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Protein

Leucine-rich repeat-containing protein 4B

Gene

LRRC4B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-388844 Receptor-type tyrosine-protein phosphatases

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 4B
Alternative name(s):
Netrin-G3 ligand
Short name:
NGL-3
Gene namesi
Name:LRRC4B
Synonyms:LRIG4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000131409.12
HGNCiHGNC:25042 LRRC4B
neXtProtiNX_Q9NT99

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini36 – 576ExtracellularSequence analysisAdd BLAST541
Transmembranei577 – 597HelicalSequence analysisAdd BLAST21
Topological domaini598 – 713CytoplasmicSequence analysisAdd BLAST116

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi94030
OpenTargetsiENSG00000131409
PharmGKBiPA134890612

Polymorphism and mutation databases

BioMutaiLRRC4B
DMDMi91207142

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000023165436 – 713Leucine-rich repeat-containing protein 4BAdd BLAST678

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi224N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi333N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi374N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi385 ↔ 436PROSITE-ProRule annotation
Glycosylationi400N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi422N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi425N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi444N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi452N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei693PhosphoserineBy similarity1

Post-translational modificationi

N-glycosylated. O-glycosylated; contains sialic acid.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9NT99
MaxQBiQ9NT99
PaxDbiQ9NT99
PeptideAtlasiQ9NT99
PRIDEiQ9NT99
ProteomicsDBi82604

PTM databases

iPTMnetiQ9NT99
PhosphoSitePlusiQ9NT99

Expressioni

Gene expression databases

BgeeiENSG00000131409
CleanExiHS_LRRC4B
ExpressionAtlasiQ9NT99 baseline and differential
GenevisibleiQ9NT99 HS

Organism-specific databases

HPAiHPA058986

Interactioni

Subunit structurei

Interacts with PTPRF. Interacts with DLG4.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125098, 7 interactors
STRINGi9606.ENSP00000373853

Structurei

3D structure databases

ProteinModelPortaliQ9NT99
SMRiQ9NT99
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 86LRRNTAdd BLAST39
Repeati87 – 108LRR 1Add BLAST22
Repeati111 – 132LRR 2Add BLAST22
Repeati135 – 156LRR 3Add BLAST22
Repeati159 – 180LRR 4Add BLAST22
Repeati183 – 205LRR 5Add BLAST23
Repeati208 – 229LRR 6Add BLAST22
Repeati230 – 251LRR 7Add BLAST22
Repeati254 – 275LRR 8Add BLAST22
Repeati278 – 299LRR 9Add BLAST22
Domaini311 – 363LRRCTAdd BLAST53
Domaini364 – 452Ig-like C2-typeAdd BLAST89

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi462 – 532Gly-richAdd BLAST71
Compositional biasi633 – 639Poly-Ala7

Domaini

The last 4 C-terminal residues bind to the first 2 PDZ domains of DLG4.By similarity

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118831
HOGENOMiHOG000252924
HOVERGENiHBG052359
InParanoidiQ9NT99
KOiK16360
OMAiNPQMEPL
OrthoDBiEOG091G037N
PhylomeDBiQ9NT99
TreeFamiTF324303

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR026883 LRRC4B
IPR000372 LRRNT
PANTHERiPTHR24369:SF102 PTHR24369:SF102, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 8 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 7 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NT99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARARGSPCP PLPPGRMSWP HGALLFLWLF SPPLGAGGGG VAVTSAAGGG
60 70 80 90 100
SPPATSCPVA CSCSNQASRV ICTRRDLAEV PASIPVNTRY LNLQENGIQV
110 120 130 140 150
IRTDTFKHLR HLEILQLSKN LVRKIEVGAF NGLPSLNTLE LFDNRLTTVP
160 170 180 190 200
TQAFEYLSKL RELWLRNNPI ESIPSYAFNR VPSLRRLDLG ELKRLEYISE
210 220 230 240 250
AAFEGLVNLR YLNLGMCNLK DIPNLTALVR LEELELSGNR LDLIRPGSFQ
260 270 280 290 300
GLTSLRKLWL MHAQVATIER NAFDDLKSLE ELNLSHNNLM SLPHDLFTPL
310 320 330 340 350
HRLERVHLNH NPWHCNCDVL WLSWWLKETV PSNTTCCARC HAPAGLKGRY
360 370 380 390 400
IGELDQSHFT CYAPVIVEPP TDLNVTEGMA AELKCRTGTS MTSVNWLTPN
410 420 430 440 450
GTLMTHGSYR VRISVLHDGT LNFTNVTVQD TGQYTCMVTN SAGNTTASAT
460 470 480 490 500
LNVSAVDPVA AGGTGSGGGG PGGSGGVGGG SGGYTYFTTV TVETLETQPG
510 520 530 540 550
EEALQPRGTE KEPPGPTTDG VWGGGRPGDA AGPASSSTTA PAPRSSRPTE
560 570 580 590 600
KAFTVPITDV TENALKDLDD VMKTTKIIIG CFVAITFMAA VMLVAFYKLR
610 620 630 640 650
KQHQLHKHHG PTRTVEIINV EDELPAASAV SVAAAAAVAS GGGVGGDSHL
660 670 680 690 700
ALPALERDHL NHHHYVAAAF KAHYSSNPSG GGCGGKGPPG LNSIHEPLLF
710
KSGSKENVQE TQI
Length:713
Mass (Da):76,434
Last modified:April 4, 2006 - v3
Checksum:i085B5CACE28038D9
GO

Sequence cautioni

The sequence AAH19687 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti637 – 638AV → TA in AAH56207 (PubMed:15489334).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008743 Genomic DNA No translation available.
BC019687 mRNA Translation: AAH19687.1 Different initiation.
BC056207 mRNA Translation: AAH56207.1
AL137451 mRNA Translation: CAB70743.2
CCDSiCCDS42595.1
PIRiT46266
RefSeqiNP_001073926.1, NM_001080457.1
NP_001335497.1, NM_001348568.1
XP_005259486.1, XM_005259429.4
XP_006723569.1, XM_006723506.3
XP_011525822.1, XM_011527520.2
UniGeneiHs.120873

Genome annotation databases

EnsembliENST00000389201; ENSP00000373853; ENSG00000131409
ENST00000599957; ENSP00000471502; ENSG00000131409
GeneIDi94030
KEGGihsa:94030
UCSCiuc002pss.4 human

Similar proteinsi

Entry informationi

Entry nameiLRC4B_HUMAN
AccessioniPrimary (citable) accession number: Q9NT99
Secondary accession number(s): Q3ZCQ4, Q58F20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: June 20, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM

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