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Entry version 190 (07 Apr 2021)
Sequence version 2 (23 Apr 2003)
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Protein

Structural maintenance of chromosomes protein 4

Gene

SMC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi113 – 120ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATPase activity Source: InterPro
  • ATP binding Source: UniProtKB
  • chromatin binding Source: Ensembl
  • single-stranded DNA binding Source: Ensembl

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, DNA condensation, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9NTJ3

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2299718, Condensation of Prophase Chromosomes
R-HSA-2514853, Condensation of Prometaphase Chromosomes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Structural maintenance of chromosomes protein 4
Short name:
SMC protein 4
Short name:
SMC-4
Alternative name(s):
Chromosome-associated polypeptide C
Short name:
hCAP-C
XCAP-C homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SMC4
Synonyms:CAPC, SMC4L1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14013, SMC4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605575, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NTJ3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000113810.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10051

Open Targets

More...
OpenTargetsi
ENSG00000113810

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37834

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NTJ3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SMC4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
30173386

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001190061 – 1288Structural maintenance of chromosomes protein 4Add BLAST1288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei22PhosphoserineCombined sources1
Modified residuei28PhosphoserineCombined sources1
Modified residuei39PhosphothreonineCombined sources1
Modified residuei41PhosphoserineCombined sources1
Modified residuei50PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei381N6-acetyllysineBy similarity1
Modified residuei679N6-acetyllysineCombined sources1
Modified residuei982PhosphoserineCombined sources1
Modified residuei1056PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NTJ3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NTJ3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NTJ3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NTJ3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NTJ3

PeptideAtlas

More...
PeptideAtlasi
Q9NTJ3

PRoteomics IDEntifications database

More...
PRIDEi
Q9NTJ3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82617 [Q9NTJ3-1]
82618 [Q9NTJ3-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2082, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9NTJ3, 1 site, 1 N-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NTJ3

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q9NTJ3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NTJ3

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9NTJ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Higher expression in testis, colon, thymus.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000113810, Expressed in ventricular zone and 229 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NTJ3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NTJ3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000113810, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a heterodimer with SMC2.

Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
115362, 126 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-979, Condensin I complex
CPX-985, Condensin II complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9NTJ3

Database of interacting proteins

More...
DIPi
DIP-32946N

Protein interaction database and analysis system

More...
IntActi
Q9NTJ3, 62 interactors

Molecular INTeraction database

More...
MINTi
Q9NTJ3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000349961

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NTJ3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11288
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NTJ3

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini613 – 727SMC hingeAdd BLAST115

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili272 – 588Sequence analysisAdd BLAST317
Coiled coili767 – 1020Sequence analysisAdd BLAST254
Coiled coili1109 – 1129Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi18 – 23Poly-Pro6
Compositional biasi66 – 71Poly-Pro6
Compositional biasi1191 – 1226Ala/Asp-rich (DA-box)Add BLAST36

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with SMC2, forming a V-shaped heterodimer.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SMC family. SMC4 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0996, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00900000141094

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001042_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NTJ3

Identification of Orthologs from Complete Genome Data

More...
OMAi
VGHYIKE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NTJ3

TreeFam database of animal gene trees

More...
TreeFami
TF101158

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03274, ABC_SMC4_euk, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027417, P-loop_NTPase
IPR003395, RecF/RecN/SMC_N
IPR024704, SMC
IPR041738, SMC4_ABC_euk
IPR010935, SMC_hinge
IPR036277, SMC_hinge_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06470, SMC_hinge, 1 hit
PF02463, SMC_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005719, SMC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00968, SMC_hinge, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit
SSF75553, SSF75553, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NTJ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPRKGTQPST ARRREEGPPP PSPDGASSDA EPEPPSGRTE SPATAAETAS
60 70 80 90 100
EELDNRSLEE ILNSIPPPPP PAMTNEAGAP RLMITHIVNQ NFKSYAGEKI
110 120 130 140 150
LGPFHKRFSC IIGPNGSGKS NVIDSMLFVF GYRAQKIRSK KLSVLIHNSD
160 170 180 190 200
EHKDIQSCTV EVHFQKIIDK EGDDYEVIPN SNFYVSRTAC RDNTSVYHIS
210 220 230 240 250
GKKKTFKDVG NLLRSHGIDL DHNRFLILQG EVEQIAMMKP KGQTEHDEGM
260 270 280 290 300
LEYLEDIIGC GRLNEPIKVL CRRVEILNEH RGEKLNRVKM VEKEKDALEG
310 320 330 340 350
EKNIAIEFLT LENEIFRKKN HVCQYYIYEL QKRIAEMETQ KEKIHEDTKE
360 370 380 390 400
INEKSNILSN EMKAKNKDVK DTEKKLNKIT KFIEENKEKF TQLDLEDVQV
410 420 430 440 450
REKLKHATSK AKKLEKQLQK DKEKVEEFKS IPAKSNNIIN ETTTRNNALE
460 470 480 490 500
KEKEKEEKKL KEVMDSLKQE TQGLQKEKES REKELMGFSK SVNEARSKMD
510 520 530 540 550
VAQSELDIYL SRHNTAVSQL TKAKEALIAA SETLKERKAA IRDIEGKLPQ
560 570 580 590 600
TEQELKEKEK ELQKLTQEET NFKSLVHDLF QKVEEAKSSL AMNRSRGKVL
610 620 630 640 650
DAIIQEKKSG RIPGIYGRLG DLGAIDEKYD VAISSCCHAL DYIVVDSIDI
660 670 680 690 700
AQECVNFLKR QNIGVATFIG LDKMAVWAKK MTEIQTPENT PRLFDLVKVK
710 720 730 740 750
DEKIRQAFYF ALRDTLVADN LDQATRVAYQ KDRRWRVVTL QGQIIEQSGT
760 770 780 790 800
MTGGGSKVMK GRMGSSLVIE ISEEEVNKME SQLQNDSKKA MQIQEQKVQL
810 820 830 840 850
EERVVKLRHS EREMRNTLEK FTASIQRLIE QEEYLNVQVK ELEANVLATA
860 870 880 890 900
PDKKKQKLLE ENVSAFKTEY DAVAEKAGKV EAEVKRLHNT IVEINNHKLK
910 920 930 940 950
AQQDKLDKIN KQLDECASAI TKAQVAIKTA DRNLQKAQDS VLRTEKEIKD
960 970 980 990 1000
TEKEVDDLTA ELKSLEDKAA EVVKNTNAAE ESLPEIQKEH RNLLQELKVI
1010 1020 1030 1040 1050
QENEHALQKD ALSIKLKLEQ IDGHIAEHNS KIKYWHKEIS KISLHPIEDN
1060 1070 1080 1090 1100
PIEEISVLSP EDLEAIKNPD SITNQIALLE ARCHEMKPNL GAIAEYKKKE
1110 1120 1130 1140 1150
ELYLQRVAEL DKITYERDSF RQAYEDLRKQ RLNEFMAGFY IITNKLKENY
1160 1170 1180 1190 1200
QMLTLGGDAE LELVDSLDPF SEGIMFSVRP PKKSWKKIFN LSGGEKTLSS
1210 1220 1230 1240 1250
LALVFALHHY KPTPLYFMDE IDAALDFKNV SIVAFYIYEQ TKNAQFIIIS
1260 1270 1280
LRNNMFEISD RLIGIYKTYN ITKSVAVNPK EIASKGLC
Length:1,288
Mass (Da):147,182
Last modified:April 23, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9D164D6EB0602464
GO
Isoform 2 (identifier: Q9NTJ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     980-1037: Missing.

Show »
Length:1,230
Mass (Da):140,278
Checksum:iDBFFD68DB1C10454
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PD53E9PD53_HUMAN
Structural maintenance of chromosom...
SMC4
1,263Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JR83C9JR83_HUMAN
Structural maintenance of chromosom...
SMC4
423Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JJ64C9JJ64_HUMAN
Structural maintenance of chromosom...
SMC4
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JWF0C9JWF0_HUMAN
Structural maintenance of chromosom...
SMC4
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IYK2C9IYK2_HUMAN
Structural maintenance of chromosom...
SMC4
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCB7F8WCB7_HUMAN
Structural maintenance of chromosom...
SMC4
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J578C9J578_HUMAN
Structural maintenance of chromosom...
SMC4
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J9E4C9J9E4_HUMAN
Structural maintenance of chromosom...
SMC4
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JVD8C9JVD8_HUMAN
Structural maintenance of chromosom...
SMC4
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti272R → Q in AAC72361 (PubMed:9789013).Curated1
Sequence conflicti283E → D in CAB66811 (PubMed:11230166).Curated1
Sequence conflicti392 – 393QL → HV in AAC72361 (PubMed:9789013).Curated2
Sequence conflicti594R → S in AAC72361 (PubMed:9789013).Curated1
Sequence conflicti645V → G in CAD38803 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052439181S → R. Corresponds to variant dbSNP:rs35214835Ensembl.1
Natural variantiVAR_052440356N → S. Corresponds to variant dbSNP:rs33999879Ensembl.1
Natural variantiVAR_059843415E → D. Corresponds to variant dbSNP:rs2164675Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_007245980 – 1037Missing in isoform 2. 1 PublicationAdd BLAST58

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB019987 mRNA Translation: BAA73535.1
AL136877 mRNA Translation: CAB66811.1
AL833949 mRNA Translation: CAD38803.1
AC024221 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78639.1
CH471052 Genomic DNA Translation: EAW78640.1
AF092564 mRNA Translation: AAC72361.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3189.1 [Q9NTJ3-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T46486

NCBI Reference Sequences

More...
RefSeqi
NP_001002800.1, NM_001002800.2 [Q9NTJ3-1]
NP_001275682.1, NM_001288753.1
NP_005487.3, NM_005496.3 [Q9NTJ3-1]
XP_011510613.1, XM_011512311.2 [Q9NTJ3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000344722; ENSP00000341382; ENSG00000113810 [Q9NTJ3-1]
ENST00000357388; ENSP00000349961; ENSG00000113810 [Q9NTJ3-1]
ENST00000462787; ENSP00000420734; ENSG00000113810 [Q9NTJ3-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10051

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10051

UCSC genome browser

More...
UCSCi
uc003fdh.5, human [Q9NTJ3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019987 mRNA Translation: BAA73535.1
AL136877 mRNA Translation: CAB66811.1
AL833949 mRNA Translation: CAD38803.1
AC024221 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78639.1
CH471052 Genomic DNA Translation: EAW78640.1
AF092564 mRNA Translation: AAC72361.1
CCDSiCCDS3189.1 [Q9NTJ3-1]
PIRiT46486
RefSeqiNP_001002800.1, NM_001002800.2 [Q9NTJ3-1]
NP_001275682.1, NM_001288753.1
NP_005487.3, NM_005496.3 [Q9NTJ3-1]
XP_011510613.1, XM_011512311.2 [Q9NTJ3-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4U4PX-ray1.89B566-809[»]
SMRiQ9NTJ3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115362, 126 interactors
ComplexPortaliCPX-979, Condensin I complex
CPX-985, Condensin II complex
CORUMiQ9NTJ3
DIPiDIP-32946N
IntActiQ9NTJ3, 62 interactors
MINTiQ9NTJ3
STRINGi9606.ENSP00000349961

PTM databases

GlyConnecti2082, 1 N-Linked glycan (1 site)
GlyGeniQ9NTJ3, 1 site, 1 N-linked glycan (1 site)
iPTMnetiQ9NTJ3
MetOSiteiQ9NTJ3
PhosphoSitePlusiQ9NTJ3
SwissPalmiQ9NTJ3

Genetic variation databases

BioMutaiSMC4
DMDMi30173386

Proteomic databases

EPDiQ9NTJ3
jPOSTiQ9NTJ3
MassIVEiQ9NTJ3
MaxQBiQ9NTJ3
PaxDbiQ9NTJ3
PeptideAtlasiQ9NTJ3
PRIDEiQ9NTJ3
ProteomicsDBi82617 [Q9NTJ3-1]
82618 [Q9NTJ3-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
18504, 244 antibodies

The DNASU plasmid repository

More...
DNASUi
10051

Genome annotation databases

EnsembliENST00000344722; ENSP00000341382; ENSG00000113810 [Q9NTJ3-1]
ENST00000357388; ENSP00000349961; ENSG00000113810 [Q9NTJ3-1]
ENST00000462787; ENSP00000420734; ENSG00000113810 [Q9NTJ3-2]
GeneIDi10051
KEGGihsa:10051
UCSCiuc003fdh.5, human [Q9NTJ3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10051
DisGeNETi10051

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SMC4
HGNCiHGNC:14013, SMC4
HPAiENSG00000113810, Tissue enhanced (lymphoid)
MIMi605575, gene
neXtProtiNX_Q9NTJ3
OpenTargetsiENSG00000113810
PharmGKBiPA37834
VEuPathDBiHostDB:ENSG00000113810.15

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0996, Eukaryota
GeneTreeiENSGT00900000141094
HOGENOMiCLU_001042_4_1_1
InParanoidiQ9NTJ3
OMAiVGHYIKE
PhylomeDBiQ9NTJ3
TreeFamiTF101158

Enzyme and pathway databases

PathwayCommonsiQ9NTJ3
ReactomeiR-HSA-2299718, Condensation of Prophase Chromosomes
R-HSA-2514853, Condensation of Prometaphase Chromosomes

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
10051, 781 hits in 1003 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SMC4, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SMC4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10051
PharosiQ9NTJ3, Tbio

Protein Ontology

More...
PROi
PR:Q9NTJ3
RNActiQ9NTJ3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000113810, Expressed in ventricular zone and 229 other tissues
ExpressionAtlasiQ9NTJ3, baseline and differential
GenevisibleiQ9NTJ3, HS

Family and domain databases

CDDicd03274, ABC_SMC4_euk, 2 hits
InterProiView protein in InterPro
IPR027417, P-loop_NTPase
IPR003395, RecF/RecN/SMC_N
IPR024704, SMC
IPR041738, SMC4_ABC_euk
IPR010935, SMC_hinge
IPR036277, SMC_hinge_sf
PfamiView protein in Pfam
PF06470, SMC_hinge, 1 hit
PF02463, SMC_N, 1 hit
PIRSFiPIRSF005719, SMC, 1 hit
SMARTiView protein in SMART
SM00968, SMC_hinge, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
SSF75553, SSF75553, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMC4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NTJ3
Secondary accession number(s): A6NLT9
, D3DNL8, O95752, Q8NDL4, Q9UNT9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: April 7, 2021
This is version 190 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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