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UniProtKB - Q9NT99 (LRC4B_HUMAN)
Protein
Leucine-rich repeat-containing protein 4B
Gene
LRRC4B
Organism
Homo sapiens (Human)
Status
Functioni
Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity).
By similarityGO - Molecular functioni
- signaling receptor binding Source: GO_Central
GO - Biological processi
- positive regulation of synapse assembly Source: BHF-UCL
- regulation of postsynaptic density assembly Source: GO_Central
- regulation of presynapse assembly Source: GO_Central
- synaptic membrane adhesion Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q9NT99 |
Reactomei | R-HSA-388844, Receptor-type tyrosine-protein phosphatases |
SignaLinki | Q9NT99 |
SIGNORi | Q9NT99 |
Protein family/group databases
TCDBi | 8.A.43.1.24, the neat-domain containing methaemoglobin heme sequestration (n-mhs) family |
Names & Taxonomyi
Protein namesi | Recommended name: Leucine-rich repeat-containing protein 4BAlternative name(s): Netrin-G3 ligand Short name: NGL-3 |
Gene namesi | Name:LRRC4B Synonyms:LRIG4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25042, LRRC4B |
neXtProti | NX_Q9NT99 |
VEuPathDBi | HostDB:ENSG00000131409 |
Subcellular locationi
Plasma membrane
- presynaptic cell membrane By similarity
Other locations
Plasma Membrane
- integral component of postsynaptic density membrane Source: GO_Central
- plasma membrane Source: GO_Central
- presynaptic membrane Source: UniProtKB-SubCell
Other locations
- cerebellar mossy fiber Source: Ensembl
- glutamatergic synapse Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 36 – 576 | ExtracellularSequence analysisAdd BLAST | 541 | |
Transmembranei | 577 – 597 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 598 – 713 | CytoplasmicSequence analysisAdd BLAST | 116 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Membrane, SynapsePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000131409 |
PharmGKBi | PA134890612 |
Miscellaneous databases
Pharosi | Q9NT99, Tbio |
Genetic variation databases
BioMutai | LRRC4B |
DMDMi | 91207142 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 35 | Sequence analysisAdd BLAST | 35 | |
ChainiPRO_0000231654 | 36 – 713 | Leucine-rich repeat-containing protein 4BAdd BLAST | 678 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 224 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 283 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 333 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 374 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 385 ↔ 436 | PROSITE-ProRule annotation | ||
Glycosylationi | 400 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 422 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 425 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 444 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 452 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 693 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
N-glycosylated. O-glycosylated; contains sialic acid.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q9NT99 |
MassIVEi | Q9NT99 |
MaxQBi | Q9NT99 |
PaxDbi | Q9NT99 |
PeptideAtlasi | Q9NT99 |
PRIDEi | Q9NT99 |
ProteomicsDBi | 82604 |
PTM databases
GlyGeni | Q9NT99, 10 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q9NT99 |
PhosphoSitePlusi | Q9NT99 |
Expressioni
Gene expression databases
Bgeei | ENSG00000131409, Expressed in frontal cortex and 123 other tissues |
ExpressionAtlasi | Q9NT99, baseline and differential |
Genevisiblei | Q9NT99, HS |
Organism-specific databases
HPAi | ENSG00000131409, Tissue enhanced (brain, cervix, pituitary gland) |
Interactioni
Subunit structurei
Interacts with PTPRF.
Interacts with DLG4.
By similarityGO - Molecular functioni
- signaling receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 125098, 11 interactors |
IntActi | Q9NT99, 4 interactors |
STRINGi | 9606.ENSP00000471502 |
Miscellaneous databases
RNActi | Q9NT99, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 48 – 86 | LRRNTAdd BLAST | 39 | |
Repeati | 87 – 108 | LRR 1Add BLAST | 22 | |
Repeati | 111 – 132 | LRR 2Add BLAST | 22 | |
Repeati | 135 – 156 | LRR 3Add BLAST | 22 | |
Repeati | 159 – 180 | LRR 4Add BLAST | 22 | |
Repeati | 183 – 205 | LRR 5Add BLAST | 23 | |
Repeati | 208 – 229 | LRR 6Add BLAST | 22 | |
Repeati | 230 – 251 | LRR 7Add BLAST | 22 | |
Repeati | 254 – 275 | LRR 8Add BLAST | 22 | |
Repeati | 278 – 299 | LRR 9Add BLAST | 22 | |
Domaini | 311 – 363 | LRRCTAdd BLAST | 53 | |
Domaini | 364 – 452 | Ig-like C2-typeAdd BLAST | 89 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 497 – 551 | DisorderedSequence analysisAdd BLAST | 55 | |
Regioni | 694 – 713 | DisorderedSequence analysisAdd BLAST | 20 |
Domaini
The last 4 C-terminal residues bind to the first 2 PDZ domains of DLG4.By similarity
Keywords - Domaini
Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000160261 |
HOGENOMi | CLU_000288_18_24_1 |
InParanoidi | Q9NT99 |
OMAi | TSCPEAC |
OrthoDBi | 282791at2759 |
PhylomeDBi | Q9NT99 |
TreeFami | TF324303 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR026883, LRRC4B IPR000372, LRRNT |
PANTHERi | PTHR24369:SF102, PTHR24369:SF102, 1 hit |
Pfami | View protein in Pfam PF07679, I-set, 1 hit PF13855, LRR_8, 4 hits |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit SM00369, LRR_TYP, 8 hits SM00082, LRRCT, 1 hit SM00013, LRRNT, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS51450, LRR, 7 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9NT99-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARARGSPCP PLPPGRMSWP HGALLFLWLF SPPLGAGGGG VAVTSAAGGG
60 70 80 90 100
SPPATSCPVA CSCSNQASRV ICTRRDLAEV PASIPVNTRY LNLQENGIQV
110 120 130 140 150
IRTDTFKHLR HLEILQLSKN LVRKIEVGAF NGLPSLNTLE LFDNRLTTVP
160 170 180 190 200
TQAFEYLSKL RELWLRNNPI ESIPSYAFNR VPSLRRLDLG ELKRLEYISE
210 220 230 240 250
AAFEGLVNLR YLNLGMCNLK DIPNLTALVR LEELELSGNR LDLIRPGSFQ
260 270 280 290 300
GLTSLRKLWL MHAQVATIER NAFDDLKSLE ELNLSHNNLM SLPHDLFTPL
310 320 330 340 350
HRLERVHLNH NPWHCNCDVL WLSWWLKETV PSNTTCCARC HAPAGLKGRY
360 370 380 390 400
IGELDQSHFT CYAPVIVEPP TDLNVTEGMA AELKCRTGTS MTSVNWLTPN
410 420 430 440 450
GTLMTHGSYR VRISVLHDGT LNFTNVTVQD TGQYTCMVTN SAGNTTASAT
460 470 480 490 500
LNVSAVDPVA AGGTGSGGGG PGGSGGVGGG SGGYTYFTTV TVETLETQPG
510 520 530 540 550
EEALQPRGTE KEPPGPTTDG VWGGGRPGDA AGPASSSTTA PAPRSSRPTE
560 570 580 590 600
KAFTVPITDV TENALKDLDD VMKTTKIIIG CFVAITFMAA VMLVAFYKLR
610 620 630 640 650
KQHQLHKHHG PTRTVEIINV EDELPAASAV SVAAAAAVAS GGGVGGDSHL
660 670 680 690 700
ALPALERDHL NHHHYVAAAF KAHYSSNPSG GGCGGKGPPG LNSIHEPLLF
710
KSGSKENVQE TQI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM0R2G0 | M0R2G0_HUMAN | Leucine-rich repeat-containing prot... | LRRC4B | 238 | Annotation score: |
Sequence cautioni
The sequence AAH19687 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 637 – 638 | AV → TA in AAH56207 (PubMed:15489334).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008743 Genomic DNA No translation available. BC019687 mRNA Translation: AAH19687.1 Different initiation. BC056207 mRNA Translation: AAH56207.1 AL137451 mRNA Translation: CAB70743.2 |
CCDSi | CCDS42595.1 |
PIRi | T46266 |
RefSeqi | NP_001073926.1, NM_001080457.1 NP_001335497.1, NM_001348568.1 XP_005259486.1, XM_005259429.4 XP_006723569.1, XM_006723506.3 XP_011525822.1, XM_011527520.2 |
Genome annotation databases
Ensembli | ENST00000389201.7; ENSP00000373853.3; ENSG00000131409.13 ENST00000599957.5; ENSP00000471502.1; ENSG00000131409.13 ENST00000652263.1; ENSP00000498662.1; ENSG00000131409.13 |
GeneIDi | 94030 |
KEGGi | hsa:94030 |
MANE-Selecti | ENST00000652263.1; ENSP00000498662.1; NM_001080457.2; NP_001073926.1 |
UCSCi | uc002pss.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC008743 Genomic DNA No translation available. BC019687 mRNA Translation: AAH19687.1 Different initiation. BC056207 mRNA Translation: AAH56207.1 AL137451 mRNA Translation: CAB70743.2 |
CCDSi | CCDS42595.1 |
PIRi | T46266 |
RefSeqi | NP_001073926.1, NM_001080457.1 NP_001335497.1, NM_001348568.1 XP_005259486.1, XM_005259429.4 XP_006723569.1, XM_006723506.3 XP_011525822.1, XM_011527520.2 |
3D structure databases
AlphaFoldDBi | Q9NT99 |
SMRi | Q9NT99 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125098, 11 interactors |
IntActi | Q9NT99, 4 interactors |
STRINGi | 9606.ENSP00000471502 |
Protein family/group databases
TCDBi | 8.A.43.1.24, the neat-domain containing methaemoglobin heme sequestration (n-mhs) family |
PTM databases
GlyGeni | Q9NT99, 10 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q9NT99 |
PhosphoSitePlusi | Q9NT99 |
Genetic variation databases
BioMutai | LRRC4B |
DMDMi | 91207142 |
Proteomic databases
EPDi | Q9NT99 |
MassIVEi | Q9NT99 |
MaxQBi | Q9NT99 |
PaxDbi | Q9NT99 |
PeptideAtlasi | Q9NT99 |
PRIDEi | Q9NT99 |
ProteomicsDBi | 82604 |
Protocols and materials databases
Antibodypediai | 53687, 79 antibodies from 18 providers |
DNASUi | 94030 |
Genome annotation databases
Ensembli | ENST00000389201.7; ENSP00000373853.3; ENSG00000131409.13 ENST00000599957.5; ENSP00000471502.1; ENSG00000131409.13 ENST00000652263.1; ENSP00000498662.1; ENSG00000131409.13 |
GeneIDi | 94030 |
KEGGi | hsa:94030 |
MANE-Selecti | ENST00000652263.1; ENSP00000498662.1; NM_001080457.2; NP_001073926.1 |
UCSCi | uc002pss.4, human |
Organism-specific databases
CTDi | 94030 |
GeneCardsi | LRRC4B |
HGNCi | HGNC:25042, LRRC4B |
HPAi | ENSG00000131409, Tissue enhanced (brain, cervix, pituitary gland) |
neXtProti | NX_Q9NT99 |
OpenTargetsi | ENSG00000131409 |
PharmGKBi | PA134890612 |
VEuPathDBi | HostDB:ENSG00000131409 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000160261 |
HOGENOMi | CLU_000288_18_24_1 |
InParanoidi | Q9NT99 |
OMAi | TSCPEAC |
OrthoDBi | 282791at2759 |
PhylomeDBi | Q9NT99 |
TreeFami | TF324303 |
Enzyme and pathway databases
PathwayCommonsi | Q9NT99 |
Reactomei | R-HSA-388844, Receptor-type tyrosine-protein phosphatases |
SignaLinki | Q9NT99 |
SIGNORi | Q9NT99 |
Miscellaneous databases
BioGRID-ORCSi | 94030, 11 hits in 1070 CRISPR screens |
ChiTaRSi | LRRC4B, human |
GenomeRNAii | 94030 |
Pharosi | Q9NT99, Tbio |
PROi | PR:Q9NT99 |
RNActi | Q9NT99, protein |
Gene expression databases
Bgeei | ENSG00000131409, Expressed in frontal cortex and 123 other tissues |
ExpressionAtlasi | Q9NT99, baseline and differential |
Genevisiblei | Q9NT99, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR026883, LRRC4B IPR000372, LRRNT |
PANTHERi | PTHR24369:SF102, PTHR24369:SF102, 1 hit |
Pfami | View protein in Pfam PF07679, I-set, 1 hit PF13855, LRR_8, 4 hits |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00408, IGc2, 1 hit SM00369, LRR_TYP, 8 hits SM00082, LRRCT, 1 hit SM00013, LRRNT, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS51450, LRR, 7 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | LRC4B_HUMAN | |
Accessioni | Q9NT99Primary (citable) accession number: Q9NT99 Secondary accession number(s): Q3ZCQ4, Q58F20 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 4, 2006 |
Last sequence update: | April 4, 2006 | |
Last modified: | May 25, 2022 | |
This is version 160 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM