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Entry version 182 (25 May 2022)
Sequence version 2 (31 Oct 2003)
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Protein

NAD-dependent protein deacetylase sirtuin-3, mitochondrial

Gene

SIRT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NAD-dependent protein deacetylase (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090, PubMed:19535340).

Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090).

Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5PO (PubMed:16788062, PubMed:18680753, PubMed:24121500, PubMed:24252090, PubMed:19535340).

Contributes to the regulation of the cellular energy metabolism (PubMed:24252090).

Important for regulating tissue-specific ATP levels (PubMed:18794531).

In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301).

Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation (By similarity).

By similarity9 Publications

Miscellaneous

Has some ability to deacetylate histones in vitro, but seeing its subcellular location, this is unlikely in vivo.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+2 PublicationsNote: Binds 1 zinc ion per subunit.2 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=600 µM for NAD1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei248Proton acceptor3 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi256Zinc2 Publications1
Metal bindingi259Zinc2 Publications1
Metal bindingi280Zinc2 Publications1
Metal bindingi283Zinc2 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi145 – 165NAD1 PublicationAdd BLAST21
Nucleotide bindingi228 – 231NAD1 Publication4
Nucleotide bindingi319 – 321NAD1 Publication3
Nucleotide bindingi344 – 346NAD1 Publication3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.3.1.24, 2681
2.3.1.286, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9NTG7

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis
R-HSA-9615017, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
R-HSA-9617629, Regulation of FOXO transcriptional activity by acetylation

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q9NTG7

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q9NTG7

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9NTG7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (EC:2.3.1.2867 Publications)
Short name:
hSIRT3
Alternative name(s):
Regulatory protein SIR2 homolog 3
SIR2-like protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SIRT3
Synonyms:SIR2L3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14931, SIRT3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604481, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NTG7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000142082

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi7R → G or Q: Suppresses targeting to mitochondrion; when associated with G-13 or Q-13. 1 Publication1
Mutagenesisi13R → G or Q: Suppresses targeting to mitochondrion; when associated with G-7 or Q-7. 1 Publication1
Mutagenesisi17R → G or Q: Reduces targeting to mitochondrion; when associated with G-21 or Q-21. 1 Publication1
Mutagenesisi21R → G or Q: Reduces targeting to mitochondrion; when associated with G-17 or Q-17. 1 Publication1
Mutagenesisi99 – 100RR → GG: Abolishes processing by MPP (in vitro). 1 Publication2
Mutagenesisi229N → A: Loss of function. 1 Publication1
Mutagenesisi248H → Y: Loss of function. 3 Publications1

Organism-specific databases

DisGeNET

More...
DisGeNETi
23410

Open Targets

More...
OpenTargetsi
ENSG00000142082

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37936

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NTG7, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4461

Drug and drug target database

More...
DrugBanki
DB02059, Adenosine-5-Diphosphoribose

DrugCentral

More...
DrugCentrali
Q9NTG7

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2709

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SIRT3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
38258651

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – ?MitochondrionSequence analysis
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000032612? – 399NAD-dependent protein deacetylase sirtuin-3, mitochondrial

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei122N6-succinyllysineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Processed by mitochondrial processing peptidase (MPP) to give a 28 kDa product. Such processing is probably essential for its enzymatic activity.1 Publication

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NTG7

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NTG7

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9NTG7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NTG7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NTG7

PeptideAtlas

More...
PeptideAtlasi
Q9NTG7

PRoteomics IDEntifications database

More...
PRIDEi
Q9NTG7

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
82606 [Q9NTG7-1]
82607 [Q9NTG7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NTG7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NTG7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000142082, Expressed in anterior cingulate cortex and 226 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NTG7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NTG7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000142082, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Upon metabolic stress, forms a complex composed of FOXO3, SIRT3 and mitochondrial RNA polymerase POLRMT; the complex is recruited to mtDNA in a SIRT3-dependent manner (PubMed:23283301). Also forms a complex composed of FOXO3, SIRT3, TFAM and POLRMT (PubMed:29445193).

Interacts with NDUFA9, ACSS1, IDH2 and GDH (PubMed:16788062, PubMed:18794531, PubMed:19535340, PubMed:18680753).

Interacts with PCCA (PubMed:23438705).

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
116982, 87 interactors

Database of interacting proteins

More...
DIPi
DIP-46861N

Protein interaction database and analysis system

More...
IntActi
Q9NTG7, 56 interactors

Molecular INTeraction database

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MINTi
Q9NTG7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000372191

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9NTG7

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NTG7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1399
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q9NTG7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NTG7

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9NTG7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini126 – 382Deacetylase sirtuin-typePROSITE-ProRule annotationAdd BLAST257

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni49 – 74DisorderedSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sirtuin family. Class I subfamily.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2682, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000159464

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_023643_7_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NTG7

Identification of Orthologs from Complete Genome Data

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OMAi
PCSRLPR

Database of Orthologous Groups

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OrthoDBi
973532at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9NTG7

TreeFam database of animal gene trees

More...
TreeFami
TF106181

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1600.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029035, DHS-like_NAD/FAD-binding_dom
IPR003000, Sirtuin
IPR026591, Sirtuin_cat_small_dom_sf
IPR026590, Ssirtuin_cat_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02146, SIR2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52467, SSF52467, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50305, SIRTUIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NTG7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFWGWRAAA ALRLWGRVVE RVEAGGGVGP FQACGCRLVL GGRDDVSAGL
60 70 80 90 100
RGSHGARGEP LDPARPLQRP PRPEVPRAFR RQPRAAAPSF FFSSIKGGRR
110 120 130 140 150
SISFSVGASS VVGSGGSSDK GKLSLQDVAE LIRARACQRV VVMVGAGIST
160 170 180 190 200
PSGIPDFRSP GSGLYSNLQQ YDLPYPEAIF ELPFFFHNPK PFFTLAKELY
210 220 230 240 250
PGNYKPNVTH YFLRLLHDKG LLLRLYTQNI DGLERVSGIP ASKLVEAHGT
260 270 280 290 300
FASATCTVCQ RPFPGEDIRA DVMADRVPRC PVCTGVVKPD IVFFGEPLPQ
310 320 330 340 350
RFLLHVVDFP MADLLLILGT SLEVEPFASL TEAVRSSVPR LLINRDLVGP
360 370 380 390
LAWHPRSRDV AQLGDVVHGV ESLVELLGWT EEMRDLVQRE TGKLDGPDK
Length:399
Mass (Da):43,573
Last modified:October 31, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4BA8BD3AC5FC7901
GO
Isoform 2 (identifier: Q9NTG7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-142: Missing.

Show »
Length:257
Mass (Da):28,567
Checksum:i33043FAB6B3F0307
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PK80E9PK80_HUMAN
NAD-dependent protein deacetylase
SIRT3
318Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PN58E9PN58_HUMAN
NAD-dependent protein deacetylase s...
SIRT3
353Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PM75E9PM75_HUMAN
NAD-dependent protein deacetylase s...
SIRT3
345Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7WNN4B7WNN4_HUMAN
NAD-dependent protein deacetylase s...
SIRT3
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PM52E9PM52_HUMAN
NAD-dependent protein deacetylase s...
SIRT3
23Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJS6E9PJS6_HUMAN
NAD-dependent protein deacetylase s...
SIRT3
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNA0E9PNA0_HUMAN
NAD-dependent protein deacetylase s...
SIRT3
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PR48E9PR48_HUMAN
NAD-dependent protein deacetylase s...
SIRT3
18Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIT6E9PIT6_HUMAN
NAD-dependent protein deacetylase s...
SIRT3
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05197780R → W. Corresponds to variant dbSNP:rs28365927Ensembl.1
Natural variantiVAR_051978208V → I. Corresponds to variant dbSNP:rs11246020Ensembl.1
Natural variantiVAR_051979369G → S. Corresponds to variant dbSNP:rs3020901Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0437921 – 142Missing in isoform 2. 1 PublicationAdd BLAST142

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF083108 mRNA Translation: AAD40851.1
AK299438 mRNA Translation: BAH13032.1
AC136475 Genomic DNA No translation available.
BC001042 mRNA Translation: AAH01042.1
AL137276 mRNA Translation: CAB70674.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53590.1 [Q9NTG7-2]
CCDS7691.1 [Q9NTG7-1]

Protein sequence database of the Protein Information Resource

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PIRi
T46348

NCBI Reference Sequences

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RefSeqi
NP_001017524.1, NM_001017524.2 [Q9NTG7-2]
NP_036371.1, NM_012239.5 [Q9NTG7-1]
XP_016872919.1, XM_017017430.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000382743.9; ENSP00000372191.4; ENSG00000142082.15
ENST00000529382.5; ENSP00000437216.1; ENSG00000142082.15 [Q9NTG7-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23410

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23410

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

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MANE-Selecti
ENST00000382743.9; ENSP00000372191.4; NM_012239.6; NP_036371.1

UCSC genome browser

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UCSCi
uc001lok.5, human [Q9NTG7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083108 mRNA Translation: AAD40851.1
AK299438 mRNA Translation: BAH13032.1
AC136475 Genomic DNA No translation available.
BC001042 mRNA Translation: AAH01042.1
AL137276 mRNA Translation: CAB70674.1
CCDSiCCDS53590.1 [Q9NTG7-2]
CCDS7691.1 [Q9NTG7-1]
PIRiT46348
RefSeqiNP_001017524.1, NM_001017524.2 [Q9NTG7-2]
NP_036371.1, NM_012239.5 [Q9NTG7-1]
XP_016872919.1, XM_017017430.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GLRX-ray1.80A118-399[»]
3GLSX-ray2.70A/B/C/D/E/F118-399[»]
3GLTX-ray2.10A118-399[»]
3GLUX-ray2.50A118-399[»]
4BN4X-ray1.30A116-399[»]
4BN5X-ray3.25A/B/C/D/E/F/G/H/I/J/K/L119-399[»]
4BV3X-ray2.00A116-399[»]
4BVBX-ray2.00A116-399[»]
4BVEX-ray2.05A116-399[»]
4BVFX-ray2.70A116-399[»]
4BVGX-ray2.50A116-399[»]
4BVHX-ray1.90A/B/C116-399[»]
4C78X-ray2.00A116-399[»]
4C7BX-ray2.10A117-399[»]
4FVTX-ray2.47A122-395[»]
4FZ3X-ray2.10A118-399[»]
4HD8X-ray2.30A116-399[»]
4JSRX-ray1.70A118-399[»]
4JT8X-ray2.26A118-399[»]
4JT9X-ray2.24A118-399[»]
4O8ZX-ray2.00A116-399[»]
5BWNX-ray1.94A118-399[»]
5BWOX-ray2.38A118-399[»]
5D7NX-ray1.83A/B/C/D/E/F118-395[»]
5H4DX-ray3.21A/H121-391[»]
5Y4HX-ray2.60A118-399[»]
5YTKX-ray2.70A/B/C/D/E/F121-394[»]
5Z93X-ray1.95A117-399[»]
5Z94X-ray1.90A/B117-399[»]
5ZGCX-ray2.90A/B/C/D/E/F121-394[»]
6ISOX-ray2.95A/B/E/G/I/K121-394[»]
AlphaFoldDBiQ9NTG7
SMRiQ9NTG7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116982, 87 interactors
DIPiDIP-46861N
IntActiQ9NTG7, 56 interactors
MINTiQ9NTG7
STRINGi9606.ENSP00000372191

Chemistry databases

BindingDBiQ9NTG7
ChEMBLiCHEMBL4461
DrugBankiDB02059, Adenosine-5-Diphosphoribose
DrugCentraliQ9NTG7
GuidetoPHARMACOLOGYi2709

PTM databases

iPTMnetiQ9NTG7
PhosphoSitePlusiQ9NTG7

Genetic variation databases

BioMutaiSIRT3
DMDMi38258651

Proteomic databases

EPDiQ9NTG7
jPOSTiQ9NTG7
MassIVEiQ9NTG7
MaxQBiQ9NTG7
PaxDbiQ9NTG7
PeptideAtlasiQ9NTG7
PRIDEiQ9NTG7
ProteomicsDBi82606 [Q9NTG7-1]
82607 [Q9NTG7-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
9472, 774 antibodies from 47 providers

The DNASU plasmid repository

More...
DNASUi
23410

Genome annotation databases

EnsembliENST00000382743.9; ENSP00000372191.4; ENSG00000142082.15
ENST00000529382.5; ENSP00000437216.1; ENSG00000142082.15 [Q9NTG7-2]
GeneIDi23410
KEGGihsa:23410
MANE-SelectiENST00000382743.9; ENSP00000372191.4; NM_012239.6; NP_036371.1
UCSCiuc001lok.5, human [Q9NTG7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23410
DisGeNETi23410

GeneCards: human genes, protein and diseases

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GeneCardsi
SIRT3
HGNCiHGNC:14931, SIRT3
HPAiENSG00000142082, Low tissue specificity
MIMi604481, gene
neXtProtiNX_Q9NTG7
OpenTargetsiENSG00000142082
PharmGKBiPA37936
VEuPathDBiHostDB:ENSG00000142082

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2682, Eukaryota
GeneTreeiENSGT00940000159464
HOGENOMiCLU_023643_7_0_1
InParanoidiQ9NTG7
OMAiPCSRLPR
OrthoDBi973532at2759
PhylomeDBiQ9NTG7
TreeFamiTF106181

Enzyme and pathway databases

BRENDAi2.3.1.24, 2681
2.3.1.286, 2681
PathwayCommonsiQ9NTG7
ReactomeiR-HSA-2151201, Transcriptional activation of mitochondrial biogenesis
R-HSA-9615017, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
R-HSA-9617629, Regulation of FOXO transcriptional activity by acetylation
SABIO-RKiQ9NTG7
SignaLinkiQ9NTG7
SIGNORiQ9NTG7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
23410, 12 hits in 1094 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SIRT3, human
EvolutionaryTraceiQ9NTG7

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SIRT3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23410
PharosiQ9NTG7, Tchem

Protein Ontology

More...
PROi
PR:Q9NTG7
RNActiQ9NTG7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000142082, Expressed in anterior cingulate cortex and 226 other tissues
ExpressionAtlasiQ9NTG7, baseline and differential
GenevisibleiQ9NTG7, HS

Family and domain databases

Gene3Di3.30.1600.10, 1 hit
InterProiView protein in InterPro
IPR029035, DHS-like_NAD/FAD-binding_dom
IPR003000, Sirtuin
IPR026591, Sirtuin_cat_small_dom_sf
IPR026590, Ssirtuin_cat_dom
PfamiView protein in Pfam
PF02146, SIR2, 1 hit
SUPFAMiSSF52467, SSF52467, 1 hit
PROSITEiView protein in PROSITE
PS50305, SIRTUIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIR3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NTG7
Secondary accession number(s): B7Z5U6, Q9Y6E8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 31, 2003
Last modified: May 25, 2022
This is version 182 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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