Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cation channel sperm-associated protein subunit zeta

Gene

CATSPERZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for a distribution of the CatSper complex in linear quadrilateral nanodomains along the flagellum, maximizing fertilization inside the mammalian female reproductive tract.By similarity

Caution

A report observed N-glycosylation at Asn-58 (PubMed:19139490). However, as the protein is not predicted to localize in an extracellular compartment of the cell, additional evidences are required to confirm this result.1 Publication

GO - Biological processi

Keywordsi

Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Cation channel sperm-associated protein subunit zetaBy similarity
Short name:
CatSper-zetaBy similarity
Short name:
CatSperzetaBy similarity
Alternative name(s):
Testis-expressed protein 40Imported
Gene namesi
Name:CATSPERZImported
Synonyms:C11orf20Imported, TEX40Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:19231 CATSPERZ
MIMi617511 gene
neXtProtiNX_Q9NTU4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Flagellum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi25858
OpenTargetsiENSG00000219435
PharmGKBiPA164716726

Polymorphism and mutation databases

BioMutaiTEX40
DMDMi74719331

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003493221 – 200Cation channel sperm-associated protein subunit zetaAdd BLAST200

Proteomic databases

PaxDbiQ9NTU4
PeptideAtlasiQ9NTU4
PRIDEiQ9NTU4
ProteomicsDBi82631

PTM databases

iPTMnetiQ9NTU4
PhosphoSitePlusiQ9NTU4

Expressioni

Gene expression databases

ExpressionAtlasiQ9NTU4 baseline and differential

Organism-specific databases

HPAiHPA052822

Interactioni

Subunit structurei

Component of the CatSper complex.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000330877

Structurei

3D structure databases

ProteinModelPortaliQ9NTU4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IX8U Eukaryota
ENOG411141E LUCA
GeneTreeiENSGT00400000022853
HOGENOMiHOG000111720
InParanoidiQ9NTU4
PhylomeDBiQ9NTU4

Family and domain databases

InterProiView protein in InterPro
IPR039019 CATSPERZ
PANTHERiPTHR42155 PTHR42155, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NTU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEKPSKVSL KSSDRQGSDE ESVHSDTRDL WTTTTLSQAQ LNMPLSEVCE
60 70 80 90 100
GFDEEGRNIS KTRGWHSPGR GSLDEGYKAS HKPEELDEHA LVELELHRGS
110 120 130 140 150
SMEINLGEKD TASQIEAEKS SSMSSLNIAK HMPHRAYWAE QQSRLPLPLM
160 170 180 190 200
ELMENEALEI LTKALRSYQL GIGRDHFLTK ELQRYIEGLK KRRSKRLYVN
Length:200
Mass (Da):22,839
Last modified:October 1, 2000 - v1
Checksum:i25F6EC8873330DCB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04637068P → L. Corresponds to variant dbSNP:rs2286614Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117564 mRNA Translation: CAB55995.2
PIRiT17305
RefSeqiNP_001034585.1, NM_001039496.1
UniGeneiHs.97174

Genome annotation databases

EnsembliENST00000328404; ENSP00000491717; ENSG00000219435
GeneIDi25858
KEGGihsa:25858

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCTSRZ_HUMAN
AccessioniPrimary (citable) accession number: Q9NTU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 1, 2000
Last modified: July 18, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health