UniProtKB - Q9NTG7 (SIR3_HUMAN)
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
SIRT3
Functioni
NAD-dependent protein deacetylase (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090, PubMed:19535340).
Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090).
Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5PO (PubMed:16788062, PubMed:18680753, PubMed:24121500, PubMed:24252090, PubMed:19535340).
Contributes to the regulation of the cellular energy metabolism (PubMed:24252090).
Important for regulating tissue-specific ATP levels (PubMed:18794531).
In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301).
Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation (By similarity).
By similarity9 PublicationsMiscellaneous
Catalytic activityi
- H2O + N6-acetyl-L-lysyl-[protein] + NAD+ = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamidePROSITE-ProRule annotation1 Publication7 PublicationsEC:2.3.1.286PROSITE-ProRule annotation1 Publication7 Publications
Cofactori
Kineticsi
- KM=600 µM for NAD1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 248 | Proton acceptor3 Publications | 1 | |
Metal bindingi | 256 | Zinc2 Publications | 1 | |
Metal bindingi | 259 | Zinc2 Publications | 1 | |
Metal bindingi | 280 | Zinc2 Publications | 1 | |
Metal bindingi | 283 | Zinc2 Publications | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 145 – 165 | NAD1 PublicationAdd BLAST | 21 | |
Nucleotide bindingi | 228 – 231 | NAD1 Publication | 4 | |
Nucleotide bindingi | 319 – 321 | NAD1 Publication | 3 | |
Nucleotide bindingi | 344 – 346 | NAD1 Publication | 3 |
GO - Molecular functioni
- NAD+ ADP-ribosyltransferase activity Source: ProtInc
- NAD+ binding Source: GO_Central
- NAD-dependent histone deacetylase activity Source: GO_Central
- NAD-dependent protein deacetylase activity Source: UniProtKB
- sequence-specific DNA binding Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- aerobic respiration Source: UniProtKB
- peptidyl-lysine deacetylation Source: UniProtKB
- positive regulation of catalase activity Source: CACAO
- positive regulation of ceramide biosynthetic process Source: UniProtKB
- positive regulation of superoxide dismutase activity Source: CACAO
- protein ADP-ribosylation Source: GO_Central
- protein deacetylation Source: UniProtKB
Keywordsi
Molecular function | Transferase |
Ligand | Metal-binding, NAD, Zinc |
Enzyme and pathway databases
BRENDAi | 2.3.1.24, 2681 2.3.1.286, 2681 |
PathwayCommonsi | Q9NTG7 |
Reactomei | R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis R-HSA-9615017, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9617629, Regulation of FOXO transcriptional activity by acetylation |
SABIO-RKi | Q9NTG7 |
SignaLinki | Q9NTG7 |
SIGNORi | Q9NTG7 |
Names & Taxonomyi
Protein namesi | Recommended name: NAD-dependent protein deacetylase sirtuin-3, mitochondrial (EC:2.3.1.2867 Publications)Short name: hSIRT3 Alternative name(s): Regulatory protein SIR2 homolog 3 SIR2-like protein 3 |
Gene namesi | Name:SIRT3 Synonyms:SIR2L3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14931, SIRT3 |
MIMi | 604481, gene |
neXtProti | NX_Q9NTG7 |
VEuPathDBi | HostDB:ENSG00000142082 |
Subcellular locationi
Mitochondrion
- Mitochondrion matrix 6 Publications
Mitochondrion
- mitochondrial matrix Source: UniProtKB
- mitochondrion Source: UniProtKB
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Other locations
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 7 | R → G or Q: Suppresses targeting to mitochondrion; when associated with G-13 or Q-13. 1 Publication | 1 | |
Mutagenesisi | 13 | R → G or Q: Suppresses targeting to mitochondrion; when associated with G-7 or Q-7. 1 Publication | 1 | |
Mutagenesisi | 17 | R → G or Q: Reduces targeting to mitochondrion; when associated with G-21 or Q-21. 1 Publication | 1 | |
Mutagenesisi | 21 | R → G or Q: Reduces targeting to mitochondrion; when associated with G-17 or Q-17. 1 Publication | 1 | |
Mutagenesisi | 99 – 100 | RR → GG: Abolishes processing by MPP (in vitro). 1 Publication | 2 | |
Mutagenesisi | 229 | N → A: Loss of function. 1 Publication | 1 | |
Mutagenesisi | 248 | H → Y: Loss of function. 3 Publications | 1 |
Organism-specific databases
DisGeNETi | 23410 |
OpenTargetsi | ENSG00000142082 |
PharmGKBi | PA37936 |
Miscellaneous databases
Pharosi | Q9NTG7, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4461 |
DrugBanki | DB02059, Adenosine-5-Diphosphoribose |
DrugCentrali | Q9NTG7 |
GuidetoPHARMACOLOGYi | 2709 |
Genetic variation databases
BioMutai | SIRT3 |
DMDMi | 38258651 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – ? | MitochondrionSequence analysis | ||
ChainiPRO_0000032612 | ? – 399 | NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 122 | N6-succinyllysineBy similarity | 1 |
Post-translational modificationi
Proteomic databases
EPDi | Q9NTG7 |
jPOSTi | Q9NTG7 |
MassIVEi | Q9NTG7 |
MaxQBi | Q9NTG7 |
PaxDbi | Q9NTG7 |
PeptideAtlasi | Q9NTG7 |
PRIDEi | Q9NTG7 |
ProteomicsDBi | 82606 [Q9NTG7-1] 82607 [Q9NTG7-2] |
PTM databases
iPTMneti | Q9NTG7 |
PhosphoSitePlusi | Q9NTG7 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000142082, Expressed in anterior cingulate cortex and 226 other tissues |
ExpressionAtlasi | Q9NTG7, baseline and differential |
Genevisiblei | Q9NTG7, HS |
Organism-specific databases
HPAi | ENSG00000142082, Low tissue specificity |
Interactioni
Subunit structurei
Upon metabolic stress, forms a complex composed of FOXO3, SIRT3 and mitochondrial RNA polymerase POLRMT; the complex is recruited to mtDNA in a SIRT3-dependent manner (PubMed:23283301). Also forms a complex composed of FOXO3, SIRT3, TFAM and POLRMT (PubMed:29445193).
Interacts with NDUFA9, ACSS1, IDH2 and GDH (PubMed:16788062, PubMed:18794531, PubMed:19535340, PubMed:18680753).
Interacts with PCCA (PubMed:23438705).
7 PublicationsBinary interactionsi
Q9NTG7
With | #Exp. | IntAct |
---|---|---|
ATP5F1A [P25705] | 2 | EBI-724621,EBI-351437 |
GRN - isoform 2 [P28799-2] | 3 | EBI-724621,EBI-25860013 |
OPA1 [O60313] | 3 | EBI-724621,EBI-1054131 |
SKP2 [Q13309] | 5 | EBI-724621,EBI-456291 |
Protein-protein interaction databases
BioGRIDi | 116982, 87 interactors |
DIPi | DIP-46861N |
IntActi | Q9NTG7, 56 interactors |
MINTi | Q9NTG7 |
STRINGi | 9606.ENSP00000372191 |
Chemistry databases
BindingDBi | Q9NTG7 |
Miscellaneous databases
RNActi | Q9NTG7, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q9NTG7 |
SMRi | Q9NTG7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9NTG7 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 126 – 382 | Deacetylase sirtuin-typePROSITE-ProRule annotationAdd BLAST | 257 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 49 – 74 | DisorderedSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG2682, Eukaryota |
GeneTreei | ENSGT00940000159464 |
HOGENOMi | CLU_023643_7_0_1 |
InParanoidi | Q9NTG7 |
OMAi | PCSRLPR |
OrthoDBi | 973532at2759 |
PhylomeDBi | Q9NTG7 |
TreeFami | TF106181 |
Family and domain databases
Gene3Di | 3.30.1600.10, 1 hit |
InterProi | View protein in InterPro IPR029035, DHS-like_NAD/FAD-binding_dom IPR003000, Sirtuin IPR026591, Sirtuin_cat_small_dom_sf IPR026590, Ssirtuin_cat_dom |
Pfami | View protein in Pfam PF02146, SIR2, 1 hit |
SUPFAMi | SSF52467, SSF52467, 1 hit |
PROSITEi | View protein in PROSITE PS50305, SIRTUIN, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAFWGWRAAA ALRLWGRVVE RVEAGGGVGP FQACGCRLVL GGRDDVSAGL
60 70 80 90 100
RGSHGARGEP LDPARPLQRP PRPEVPRAFR RQPRAAAPSF FFSSIKGGRR
110 120 130 140 150
SISFSVGASS VVGSGGSSDK GKLSLQDVAE LIRARACQRV VVMVGAGIST
160 170 180 190 200
PSGIPDFRSP GSGLYSNLQQ YDLPYPEAIF ELPFFFHNPK PFFTLAKELY
210 220 230 240 250
PGNYKPNVTH YFLRLLHDKG LLLRLYTQNI DGLERVSGIP ASKLVEAHGT
260 270 280 290 300
FASATCTVCQ RPFPGEDIRA DVMADRVPRC PVCTGVVKPD IVFFGEPLPQ
310 320 330 340 350
RFLLHVVDFP MADLLLILGT SLEVEPFASL TEAVRSSVPR LLINRDLVGP
360 370 380 390
LAWHPRSRDV AQLGDVVHGV ESLVELLGWT EEMRDLVQRE TGKLDGPDK
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PK80 | E9PK80_HUMAN | NAD-dependent protein deacetylase | SIRT3 | 318 | Annotation score: | ||
E9PN58 | E9PN58_HUMAN | NAD-dependent protein deacetylase s... | SIRT3 | 353 | Annotation score: | ||
E9PM75 | E9PM75_HUMAN | NAD-dependent protein deacetylase s... | SIRT3 | 345 | Annotation score: | ||
B7WNN4 | B7WNN4_HUMAN | NAD-dependent protein deacetylase s... | SIRT3 | 134 | Annotation score: | ||
E9PM52 | E9PM52_HUMAN | NAD-dependent protein deacetylase s... | SIRT3 | 23 | Annotation score: | ||
E9PJS6 | E9PJS6_HUMAN | NAD-dependent protein deacetylase s... | SIRT3 | 95 | Annotation score: | ||
E9PNA0 | E9PNA0_HUMAN | NAD-dependent protein deacetylase s... | SIRT3 | 93 | Annotation score: | ||
E9PR48 | E9PR48_HUMAN | NAD-dependent protein deacetylase s... | SIRT3 | 18 | Annotation score: | ||
E9PIT6 | E9PIT6_HUMAN | NAD-dependent protein deacetylase s... | SIRT3 | 46 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051977 | 80 | R → W. Corresponds to variant dbSNP:rs28365927Ensembl. | 1 | |
Natural variantiVAR_051978 | 208 | V → I. Corresponds to variant dbSNP:rs11246020Ensembl. | 1 | |
Natural variantiVAR_051979 | 369 | G → S. Corresponds to variant dbSNP:rs3020901Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043792 | 1 – 142 | Missing in isoform 2. 1 PublicationAdd BLAST | 142 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF083108 mRNA Translation: AAD40851.1 AK299438 mRNA Translation: BAH13032.1 AC136475 Genomic DNA No translation available. BC001042 mRNA Translation: AAH01042.1 AL137276 mRNA Translation: CAB70674.1 |
CCDSi | CCDS53590.1 [Q9NTG7-2] CCDS7691.1 [Q9NTG7-1] |
PIRi | T46348 |
RefSeqi | NP_001017524.1, NM_001017524.2 [Q9NTG7-2] NP_036371.1, NM_012239.5 [Q9NTG7-1] XP_016872919.1, XM_017017430.1 |
Genome annotation databases
Ensembli | ENST00000382743.9; ENSP00000372191.4; ENSG00000142082.15 ENST00000529382.5; ENSP00000437216.1; ENSG00000142082.15 [Q9NTG7-2] |
GeneIDi | 23410 |
KEGGi | hsa:23410 |
MANE-Selecti | ENST00000382743.9; ENSP00000372191.4; NM_012239.6; NP_036371.1 |
UCSCi | uc001lok.5, human [Q9NTG7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF083108 mRNA Translation: AAD40851.1 AK299438 mRNA Translation: BAH13032.1 AC136475 Genomic DNA No translation available. BC001042 mRNA Translation: AAH01042.1 AL137276 mRNA Translation: CAB70674.1 |
CCDSi | CCDS53590.1 [Q9NTG7-2] CCDS7691.1 [Q9NTG7-1] |
PIRi | T46348 |
RefSeqi | NP_001017524.1, NM_001017524.2 [Q9NTG7-2] NP_036371.1, NM_012239.5 [Q9NTG7-1] XP_016872919.1, XM_017017430.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3GLR | X-ray | 1.80 | A | 118-399 | [»] | |
3GLS | X-ray | 2.70 | A/B/C/D/E/F | 118-399 | [»] | |
3GLT | X-ray | 2.10 | A | 118-399 | [»] | |
3GLU | X-ray | 2.50 | A | 118-399 | [»] | |
4BN4 | X-ray | 1.30 | A | 116-399 | [»] | |
4BN5 | X-ray | 3.25 | A/B/C/D/E/F/G/H/I/J/K/L | 119-399 | [»] | |
4BV3 | X-ray | 2.00 | A | 116-399 | [»] | |
4BVB | X-ray | 2.00 | A | 116-399 | [»] | |
4BVE | X-ray | 2.05 | A | 116-399 | [»] | |
4BVF | X-ray | 2.70 | A | 116-399 | [»] | |
4BVG | X-ray | 2.50 | A | 116-399 | [»] | |
4BVH | X-ray | 1.90 | A/B/C | 116-399 | [»] | |
4C78 | X-ray | 2.00 | A | 116-399 | [»] | |
4C7B | X-ray | 2.10 | A | 117-399 | [»] | |
4FVT | X-ray | 2.47 | A | 122-395 | [»] | |
4FZ3 | X-ray | 2.10 | A | 118-399 | [»] | |
4HD8 | X-ray | 2.30 | A | 116-399 | [»] | |
4JSR | X-ray | 1.70 | A | 118-399 | [»] | |
4JT8 | X-ray | 2.26 | A | 118-399 | [»] | |
4JT9 | X-ray | 2.24 | A | 118-399 | [»] | |
4O8Z | X-ray | 2.00 | A | 116-399 | [»] | |
5BWN | X-ray | 1.94 | A | 118-399 | [»] | |
5BWO | X-ray | 2.38 | A | 118-399 | [»] | |
5D7N | X-ray | 1.83 | A/B/C/D/E/F | 118-395 | [»] | |
5H4D | X-ray | 3.21 | A/H | 121-391 | [»] | |
5Y4H | X-ray | 2.60 | A | 118-399 | [»] | |
5YTK | X-ray | 2.70 | A/B/C/D/E/F | 121-394 | [»] | |
5Z93 | X-ray | 1.95 | A | 117-399 | [»] | |
5Z94 | X-ray | 1.90 | A/B | 117-399 | [»] | |
5ZGC | X-ray | 2.90 | A/B/C/D/E/F | 121-394 | [»] | |
6ISO | X-ray | 2.95 | A/B/E/G/I/K | 121-394 | [»] | |
AlphaFoldDBi | Q9NTG7 | |||||
SMRi | Q9NTG7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116982, 87 interactors |
DIPi | DIP-46861N |
IntActi | Q9NTG7, 56 interactors |
MINTi | Q9NTG7 |
STRINGi | 9606.ENSP00000372191 |
Chemistry databases
BindingDBi | Q9NTG7 |
ChEMBLi | CHEMBL4461 |
DrugBanki | DB02059, Adenosine-5-Diphosphoribose |
DrugCentrali | Q9NTG7 |
GuidetoPHARMACOLOGYi | 2709 |
PTM databases
iPTMneti | Q9NTG7 |
PhosphoSitePlusi | Q9NTG7 |
Genetic variation databases
BioMutai | SIRT3 |
DMDMi | 38258651 |
Proteomic databases
EPDi | Q9NTG7 |
jPOSTi | Q9NTG7 |
MassIVEi | Q9NTG7 |
MaxQBi | Q9NTG7 |
PaxDbi | Q9NTG7 |
PeptideAtlasi | Q9NTG7 |
PRIDEi | Q9NTG7 |
ProteomicsDBi | 82606 [Q9NTG7-1] 82607 [Q9NTG7-2] |
Protocols and materials databases
Antibodypediai | 9472, 774 antibodies from 47 providers |
DNASUi | 23410 |
Genome annotation databases
Ensembli | ENST00000382743.9; ENSP00000372191.4; ENSG00000142082.15 ENST00000529382.5; ENSP00000437216.1; ENSG00000142082.15 [Q9NTG7-2] |
GeneIDi | 23410 |
KEGGi | hsa:23410 |
MANE-Selecti | ENST00000382743.9; ENSP00000372191.4; NM_012239.6; NP_036371.1 |
UCSCi | uc001lok.5, human [Q9NTG7-1] |
Organism-specific databases
CTDi | 23410 |
DisGeNETi | 23410 |
GeneCardsi | SIRT3 |
HGNCi | HGNC:14931, SIRT3 |
HPAi | ENSG00000142082, Low tissue specificity |
MIMi | 604481, gene |
neXtProti | NX_Q9NTG7 |
OpenTargetsi | ENSG00000142082 |
PharmGKBi | PA37936 |
VEuPathDBi | HostDB:ENSG00000142082 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2682, Eukaryota |
GeneTreei | ENSGT00940000159464 |
HOGENOMi | CLU_023643_7_0_1 |
InParanoidi | Q9NTG7 |
OMAi | PCSRLPR |
OrthoDBi | 973532at2759 |
PhylomeDBi | Q9NTG7 |
TreeFami | TF106181 |
Enzyme and pathway databases
BRENDAi | 2.3.1.24, 2681 2.3.1.286, 2681 |
PathwayCommonsi | Q9NTG7 |
Reactomei | R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis R-HSA-9615017, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-HSA-9617629, Regulation of FOXO transcriptional activity by acetylation |
SABIO-RKi | Q9NTG7 |
SignaLinki | Q9NTG7 |
SIGNORi | Q9NTG7 |
Miscellaneous databases
BioGRID-ORCSi | 23410, 12 hits in 1094 CRISPR screens |
ChiTaRSi | SIRT3, human |
EvolutionaryTracei | Q9NTG7 |
GeneWikii | SIRT3 |
GenomeRNAii | 23410 |
Pharosi | Q9NTG7, Tchem |
PROi | PR:Q9NTG7 |
RNActi | Q9NTG7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000142082, Expressed in anterior cingulate cortex and 226 other tissues |
ExpressionAtlasi | Q9NTG7, baseline and differential |
Genevisiblei | Q9NTG7, HS |
Family and domain databases
Gene3Di | 3.30.1600.10, 1 hit |
InterProi | View protein in InterPro IPR029035, DHS-like_NAD/FAD-binding_dom IPR003000, Sirtuin IPR026591, Sirtuin_cat_small_dom_sf IPR026590, Ssirtuin_cat_dom |
Pfami | View protein in Pfam PF02146, SIR2, 1 hit |
SUPFAMi | SSF52467, SSF52467, 1 hit |
PROSITEi | View protein in PROSITE PS50305, SIRTUIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SIR3_HUMAN | |
Accessioni | Q9NTG7Primary (citable) accession number: Q9NTG7 Secondary accession number(s): B7Z5U6, Q9Y6E8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2003 |
Last sequence update: | October 31, 2003 | |
Last modified: | May 25, 2022 | |
This is version 182 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families