UniProtKB - Q9NTW7 (ZF64B_HUMAN)
Protein
Zinc finger protein 64
Gene
ZFP64
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 175 – 197 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 203 – 225 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 231 – 253 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 299 – 324 | C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 330 – 352 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 358 – 380 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 386 – 408 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 414 – 436 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 442 – 465 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 467 – 489 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 495 – 517 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 523 – 546 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 580 – 602 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of gene expression Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9NTW7 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 64CuratedShort name: Zfp-64 Alternative name(s): Zinc finger protein 338Imported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15940, ZFP64 |
MIMi | 618111, gene |
neXtProti | NX_Q9NTW7 |
VEuPathDBi | HostDB:ENSG00000020256.19 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 55734 |
OpenTargetsi | ENSG00000020256 |
PharmGKBi | PA38060 |
Miscellaneous databases
Pharosi | Q9NTW7, Tbio |
Genetic variation databases
BioMutai | ZFP64 |
DMDMi | 116242854 30316391 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047308 | 1 – 645 | Zinc finger protein 64Add BLAST | 645 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 6 (identifier: Q9NTW7-4) | |||||
Cross-linki | 286 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Cross-linki | 397 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | |||
Modified residuei | 545 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9NTW7 |
jPOSTi | Q9NTW7 |
MassIVEi | Q9NTW7 |
MaxQBi | Q9NTW7 |
PaxDbi | Q9NTW7 |
PeptideAtlasi | Q9NTW7 |
PRIDEi | Q9NTW7 |
ProteomicsDBi | 63393 81951 81952 82633 [Q9NTW7-1] 82634 [Q9NTW7-2] 82635 [Q9NTW7-3] |
PTM databases
iPTMneti | Q9NTW7 |
PhosphoSitePlusi | Q9NTW7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000020256, Expressed in vagina and 242 other tissues |
ExpressionAtlasi | Q9NTW7, baseline and differential |
Genevisiblei | Q9NTW7, HS |
Organism-specific databases
HPAi | ENSG00000020256, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ9NTW7
Isoform 1 [Q9NTW7-5]
With | #Exp. | IntAct |
---|---|---|
TAB2 [Q9NYJ8] | 3 | EBI-23201521,EBI-358708 |
Protein-protein interaction databases
BioGRIDi | 120853, 39 interactors |
IntActi | Q9NTW7, 26 interactors |
MINTi | Q9NTW7 |
STRINGi | 9606.ENSP00000216923 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9NTW7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 175 – 197 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 203 – 225 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 231 – 253 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 299 – 324 | C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 330 – 352 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 358 – 380 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 386 – 408 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 414 – 436 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 442 – 465 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 467 – 489 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 495 – 517 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 523 – 546 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 580 – 602 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000156405 |
HOGENOMi | CLU_002678_71_1_1 |
InParanoidi | Q9NPA5 |
OMAi | VRCAMKG |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9NTW7 |
TreeFami | TF333046 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 15 hits |
SUPFAMi | SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 3 (identifier: Q9NTW7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNASSEGESF AGSVQIPGGT TVLVELTPDI HICGICKQQF NNLDAFVAHK
60 70 80 90 100
QSGCQLTGTS AAAPSTVQFV SEETVPATQT QTTTRTITSE TQTITVSAPE
110 120 130 140 150
FVFEHGYQTY LPTESNENQT ATVISLPAKS RTKKPTTPPA QKRLNCCYPG
160 170 180 190 200
CQFKTAYGMK DMERHLKIHT GDKPHKCEVC GKCFSRKDKL KTHMRCHTGV
210 220 230 240 250
KPYKCKTCDY AAADSSSLNK HLRIHSDERP FKCQICPYAS RNSSQLTVHL
260 270 280 290 300
RSHTASELDD DVPKANCLST ESTDTPKAPV ITLPSEAREQ MATLGERTFN
310 320 330 340 350
CCYPGCHFKT VHGMKDLDRH LRIHTGDKPH KCEFCDKCFS RKDNLTMHMR
360 370 380 390 400
CHTSVKPHKC HLCDYAAVDS SSLKKHLRIH SDERPYKCQL CPYASRNSSQ
410 420 430 440 450
LTVHLRSHTG DTPFQCWLCS AKFKISSDLK RHMIVHSGEK PFKCEFCDVR
460 470 480 490 500
CTMKANLKSH IRIKHTFKCL HCAFQGRDRA DLLEHSRLHQ ADHPEKCPEC
510 520 530 540 550
SYSCSSAAAL RVHSRVHCKD RPFKCDFCSF DTKRPSSLAK HVDKVHRDEA
560 570 580 590 600
KTENRAPLGK EGLREGSSQH VAKIVTQRAF RCETCGASFV RDDSLRCHKK
610 620 630 640
QHSDQSENKN SDLVTFPPES GASGQLSTLV SVGQLEAPLE PSQDL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2A2N5 | A2A2N5_HUMAN | Zinc finger protein 64 | ZFP64 | 221 | Annotation score: | ||
H0Y669 | H0Y669_HUMAN | Zinc finger protein 64 | ZFP64 | 120 | Annotation score: | ||
A2A2N6 | A2A2N6_HUMAN | Zinc finger protein 64 | ZFP64 | 131 | Annotation score: |
Sequence cautioni
The sequence BAD96432 differs from that shown. Reason: Erroneous translation. Translation C-terminally extended.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 240 | S → G in BAD96432 (Ref. 3) Curated | 1 | |
Sequence conflicti | 521 | R → C in AAP88762 (Ref. 2) Curated | 1 | |
Sequence conflicti | 521 | R → C in BC021087 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Natural variantiVAR_028019 | 68 | Q → P. Corresponds to variant dbSNP:rs7353222Ensembl. | 1 | ||
Natural variantiVAR_028020 | 139 | P → L. Corresponds to variant dbSNP:rs6021773Ensembl. | 1 | ||
Natural variantiVAR_035564 | 593 | D → E in a breast cancer sample; somatic mutation. 1 Publication | 1 | ||
Natural variantiVAR_035565 | 609 | K → N in a breast cancer sample; somatic mutation. 1 Publication | 1 | ||
Isoform 1 (identifier: Q9NTW7-5) | |||||
Natural variantiVAR_082942 | 425 | F → YCuratedCorresponds to variant dbSNP:rs16996517Ensembl. | 1 | ||
Natural variantiVAR_082943 | 451 | S → N1 PublicationCorresponds to variant dbSNP:rs3746414Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007285 | 1 – 219 | Missing in isoform 4. 1 PublicationAdd BLAST | 219 | |
Alternative sequenceiVSP_046896 | 16 – 18 | IPG → S in isoform 6. Curated | 3 | |
Alternative sequenceiVSP_060092 | 96 – 149 | Missing in isoform 2. Add BLAST | 54 | |
Alternative sequenceiVSP_007286 | 220 – 254 | KHLRI…LRSHT → MSRRKQAKPQHLNSEEPRPA RRECAEVAPQVAGEP in isoform 4. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_046897 | 236 – 390 | Missing in isoform 6, isoform 1 and isoform 2. CuratedAdd BLAST | 155 | |
Alternative sequenceiVSP_038213 | 411 – 415 | DTPFQ → CCYVA in isoform 5. 1 Publication | 5 | |
Alternative sequenceiVSP_046898 | 412 – 645 | TPFQC…PSQDL → APFQCWLCSAKFKISSDLKR HMRVHSGEKPFKCEFCNVRC TMKGNLKSHIRIKHSGNNFK CPHCDFLGDSKATLRKHSRV HQSEHPEKCSECSYSCSSKA ALRIHERIHCTDRPFKCNYC SFDTKQPSNLSKHMKKFHGD MVKTEALERKDTGRQSSRQV AKLDAKKSFHCDICDASFMR EDSLRSHKRQHSEYSESKNS DVTVLQFQIDPSKQPATPLT VGHLQVPLQPSQVPQFSEGR VKIIVGHQVPQANTIVQAAA AAVNIVPPALVAQNPEELPG NSRLQILRQVSLIAPPQSSR CPSEAGAMTQPAVLLTTHEQ TDGATLHQTLIPTASGGPQE GSGNQTFITSSGITCTDFEG LNALIQEGTAEVTVVSDGGQ NIAVATTAPPVFSSSSQQEL PKQTYSIIQGAAHPALLCPA DSIPD in isoform 6, isoform 1 and isoform 2. CuratedAdd BLAST | 234 | |
Alternative sequenceiVSP_038214 | 416 – 645 | Missing in isoform 5. 1 PublicationAdd BLAST | 230 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001596 mRNA Translation: BAA91777.1 AK001744 mRNA Translation: BAA91876.1 AK022690 mRNA Translation: BAB14182.1 BT009760 mRNA Translation: AAP88762.1 AK222712 mRNA Translation: BAD96432.1 Sequence problems. AL109984 Genomic DNA No translation available. AL121771 Genomic DNA No translation available. AL121923 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75591.1 BC021087 mRNA No translation available. BC012759 mRNA Translation: AAH12759.1 BC041622 mRNA Translation: AAH41622.1 |
CCDSi | CCDS13439.1 [Q9NTW7-1] CCDS13440.1 [Q9NTW7-5] CCDS13441.1 [Q9NTW7-6] CCDS13442.1 [Q9NTW7-4] CCDS82630.1 [Q9NTW7-2] |
RefSeqi | NP_001306075.1, NM_001319146.1 [Q9NTW7-2] NP_060667.2, NM_018197.2 [Q9NTW7-5] NP_071371.3, NM_022088.4 [Q9NTW7-6] NP_955458.1, NM_199426.1 [Q9NTW7-4] NP_955459.2, NM_199427.2 [Q9NTW7-1] |
Genome annotation databases
Ensembli | ENST00000216923; ENSP00000216923; ENSG00000020256 [Q9NTW7-5] ENST00000346617; ENSP00000344615; ENSG00000020256 [Q9NTW7-6] ENST00000361387; ENSP00000355179; ENSG00000020256 [Q9NTW7-1] ENST00000371515; ENSP00000360570; ENSG00000020256 [Q9NTW7-4] ENST00000371518; ENSP00000360573; ENSG00000020256 [Q9NTW7-3] ENST00000371523; ENSP00000360578; ENSG00000020256 [Q9NTW7-2] |
GeneIDi | 55734 |
KEGGi | hsa:55734 |
UCSCi | uc002xwj.4, human [Q9NTW7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001596 mRNA Translation: BAA91777.1 AK001744 mRNA Translation: BAA91876.1 AK022690 mRNA Translation: BAB14182.1 BT009760 mRNA Translation: AAP88762.1 AK222712 mRNA Translation: BAD96432.1 Sequence problems. AL109984 Genomic DNA No translation available. AL121771 Genomic DNA No translation available. AL121923 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75591.1 BC021087 mRNA No translation available. BC012759 mRNA Translation: AAH12759.1 BC041622 mRNA Translation: AAH41622.1 |
CCDSi | CCDS13439.1 [Q9NTW7-1] CCDS13440.1 [Q9NTW7-5] CCDS13441.1 [Q9NTW7-6] CCDS13442.1 [Q9NTW7-4] CCDS82630.1 [Q9NTW7-2] |
RefSeqi | NP_001306075.1, NM_001319146.1 [Q9NTW7-2] NP_060667.2, NM_018197.2 [Q9NTW7-5] NP_071371.3, NM_022088.4 [Q9NTW7-6] NP_955458.1, NM_199426.1 [Q9NTW7-4] NP_955459.2, NM_199427.2 [Q9NTW7-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1X5W | NMR | - | A | - | [»] | |
2DMD | NMR | - | A | 174-235 | [»] | |
SMRi | Q9NTW7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120853, 39 interactors |
IntActi | Q9NTW7, 26 interactors |
MINTi | Q9NTW7 |
STRINGi | 9606.ENSP00000216923 |
PTM databases
iPTMneti | Q9NTW7 |
PhosphoSitePlusi | Q9NTW7 |
Genetic variation databases
BioMutai | ZFP64 |
DMDMi | 116242854 30316391 |
Proteomic databases
EPDi | Q9NTW7 |
jPOSTi | Q9NTW7 |
MassIVEi | Q9NTW7 |
MaxQBi | Q9NTW7 |
PaxDbi | Q9NTW7 |
PeptideAtlasi | Q9NTW7 |
PRIDEi | Q9NTW7 |
ProteomicsDBi | 63393 81951 81952 82633 [Q9NTW7-1] 82634 [Q9NTW7-2] 82635 [Q9NTW7-3] |
Protocols and materials databases
Antibodypediai | 13873, 201 antibodies |
DNASUi | 55734 |
Genome annotation databases
Ensembli | ENST00000216923; ENSP00000216923; ENSG00000020256 [Q9NTW7-5] ENST00000346617; ENSP00000344615; ENSG00000020256 [Q9NTW7-6] ENST00000361387; ENSP00000355179; ENSG00000020256 [Q9NTW7-1] ENST00000371515; ENSP00000360570; ENSG00000020256 [Q9NTW7-4] ENST00000371518; ENSP00000360573; ENSG00000020256 [Q9NTW7-3] ENST00000371523; ENSP00000360578; ENSG00000020256 [Q9NTW7-2] |
GeneIDi | 55734 |
KEGGi | hsa:55734 |
UCSCi | uc002xwj.4, human [Q9NTW7-1] |
Organism-specific databases
CTDi | 55734 |
DisGeNETi | 55734 |
GeneCardsi | ZFP64 |
HGNCi | HGNC:15940, ZFP64 |
HPAi | ENSG00000020256, Low tissue specificity |
MIMi | 618111, gene |
neXtProti | NX_Q9NTW7 |
OpenTargetsi | ENSG00000020256 |
PharmGKBi | PA38060 |
VEuPathDBi | HostDB:ENSG00000020256.19 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000156405 |
HOGENOMi | CLU_002678_71_1_1 |
InParanoidi | Q9NPA5 |
OMAi | VRCAMKG |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q9NTW7 |
TreeFami | TF333046 |
Enzyme and pathway databases
PathwayCommonsi | Q9NTW7 |
Miscellaneous databases
BioGRID-ORCSi | 55734, 23 hits in 1018 CRISPR screens |
ChiTaRSi | ZFP64, human |
GeneWikii | ZFP64 |
GenomeRNAii | 55734 |
Pharosi | Q9NTW7, Tbio |
PROi | PR:Q9NTW7 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000020256, Expressed in vagina and 242 other tissues |
ExpressionAtlasi | Q9NTW7, baseline and differential |
Genevisiblei | Q9NTW7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 6 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 15 hits |
SUPFAMi | SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 6 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZF64B_HUMAN | |
Accessioni | Q9NTW7Primary (citable) accession number: Q9NTW7 Secondary accession number(s): A2A2N4 Q9NVH4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 27, 2002 |
Last sequence update: | April 30, 2003 | |
Last modified: | April 7, 2021 | |
This is version 185 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families