UniProtKB - Q9NTI7 (INKA2_HUMAN)

BLAST

>sp|Q9NTI7|INKA2_HUMAN PAK4-inhibitor INKA2 OS=Homo sapiens OX=9606 GN=INKA2 PE=1 SV=1
MTMESREMDCYLRRLKQELMSMKEVGDGLQDQMNCMMGALQELKLLQVQTALEQLEISGG
GPVPGSPEGPRTQCEHPCWEGGRGPARPTVCSPSSQPSLGSSTKFPSHRSVCGRDLAPLP
RTQPHQSCAQQGPERVEPDDWTSTLMSRGRNRQPLVLGDNVFADLVGNWLDLPELEKGGE
KGETGGAREPKGEKGQPQELGRRFALTANIFKKFLRSVRPDRDRLLKEKPGWVTPMVPES
RTGRSQKVKKRSLSKGSGHFPFPGTGEHRRGENPPTSCPKALEHSPSGFDINTAVWV

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History
Entry version 115 (07 Nov 2018)
Sequence version 1 (01 Oct 2000)
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Protein

PAK4-inhibitor INKA2

Gene

INKA2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity.By similarity

GO - Molecular functionⁱ

protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 26607847
protein serine/threonine kinase inhibitor activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: PAK4-inhibitor INKA2Curated Alternative name(s): Induced in neural crest by AP2-alpha protein-related homolog1 Publication Short name: HInca-r1 Publication Inka box actin regulator 2Imported
Gene namesⁱ	Name:INKA2Imported Synonyms:C1orf183Imported, FAM212B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000197852.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28045 INKA2
neXtProtⁱ	NX_Q9NTI7

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55924
Open Targets More...OpenTargetsⁱ	ENSG00000197852
PharmGKBⁱ	PA142672431

Polymorphism and mutation databases

BioMutaⁱ	FAM212B

BioMutaⁱ

FAM212B

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000304994	1 – 297	PAK4-inhibitor INKA2Add BLAST		297

Proteomic databases

PaxDbⁱ	Q9NTI7
PeptideAtlas More...PeptideAtlasⁱ	Q9NTI7
PRIDEⁱ	Q9NTI7
ProteomicsDBⁱ	82615

PTM databases

iPTMnetⁱ	Q9NTI7
PhosphoSitePlusⁱ	Q9NTI7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000197852 Expressed in 159 organ(s), highest expression level in prostate gland
CleanExⁱ	HS_C1orf183
ExpressionAtlasⁱ	Q9NTI7 baseline and differential
Genevisibleⁱ	Q9NTI7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA027809 HPA027811

HPAⁱ

HPA027809
HPA027811

Interactionⁱ

Subunit structureⁱ

Interacts with PAK4 (PubMed:26607847).1 Publication

GO - Molecular functionⁱ

protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 26607847

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	121003, 10 interactors

BioGridⁱ

121003, 10 interactors

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NTI7
SMRⁱ	Q9NTI7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	137 – 180	Inka boxBy similarityAdd BLAST		44

Domainⁱ

The Inka box (also named iBox or inca box) binds and inhibits PAK4 by binding a substrate-like manner.By similarity

Sequence similaritiesⁱ

Belongs to the INKA family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IF94 Eukaryota ENOG4111HME LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063849
HOGENOMⁱ	HOG000111266
HOVERGENⁱ	HBG107564
InParanoidⁱ	Q9NTI7
OMAⁱ	PGWVTPT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ADX
PhylomeDBⁱ	Q9NTI7
TreeFamⁱ	TF332839

Family and domain databases

InterProⁱ	View protein in InterPro IPR029267 FAM212 IPR039201 Inka
PANTHERⁱ	PTHR28615 PTHR28615, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15342 FAM212, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q9NTI7-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MTMESREMDC YLRRLKQELM SMKEVGDGLQ DQMNCMMGAL QELKLLQVQT 
        60         70         80         90        100
ALEQLEISGG GPVPGSPEGP RTQCEHPCWE GGRGPARPTV CSPSSQPSLG 
       110        120        130        140        150
SSTKFPSHRS VCGRDLAPLP RTQPHQSCAQ QGPERVEPDD WTSTLMSRGR 
       160        170        180        190        200
NRQPLVLGDN VFADLVGNWL DLPELEKGGE KGETGGAREP KGEKGQPQEL 
       210        220        230        240        250
GRRFALTANI FKKFLRSVRP DRDRLLKEKP GWVTPMVPES RTGRSQKVKK 
       260        270        280        290 
RSLSKGSGHF PFPGTGEHRR GENPPTSCPK ALEHSPSGFD INTAVWV

Length:297

Mass (Da):32,759

Last modified:October 1, 2000 - v1

Checksum:ⁱAC9E28218271E5E2

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PR53	E9PR53_HUMAN	PAK4-inhibitor INKA2 PAK4-inhibitor INKA2	INKA2	114	Annotation score:
E9PND8	E9PND8_HUMAN	PAK4-inhibitor INKA2 PAK4-inhibitor INKA2	INKA2	181	Annotation score:

Sequence cautionⁱ

The sequence BAG57355 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence CAB69909 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL137198 mRNA Translation: CAB69908.1 AL137199 mRNA Translation: CAB69909.1 Different initiation. AK055667 mRNA Translation: BAG51550.1 AK293989 mRNA Translation: BAG57355.1 Different initiation. AL049557 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56505.1 BC031558 mRNA Translation: AAH31558.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS841.1
NCBI Reference Sequences More...RefSeqⁱ	NP_061972.1, NM_019099.4 NP_945120.1, NM_198926.2
UniGeneⁱ	Hs.193406

Genome annotation databases

Ensemblⁱ	ENST00000357260; ENSP00000349805; ENSG00000197852
GeneIDⁱ	55924
KEGGⁱ	hsa:55924
UCSC genome browser More...UCSCⁱ	uc001ebo.2 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NTI7	Chromosome 1 open reading frame 183		PANTR		297	UniRef100_Q9NTI7
Uncharacterized protein		PANPA		297
UPI000036656B		HUMAN		278
UPI0007DB9862		PANTR		442

Protein	Similar proteins		Species	Score	Length	Source
Q9NTI7	Chromosome 1 open reading frame 183		PANTR		297	UniRef90_Q9NTI7
Uncharacterized protein		PANPA		297
UPI000036656B		HUMAN		278
UPI0007DB9862		PANTR		442

Protein	Similar proteins		Species	Score	Length	Source
Q9NTI7	Chromosome 1 open reading frame 183		PANTR		297	UniRef50_Q9NTI7
Uncharacterized protein		PANPA		297
Isoform 2 of PAK4-inhibitor INKA2		MOUSE		281
Uncharacterized protein		FUKDA		423
protein FAM212B		ODORO		422
+7

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL137198 mRNA Translation: CAB69908.1 AL137199 mRNA Translation: CAB69909.1 Different initiation. AK055667 mRNA Translation: BAG51550.1 AK293989 mRNA Translation: BAG57355.1 Different initiation. AL049557 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56505.1 BC031558 mRNA Translation: AAH31558.1
CCDSⁱ	CCDS841.1
RefSeqⁱ	NP_061972.1, NM_019099.4 NP_945120.1, NM_198926.2
UniGeneⁱ	Hs.193406

3D structure databases

ProteinModelPortalⁱ	Q9NTI7
SMRⁱ	Q9NTI7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121003, 10 interactors

BioGridⁱ

121003, 10 interactors

PTM databases

iPTMnetⁱ	Q9NTI7
PhosphoSitePlusⁱ	Q9NTI7

Polymorphism and mutation databases

BioMutaⁱ	FAM212B

BioMutaⁱ

FAM212B

Proteomic databases

PaxDbⁱ	Q9NTI7
PeptideAtlasⁱ	Q9NTI7
PRIDEⁱ	Q9NTI7
ProteomicsDBⁱ	82615

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	55924
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000357260; ENSP00000349805; ENSG00000197852
GeneIDⁱ	55924
KEGGⁱ	hsa:55924
UCSCⁱ	uc001ebo.2 human

Organism-specific databases

CTDⁱ	55924
DisGeNETⁱ	55924
EuPathDBⁱ	HostDB:ENSG00000197852.9
HGNCⁱ	HGNC:28045 INKA2
HPAⁱ	HPA027809 HPA027811
neXtProtⁱ	NX_Q9NTI7
OpenTargetsⁱ	ENSG00000197852
PharmGKBⁱ	PA142672431
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IF94 Eukaryota ENOG4111HME LUCA
GeneTreeⁱ	ENSGT00530000063849
HOGENOMⁱ	HOG000111266
HOVERGENⁱ	HBG107564
InParanoidⁱ	Q9NTI7
OMAⁱ	PGWVTPT
OrthoDBⁱ	EOG091G0ADX
PhylomeDBⁱ	Q9NTI7
TreeFamⁱ	TF332839

Miscellaneous databases

GenomeRNAiⁱ	55924
Protein Ontology More...PROⁱ	PR:Q9NTI7

Gene expression databases

Bgeeⁱ	ENSG00000197852 Expressed in 159 organ(s), highest expression level in prostate gland
CleanExⁱ	HS_C1orf183
ExpressionAtlasⁱ	Q9NTI7 baseline and differential
Genevisibleⁱ	Q9NTI7 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR029267 FAM212 IPR039201 Inka
PANTHERⁱ	PTHR28615 PTHR28615, 1 hit
Pfamⁱ	View protein in Pfam PF15342 FAM212, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	INKA2_HUMAN
Accessionⁱ	Q9NTI7Primary (citable) accession number: Q9NTI7 Secondary accession number(s): B3KP38, B4DF94, Q9NTI6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
	Last sequence update:	October 1, 2000
	Last modified:	November 7, 2018
	This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NTI7 (INKA2_HUMAN)

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PAK4-inhibitor INKA2

INKA2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ