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Protein

Semaphorin-4G

Gene

SEMA4G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity).By similarity

GO - Molecular functioni

  • chemorepellent activity Source: GO_Central
  • neuropilin binding Source: GO_Central
  • semaphorin receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-4G
Gene namesi
Name:SEMA4G
Synonyms:KIAA1619
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000095539.15
HGNCiHGNC:10735 SEMA4G
neXtProtiNX_Q9NTN9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 675ExtracellularSequence analysisAdd BLAST658
Transmembranei676 – 696HelicalSequence analysisAdd BLAST21
Topological domaini697 – 838CytoplasmicSequence analysisAdd BLAST142

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57715
OpenTargetsiENSG00000095539
PharmGKBiPA35657

Polymorphism and mutation databases

BioMutaiSEMA4G
DMDMi13633937

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000003233318 – 838Semaphorin-4GAdd BLAST821

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi104 ↔ 115By similarity
Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi133 ↔ 142By similarity
Disulfide bondi270 ↔ 377By similarity
Disulfide bondi294 ↔ 337By similarity
Glycosylationi388N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi508 ↔ 525By similarity
Disulfide bondi517 ↔ 534By similarity
Glycosylationi542N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi584 ↔ 632By similarity
Glycosylationi598N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei795PhosphoserineCombined sources1
Modified residuei837PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9NTN9
PaxDbiQ9NTN9
PeptideAtlasiQ9NTN9
PRIDEiQ9NTN9
ProteomicsDBi82627
82628 [Q9NTN9-2]
82629 [Q9NTN9-3]

PTM databases

GlyConnecti1735
iPTMnetiQ9NTN9
PhosphoSitePlusiQ9NTN9

Expressioni

Gene expression databases

BgeeiENSG00000095539 Expressed in 146 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_SEMA4G
ExpressionAtlasiQ9NTN9 baseline and differential
GenevisibleiQ9NTN9 HS

Organism-specific databases

HPAiHPA038362
HPA077752

Interactioni

Subunit structurei

Interacts with PLXNB2.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121738, 8 interactors
IntActiQ9NTN9, 10 interactors
STRINGi9606.ENSP00000210633

Structurei

3D structure databases

ProteinModelPortaliQ9NTN9
SMRiQ9NTN9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 505SemaPROSITE-ProRule annotationAdd BLAST471
Domaini507 – 558PSIAdd BLAST52
Domaini567 – 649Ig-like C2-typeAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi565 – 568Poly-Pro4
Compositional biasi763 – 774Poly-ProAdd BLAST12

Sequence similaritiesi

Belongs to the semaphorin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000118854
HOGENOMiHOG000116087
HOVERGENiHBG061165
InParanoidiQ9NTN9
KOiK06521
OMAiLTTQWKT
OrthoDBiEOG091G01W0
PhylomeDBiQ9NTN9
TreeFamiTF316102

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR002165 Plexin_repeat
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51004 SEMA, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NTN9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWGRLWPLLL SILTATAVPG PSLRRPSREL DATPRMTIPY EELSGTRHFK
60 70 80 90 100
GQAQNYSTLL LEEASARLLV GARGALFSLS ANDIGDGAHK EIHWEASPEM
110 120 130 140 150
QSKCHQKGKN NQTECFNHVR FLQRLNSTHL YACGTHAFQP LCAAIDAEAF
160 170 180 190 200
TLPTSFEEGK EKCPYDPARG FTGLIIDGGL YTATRYEFRS IPDIRRSRHP
210 220 230 240 250
HSLRTEETPM HWLNDAEFVF SVLVRESKAS AVGDDDKVYY FFTERATEEG
260 270 280 290 300
SGSFTQSRSS HRVARVARVC KGDLGGKKIL QKKWTSFLKA RLICHIPLYE
310 320 330 340 350
TLRGVCSLDA ETSSRTHFYA AFTLSTQWKT LEASAICRYD LAEIQAVFAG
360 370 380 390 400
PYMEYQDGSR RWGRYEGGVP EPRPGSCITD SLRSQGYNSS QDLPSLVLDF
410 420 430 440 450
VKLHPLMARP VVPTRGRPLL LKRNIRYTHL TGTPVTTPAG PTYDLLFLGT
460 470 480 490 500
ADGWIHKAVV LGSGMHIIEE TQVFRESQSV ENLVISLLQH SLYVGAPSGV
510 520 530 540 550
IQLPLSSCSR YRSCYDCILA RDPYCGWDPG THACAAATTI ANRTALIQDI
560 570 580 590 600
ERGNRGCESS RDTGPPPPLK TRSVLRGDDV LLPCDQPSNL ARALWLLNGS
610 620 630 640 650
MGLSDGQGGY RVGVDGLLVT DAQPEHSGNY GCYAEENGLR TLLASYSLTV
660 670 680 690 700
RPATPAPAPK APATPGAQLA PDVRLLYVLA IAALGGLCLI LASSLLYVAC
710 720 730 740 750
LREGRRGRRR KYSLGRASRA GGSAVQLQTV SGQCPGEEDE GDDEGAGGLE
760 770 780 790 800
GSCLQIIPGE GAPAPPPPPP PPPPAELTNG LVALPSRLRR MNGNSYVLLR
810 820 830
QSNNGVPAGP CSFAEELSRI LEKRKHTQLV EQLDESSV
Length:838
Mass (Da):91,497
Last modified:October 1, 2000 - v1
Checksum:i9B281AEE8681F245
GO
Isoform 2 (identifier: Q9NTN9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     543-543: R → RSQGSR

Note: No experimental confirmation available.
Show »
Length:843
Mass (Da):92,012
Checksum:i6AEE7436BCEC60CD
GO
Isoform 3 (identifier: Q9NTN9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     543-543: R → RSQGSR
     565-838: PPPPLKTRSV...LVEQLDESSV → RALQVHMGSM...PHSPWSFSRV

Note: No experimental confirmation available.
Show »
Length:702
Mass (Da):77,577
Checksum:iC1D05183AF6793CA
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RFG2E5RFG2_HUMAN
Semaphorin-4G
SEMA4G
522Annotation score:
E5RGX4E5RGX4_HUMAN
Semaphorin-4G
SEMA4G
170Annotation score:
Q9NWU8Q9NWU8_HUMAN
SEMA4G protein
SEMA4G
127Annotation score:
H0YBN3H0YBN3_HUMAN
Semaphorin-4G
SEMA4G
131Annotation score:

Sequence cautioni

The sequence BAB13445 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_035067543R → RSQGSR in isoform 2 and isoform 3. 1 Publication1
Alternative sequenceiVSP_043883565 – 838PPPPL…DESSV → RALQVHMGSMSPPSAWPCVL DGPETRQDLCQPPKPCVHSH AHMEECLSAGLQCPHPHLLL VHSCFIPASGLGVPSQLPHP IWSSSPAPCGDLFVKSLGTG QPGEVRLHHSPPLPSCVALV NQPPHSPWSFSRV in isoform 3. 1 PublicationAdd BLAST274

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046839 mRNA Translation: BAB13445.1 Different initiation.
AL133215 Genomic DNA No translation available.
BC051030 mRNA Translation: AAH51030.1
BC128579 mRNA Translation: AAI28580.1
CCDSiCCDS55724.1 [Q9NTN9-3]
CCDS7501.1 [Q9NTN9-2]
RefSeqiNP_001190173.1, NM_001203244.1 [Q9NTN9-3]
NP_060363.2, NM_017893.3 [Q9NTN9-2]
XP_005270065.1, XM_005270008.2
UniGeneiHs.591923
Hs.735152

Genome annotation databases

EnsembliENST00000210633; ENSP00000210633; ENSG00000095539 [Q9NTN9-2]
ENST00000370250; ENSP00000359270; ENSG00000095539 [Q9NTN9-1]
ENST00000517724; ENSP00000430175; ENSG00000095539 [Q9NTN9-3]
ENST00000521006; ENSP00000430881; ENSG00000095539 [Q9NTN9-1]
GeneIDi57715
KEGGihsa:57715
UCSCiuc001krv.4 human [Q9NTN9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046839 mRNA Translation: BAB13445.1 Different initiation.
AL133215 Genomic DNA No translation available.
BC051030 mRNA Translation: AAH51030.1
BC128579 mRNA Translation: AAI28580.1
CCDSiCCDS55724.1 [Q9NTN9-3]
CCDS7501.1 [Q9NTN9-2]
RefSeqiNP_001190173.1, NM_001203244.1 [Q9NTN9-3]
NP_060363.2, NM_017893.3 [Q9NTN9-2]
XP_005270065.1, XM_005270008.2
UniGeneiHs.591923
Hs.735152

3D structure databases

ProteinModelPortaliQ9NTN9
SMRiQ9NTN9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121738, 8 interactors
IntActiQ9NTN9, 10 interactors
STRINGi9606.ENSP00000210633

PTM databases

GlyConnecti1735
iPTMnetiQ9NTN9
PhosphoSitePlusiQ9NTN9

Polymorphism and mutation databases

BioMutaiSEMA4G
DMDMi13633937

Proteomic databases

MaxQBiQ9NTN9
PaxDbiQ9NTN9
PeptideAtlasiQ9NTN9
PRIDEiQ9NTN9
ProteomicsDBi82627
82628 [Q9NTN9-2]
82629 [Q9NTN9-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000210633; ENSP00000210633; ENSG00000095539 [Q9NTN9-2]
ENST00000370250; ENSP00000359270; ENSG00000095539 [Q9NTN9-1]
ENST00000517724; ENSP00000430175; ENSG00000095539 [Q9NTN9-3]
ENST00000521006; ENSP00000430881; ENSG00000095539 [Q9NTN9-1]
GeneIDi57715
KEGGihsa:57715
UCSCiuc001krv.4 human [Q9NTN9-1]

Organism-specific databases

CTDi57715
DisGeNETi57715
EuPathDBiHostDB:ENSG00000095539.15
GeneCardsiSEMA4G
HGNCiHGNC:10735 SEMA4G
HPAiHPA038362
HPA077752
neXtProtiNX_Q9NTN9
OpenTargetsiENSG00000095539
PharmGKBiPA35657
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000118854
HOGENOMiHOG000116087
HOVERGENiHBG061165
InParanoidiQ9NTN9
KOiK06521
OMAiLTTQWKT
OrthoDBiEOG091G01W0
PhylomeDBiQ9NTN9
TreeFamiTF316102

Miscellaneous databases

ChiTaRSiSEMA4G human
GeneWikiiSEMA4G
GenomeRNAii57715
PROiPR:Q9NTN9

Gene expression databases

BgeeiENSG00000095539 Expressed in 146 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_SEMA4G
ExpressionAtlasiQ9NTN9 baseline and differential
GenevisibleiQ9NTN9 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR002165 Plexin_repeat
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51004 SEMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEM4G_HUMAN
AccessioniPrimary (citable) accession number: Q9NTN9
Secondary accession number(s): A1A5C6
, A6NJY8, Q58EY1, Q9HCF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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