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Protein

Cystathionine beta-synthase

Gene

DKFZp727E011

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-serine + L-homocysteine = L-cystathionine + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotation
Biological processAmino-acid biosynthesis, Cysteine biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cystathionine beta-synthaseUniRule annotation (EC:4.2.1.22UniRule annotation)
Gene namesi
Name:DKFZp727E011Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26123

PTM / Processingi

Proteomic databases

PeptideAtlasiQ9NTF0
PRIDEiQ9NTF0

Expressioni

Gene expression databases

GenevisibleiQ9NTF0 HS

Structurei

3D structure databases

ProteinModelPortaliQ9NTF0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini342 – 400CBSInterPro annotationAdd BLAST59

Sequence similaritiesi

Belongs to the cysteine synthase/cystathionine beta-synthase family.UniRule annotation

Keywords - Domaini

CBS domainPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1252 Eukaryota
COG0031 LUCA
HOVERGENiHBG000918
KOiK01697

Family and domain databases

InterProiView protein in InterPro
IPR000644 CBS_dom
IPR005857 Cysta_beta_synth
IPR001216 P-phosphate_BS
IPR001926 PLP-dep
IPR036052 Trypto_synt_PLP_dependent
PfamiView protein in Pfam
PF00571 CBS, 1 hit
PF00291 PALP, 1 hit
SMARTiView protein in SMART
SM00116 CBS, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR01137 cysta_beta, 1 hit
PROSITEiView protein in PROSITE
PS51371 CBS, 1 hit
PS00901 CYS_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Fragment.

Q9NTF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RPDILKKIGD TPMVRINKIG KKFGLKCELL AKCEFFNAGG SVKDRISLRM
60 70 80 90 100
IEDAERDGTL KPGDTIIEPT SGNTGIGLAL AAAVRGYRCI IVMPEKMSSE
110 120 130 140 150
KVDVLRALGA EIVRTPTNAR FDSPESHVGV AWRLKNEIPN SHILDQYRNA
160 170 180 190 200
SNPLPHYDTT ADEILQQCDG KLDMLVASVG TGGTITGIAR KLKEKCPGCR
210 220 230 240 250
IIGVDPEGSI LAEPEELNQT EQTTYEVEGI GYDFIPTVLD RTVVDKWFKS
260 270 280 290 300
NDEEAFTLAR MLIAQEGLLC GGSAGSTVAV AVKAAQELQE GQRCVVILPD
310 320 330 340 350
SVRNYMTKFL SDRWMLQKGF LKEEDLTEKK PWWWHLRVQE LGLSAPLTVL
360 370 380 390 400
PTITCGHTIE ILREKGFDQA PVVDEAGVIL GMVTLGNMLS SLLAGKVQPS
410 420 430 440 450
DQVGKVIYKQ FKQIRLTDTL GRLSHILEMD HFALVVHEQI QYHSTGKSSQ
460 470
RQMVFGVVTA IDLLNFVAAQ ERDQK
Length:475
Mass (Da):52,487
Last modified:October 1, 2000 - v1
Checksum:i3F5E2D613783A1EF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137314 mRNA Translation: CAB70691.1
RefSeqiNP_000062.1, NM_000071.2
UniGeneiHs.533013

Genome annotation databases

GeneIDi875
KEGGihsa:875

Similar proteinsi

Entry informationi

Entry nameiQ9NTF0_HUMAN
AccessioniPrimary (citable) accession number: Q9NTF0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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