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Protein

Copper homeostasis protein cutC homolog

Gene

CUTC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in copper homeostasis. Can bind one Cu1+ per subunit.2 Publications

GO - Molecular functioni

  • copper ion binding Source: UniProtKB

GO - Biological processi

  • copper ion homeostasis Source: UniProtKB
  • copper ion transport Source: UniProtKB
  • protein tetramerization Source: UniProtKB

Keywordsi

LigandCopper, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-936837 Ion transport by P-type ATPases

Protein family/group databases

TCDBi9.B.158.1.1 the cut copper homeostasis (cut) family

Names & Taxonomyi

Protein namesi
Recommended name:
Copper homeostasis protein cutC homolog
Gene namesi
Name:CUTC
ORF Names:CGI-32
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000119929.12
HGNCiHGNC:24271 CUTC
MIMi610101 gene
neXtProtiNX_Q9NTM9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi31C → A: Reduces copper binding. Reduces copper binding by 75%; when associated with A-52. 1 Publication1
Mutagenesisi52C → A: Reduces copper binding. Reduces copper binding by 75%; when associated with A-31. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000119929
PharmGKBiPA134901980

Polymorphism and mutation databases

BioMutaiCUTC
DMDMi54035909

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002150881 – 273Copper homeostasis protein cutC homologAdd BLAST273

Proteomic databases

EPDiQ9NTM9
MaxQBiQ9NTM9
PaxDbiQ9NTM9
PeptideAtlasiQ9NTM9
PRIDEiQ9NTM9
ProteomicsDBi82625

PTM databases

iPTMnetiQ9NTM9
PhosphoSitePlusiQ9NTM9

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000119929
CleanExiHS_CUTC
ExpressionAtlasiQ9NTM9 baseline and differential
GenevisibleiQ9NTM9 HS

Organism-specific databases

HPAiHPA038619

Interactioni

Subunit structurei

Homotetramer.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119267, 19 interactors
IntActiQ9NTM9, 15 interactors
STRINGi9606.ENSP00000359507

Structurei

Secondary structure

1273
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 34Combined sources9
Helixi35 – 44Combined sources10
Beta strandi47 – 51Combined sources5
Helixi55 – 57Combined sources3
Helixi64 – 71Combined sources8
Beta strandi78 – 81Combined sources4
Beta strandi84 – 87Combined sources4
Helixi93 – 108Combined sources16
Beta strandi112 – 116Combined sources5
Helixi127 – 137Combined sources11
Beta strandi142 – 144Combined sources3
Helixi146 – 150Combined sources5
Helixi154 – 164Combined sources11
Beta strandi167 – 171Combined sources5
Beta strandi175 – 177Combined sources3
Turni178 – 181Combined sources4
Helixi182 – 192Combined sources11
Beta strandi195 – 200Combined sources6
Turni206 – 208Combined sources3
Helixi209 – 216Combined sources8
Beta strandi219 – 223Combined sources5
Beta strandi226 – 229Combined sources4
Turni244 – 246Combined sources3
Beta strandi253 – 256Combined sources4
Helixi258 – 271Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IWPX-ray2.50A/B/C/D/E/F/G/H/I/J/K/L1-273[»]
ProteinModelPortaliQ9NTM9
SMRiQ9NTM9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NTM9

Family & Domainsi

Sequence similaritiesi

Belongs to the CutC family.Curated

Phylogenomic databases

eggNOGiKOG4013 Eukaryota
COG3142 LUCA
GeneTreeiENSGT00390000008454
HOGENOMiHOG000100908
HOVERGENiHBG051267
InParanoidiQ9NTM9
KOiK06201
OMAiRIIIMPG
OrthoDBiEOG091G0INY
PhylomeDBiQ9NTM9
TreeFamiTF105937

Family and domain databases

Gene3Di3.20.20.380, 1 hit
HAMAPiMF_00795 CutC, 1 hit
InterProiView protein in InterPro
IPR005627 Cu_homeostasis_CutC
IPR023648 Cu_homeostasis_CutC_dom
IPR036822 CutC_dom_sf
PANTHERiPTHR12598 PTHR12598, 1 hit
PfamiView protein in Pfam
PF03932 CutC, 1 hit
SUPFAMiSSF110395 SSF110395, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NTM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRQGASSER KRARIPSGKA GAANGFLMEV CVDSVESAVN AERGGADRIE
60 70 80 90 100
LCSGLSEGGT TPSMGVLQVV KQSVQIPVFV MIRPRGGDFL YSDREIEVMK
110 120 130 140 150
ADIRLAKLYG ADGLVFGALT EDGHIDKELC MSLMAICRPL PVTFHRAFDM
160 170 180 190 200
VHDPMAALET LLTLGFERVL TSGCDSSALE GLPLIKRLIE QAKGRIVVMP
210 220 230 240 250
GGGITDRNLQ RILEGSGATE FHCSARSTRD SGMKFRNSSV AMGASLSCSE
260 270
YSLKVTDVTK VRTLNAIAKN ILV
Length:273
Mass (Da):29,341
Last modified:October 1, 2000 - v1
Checksum:i63C007AAB05C5492
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108L → P in AAD27741 (PubMed:10810093).Curated1
Sequence conflicti186K → N in AAD27741 (PubMed:10810093).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03636377P → L in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132966 mRNA Translation: AAD27741.1
AK314687 mRNA Translation: BAG37239.1
AL133353 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49854.1
BC021105 mRNA Translation: AAH21105.1
BC028948 mRNA Translation: AAH28948.1
CCDSiCCDS7483.1
RefSeqiNP_057044.2, NM_015960.2
UniGeneiHs.16606

Genome annotation databases

EnsembliENST00000370476; ENSP00000359507; ENSG00000119929
GeneIDi51076
KEGGihsa:51076
UCSCiuc001kqd.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCUTC_HUMAN
AccessioniPrimary (citable) accession number: Q9NTM9
Secondary accession number(s): Q5TCZ8, Q9Y321
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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