ubiquitin transferase RNF146Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RNF146
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000118518.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:21336 RNF146

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612137 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NTX7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in RNF146 are a cause of susceptibility to breast cancer.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi54H → A: Partially suppression of WNT3A signaling and stabilization of AXIN1, TNKS and TNKS2 with or without WNT3A induction. No effect on TNKS1-binding. 1 Publication1
Mutagenesisi106W → A: No effect on Wnt signaling pathway. 1 Publication1
Mutagenesisi108Y → A: Loss of iso-ADP-ribose-binding. 1 Publication1
Mutagenesisi111R → A: Minor effect on iso-ADP-ribose-binding. 1 Publication1
Mutagenesisi115W → A: Strong decrease in iso-ADP-ribose-binding affinity. 1 Publication1
Mutagenesisi145Y → A: Loss of iso-ADP-ribose-binding. 1 Publication1
Mutagenesisi154Q → A: Loss of iso-ADP-ribose-binding affinity. 1 Publication1
Mutagenesisi163R → A: Abolishes the ability to recognize and bind PARsylated proteins. 1 Publication1
Mutagenesisi164R → A: Loss of iso-ADP-ribose-binding. 1 Publication1
Mutagenesisi176K → A: Minor effect on iso-ADP-ribose-binding. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		81847

Open Targets

More...OpenTargetsi		ENSG00000118518

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134910489

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NTX7 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RNF146

Domain mapping of disease mutations (DMDM)

More...DMDMi		60390653

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000561071 – 359E3 ubiquitin-protein ligase RNF146Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki85Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki95Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki131Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki176Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei290PhosphoserineBy similarity1
Modified residuei294PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated; autoubiquitinated. Polyubiquitinated in the presence of UBE2D1, UBE2D2 and UBE2D3. Multimonoubiquitinated in the presence of UBE2E1. Not ubiquitinated in the presence of UBE2H, CDC34, UBE2L3, UBE2L6, nor UBE2C. In the absence of PAR, autoubiquitination occurs on Lys-85, Lys-95 and Lys-176 via 'Lys-11' and 'Lys-48' ubiquitin linkages. In the presence of PAR, Lys-131 and Lys-176 are ubiquitinated via 'Lys-6', 'Lys-33' and 'Lys-48' ubiquitin linkages. Autoubiquitination is enhanced upon PAR-binding.3 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NTX7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NTX7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NTX7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NTX7

PeptideAtlas

More...PeptideAtlasi		Q9NTX7

PRoteomics IDEntifications database

More...PRIDEi		Q9NTX7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82642 [Q9NTX7-1]
82643 [Q9NTX7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NTX7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NTX7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Up-regulated in brains from patients with Alzheimer disease.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000118518 Expressed in cerebellar vermis and 216 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NTX7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NTX7 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000118518 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Can form homooligomers.

Interacts with PARsylated AXIN1, AXIN2, BLZF1, CASC3, H1-2, IPO7, LIG3, NCL, PARP1, XRCC1, XRCC5 and XRCC6.

Interacts with DDB1, DHX15, IQGAP1, LRPPRC, PARP2, PRKDC, RUVBL2, TNKS1 and TNKS2. Binding often leads to interactor ubiquitination, in the presence of the appropriate E1 and E2 enzymes, and proteasomal degradation.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123598, 56 interactors

Database of interacting proteins

More...DIPi		DIP-52730N

Protein interaction database and analysis system

More...IntActi		Q9NTX7, 46 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000357297

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NTX7 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1359
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NTX7

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9NTX7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini92 – 168WWEPROSITE-ProRule annotationAdd BLAST77

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WWE domain mediates non-covalent PAR-binding.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri37 – 75RING-typePROSITE-ProRule annotationAdd BLAST39

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0824 Eukaryota
ENOG410ZTFC LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000000358

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_067425_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NTX7

KEGG Orthology (KO)

More...KOi		K15700

Identification of Orthologs from Complete Genome Data

More...OMAi		AHLQING

Database of Orthologous Groups

More...OrthoDBi		1469576at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NTX7

TreeFam database of animal gene trees

More...TreeFami		TF318925

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 1 hit
3.30.720.50, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR033509 RNF146
IPR004170 WWE-dom
IPR018123 WWE-dom_subgr
IPR037197 WWE_dom_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS

The PANTHER Classification System

More...PANTHERi		PTHR13417:SF2 PTHR13417:SF2, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02825 WWE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00184 RING, 1 hit
SM00678 WWE, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF117839 SSF117839, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50918 WWE, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NTX7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMAGCGEIDH SINMLPTNRK ANESCSNTAP SLTVPECAIC LQTCVHPVSL 
        60         70         80         90        100
PCKHVFCYLC VKGASWLGKR CALCRQEIPE DFLDKPTLLS PEELKAASRG 
       110        120        130        140        150
NGEYAWYYEG RNGWWQYDER TSRELEDAFS KGKKNTEMLI AGFLYVADLE 
       160        170        180        190        200
NMVQYRRNEH GRRRKIKRDI IDIPKKGVAG LRLDCDANTV NLARESSADG 
       210        220        230        240        250
ADSVSAQSGA SVQPLVSSVR PLTSVDGQLT SPATPSPDAS TSLEDSFAHL 
       260        270        280        290        300
QLSGDNTAER SHRGEGEEDH ESPSSGRVPA PDTSIEETES DASSDSEDVS 
       310        320        330        340        350
AVVAQHSLTQ QRLLVSNANQ TVPDRSDRSG TDRSVAGGGT VSVSVRSRRP 

DGQCTVTEV
Length:359
Mass (Da):38,950
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7337C410EDA30A7E
GO
Isoform 2 (identifier: Q9NTX7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: Missing.

Show »
Length:358
Mass (Da):38,819
Checksum:iE46AA6522DA8D48B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GYY4V9GYY4_HUMAN
E3 ubiquitin-protein ligase RNF146
RNF146
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GZ53V9GZ53_HUMAN
E3 ubiquitin-protein ligase RNF146
RNF146
14Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYK9V9GYK9_HUMAN
E3 ubiquitin-protein ligase RNF146
RNF146
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JLL7A0A0G2JLL7_HUMAN
E3 ubiquitin-protein ligase RNF146
RNF146
9Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti69K → R in BAB55359 (PubMed:14702039).Curated1
Sequence conflicti74C → R in BAB55108 (PubMed:14702039).Curated1
Sequence conflicti100G → E in CAG38545 (Ref. 4) Curated1
Sequence conflicti166I → V in CAG38545 (Ref. 4) Curated1
Sequence conflicti229L → S in BAB55108 (PubMed:14702039).Curated1
Sequence conflicti329S → L in BAB55108 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06524925C → R. Corresponds to variant dbSNP:rs10081141Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0129681Missing in isoform 2. 5 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ315122 mRNA Translation: CAC85986.1
AL136829 mRNA Translation: CAB66763.1
AK027558 mRNA Translation: BAB55196.1
AK027436 mRNA Translation: BAB55108.1
AK027776 mRNA Translation: BAB55359.1
CR533514 mRNA Translation: CAG38545.1
AL109939 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48109.1
CH471051 Genomic DNA Translation: EAW48111.1
BC008235 mRNA Translation: AAH08235.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5136.1 [Q9NTX7-2]
CCDS56449.1 [Q9NTX7-1]

NCBI Reference Sequences

More...RefSeqi		NP_001229773.1, NM_001242844.1 [Q9NTX7-2]
NP_001229774.1, NM_001242845.1 [Q9NTX7-2]
NP_001229775.1, NM_001242846.1 [Q9NTX7-2]
NP_001229776.1, NM_001242847.1 [Q9NTX7-2]
NP_001229777.1, NM_001242848.1 [Q9NTX7-2]
NP_001229778.1, NM_001242849.1 [Q9NTX7-1]
NP_001229779.1, NM_001242850.1 [Q9NTX7-1]
NP_001229780.1, NM_001242851.1 [Q9NTX7-1]
NP_001229781.1, NM_001242852.1 [Q9NTX7-2]
NP_112225.2, NM_030963.3 [Q9NTX7-2]
XP_006715634.1, XM_006715571.3 [Q9NTX7-2]
XP_011534463.1, XM_011536161.2 [Q9NTX7-2]
XP_011534464.1, XM_011536162.2 [Q9NTX7-2]
XP_011534465.1, XM_011536163.2 [Q9NTX7-2]
XP_011534466.1, XM_011536164.2 [Q9NTX7-2]
XP_016866825.1, XM_017011336.1 [Q9NTX7-1]
XP_016866826.1, XM_017011337.1
XP_016866827.1, XM_017011338.1 [Q9NTX7-2]
XP_016866828.1, XM_017011339.1 [Q9NTX7-2]
XP_016866829.1, XM_017011340.1 [Q9NTX7-2]
XP_016866830.1, XM_017011341.1 [Q9NTX7-2]
XP_016866831.1, XM_017011342.1 [Q9NTX7-2]
XP_016866832.1, XM_017011343.1 [Q9NTX7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000309649; ENSP00000309365; ENSG00000118518 [Q9NTX7-2]
ENST00000368314; ENSP00000357297; ENSG00000118518 [Q9NTX7-1]
ENST00000608991; ENSP00000477168; ENSG00000118518 [Q9NTX7-2]
ENST00000610153; ENSP00000476814; ENSG00000118518 [Q9NTX7-1]
ENST00000616343; ENSP00000479890; ENSG00000118518 [Q9NTX7-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		81847

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:81847

UCSC genome browser

More...UCSCi		uc003qav.4 human [Q9NTX7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ315122 mRNA Translation: CAC85986.1
AL136829 mRNA Translation: CAB66763.1
AK027558 mRNA Translation: BAB55196.1
AK027436 mRNA Translation: BAB55108.1
AK027776 mRNA Translation: BAB55359.1
CR533514 mRNA Translation: CAG38545.1
AL109939 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48109.1
CH471051 Genomic DNA Translation: EAW48111.1
BC008235 mRNA Translation: AAH08235.1
CCDSiCCDS5136.1 [Q9NTX7-2]
CCDS56449.1 [Q9NTX7-1]
RefSeqiNP_001229773.1, NM_001242844.1 [Q9NTX7-2]
NP_001229774.1, NM_001242845.1 [Q9NTX7-2]
NP_001229775.1, NM_001242846.1 [Q9NTX7-2]
NP_001229776.1, NM_001242847.1 [Q9NTX7-2]
NP_001229777.1, NM_001242848.1 [Q9NTX7-2]
NP_001229778.1, NM_001242849.1 [Q9NTX7-1]
NP_001229779.1, NM_001242850.1 [Q9NTX7-1]
NP_001229780.1, NM_001242851.1 [Q9NTX7-1]
NP_001229781.1, NM_001242852.1 [Q9NTX7-2]
NP_112225.2, NM_030963.3 [Q9NTX7-2]
XP_006715634.1, XM_006715571.3 [Q9NTX7-2]
XP_011534463.1, XM_011536161.2 [Q9NTX7-2]
XP_011534464.1, XM_011536162.2 [Q9NTX7-2]
XP_011534465.1, XM_011536163.2 [Q9NTX7-2]
XP_011534466.1, XM_011536164.2 [Q9NTX7-2]
XP_016866825.1, XM_017011336.1 [Q9NTX7-1]
XP_016866826.1, XM_017011337.1
XP_016866827.1, XM_017011338.1 [Q9NTX7-2]
XP_016866828.1, XM_017011339.1 [Q9NTX7-2]
XP_016866829.1, XM_017011340.1 [Q9NTX7-2]
XP_016866830.1, XM_017011341.1 [Q9NTX7-2]
XP_016866831.1, XM_017011342.1 [Q9NTX7-2]
XP_016866832.1, XM_017011343.1 [Q9NTX7-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D8TNMR-A27-84[»]
3V3LX-ray1.65A/B100-184[»]
6CF6X-ray1.93C/D191-203[»]
SMRiQ9NTX7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi123598, 56 interactors
DIPiDIP-52730N
IntActiQ9NTX7, 46 interactors
STRINGi9606.ENSP00000357297

PTM databases

iPTMnetiQ9NTX7
PhosphoSitePlusiQ9NTX7

Polymorphism and mutation databases

BioMutaiRNF146
DMDMi60390653

Proteomic databases

jPOSTiQ9NTX7
MassIVEiQ9NTX7
MaxQBiQ9NTX7
PaxDbiQ9NTX7
PeptideAtlasiQ9NTX7
PRIDEiQ9NTX7
ProteomicsDBi82642 [Q9NTX7-1]
82643 [Q9NTX7-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		19579 65 antibodies

The DNASU plasmid repository

More...DNASUi		81847

Genome annotation databases

EnsembliENST00000309649; ENSP00000309365; ENSG00000118518 [Q9NTX7-2]
ENST00000368314; ENSP00000357297; ENSG00000118518 [Q9NTX7-1]
ENST00000608991; ENSP00000477168; ENSG00000118518 [Q9NTX7-2]
ENST00000610153; ENSP00000476814; ENSG00000118518 [Q9NTX7-1]
ENST00000616343; ENSP00000479890; ENSG00000118518 [Q9NTX7-1]
GeneIDi81847
KEGGihsa:81847
UCSCiuc003qav.4 human [Q9NTX7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		81847
DisGeNETi81847
EuPathDBiHostDB:ENSG00000118518.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		RNF146
HGNCiHGNC:21336 RNF146
HPAiENSG00000118518 Low tissue specificity
MIMi612137 gene
neXtProtiNX_Q9NTX7
OpenTargetsiENSG00000118518
PharmGKBiPA134910489

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0824 Eukaryota
ENOG410ZTFC LUCA
GeneTreeiENSGT00390000000358
HOGENOMiCLU_067425_0_0_1
InParanoidiQ9NTX7
KOiK15700
OMAiAHLQING
OrthoDBi1469576at2759
PhylomeDBiQ9NTX7
TreeFamiTF318925

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-4641257 Degradation of AXIN
R-HSA-5689880 Ub-specific processing proteases
R-HSA-8948751 Regulation of PTEN stability and activity
SIGNORiQ9NTX7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		81847 7 hits in 790 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RNF146 human
EvolutionaryTraceiQ9NTX7

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RNF146

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		81847
PharosiQ9NTX7 Tbio

Protein Ontology

More...PROi		PR:Q9NTX7
RNActiQ9NTX7 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000118518 Expressed in cerebellar vermis and 216 other tissues
ExpressionAtlasiQ9NTX7 baseline and differential
GenevisibleiQ9NTX7 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
3.30.720.50, 1 hit
InterProiView protein in InterPro
IPR033509 RNF146
IPR004170 WWE-dom
IPR018123 WWE-dom_subgr
IPR037197 WWE_dom_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR13417:SF2 PTHR13417:SF2, 1 hit
PfamiView protein in Pfam
PF02825 WWE, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
SM00678 WWE, 1 hit
SUPFAMiSSF117839 SSF117839, 1 hit
PROSITEiView protein in PROSITE
PS50918 WWE, 1 hit
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRN146_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NTX7
Secondary accession number(s): E1P572
, Q6FIB2, Q7L8H4, Q96K03, Q96T06, Q9NTX6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: October 1, 2000
Last modified: June 17, 2020
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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