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UniProtKB - Q9NT99 (LRC4B_HUMAN)

Entry version 160 (25 May 2022)
Sequence version 3 (04 Apr 2006)
Previous versions | rss
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Protein

Leucine-rich repeat-containing protein 4B

Gene

LRRC4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NT99

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-388844, Receptor-type tyrosine-protein phosphatases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9NT99

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9NT99

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.43.1.24, the neat-domain containing methaemoglobin heme sequestration (n-mhs) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 4B
Alternative name(s):
Netrin-G3 ligand
Short name:
NGL-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LRRC4B
Synonyms:LRIG4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25042, LRRC4B

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NT99

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000131409

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini36 – 576ExtracellularSequence analysisAdd BLAST541
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei577 – 597HelicalSequence analysisAdd BLAST21
Topological domaini598 – 713CytoplasmicSequence analysisAdd BLAST116

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000131409

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134890612

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NT99, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LRRC4B

Domain mapping of disease mutations (DMDM)

More...DMDMi		91207142

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 35Sequence analysisAdd BLAST35
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000023165436 – 713Leucine-rich repeat-containing protein 4BAdd BLAST678

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi224N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi333N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi374N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi385 ↔ 436PROSITE-ProRule annotation
Glycosylationi400N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi422N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi425N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi444N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi452N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei693PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated. O-glycosylated; contains sialic acid.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NT99

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NT99

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NT99

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NT99

PeptideAtlas

More...PeptideAtlasi		Q9NT99

PRoteomics IDEntifications database

More...PRIDEi		Q9NT99

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82604

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9NT99, 10 sites, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NT99

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NT99

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000131409, Expressed in frontal cortex and 123 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NT99, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NT99, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000131409, Tissue enhanced (brain, cervix, pituitary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PTPRF.

Interacts with DLG4.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		125098, 11 interactors

Protein interaction database and analysis system

More...IntActi		Q9NT99, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000471502

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NT99, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9NT99

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NT99

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini48 – 86LRRNTAdd BLAST39
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati87 – 108LRR 1Add BLAST22
Repeati111 – 132LRR 2Add BLAST22
Repeati135 – 156LRR 3Add BLAST22
Repeati159 – 180LRR 4Add BLAST22
Repeati183 – 205LRR 5Add BLAST23
Repeati208 – 229LRR 6Add BLAST22
Repeati230 – 251LRR 7Add BLAST22
Repeati254 – 275LRR 8Add BLAST22
Repeati278 – 299LRR 9Add BLAST22
Domaini311 – 363LRRCTAdd BLAST53
Domaini364 – 452Ig-like C2-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni497 – 551DisorderedSequence analysisAdd BLAST55
Regioni694 – 713DisorderedSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The last 4 C-terminal residues bind to the first 2 PDZ domains of DLG4.By similarity

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0619, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160261

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000288_18_24_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NT99

Identification of Orthologs from Complete Genome Data

More...OMAi		TSCPEAC

Database of Orthologous Groups

More...OrthoDBi		282791at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NT99

TreeFam database of animal gene trees

More...TreeFami		TF324303

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 1 hit
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000483, Cys-rich_flank_reg_C
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR026883, LRRC4B
IPR000372, LRRNT

The PANTHER Classification System

More...PANTHERi		PTHR24369:SF102, PTHR24369:SF102, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07679, I-set, 1 hit
PF13855, LRR_8, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00369, LRR_TYP, 8 hits
SM00082, LRRCT, 1 hit
SM00013, LRRNT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS51450, LRR, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9NT99-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARARGSPCP PLPPGRMSWP HGALLFLWLF SPPLGAGGGG VAVTSAAGGG 
        60         70         80         90        100
SPPATSCPVA CSCSNQASRV ICTRRDLAEV PASIPVNTRY LNLQENGIQV 
       110        120        130        140        150
IRTDTFKHLR HLEILQLSKN LVRKIEVGAF NGLPSLNTLE LFDNRLTTVP 
       160        170        180        190        200
TQAFEYLSKL RELWLRNNPI ESIPSYAFNR VPSLRRLDLG ELKRLEYISE 
       210        220        230        240        250
AAFEGLVNLR YLNLGMCNLK DIPNLTALVR LEELELSGNR LDLIRPGSFQ 
       260        270        280        290        300
GLTSLRKLWL MHAQVATIER NAFDDLKSLE ELNLSHNNLM SLPHDLFTPL 
       310        320        330        340        350
HRLERVHLNH NPWHCNCDVL WLSWWLKETV PSNTTCCARC HAPAGLKGRY 
       360        370        380        390        400
IGELDQSHFT CYAPVIVEPP TDLNVTEGMA AELKCRTGTS MTSVNWLTPN 
       410        420        430        440        450
GTLMTHGSYR VRISVLHDGT LNFTNVTVQD TGQYTCMVTN SAGNTTASAT 
       460        470        480        490        500
LNVSAVDPVA AGGTGSGGGG PGGSGGVGGG SGGYTYFTTV TVETLETQPG 
       510        520        530        540        550
EEALQPRGTE KEPPGPTTDG VWGGGRPGDA AGPASSSTTA PAPRSSRPTE 
       560        570        580        590        600
KAFTVPITDV TENALKDLDD VMKTTKIIIG CFVAITFMAA VMLVAFYKLR 
       610        620        630        640        650
KQHQLHKHHG PTRTVEIINV EDELPAASAV SVAAAAAVAS GGGVGGDSHL 
       660        670        680        690        700
ALPALERDHL NHHHYVAAAF KAHYSSNPSG GGCGGKGPPG LNSIHEPLLF 
       710 
KSGSKENVQE TQI
Length:713
Mass (Da):76,434
Last modified:April 4, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i085B5CACE28038D9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R2G0M0R2G0_HUMAN
Leucine-rich repeat-containing prot...
LRRC4B
238Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH19687 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti637 – 638AV → TA in AAH56207 (PubMed:15489334).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC008743 Genomic DNA No translation available.
BC019687 mRNA Translation: AAH19687.1 Different initiation.
BC056207 mRNA Translation: AAH56207.1
AL137451 mRNA Translation: CAB70743.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42595.1

Protein sequence database of the Protein Information Resource

More...PIRi		T46266

NCBI Reference Sequences

More...RefSeqi		NP_001073926.1, NM_001080457.1
NP_001335497.1, NM_001348568.1
XP_005259486.1, XM_005259429.4
XP_006723569.1, XM_006723506.3
XP_011525822.1, XM_011527520.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000389201.7; ENSP00000373853.3; ENSG00000131409.13
ENST00000599957.5; ENSP00000471502.1; ENSG00000131409.13
ENST00000652263.1; ENSP00000498662.1; ENSG00000131409.13

Database of genes from NCBI RefSeq genomes

More...GeneIDi		94030

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:94030

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000652263.1; ENSP00000498662.1; NM_001080457.2; NP_001073926.1

UCSC genome browser

More...UCSCi		uc002pss.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008743 Genomic DNA No translation available.
BC019687 mRNA Translation: AAH19687.1 Different initiation.
BC056207 mRNA Translation: AAH56207.1
AL137451 mRNA Translation: CAB70743.2
CCDSiCCDS42595.1
PIRiT46266
RefSeqiNP_001073926.1, NM_001080457.1
NP_001335497.1, NM_001348568.1
XP_005259486.1, XM_005259429.4
XP_006723569.1, XM_006723506.3
XP_011525822.1, XM_011527520.2

3D structure databases

AlphaFoldDBiQ9NT99
SMRiQ9NT99
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125098, 11 interactors
IntActiQ9NT99, 4 interactors
STRINGi9606.ENSP00000471502

Protein family/group databases

TCDBi8.A.43.1.24, the neat-domain containing methaemoglobin heme sequestration (n-mhs) family

PTM databases

GlyGeniQ9NT99, 10 sites, 1 O-linked glycan (1 site)
iPTMnetiQ9NT99
PhosphoSitePlusiQ9NT99

Genetic variation databases

BioMutaiLRRC4B
DMDMi91207142

Proteomic databases

EPDiQ9NT99
MassIVEiQ9NT99
MaxQBiQ9NT99
PaxDbiQ9NT99
PeptideAtlasiQ9NT99
PRIDEiQ9NT99
ProteomicsDBi82604

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		53687, 79 antibodies from 18 providers

The DNASU plasmid repository

More...DNASUi		94030

Genome annotation databases

EnsembliENST00000389201.7; ENSP00000373853.3; ENSG00000131409.13
ENST00000599957.5; ENSP00000471502.1; ENSG00000131409.13
ENST00000652263.1; ENSP00000498662.1; ENSG00000131409.13
GeneIDi94030
KEGGihsa:94030
MANE-SelectiENST00000652263.1; ENSP00000498662.1; NM_001080457.2; NP_001073926.1
UCSCiuc002pss.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		94030

GeneCards: human genes, protein and diseases

More...GeneCardsi		LRRC4B
HGNCiHGNC:25042, LRRC4B
HPAiENSG00000131409, Tissue enhanced (brain, cervix, pituitary gland)
neXtProtiNX_Q9NT99
OpenTargetsiENSG00000131409
PharmGKBiPA134890612
VEuPathDBiHostDB:ENSG00000131409

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0619, Eukaryota
GeneTreeiENSGT00940000160261
HOGENOMiCLU_000288_18_24_1
InParanoidiQ9NT99
OMAiTSCPEAC
OrthoDBi282791at2759
PhylomeDBiQ9NT99
TreeFamiTF324303

Enzyme and pathway databases

PathwayCommonsiQ9NT99
ReactomeiR-HSA-388844, Receptor-type tyrosine-protein phosphatases
SignaLinkiQ9NT99
SIGNORiQ9NT99

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		94030, 11 hits in 1070 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LRRC4B, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		94030
PharosiQ9NT99, Tbio

Protein Ontology

More...PROi		PR:Q9NT99
RNActiQ9NT99, protein

Gene expression databases

BgeeiENSG00000131409, Expressed in frontal cortex and 123 other tissues
ExpressionAtlasiQ9NT99, baseline and differential
GenevisibleiQ9NT99, HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483, Cys-rich_flank_reg_C
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR026883, LRRC4B
IPR000372, LRRNT
PANTHERiPTHR24369:SF102, PTHR24369:SF102, 1 hit
PfamiView protein in Pfam
PF07679, I-set, 1 hit
PF13855, LRR_8, 4 hits
SMARTiView protein in SMART
SM00409, IG, 1 hit
SM00408, IGc2, 1 hit
SM00369, LRR_TYP, 8 hits
SM00082, LRRCT, 1 hit
SM00013, LRRNT, 1 hit
SUPFAMiSSF48726, SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS51450, LRR, 7 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRC4B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NT99
Secondary accession number(s): Q3ZCQ4, Q58F20
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: May 25, 2022
This is version 160 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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