UniProtKB - Q9NTI7 (INKA2_HUMAN)
Protein
PAK4-inhibitor INKA2
Gene
INKA2
Organism
Homo sapiens (Human)
Status
Functioni
Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity.By similarity
GO - Molecular functioni
- protein kinase binding Source: UniProtKB
- protein serine/threonine kinase inhibitor activity Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q9NTI7 |
Names & Taxonomyi
Protein namesi | Recommended name: PAK4-inhibitor INKA2CuratedAlternative name(s): Induced in neural crest by AP2-alpha protein-related homolog1 Publication Short name: HInca-r1 Publication Inka box actin regulator 2Imported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28045, INKA2 |
neXtProti | NX_Q9NTI7 |
VEuPathDBi | HostDB:ENSG00000197852.9 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 55924 |
OpenTargetsi | ENSG00000197852 |
PharmGKBi | PA142672431 |
Miscellaneous databases
Pharosi | Q9NTI7, Tdark |
Genetic variation databases
BioMutai | FAM212B |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000304994 | 1 – 297 | PAK4-inhibitor INKA2Add BLAST | 297 |
Proteomic databases
PaxDbi | Q9NTI7 |
PeptideAtlasi | Q9NTI7 |
PRIDEi | Q9NTI7 |
PTM databases
iPTMneti | Q9NTI7 |
PhosphoSitePlusi | Q9NTI7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000197852, Expressed in prostate gland and 177 other tissues |
ExpressionAtlasi | Q9NTI7, baseline and differential |
Genevisiblei | Q9NTI7, HS |
Organism-specific databases
HPAi | ENSG00000197852, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with PAK4 (PubMed:26607847).
1 PublicationGO - Molecular functioni
- protein kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 121003, 11 interactors |
IntActi | Q9NTI7, 4 interactors |
STRINGi | 9606.ENSP00000349805 |
Miscellaneous databases
RNActi | Q9NTI7, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 137 – 180 | Inka boxBy similarityAdd BLAST | 44 |
Domaini
The Inka box (also named iBox or inca box) binds and inhibits PAK4 by binding a substrate-like manner.By similarity
Sequence similaritiesi
Belongs to the INKA family.Curated
Phylogenomic databases
eggNOGi | ENOG502RZNT, Eukaryota |
GeneTreei | ENSGT00530000063849 |
InParanoidi | Q9NTI7 |
OMAi | WVTPMVS |
OrthoDBi | 794088at2759 |
PhylomeDBi | Q9NTI7 |
TreeFami | TF332839 |
Family and domain databases
InterProi | View protein in InterPro IPR029267, FAM212 IPR039201, Inka |
PANTHERi | PTHR28615, PTHR28615, 1 hit |
Pfami | View protein in Pfam PF15342, FAM212, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9NTI7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTMESREMDC YLRRLKQELM SMKEVGDGLQ DQMNCMMGAL QELKLLQVQT
60 70 80 90 100
ALEQLEISGG GPVPGSPEGP RTQCEHPCWE GGRGPARPTV CSPSSQPSLG
110 120 130 140 150
SSTKFPSHRS VCGRDLAPLP RTQPHQSCAQ QGPERVEPDD WTSTLMSRGR
160 170 180 190 200
NRQPLVLGDN VFADLVGNWL DLPELEKGGE KGETGGAREP KGEKGQPQEL
210 220 230 240 250
GRRFALTANI FKKFLRSVRP DRDRLLKEKP GWVTPMVPES RTGRSQKVKK
260 270 280 290
RSLSKGSGHF PFPGTGEHRR GENPPTSCPK ALEHSPSGFD INTAVWV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PND8 | E9PND8_HUMAN | PAK4-inhibitor INKA2 | INKA2 | 181 | Annotation score: | ||
E9PR53 | E9PR53_HUMAN | PAK4-inhibitor INKA2 | INKA2 | 114 | Annotation score: |
Sequence cautioni
The sequence BAG57355 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAB69909 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL137198 mRNA Translation: CAB69908.1 AL137199 mRNA Translation: CAB69909.1 Different initiation. AK055667 mRNA Translation: BAG51550.1 AK293989 mRNA Translation: BAG57355.1 Different initiation. AL049557 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56505.1 BC031558 mRNA Translation: AAH31558.1 |
CCDSi | CCDS841.1 |
RefSeqi | NP_061972.1, NM_019099.4 NP_945120.1, NM_198926.2 |
Genome annotation databases
Ensembli | ENST00000357260; ENSP00000349805; ENSG00000197852 |
GeneIDi | 55924 |
KEGGi | hsa:55924 |
UCSCi | uc001ebo.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL137198 mRNA Translation: CAB69908.1 AL137199 mRNA Translation: CAB69909.1 Different initiation. AK055667 mRNA Translation: BAG51550.1 AK293989 mRNA Translation: BAG57355.1 Different initiation. AL049557 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56505.1 BC031558 mRNA Translation: AAH31558.1 |
CCDSi | CCDS841.1 |
RefSeqi | NP_061972.1, NM_019099.4 NP_945120.1, NM_198926.2 |
3D structure databases
SMRi | Q9NTI7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121003, 11 interactors |
IntActi | Q9NTI7, 4 interactors |
STRINGi | 9606.ENSP00000349805 |
PTM databases
iPTMneti | Q9NTI7 |
PhosphoSitePlusi | Q9NTI7 |
Genetic variation databases
BioMutai | FAM212B |
Proteomic databases
PaxDbi | Q9NTI7 |
PeptideAtlasi | Q9NTI7 |
PRIDEi | Q9NTI7 |
Protocols and materials databases
Antibodypediai | 33813, 122 antibodies |
DNASUi | 55924 |
Genome annotation databases
Ensembli | ENST00000357260; ENSP00000349805; ENSG00000197852 |
GeneIDi | 55924 |
KEGGi | hsa:55924 |
UCSCi | uc001ebo.2, human |
Organism-specific databases
CTDi | 55924 |
DisGeNETi | 55924 |
GeneCardsi | INKA2 |
HGNCi | HGNC:28045, INKA2 |
HPAi | ENSG00000197852, Low tissue specificity |
neXtProti | NX_Q9NTI7 |
OpenTargetsi | ENSG00000197852 |
PharmGKBi | PA142672431 |
VEuPathDBi | HostDB:ENSG00000197852.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RZNT, Eukaryota |
GeneTreei | ENSGT00530000063849 |
InParanoidi | Q9NTI7 |
OMAi | WVTPMVS |
OrthoDBi | 794088at2759 |
PhylomeDBi | Q9NTI7 |
TreeFami | TF332839 |
Enzyme and pathway databases
PathwayCommonsi | Q9NTI7 |
Miscellaneous databases
BioGRID-ORCSi | 55924, 16 hits in 877 CRISPR screens |
ChiTaRSi | FAM212B, human |
GenomeRNAii | 55924 |
Pharosi | Q9NTI7, Tdark |
PROi | PR:Q9NTI7 |
RNActi | Q9NTI7, protein |
Gene expression databases
Bgeei | ENSG00000197852, Expressed in prostate gland and 177 other tissues |
ExpressionAtlasi | Q9NTI7, baseline and differential |
Genevisiblei | Q9NTI7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029267, FAM212 IPR039201, Inka |
PANTHERi | PTHR28615, PTHR28615, 1 hit |
Pfami | View protein in Pfam PF15342, FAM212, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | INKA2_HUMAN | |
Accessioni | Q9NTI7Primary (citable) accession number: Q9NTI7 Secondary accession number(s): B3KP38, B4DF94, Q9NTI6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families