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Protein

PAK4-inhibitor INKA2

Gene

INKA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity.By similarity

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • protein serine/threonine kinase inhibitor activity Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
PAK4-inhibitor INKA2Curated
Alternative name(s):
Induced in neural crest by AP2-alpha protein-related homolog1 Publication
Short name:
HInca-r1 Publication
Inka box actin regulator 2Imported
Gene namesi
Name:INKA2Imported
Synonyms:C1orf183Imported, FAM212B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000197852.9
HGNCiHGNC:28045 INKA2
neXtProtiNX_Q9NTI7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55924
OpenTargetsiENSG00000197852
PharmGKBiPA142672431

Polymorphism and mutation databases

BioMutaiFAM212B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003049941 – 297PAK4-inhibitor INKA2Add BLAST297

Proteomic databases

PaxDbiQ9NTI7
PeptideAtlasiQ9NTI7
PRIDEiQ9NTI7
ProteomicsDBi82615

PTM databases

iPTMnetiQ9NTI7
PhosphoSitePlusiQ9NTI7

Expressioni

Gene expression databases

BgeeiENSG00000197852 Expressed in 159 organ(s), highest expression level in prostate gland
CleanExiHS_C1orf183
ExpressionAtlasiQ9NTI7 baseline and differential
GenevisibleiQ9NTI7 HS

Organism-specific databases

HPAiHPA027809
HPA027811

Interactioni

Subunit structurei

Interacts with PAK4 (PubMed:26607847).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121003, 10 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9NTI7
SMRiQ9NTI7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni137 – 180Inka boxBy similarityAdd BLAST44

Domaini

The Inka box (also named iBox or inca box) binds and inhibits PAK4 by binding a substrate-like manner.By similarity

Sequence similaritiesi

Belongs to the INKA family.Curated

Phylogenomic databases

eggNOGiENOG410IF94 Eukaryota
ENOG4111HME LUCA
GeneTreeiENSGT00530000063849
HOGENOMiHOG000111266
HOVERGENiHBG107564
InParanoidiQ9NTI7
OMAiPGWVTPT
OrthoDBiEOG091G0ADX
PhylomeDBiQ9NTI7
TreeFamiTF332839

Family and domain databases

InterProiView protein in InterPro
IPR029267 FAM212
IPR039201 Inka
PANTHERiPTHR28615 PTHR28615, 1 hit
PfamiView protein in Pfam
PF15342 FAM212, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9NTI7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTMESREMDC YLRRLKQELM SMKEVGDGLQ DQMNCMMGAL QELKLLQVQT
60 70 80 90 100
ALEQLEISGG GPVPGSPEGP RTQCEHPCWE GGRGPARPTV CSPSSQPSLG
110 120 130 140 150
SSTKFPSHRS VCGRDLAPLP RTQPHQSCAQ QGPERVEPDD WTSTLMSRGR
160 170 180 190 200
NRQPLVLGDN VFADLVGNWL DLPELEKGGE KGETGGAREP KGEKGQPQEL
210 220 230 240 250
GRRFALTANI FKKFLRSVRP DRDRLLKEKP GWVTPMVPES RTGRSQKVKK
260 270 280 290
RSLSKGSGHF PFPGTGEHRR GENPPTSCPK ALEHSPSGFD INTAVWV
Length:297
Mass (Da):32,759
Last modified:October 1, 2000 - v1
Checksum:iAC9E28218271E5E2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PR53E9PR53_HUMAN
PAK4-inhibitor INKA2
INKA2
114Annotation score:
E9PND8E9PND8_HUMAN
PAK4-inhibitor INKA2
INKA2
181Annotation score:

Sequence cautioni

The sequence BAG57355 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAB69909 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137198 mRNA Translation: CAB69908.1
AL137199 mRNA Translation: CAB69909.1 Different initiation.
AK055667 mRNA Translation: BAG51550.1
AK293989 mRNA Translation: BAG57355.1 Different initiation.
AL049557 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56505.1
BC031558 mRNA Translation: AAH31558.1
CCDSiCCDS841.1
RefSeqiNP_061972.1, NM_019099.4
NP_945120.1, NM_198926.2
UniGeneiHs.193406

Genome annotation databases

EnsembliENST00000357260; ENSP00000349805; ENSG00000197852
GeneIDi55924
KEGGihsa:55924
UCSCiuc001ebo.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137198 mRNA Translation: CAB69908.1
AL137199 mRNA Translation: CAB69909.1 Different initiation.
AK055667 mRNA Translation: BAG51550.1
AK293989 mRNA Translation: BAG57355.1 Different initiation.
AL049557 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56505.1
BC031558 mRNA Translation: AAH31558.1
CCDSiCCDS841.1
RefSeqiNP_061972.1, NM_019099.4
NP_945120.1, NM_198926.2
UniGeneiHs.193406

3D structure databases

ProteinModelPortaliQ9NTI7
SMRiQ9NTI7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121003, 10 interactors

PTM databases

iPTMnetiQ9NTI7
PhosphoSitePlusiQ9NTI7

Polymorphism and mutation databases

BioMutaiFAM212B

Proteomic databases

PaxDbiQ9NTI7
PeptideAtlasiQ9NTI7
PRIDEiQ9NTI7
ProteomicsDBi82615

Protocols and materials databases

DNASUi55924
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357260; ENSP00000349805; ENSG00000197852
GeneIDi55924
KEGGihsa:55924
UCSCiuc001ebo.2 human

Organism-specific databases

CTDi55924
DisGeNETi55924
EuPathDBiHostDB:ENSG00000197852.9
HGNCiHGNC:28045 INKA2
HPAiHPA027809
HPA027811
neXtProtiNX_Q9NTI7
OpenTargetsiENSG00000197852
PharmGKBiPA142672431
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF94 Eukaryota
ENOG4111HME LUCA
GeneTreeiENSGT00530000063849
HOGENOMiHOG000111266
HOVERGENiHBG107564
InParanoidiQ9NTI7
OMAiPGWVTPT
OrthoDBiEOG091G0ADX
PhylomeDBiQ9NTI7
TreeFamiTF332839

Miscellaneous databases

GenomeRNAii55924
PROiPR:Q9NTI7

Gene expression databases

BgeeiENSG00000197852 Expressed in 159 organ(s), highest expression level in prostate gland
CleanExiHS_C1orf183
ExpressionAtlasiQ9NTI7 baseline and differential
GenevisibleiQ9NTI7 HS

Family and domain databases

InterProiView protein in InterPro
IPR029267 FAM212
IPR039201 Inka
PANTHERiPTHR28615 PTHR28615, 1 hit
PfamiView protein in Pfam
PF15342 FAM212, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiINKA2_HUMAN
AccessioniPrimary (citable) accession number: Q9NTI7
Secondary accession number(s): B3KP38, B4DF94, Q9NTI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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