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Entry version 153 (12 Aug 2020)
Sequence version 2 (19 Sep 2002)
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Protein

Polycystic kidney disease and receptor for egg jelly-related protein

Gene

PKDREJ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May have a central role in fertilization. May generate a Ca2+ transporting channel directly involved in initiating the acrosome reaction of the sperm.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9NTG1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polycystic kidney disease and receptor for egg jelly-related protein
Alternative name(s):
PKD and REJ homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PKDREJ
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000130943.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9015, PKDREJ

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604670, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NTG1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 1184ExtracellularSequence analysisAdd BLAST1165
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1185 – 1205HelicalSequence analysisAdd BLAST21
Topological domaini1206 – 1389CytoplasmicSequence analysisAdd BLAST184
Transmembranei1390 – 1410HelicalSequence analysisAdd BLAST21
Topological domaini1411 – 1427ExtracellularSequence analysisAdd BLAST17
Transmembranei1428 – 1448HelicalSequence analysisAdd BLAST21
Topological domaini1449 – 1576CytoplasmicSequence analysisAdd BLAST128
Transmembranei1577 – 1597HelicalSequence analysisAdd BLAST21
Topological domaini1598 – 1607ExtracellularSequence analysis10
Transmembranei1608 – 1628HelicalSequence analysisAdd BLAST21
Topological domaini1629 – 1708CytoplasmicSequence analysisAdd BLAST80
Transmembranei1709 – 1729HelicalSequence analysisAdd BLAST21
Topological domaini1730 – 1966ExtracellularSequence analysisAdd BLAST237
Transmembranei1967 – 1987HelicalSequence analysisAdd BLAST21
Topological domaini1988 – 1996CytoplasmicSequence analysis9
Transmembranei1997 – 2017HelicalSequence analysisAdd BLAST21
Topological domaini2018 – 2042ExtracellularSequence analysisAdd BLAST25
Transmembranei2043 – 2063HelicalSequence analysisAdd BLAST21
Topological domaini2064 – 2091CytoplasmicSequence analysisAdd BLAST28
Transmembranei2092 – 2112HelicalSequence analysisAdd BLAST21
Topological domaini2113 – 2145ExtracellularSequence analysisAdd BLAST33
Transmembranei2146 – 2166HelicalSequence analysisAdd BLAST21
Topological domaini2167 – 2253CytoplasmicSequence analysisAdd BLAST87

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10343

Open Targets

More...
OpenTargetsi
ENSG00000130943

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33347

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NTG1, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PKDREJ

Domain mapping of disease mutations (DMDM)

More...
DMDMi
23396800

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002429920 – 2253Polycystic kidney disease and receptor for egg jelly-related proteinAdd BLAST2234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi242N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi345N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi349N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi481N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi674N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi849N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi890N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi923N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi939N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi958N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi965N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1836N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1893N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1944N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NTG1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NTG1

PeptideAtlas

More...
PeptideAtlasi
Q9NTG1

PRoteomics IDEntifications database

More...
PRIDEi
Q9NTG1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82605

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9NTG1, 17 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NTG1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NTG1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Exclusively expressed in testis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000130943, Expressed in sperm and 38 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NTG1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000130943, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form homomultimers or heteromultimers in combination with an as yet unidentified subunits.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
115625, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NTG1, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000253255

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NTG1, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini215 – 913REJPROSITE-ProRule annotationAdd BLAST699
Domaini1230 – 1347PLATPROSITE-ProRule annotationAdd BLAST118

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the polycystin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3599, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162080

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001765_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NTG1

KEGG Orthology (KO)

More...
KOi
K19921

Identification of Orthologs from Complete Genome Data

More...
OMAi
RFFYDVR

Database of Orthologous Groups

More...
OrthoDBi
1276906at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NTG1

TreeFam database of animal gene trees

More...
TreeFami
TF316484

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01752, PLAT_polycystin, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000203, GPS
IPR002859, PKD/REJ-like
IPR013122, PKD1_2_channel
IPR003915, PKD_2
IPR001024, PLAT/LH2_dom
IPR036392, PLAT/LH2_dom_sf
IPR042060, PLAT_polycystin1
IPR014010, REJ_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08016, PKD_channel, 1 hit
PF01477, PLAT, 1 hit
PF02010, REJ, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01433, POLYCYSTIN2

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00303, GPS, 1 hit
SM00308, LH2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49723, SSF49723, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50095, PLAT, 1 hit
PS51111, REJ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NTG1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPGPALLLL GVGLSLSVGR LPLPPVPRGA QAAVSGAPGG LLRGAPGLGV
60 70 80 90 100
RGGRALLSLR PSAVRAGGAV LSGRGSLCFP HGGTGRRWYC LDLRVLLSAQ
110 120 130 140 150
RLPWPAAPAL ALVDLQLSAR GGRLSLTWSV RLPRSPGRLA WAFRLRLLGP
160 170 180 190 200
GAARPASPAA RVSPRSAAPG PRPQQGFVAR TECPTDGPAR VMLQAVNSSS
210 220 230 240 250
HRAVESSVSC QINACVIQRV RINTDQKGAP VRLSMQAEAT INASVQLDCP
260 270 280 290 300
AARAIAQYWQ VFSVPAVGQA PDWTQPLDLP QLEIRNSPLF IHIPNNSLQW
310 320 330 340 350
GVYVFNFTVS ITTGNPKMPE VKDSDAVYVW IVRSSLQAVM LGDANITANF
360 370 380 390 400
TEQLILDGST SSDPDADSPL QGLQFFWYCT TDPRNYGGDR IILGSKEVCH
410 420 430 440 450
PEQANLKWPW ASGPVLTLLP ETLKGDHVYF FRMVIRKDSR TAFSDKRVHV
460 470 480 490 500
LQGPKAIAHI TCIENCERNF IVSDRFSLFL NCTNCASRDF YKWSILSSSG
510 520 530 540 550
GEMLFDWMGE TVTGRNGAYL SIKAFAFRHF LEAEFSISLY LACWSGVTSV
560 570 580 590 600
FRHSFIINHG PQIGECKINP AKGIALITKF VVQCSNFRDK HVPLTYKIIV
610 620 630 640 650
SDLHSVGEIS SVKENTLGTI LYLGPQSTVP PSFLPVGMLA SQYGLKIYAQ
660 670 680 690 700
VYDSLGAFSQ VTLHATAQAP TDKNSSKTVL NQLLSFTVGP SSLLSTLIQK
710 720 730 740 750
KDFLPAGYLL YIVASVLNNM KTELPLRDDR VNLRKHLIDQ SFLLPVSTLV
760 770 780 790 800
EIGQVVMTIT KLTQKPSEFT WDAQKRATMR VWQANQALQE YQQKDKRFRS
810 820 830 840 850
EQIEIVSTGI LMSLSNILKM TSPHQVVKDP FYVIESLSDT ILANKVPGNK
860 870 880 890 900
TTSMRTPNFN MYVKKVEKWG INQLFRNEKH CRNCFYPTLN VSSVPGLSAN
910 920 930 940 950
GPISTMFCDF TNDLFPWLND QENTSVEVSG FRMTGVADNG SVLEITPDVA
960 970 980 990 1000
EVYLVRKNLT FAAFNLTVGP NSEVDGSLKK TTGGFSFQVD STVLREVLVH
1010 1020 1030 1040 1050
IVTEVMVLFT VLVYTGSQIT PTALVATFLV PHDIPPFASQ SALFDPACTV
1060 1070 1080 1090 1100
KKARVVCLPV SLLQLIAQHS HSPHCTVSIV LQAPRFVMKL NDKLVRISIF
1110 1120 1130 1140 1150
SVQCLDMYGI QSEWREGYCI LGEKTSWYEV HCICKNVVRA RRQLGTIGLT
1160 1170 1180 1190 1200
GIHLHTHYVM AKVIVIPNPV DLRLNIIKSL HQNPVTLFTV LFIILLYVGL
1210 1220 1230 1240 1250
AFWALYRDEM DQHLRGHVIV LPDNDPYDNL CYLVTIFTGS RWGSGTRANV
1260 1270 1280 1290 1300
FVQLRGTVST SDVHCLSHPH FTTLYRGSIN TFLLTTKSDL GDIHSIRVWH
1310 1320 1330 1340 1350
NNEGRSPSWY LSRIKVENLF SRHIWLFICQ KWLSVDTTLD RTFHVTHPDE
1360 1370 1380 1390 1400
RLTRKDFFFI DVSSNLRKNH MWFSIFASVV AKTFNRLQRL SCCLAMLLSS
1410 1420 1430 1440 1450
LLCNIMFFNL NRQEQTESRE RKYMRSMMIG IESVLITIPV QLLITFLFTC
1460 1470 1480 1490 1500
SQRKPQADLK EVSPQKHPLM SEASEHWEEY LRKWHAYETA KVHPREVAKP
1510 1520 1530 1540 1550
ASKGKPRLPK ASPKATSKPK HRHRKAQIKT PETLGPNTNS NNNIEDDQDV
1560 1570 1580 1590 1600
HSEQHPSQKD LQQLKKKPRI VLPWWCVYVA WFLVFATSSI SSFFIVFYGL
1610 1620 1630 1640 1650
TYGYDKSIEW LFASFCSFCQ SVLLVQPSKI ILLSGFRTNK PKYCKNLSWS
1660 1670 1680 1690 1700
TKYKYTEIRL DGMRMHPEEM QRIHDQIVRI RGTRMYQPLT EDEIRIFKRK
1710 1720 1730 1740 1750
KRIKRRALLF LSYILTHFIF LALLLILIVL LRHTDCFYYN QFIRDRFSMD
1760 1770 1780 1790 1800
LATVTKLEDI YRWLNSVLLP LLHNDLNPTF LPESSSKILG LPLMRQVRAK
1810 1820 1830 1840 1850
SSEKMCLPAE KFVQNSIRRE IHCHPKYGID PEDTKNYSGF WNEVDKQAID
1860 1870 1880 1890 1900
ESTNGFTYKP QGTQWLYYSY GLLHTYGSGG YALYFFPEQQ RFNSTLRLKE
1910 1920 1930 1940 1950
LQESNWLDEK TWAVVLELTT FNPDINLFCS ISVIFEVSQL GVVNTSISLH
1960 1970 1980 1990 2000
SFSLADFDRK ASAEIYLYVA ILIFFLAYVV DEGCIIMQER ASYVRSVYNL
2010 2020 2030 2040 2050
LNFALKCIFT VLIVLFLRKH FLATGIIRFY LSNPEDFIPF HAVSQVDHIM
2060 2070 2080 2090 2100
RIILGFLLFL TILKTLRYSR FFYDVRLAQR AIQAALPGIC HMAFVVSVYF
2110 2120 2130 2140 2150
FVYMAFGYLV FGQHEWNYSN LIHSTQTVFS YCVSAFQNTE FSNNRILGVL
2160 2170 2180 2190 2200
FLSSFMLVMI CVLINLFQAV ILSAYEEMKQ PVYEEPSDEV EAMTYLCRKL
2210 2220 2230 2240 2250
RTMFSFLTSQ SKAKDEPEFF IDMLYGQPEK NSHRYLGLKT RNINGKKMVY

LVV
Length:2,253
Mass (Da):255,449
Last modified:September 19, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0878D9FE9106AAE4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05955026V → A. Corresponds to variant dbSNP:rs7293071Ensembl.1
Natural variantiVAR_050544528R → Q. Corresponds to variant dbSNP:rs6008394Ensembl.1
Natural variantiVAR_036573669A → G in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_050545914L → P. Corresponds to variant dbSNP:rs6519993Ensembl.1
Natural variantiVAR_050546992T → P. Corresponds to variant dbSNP:rs7291444Ensembl.1
Natural variantiVAR_050547993V → A. Corresponds to variant dbSNP:rs34798212Ensembl.1
Natural variantiVAR_0505481091N → S. Corresponds to variant dbSNP:rs6008384Ensembl.1
Natural variantiVAR_0343861147I → M. Corresponds to variant dbSNP:rs36125344Ensembl.1
Natural variantiVAR_0505491411N → D. Corresponds to variant dbSNP:rs35276226Ensembl.1
Natural variantiVAR_0505501528I → M. Corresponds to variant dbSNP:rs4823496Ensembl.1
Natural variantiVAR_0505511729V → I. Corresponds to variant dbSNP:rs9626829Ensembl.1
Natural variantiVAR_0365741875T → I in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1203491707Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF116458 mRNA Translation: AAD18021.1
AL031034 Genomic DNA No translation available.
AL078611 Genomic DNA No translation available.
Z93024 Genomic DNA No translation available.
CH471138 Genomic DNA Translation: EAW73411.1
AL137288 mRNA Translation: CAB70680.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14073.1

Protein sequence database of the Protein Information Resource

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PIRi
T46355

NCBI Reference Sequences

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RefSeqi
NP_006062.1, NM_006071.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000253255; ENSP00000253255; ENSG00000130943

Database of genes from NCBI RefSeq genomes

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GeneIDi
10343

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:10343

UCSC genome browser

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UCSCi
uc003bhh.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116458 mRNA Translation: AAD18021.1
AL031034 Genomic DNA No translation available.
AL078611 Genomic DNA No translation available.
Z93024 Genomic DNA No translation available.
CH471138 Genomic DNA Translation: EAW73411.1
AL137288 mRNA Translation: CAB70680.1
CCDSiCCDS14073.1
PIRiT46355
RefSeqiNP_006062.1, NM_006071.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi115625, 3 interactors
IntActiQ9NTG1, 3 interactors
STRINGi9606.ENSP00000253255

PTM databases

GlyGeniQ9NTG1, 17 sites
iPTMnetiQ9NTG1
PhosphoSitePlusiQ9NTG1

Polymorphism and mutation databases

BioMutaiPKDREJ
DMDMi23396800

Proteomic databases

MassIVEiQ9NTG1
PaxDbiQ9NTG1
PeptideAtlasiQ9NTG1
PRIDEiQ9NTG1
ProteomicsDBi82605

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
28028, 29 antibodies

Genome annotation databases

EnsembliENST00000253255; ENSP00000253255; ENSG00000130943
GeneIDi10343
KEGGihsa:10343
UCSCiuc003bhh.4, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10343
DisGeNETi10343
EuPathDBiHostDB:ENSG00000130943.6

GeneCards: human genes, protein and diseases

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GeneCardsi
PKDREJ
HGNCiHGNC:9015, PKDREJ
HPAiENSG00000130943, Tissue enriched (testis)
MIMi604670, gene
neXtProtiNX_Q9NTG1
OpenTargetsiENSG00000130943
PharmGKBiPA33347

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3599, Eukaryota
GeneTreeiENSGT00940000162080
HOGENOMiCLU_001765_0_0_1
InParanoidiQ9NTG1
KOiK19921
OMAiRFFYDVR
OrthoDBi1276906at2759
PhylomeDBiQ9NTG1
TreeFamiTF316484

Enzyme and pathway databases

PathwayCommonsiQ9NTG1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
10343, 2 hits in 863 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10343
PharosiQ9NTG1, Tdark

Protein Ontology

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PROi
PR:Q9NTG1
RNActiQ9NTG1, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000130943, Expressed in sperm and 38 other tissues
GenevisibleiQ9NTG1, HS

Family and domain databases

CDDicd01752, PLAT_polycystin, 1 hit
InterProiView protein in InterPro
IPR000203, GPS
IPR002859, PKD/REJ-like
IPR013122, PKD1_2_channel
IPR003915, PKD_2
IPR001024, PLAT/LH2_dom
IPR036392, PLAT/LH2_dom_sf
IPR042060, PLAT_polycystin1
IPR014010, REJ_dom
PfamiView protein in Pfam
PF08016, PKD_channel, 1 hit
PF01477, PLAT, 1 hit
PF02010, REJ, 1 hit
PRINTSiPR01433, POLYCYSTIN2
SMARTiView protein in SMART
SM00303, GPS, 1 hit
SM00308, LH2, 1 hit
SUPFAMiSSF49723, SSF49723, 1 hit
PROSITEiView protein in PROSITE
PS50095, PLAT, 1 hit
PS51111, REJ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKDRE_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NTG1
Secondary accession number(s): B1AJY3, O95850
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: September 19, 2002
Last modified: August 12, 2020
This is version 153 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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