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UniProtKB - Q9NTG7 (SIR3_HUMAN)

Entry version 173 (17 Jun 2020)
Sequence version 2 (31 Oct 2003)
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Protein

NAD-dependent protein deacetylase sirtuin-3, mitochondrial

Gene

SIRT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NAD-dependent protein deacetylase (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090, PubMed:19535340). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090). Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5PO (PubMed:16788062, PubMed:18680753, PubMed:24121500, PubMed:24252090, PubMed:19535340). Contributes to the regulation of the cellular energy metabolism (PubMed:24252090). Important for regulating tissue-specific ATP levels (PubMed:18794531). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301). Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation (By similarity).By similarity9 Publications

Miscellaneous

Has some ability to deacetylate histones in vitro, but seeing its subcellular location, this is unlikely in vivo.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+2 PublicationsNote: Binds 1 zinc ion per subunit.2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=600 µM for NAD1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei248Proton acceptor3 Publications1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi256Zinc2 Publications1
    Metal bindingi259Zinc2 Publications1
    Metal bindingi280Zinc2 Publications1
    Metal bindingi283Zinc2 Publications1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi145 – 165NAD1 PublicationAdd BLAST21
    Nucleotide bindingi228 – 231NAD1 Publication4
    Nucleotide bindingi319 – 321NAD1 Publication3
    Nucleotide bindingi344 – 346NAD1 Publication3

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionTransferase
    LigandMetal-binding, NAD, Zinc

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
    R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
    R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		Q9NTG7

    SIGNOR Signaling Network Open Resource

    More...    SIGNORi    		Q9NTG7

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    NAD-dependent protein deacetylase sirtuin-3, mitochondrial (EC:2.3.1.2867 Publications)
    Short name:
    hSIRT3
    Alternative name(s):
    Regulatory protein SIR2 homolog 3
    SIR2-like protein 3
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SIRT3
    Synonyms:SIR2L3
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...    EuPathDBi    		HostDB:ENSG00000142082.14

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:14931 SIRT3

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		604481 gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_Q9NTG7

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Mitochondrion

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi7R → G or Q: Suppresses targeting to mitochondrion; when associated with G-13 or Q-13. 1 Publication1
    Mutagenesisi13R → G or Q: Suppresses targeting to mitochondrion; when associated with G-7 or Q-7. 1 Publication1
    Mutagenesisi17R → G or Q: Reduces targeting to mitochondrion; when associated with G-21 or Q-21. 1 Publication1
    Mutagenesisi21R → G or Q: Reduces targeting to mitochondrion; when associated with G-17 or Q-17. 1 Publication1
    Mutagenesisi99 – 100RR → GG: Abolishes processing by MPP (in vitro). 1 Publication2
    Mutagenesisi229N → A: Loss of function. 1 Publication1
    Mutagenesisi248H → Y: Loss of function. 3 Publications1

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		23410

    Open Targets

    More...    OpenTargetsi    		ENSG00000142082

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA37936

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		Q9NTG7 Tchem

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...    ChEMBLi    		CHEMBL4461

    Drug and drug target database

    More...    DrugBanki    		DB02059 Adenosine-5-Diphosphoribose

    DrugCentral

    More...    DrugCentrali    		Q9NTG7

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...    GuidetoPHARMACOLOGYi    		2709

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		SIRT3

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		38258651

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – ?MitochondrionSequence analysis
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000032612? – 399NAD-dependent protein deacetylase sirtuin-3, mitochondrial

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei122N6-succinyllysineBy similarity1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Processed by mitochondrial processing peptidase (MPP) to give a 28 kDa product. Such processing is probably essential for its enzymatic activity.1 Publication

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		Q9NTG7

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		Q9NTG7

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		Q9NTG7

    MaxQB - The MaxQuant DataBase

    More...    MaxQBi    		Q9NTG7

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		Q9NTG7

    PeptideAtlas

    More...    PeptideAtlasi    		Q9NTG7

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q9NTG7

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		82606 [Q9NTG7-1]
    82607 [Q9NTG7-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		Q9NTG7

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		Q9NTG7

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Widely expressed.2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000142082 Expressed in anterior cingulate cortex and 213 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		Q9NTG7 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		Q9NTG7 HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000142082 Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Upon metabolic stress, forms a complex composed of FOXO3, SIRT3 and mitochondrial RNA polymerase POLRMT; the complex is recruited to mtDNA in a SIRT3-dependent manner (PubMed:23283301). Also forms a complex composed of FOXO3, SIRT3, TFAM and POLRMT (PubMed:29445193).

    Interacts with NDUFA9, ACSS1, IDH2 and GDH (PubMed:16788062, PubMed:18794531, PubMed:19535340, PubMed:18680753).

    Interacts with PCCA (PubMed:23438705).

    7 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Hide details

    GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		116982, 61 interactors

    Database of interacting proteins

    More...    DIPi    		DIP-46861N

    Protein interaction database and analysis system

    More...    IntActi    		Q9NTG7, 55 interactors

    Molecular INTeraction database

    More...    MINTi    		Q9NTG7

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000372191

    Chemistry databases

    BindingDB database of measured binding affinities

    More...    BindingDBi    		Q9NTG7

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		Q9NTG7 protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1399
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		Q9NTG7

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...    EvolutionaryTracei    		Q9NTG7

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini126 – 382Deacetylase sirtuin-typePROSITE-ProRule annotationAdd BLAST257

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the sirtuin family. Class I subfamily.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG2682 Eukaryota
    COG0846 LUCA

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000159464

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_023643_7_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		Q9NTG7

    KEGG Orthology (KO)

    More...    KOi    		K11413

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		GNYRPNA

    Database of Orthologous Groups

    More...    OrthoDBi    		973532at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		Q9NTG7

    TreeFam database of animal gene trees

    More...    TreeFami    		TF106181

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...    Gene3Di    		3.30.1600.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR029035 DHS-like_NAD/FAD-binding_dom
    IPR003000 Sirtuin
    IPR026591 Sirtuin_cat_small_dom_sf
    IPR017328 Sirtuin_class_I
    IPR026590 Ssirtuin_cat_dom

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF02146 SIR2, 1 hit

    PIRSF; a whole-protein classification database

    More...    PIRSFi    		PIRSF037938 SIR2_euk, 1 hit

    Superfamily database of structural and functional annotation

    More...    SUPFAMi    		SSF52467 SSF52467, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS50305 SIRTUIN, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9NTG7-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MAFWGWRAAA ALRLWGRVVE RVEAGGGVGP FQACGCRLVL GGRDDVSAGL 
            60         70         80         90        100
    RGSHGARGEP LDPARPLQRP PRPEVPRAFR RQPRAAAPSF FFSSIKGGRR 
           110        120        130        140        150
    SISFSVGASS VVGSGGSSDK GKLSLQDVAE LIRARACQRV VVMVGAGIST 
           160        170        180        190        200
    PSGIPDFRSP GSGLYSNLQQ YDLPYPEAIF ELPFFFHNPK PFFTLAKELY 
           210        220        230        240        250
    PGNYKPNVTH YFLRLLHDKG LLLRLYTQNI DGLERVSGIP ASKLVEAHGT 
           260        270        280        290        300
    FASATCTVCQ RPFPGEDIRA DVMADRVPRC PVCTGVVKPD IVFFGEPLPQ 
           310        320        330        340        350
    RFLLHVVDFP MADLLLILGT SLEVEPFASL TEAVRSSVPR LLINRDLVGP 
           360        370        380        390 
    LAWHPRSRDV AQLGDVVHGV ESLVELLGWT EEMRDLVQRE TGKLDGPDK
    Length:399
    Mass (Da):43,573
    Last modified:October 31, 2003 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4BA8BD3AC5FC7901
    GO
    Isoform 2 (identifier: Q9NTG7-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-142: Missing.

    Show »
    Length:257
    Mass (Da):28,567
    Checksum:i33043FAB6B3F0307
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    E9PK80E9PK80_HUMAN
    NAD-dependent protein deacetylase
    SIRT3
    		318Annotation score:

    Annotation score:3 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PM75E9PM75_HUMAN
    NAD-dependent protein deacetylase s...
    SIRT3
    		345Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PN58E9PN58_HUMAN
    NAD-dependent protein deacetylase s...
    SIRT3
    		353Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    B7WNN4B7WNN4_HUMAN
    NAD-dependent protein deacetylase s...
    SIRT3
    		134Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PJS6E9PJS6_HUMAN
    NAD-dependent protein deacetylase s...
    SIRT3
    		95Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PM52E9PM52_HUMAN
    NAD-dependent protein deacetylase s...
    SIRT3
    		23Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PIT6E9PIT6_HUMAN
    NAD-dependent protein deacetylase s...
    SIRT3
    		46Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PNA0E9PNA0_HUMAN
    NAD-dependent protein deacetylase s...
    SIRT3
    		93Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    E9PR48E9PR48_HUMAN
    NAD-dependent protein deacetylase s...
    SIRT3
    		18Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05197780R → W. Corresponds to variant dbSNP:rs28365927Ensembl.1
    Natural variantiVAR_051978208V → I. Corresponds to variant dbSNP:rs11246020Ensembl.1
    Natural variantiVAR_051979369G → S. Corresponds to variant dbSNP:rs3020901Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0437921 – 142Missing in isoform 2. 1 PublicationAdd BLAST142

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		AF083108 mRNA Translation: AAD40851.1
    AK299438 mRNA Translation: BAH13032.1
    AC136475 Genomic DNA No translation available.
    BC001042 mRNA Translation: AAH01042.1
    AL137276 mRNA Translation: CAB70674.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS53590.1 [Q9NTG7-2]
    CCDS7691.1 [Q9NTG7-1]

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		T46348

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001017524.1, NM_001017524.2 [Q9NTG7-2]
    NP_036371.1, NM_012239.5 [Q9NTG7-1]
    XP_016872919.1, XM_017017430.1

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000382743; ENSP00000372191; ENSG00000142082 [Q9NTG7-1]
    ENST00000529382; ENSP00000437216; ENSG00000142082 [Q9NTG7-2]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		23410

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:23410

    UCSC genome browser

    More...    UCSCi    		uc001lok.5 human [Q9NTG7-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AF083108 mRNA Translation: AAD40851.1
    AK299438 mRNA Translation: BAH13032.1
    AC136475 Genomic DNA No translation available.
    BC001042 mRNA Translation: AAH01042.1
    AL137276 mRNA Translation: CAB70674.1
    CCDSiCCDS53590.1 [Q9NTG7-2]
    CCDS7691.1 [Q9NTG7-1]
    PIRiT46348
    RefSeqiNP_001017524.1, NM_001017524.2 [Q9NTG7-2]
    NP_036371.1, NM_012239.5 [Q9NTG7-1]
    XP_016872919.1, XM_017017430.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3GLRX-ray1.80A118-399[»]
    3GLSX-ray2.70A/B/C/D/E/F118-399[»]
    3GLTX-ray2.10A118-399[»]
    3GLUX-ray2.50A118-399[»]
    4BN4X-ray1.30A116-399[»]
    4BN5X-ray3.25A/B/C/D/E/F/G/H/I/J/K/L119-399[»]
    4BV3X-ray2.00A116-399[»]
    4BVBX-ray2.00A116-399[»]
    4BVEX-ray2.05A116-399[»]
    4BVFX-ray2.70A116-399[»]
    4BVGX-ray2.50A116-399[»]
    4BVHX-ray1.90A/B/C116-399[»]
    4C78X-ray2.00A116-399[»]
    4C7BX-ray2.10A117-399[»]
    4FVTX-ray2.47A122-395[»]
    4FZ3X-ray2.10A118-399[»]
    4HD8X-ray2.30A116-399[»]
    4JSRX-ray1.70A118-399[»]
    4JT8X-ray2.26A118-399[»]
    4JT9X-ray2.24A118-399[»]
    4O8ZX-ray2.00A116-399[»]
    5BWNX-ray1.94A118-399[»]
    5BWOX-ray2.38A118-399[»]
    5D7NX-ray1.83A/B/C/D/E/F118-395[»]
    5H4DX-ray3.21A/H121-391[»]
    5Y4HX-ray2.60A118-399[»]
    5YTKX-ray2.70A/B/C/D/E/F121-394[»]
    5Z93X-ray1.95A117-399[»]
    5Z94X-ray1.90A/B117-399[»]
    5ZGCX-ray2.90A/B/C/D/E/F121-394[»]
    6ISOX-ray2.95A/B/E/G/I/K121-394[»]
    SMRiQ9NTG7
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi116982, 61 interactors
    DIPiDIP-46861N
    IntActiQ9NTG7, 55 interactors
    MINTiQ9NTG7
    STRINGi9606.ENSP00000372191

    Chemistry databases

    BindingDBiQ9NTG7
    ChEMBLiCHEMBL4461
    DrugBankiDB02059 Adenosine-5-Diphosphoribose
    DrugCentraliQ9NTG7
    GuidetoPHARMACOLOGYi2709

    PTM databases

    iPTMnetiQ9NTG7
    PhosphoSitePlusiQ9NTG7

    Polymorphism and mutation databases

    BioMutaiSIRT3
    DMDMi38258651

    Proteomic databases

    EPDiQ9NTG7
    jPOSTiQ9NTG7
    MassIVEiQ9NTG7
    MaxQBiQ9NTG7
    PaxDbiQ9NTG7
    PeptideAtlasiQ9NTG7
    PRIDEiQ9NTG7
    ProteomicsDBi82606 [Q9NTG7-1]
    82607 [Q9NTG7-2]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		9472 730 antibodies

    Genome annotation databases

    EnsembliENST00000382743; ENSP00000372191; ENSG00000142082 [Q9NTG7-1]
    ENST00000529382; ENSP00000437216; ENSG00000142082 [Q9NTG7-2]
    GeneIDi23410
    KEGGihsa:23410
    UCSCiuc001lok.5 human [Q9NTG7-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		23410
    DisGeNETi23410
    EuPathDBiHostDB:ENSG00000142082.14

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		SIRT3
    HGNCiHGNC:14931 SIRT3
    HPAiENSG00000142082 Low tissue specificity
    MIMi604481 gene
    neXtProtiNX_Q9NTG7
    OpenTargetsiENSG00000142082
    PharmGKBiPA37936

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG2682 Eukaryota
    COG0846 LUCA
    GeneTreeiENSGT00940000159464
    HOGENOMiCLU_023643_7_0_1
    InParanoidiQ9NTG7
    KOiK11413
    OMAiGNYRPNA
    OrthoDBi973532at2759
    PhylomeDBiQ9NTG7
    TreeFamiTF106181

    Enzyme and pathway databases

    ReactomeiR-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
    R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
    R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation
    SABIO-RKiQ9NTG7
    SIGNORiQ9NTG7

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		23410 1 hit in 788 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		SIRT3 human
    EvolutionaryTraceiQ9NTG7

    The Gene Wiki collection of pages on human genes and proteins

    More...    GeneWikii    		SIRT3

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		23410
    PharosiQ9NTG7 Tchem

    Protein Ontology

    More...    PROi    		PR:Q9NTG7
    RNActiQ9NTG7 protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000142082 Expressed in anterior cingulate cortex and 213 other tissues
    ExpressionAtlasiQ9NTG7 baseline and differential
    GenevisibleiQ9NTG7 HS

    Family and domain databases

    Gene3Di3.30.1600.10, 1 hit
    InterProiView protein in InterPro
    IPR029035 DHS-like_NAD/FAD-binding_dom
    IPR003000 Sirtuin
    IPR026591 Sirtuin_cat_small_dom_sf
    IPR017328 Sirtuin_class_I
    IPR026590 Ssirtuin_cat_dom
    PfamiView protein in Pfam
    PF02146 SIR2, 1 hit
    PIRSFiPIRSF037938 SIR2_euk, 1 hit
    SUPFAMiSSF52467 SSF52467, 1 hit
    PROSITEiView protein in PROSITE
    PS50305 SIRTUIN, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIR3_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NTG7
    Secondary accession number(s): B7Z5U6, Q9Y6E8
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
    Last sequence update: October 31, 2003
    Last modified: June 17, 2020
    This is version 173 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    4. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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