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Protein

Sister chromatid cohesion protein PDS5 homolog B

Gene

PDS5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi1249 – 1261A.T hook 1Sequence analysisAdd BLAST13
DNA bindingi1287 – 1299A.T hook 2Sequence analysisAdd BLAST13
DNA bindingi1372 – 1384A.T hook 3Sequence analysisAdd BLAST13

GO - Molecular functioni

  • ATP binding Source: ProtInc
  • DNA binding Source: MGI

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-2467813 Separation of Sister Chromatids
R-HSA-2468052 Establishment of Sister Chromatid Cohesion
R-HSA-2470946 Cohesin Loading onto Chromatin
R-HSA-2500257 Resolution of Sister Chromatid Cohesion

Names & Taxonomyi

Protein namesi
Recommended name:
Sister chromatid cohesion protein PDS5 homolog B
Alternative name(s):
Androgen-induced proliferation inhibitor
Androgen-induced prostate proliferative shutoff-associated protein AS3
Gene namesi
Name:PDS5B
Synonyms:APRIN, AS3Imported, KIAA0979Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000083642.18
HGNCiHGNC:20418 PDS5B
MIMi605333 gene
neXtProtiNX_Q9NTI5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23047
OpenTargetsiENSG00000083642
PharmGKBiPA162399098

Polymorphism and mutation databases

BioMutaiPDS5B
DMDMi74725312

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002874241 – 1447Sister chromatid cohesion protein PDS5 homolog BAdd BLAST1447

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1136N6-acetyllysineCombined sources1
Modified residuei1140PhosphoserineCombined sources1
Modified residuei1162PhosphoserineCombined sources1
Modified residuei1166PhosphoserineCombined sources1
Modified residuei1176PhosphoserineCombined sources1
Modified residuei1182PhosphoserineCombined sources1
Modified residuei1191PhosphoserineCombined sources1
Modified residuei1255PhosphothreonineCombined sources1
Modified residuei1257PhosphoserineCombined sources1
Modified residuei1259PhosphoserineCombined sources1
Modified residuei1283PhosphoserineCombined sources1
Modified residuei1319PhosphoserineCombined sources1
Modified residuei1334PhosphoserineCombined sources1
Modified residuei1358PhosphoserineCombined sources1
Modified residuei1366PhosphoserineBy similarity1
Modified residuei1367PhosphothreonineCombined sources1
Modified residuei1369PhosphoserineBy similarity1
Modified residuei1370PhosphothreonineCombined sources1
Modified residuei1381PhosphothreonineCombined sources1
Modified residuei1383PhosphoserineCombined sources1
Modified residuei1417PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NTI5
MaxQBiQ9NTI5
PaxDbiQ9NTI5
PeptideAtlasiQ9NTI5
PRIDEiQ9NTI5
ProteomicsDBi82610
82611 [Q9NTI5-2]
82612 [Q9NTI5-3]
82613 [Q9NTI5-4]
82614 [Q9NTI5-5]

PTM databases

iPTMnetiQ9NTI5
PhosphoSitePlusiQ9NTI5

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Inductioni

By the synthetic androgen R1881 in prostate carcinoma cells undergoing proliferative arrest. Maximum levels occur 18-20 hours after androgen exposure.1 Publication

Gene expression databases

BgeeiENSG00000083642 Expressed in 221 organ(s), highest expression level in kidney
CleanExiHS_PDS5B
ExpressionAtlasiQ9NTI5 baseline and differential
GenevisibleiQ9NTI5 HS

Organism-specific databases

HPAiHPA039513
HPA040015

Interactioni

Subunit structurei

Interacts with the cohesin complex. Interacts with RAD21; the interaction is direct. Interacts with WAPL (via FGF motifs) or CDCA5 (via the FGF motif); the interaction is direct, cohesin-dependent and competitive (Probable).3 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi116685, 63 interactors
CORUMiQ9NTI5
DIPiDIP-35420N
IntActiQ9NTI5, 25 interactors
MINTiQ9NTI5
STRINGi9606.ENSP00000313851

Structurei

Secondary structure

11447
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NTI5
SMRiQ9NTI5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati383 – 419HEATSequence analysisAdd BLAST37

Sequence similaritiesi

Belongs to the PDS5 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1525 Eukaryota
ENOG410XQW7 LUCA
GeneTreeiENSGT00390000012488
HOVERGENiHBG108241
InParanoidiQ9NTI5
KOiK11267
OMAiYVFSAHF
OrthoDBiEOG091G00ZG
PhylomeDBiQ9NTI5
TreeFamiTF106415

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR039776 Pds5
PANTHERiPTHR12663 PTHR12663, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q9NTI5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAHSKTRTND GKITYPPGVK EISDKISKEE MVRRLKMVVK TFMDMDQDSE
60 70 80 90 100
EEKELYLNLA LHLASDFFLK HPDKDVRLLV ACCLADIFRI YAPEAPYTSP
110 120 130 140 150
DKLKDIFMFI TRQLKGLEDT KSPQFNRYFY LLENIAWVKS YNICFELEDS
160 170 180 190 200
NEIFTQLYRT LFSVINNGHN QKVHMHMVDL MSSIICEGDT VSQELLDTVL
210 220 230 240 250
VNLVPAHKNL NKQAYDLAKA LLKRTAQAIE PYITNFFNQV LMLGKTSISD
260 270 280 290 300
LSEHVFDLIL ELYNIDSHLL LSVLPQLEFK LKSNDNEERL QVVKLLAKMF
310 320 330 340 350
GAKDSELASQ NKPLWQCYLG RFNDIHVPIR LECVKFASHC LMNHPDLAKD
360 370 380 390 400
LTEYLKVRSH DPEEAIRHDV IVSIVTAAKK DILLVNDHLL NFVRERTLDK
410 420 430 440 450
RWRVRKEAMM GLAQIYKKYA LQSAAGKDAA KQIAWIKDKL LHIYYQNSID
460 470 480 490 500
DRLLVERIFA QYMVPHNLET TERMKCLYYL YATLDLNAVK ALNEMWKCQN
510 520 530 540 550
LLRHQVKDLL DLIKQPKTDA SVKAIFSKVM VITRNLPDPG KAQDFMKKFT
560 570 580 590 600
QVLEDDEKIR KQLEVLVSPT CSCKQAEGCV REITKKLGNP KQPTNPFLEM
610 620 630 640 650
IKFLLERIAP VHIDTESISA LIKQVNKSID GTADDEDEGV PTDQAIRAGL
660 670 680 690 700
ELLKVLSFTH PISFHSAETF ESLLACLKMD DEKVAEAALQ IFKNTGSKIE
710 720 730 740 750
EDFPHIRSAL LPVLHHKSKK GPPRQAKYAI HCIHAIFSSK ETQFAQIFEP
760 770 780 790 800
LHKSLDPSNL EHLITPLVTI GHIALLAPDQ FAAPLKSLVA TFIVKDLLMN
810 820 830 840 850
DRLPGKKTTK LWVPDEEVSP ETMVKIQAIK MMVRWLLGMK NNHSKSGTST
860 870 880 890 900
LRLLTTILHS DGDLTEQGKI SKPDMSRLRL AAGSAIVKLA QEPCYHEIIT
910 920 930 940 950
LEQYQLCALA INDECYQVRQ VFAQKLHKGL SRLRLPLEYM AICALCAKDP
960 970 980 990 1000
VKERRAHARQ CLVKNINVRR EYLKQHAAVS EKLLSLLPEY VVPYTIHLLA
1010 1020 1030 1040 1050
HDPDYVKVQD IEQLKDVKEC LWFVLEILMA KNENNSHAFI RKMVENIKQT
1060 1070 1080 1090 1100
KDAQGPDDAK MNEKLYTVCD VAMNIIMSKS TTYSLESPKD PVLPARFFTQ
1110 1120 1130 1140 1150
PDKNFSNTKN YLPPEMKSFF TPGKPKTTNV LGAVNKPLSS AGKQSQTKSS
1160 1170 1180 1190 1200
RMETVSNASS SSNPSSPGRI KGRLDSSEMD HSENEDYTMS SPLPGKKSDK
1210 1220 1230 1240 1250
RDDSDLVRSE LEKPRGRKKT PVTEQEEKLG MDDLTKLVQE QKPKGSQRSR
1260 1270 1280 1290 1300
KRGHTASESD EQQWPEEKRL KEDILENEDE QNSPPKKGKR GRPPKPLGGG
1310 1320 1330 1340 1350
TPKEEPTMKT SKKGSKKKSG PPAPEEEEEE ERQSGNTEQK SKSKQHRVSR
1360 1370 1380 1390 1400
RAQQRAESPE SSAIESTQST PQKGRGRPSK TPSPSQPKKN VRVGRSKQAA
1410 1420 1430 1440
TKENDSSEEV DVFQGSSPVD DIPQEETEEE EVSTVNVRRR SAKRERR
Length:1,447
Mass (Da):164,667
Last modified:October 1, 2000 - v1
Checksum:i145C30308EA3EFD5
GO
Isoform 21 Publication (identifier: Q9NTI5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1392-1447: Missing.

Show »
Length:1,391
Mass (Da):158,280
Checksum:i9C5FD7A7F8C4A18F
GO
Isoform 31 Publication (identifier: Q9NTI5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     491-529: ALNEMWKCQN...ASVKAIFSKV → YVSNIKFCSF...KCNLCSVNIV
     530-1447: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:529
Mass (Da):61,437
Checksum:i05CDB3E2A92F46DD
GO
Isoform 41 Publication (identifier: Q9NTI5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-122: DIFMFITRQLKGLEDTKS → ASTDLNNSKIDRYFDLSF
     123-1447: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:122
Mass (Da):14,108
Checksum:iB8EAB2D511A217CB
GO
Isoform 51 Publication (identifier: Q9NTI5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1230: Missing.
     1356-1447: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:125
Mass (Da):14,281
Checksum:i492809836D3665D3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A9IYQ1A9IYQ1_HUMAN
Sister chromatid cohesion protein P...
PDS5B
302Annotation score:

Sequence cautioni

The sequence BAA76823 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti256F → S in AAD22134 (PubMed:10215036).Curated1
Sequence conflicti326H → N in AAH39256 (PubMed:15489334).Curated1
Sequence conflicti394R → G in AAD22134 (PubMed:10215036).Curated1
Sequence conflicti535N → S in AAD22134 (PubMed:10215036).Curated1
Sequence conflicti742T → A in AAD22134 (PubMed:10215036).Curated1
Sequence conflicti1115E → G in AAD22134 (PubMed:10215036).Curated1
Sequence conflicti1156S → G in AAD22134 (PubMed:10215036).Curated1
Sequence conflicti1197K → R in AAD22134 (PubMed:10215036).Curated1
Sequence conflicti1225Q → R in AAD22134 (PubMed:10215036).Curated1
Sequence conflicti1242K → R in AAD22134 (PubMed:10215036).Curated1
Sequence conflicti1359P → S in AAD22134 (PubMed:10215036).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0523961 – 1230Missing in isoform 5. 1 PublicationAdd BLAST1230
Alternative sequenceiVSP_052397105 – 122DIFMF…EDTKS → ASTDLNNSKIDRYFDLSF in isoform 4. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_052398123 – 1447Missing in isoform 4. 1 PublicationAdd BLAST1325
Alternative sequenceiVSP_052399491 – 529ALNEM…IFSKV → YVSNIKFCSFHPLQYIGFYG KETTNTCILKCNLCSVNIV in isoform 3. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_052400530 – 1447Missing in isoform 3. 1 PublicationAdd BLAST918
Alternative sequenceiVSP_0524011356 – 1447Missing in isoform 5. 1 PublicationAdd BLAST92
Alternative sequenceiVSP_0524021392 – 1447Missing in isoform 2. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95825 mRNA Translation: AAD22134.2
AB023196 mRNA Translation: BAA76823.2 Different initiation.
AK026889 mRNA Translation: BAB15584.1
AL137201 mRNA Translation: CAB69911.1
AL138820, Z75889 Genomic DNA Translation: CAH73160.2
Z75889, AL138820 Genomic DNA Translation: CAI10806.2
BC039256 mRNA Translation: AAH39256.1
BC070274 mRNA Translation: AAH70274.1
CCDSiCCDS41878.1 [Q9NTI5-1]
RefSeqiNP_055847.1, NM_015032.3 [Q9NTI5-1]
XP_016875939.1, XM_017020450.1 [Q9NTI5-1]
UniGeneiHs.744901

Genome annotation databases

EnsembliENST00000315596; ENSP00000313851; ENSG00000083642 [Q9NTI5-1]
ENST00000450460; ENSP00000401619; ENSG00000083642 [Q9NTI5-2]
GeneIDi23047
KEGGihsa:23047
UCSCiuc010abf.4 human [Q9NTI5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95825 mRNA Translation: AAD22134.2
AB023196 mRNA Translation: BAA76823.2 Different initiation.
AK026889 mRNA Translation: BAB15584.1
AL137201 mRNA Translation: CAB69911.1
AL138820, Z75889 Genomic DNA Translation: CAH73160.2
Z75889, AL138820 Genomic DNA Translation: CAI10806.2
BC039256 mRNA Translation: AAH39256.1
BC070274 mRNA Translation: AAH70274.1
CCDSiCCDS41878.1 [Q9NTI5-1]
RefSeqiNP_055847.1, NM_015032.3 [Q9NTI5-1]
XP_016875939.1, XM_017020450.1 [Q9NTI5-1]
UniGeneiHs.744901

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5HDTX-ray2.71A/B21-1120[»]
ProteinModelPortaliQ9NTI5
SMRiQ9NTI5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116685, 63 interactors
CORUMiQ9NTI5
DIPiDIP-35420N
IntActiQ9NTI5, 25 interactors
MINTiQ9NTI5
STRINGi9606.ENSP00000313851

PTM databases

iPTMnetiQ9NTI5
PhosphoSitePlusiQ9NTI5

Polymorphism and mutation databases

BioMutaiPDS5B
DMDMi74725312

Proteomic databases

EPDiQ9NTI5
MaxQBiQ9NTI5
PaxDbiQ9NTI5
PeptideAtlasiQ9NTI5
PRIDEiQ9NTI5
ProteomicsDBi82610
82611 [Q9NTI5-2]
82612 [Q9NTI5-3]
82613 [Q9NTI5-4]
82614 [Q9NTI5-5]

Protocols and materials databases

DNASUi23047
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315596; ENSP00000313851; ENSG00000083642 [Q9NTI5-1]
ENST00000450460; ENSP00000401619; ENSG00000083642 [Q9NTI5-2]
GeneIDi23047
KEGGihsa:23047
UCSCiuc010abf.4 human [Q9NTI5-1]

Organism-specific databases

CTDi23047
DisGeNETi23047
EuPathDBiHostDB:ENSG00000083642.18
GeneCardsiPDS5B
HGNCiHGNC:20418 PDS5B
HPAiHPA039513
HPA040015
MIMi605333 gene
neXtProtiNX_Q9NTI5
OpenTargetsiENSG00000083642
PharmGKBiPA162399098
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1525 Eukaryota
ENOG410XQW7 LUCA
GeneTreeiENSGT00390000012488
HOVERGENiHBG108241
InParanoidiQ9NTI5
KOiK11267
OMAiYVFSAHF
OrthoDBiEOG091G00ZG
PhylomeDBiQ9NTI5
TreeFamiTF106415

Enzyme and pathway databases

ReactomeiR-HSA-2467813 Separation of Sister Chromatids
R-HSA-2468052 Establishment of Sister Chromatid Cohesion
R-HSA-2470946 Cohesin Loading onto Chromatin
R-HSA-2500257 Resolution of Sister Chromatid Cohesion

Miscellaneous databases

ChiTaRSiPDS5B human
GeneWikiiPDS5B
GenomeRNAii23047
PROiPR:Q9NTI5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000083642 Expressed in 221 organ(s), highest expression level in kidney
CleanExiHS_PDS5B
ExpressionAtlasiQ9NTI5 baseline and differential
GenevisibleiQ9NTI5 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR039776 Pds5
PANTHERiPTHR12663 PTHR12663, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPDS5B_HUMAN
AccessioniPrimary (citable) accession number: Q9NTI5
Secondary accession number(s): Q5R3S3
, Q5W0K8, Q6NSC3, Q8IXT6, Q9H5N8, Q9Y2I5, Q9Y451
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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