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Entry version 178 (17 Jun 2020)
Sequence version 2 (22 Aug 2003)
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Protein

BMP-2-inducible protein kinase

Gene

BMP2K

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in osteoblast differentiation.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei79ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei180Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi57 – 65ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9NSY1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BMP-2-inducible protein kinase (EC:2.7.11.1)
Short name:
BIKe
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BMP2K
Synonyms:BIKE
ORF Names:HRIHFB2017
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000138756.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18041 BMP2K

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617648 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NSY1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55589

Open Targets

More...
OpenTargetsi
ENSG00000138756

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134992822

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NSY1 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4522

Drug and drug target database

More...
DrugBanki
DB12010 Fostamatinib

DrugCentral

More...
DrugCentrali
Q9NSY1

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1941

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BMP2K

Domain mapping of disease mutations (DMDM)

More...
DMDMi
34222653

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000856631 – 1161BMP-2-inducible protein kinaseAdd BLAST1161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei14PhosphoserineCombined sources1
Modified residuei689PhosphoserineCombined sources1
Modified residuei742PhosphoserineCombined sources1
Modified residuei817PhosphoserineCombined sources1
Modified residuei818PhosphoserineCombined sources1
Modified residuei834PhosphothreonineCombined sources1
Modified residuei928PhosphoserineBy similarity1
Modified residuei1029PhosphoserineCombined sources1
Modified residuei1031PhosphoserineBy similarity1
Modified residuei1032PhosphoserineCombined sources1
Modified residuei1039PhosphoserineCombined sources1
Modified residuei1041PhosphoserineCombined sources1
Modified residuei1076PhosphoserineCombined sources1
Modified residuei1107PhosphoserineCombined sources1
Modified residuei1111PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NSY1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NSY1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NSY1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NSY1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NSY1

PeptideAtlas

More...
PeptideAtlasi
Q9NSY1

PRoteomics IDEntifications database

More...
PRIDEi
Q9NSY1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82594 [Q9NSY1-1]
82595 [Q9NSY1-2]
82596 [Q9NSY1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NSY1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NSY1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138756 Expressed in intestine and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NSY1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NSY1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000138756 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120735, 64 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NSY1, 55 interactors

Molecular INTeraction database

More...
MINTi
Q9NSY1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000334836

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9NSY1

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NSY1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11161
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NSY1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 316Protein kinasePROSITE-ProRule annotationAdd BLAST266

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi12 – 40Gly-richAdd BLAST29
Compositional biasi425 – 559Gln/His-richAdd BLAST135

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1989 Eukaryota
ENOG410Y515 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157548

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000288_109_5_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NSY1

KEGG Orthology (KO)

More...
KOi
K08854

Identification of Orthologs from Complete Genome Data

More...
OMAi
PTMMPQY

Database of Orthologous Groups

More...
OrthoDBi
826336at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NSY1

TreeFam database of animal gene trees

More...
TreeFami
TF335936

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026105 BMP-2-ind_kinase
IPR028182 BMP2K_C
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS

The PANTHER Classification System

More...
PANTHERi
PTHR22967:SF10 PTHR22967:SF10, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15282 BMP2K_C, 1 hit
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NSY1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKKFSRMPKS EGGSGGGAAG GGAGGAGAGA GCGSGGSSVG VRVFAVGRHQ
60 70 80 90 100
VTLEESLAEG GFSTVFLVRT HGGIRCALKR MYVNNMPDLN VCKREITIMK
110 120 130 140 150
ELSGHKNIVG YLDCAVNSIS DNVWEVLILM EYCRAGQVVN QMNKKLQTGF
160 170 180 190 200
TEPEVLQIFC DTCEAVARLH QCKTPIIHRD LKVENILLND GGNYVLCDFG
210 220 230 240 250
SATNKFLNPQ KDGVNVVEEE IKKYTTLSYR APEMINLYGG KPITTKADIW
260 270 280 290 300
ALGCLLYKLC FFTLPFGESQ VAICDGNFTI PDNSRYSRNI HCLIRFMLEP
310 320 330 340 350
DPEHRPDIFQ VSYFAFKFAK KDCPVSNINN SSIPSALPEP MTASEAAARK
360 370 380 390 400
SQIKARITDT IGPTETSIAP RQRPKANSAT TATPSVLTIQ SSATPVKVLA
410 420 430 440 450
PGEFGNHRPK GALRPGNGPE ILLGQGPPQQ PPQQHRVLQQ LQQGDWRLQQ
460 470 480 490 500
LHLQHRHPHQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQHHHH HHHHLLQDAY
510 520 530 540 550
MQQYQHATQQ QQMLQQQFLM HSVYQPQPSA SQYPTMMPQY QQAFFQQQML
560 570 580 590 600
AQHQPSQQQA SPEYLTSPQE FSPALVSYTS SLPAQVGTIM DSSYSANRSV
610 620 630 640 650
ADKEAIANFT NQKNISNPPD MSGWNPFGED NFSKLTEEEL LDREFDLLRS
660 670 680 690 700
NRLEERASSD KNVDSLSAPH NHPPEDPFGS VPFISHSGSP EKKAEHSSIN
710 720 730 740 750
QENGTANPIK NGKTSPASKD QRTGKKTSVQ GQVQKGNDES ESDFESDPPS
760 770 780 790 800
PKSSEEEEQD DEEVLQGEQG DFNDDDTEPE NLGHRPLLMD SEDEEEEEKH
810 820 830 840 850
SSDSDYEQAK AKYSDMSSVY RDRSGSGPTQ DLNTILLTSA QLSSDVAVET
860 870 880 890 900
PKQEFDVFGA VPFFAVRAQQ PQQEKNEKNL PQHRFPAAGL EQEEFDVFTK
910 920 930 940 950
APFSKKVNVQ ECHAVGPEAH TIPGYPKSVD VFGSTPFQPF LTSTSKSESN
960 970 980 990 1000
EDLFGLVPFD EITGSQQQKV KQRSLQKLSS RQRRTKQDMS KSNGKRHHGT
1010 1020 1030 1040 1050
PTSTKKTLKP TYRTPERARR HKKVGRRDSQ SSNEFLTISD SKENISVALT
1060 1070 1080 1090 1100
DGKDRGNVLQ PEESLLDPFG AKPFHSPDLS WHPPHQGLSD IRADHNTVLP
1110 1120 1130 1140 1150
GRPRQNSLHG SFHSADVLKM DDFGAVPFTE LVVQSITPHQ SQQSQPVELD
1160
PFGAAPFPSK Q
Length:1,161
Mass (Da):129,172
Last modified:August 22, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5C38A86E95935EC2
GO
Isoform 2 (identifier: Q9NSY1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     651-662: NRLEERASSDKN → SKGHLKAYFASQ
     663-1161: Missing.

Show »
Length:662
Mass (Da):73,838
Checksum:iED443E4DC0696FF3
GO
Isoform 3 (identifier: Q9NSY1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     330-340: NSSIPSALPEP → KCCKQLLRHGALLTEILLFLQLFLNR
     651-662: NRLEERASSDKN → SKGHLKAYFASQ
     663-1161: Missing.

Show »
Length:677
Mass (Da):75,812
Checksum:iFF17E464DB5F952C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y9P1H0Y9P1_HUMAN
BMP-2-inducible protein kinase
BMP2K
854Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K4DI97K4DI97_HUMAN
BMP-2-inducible protein kinase
BMP2K hCG_22989
355Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti342T → A in AAH36021 (PubMed:15489334).Curated1
Sequence conflicti471 – 486Missing in CAB70863 (PubMed:17974005).CuratedAdd BLAST16
Sequence conflicti478Q → R in AAH36021 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04038868V → M in a lung squamous cell carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs770167074Ensembl.1
Natural variantiVAR_040389212D → V1 PublicationCorresponds to variant dbSNP:rs56143363Ensembl.1
Natural variantiVAR_040390288R → H1 PublicationCorresponds to variant dbSNP:rs55782848Ensembl.1
Natural variantiVAR_051618405G → S1 PublicationCorresponds to variant dbSNP:rs2288255Ensembl.1
Natural variantiVAR_059765486Q → H. Corresponds to variant dbSNP:rs2114202Ensembl.1
Natural variantiVAR_0516191002T → S. Corresponds to variant dbSNP:rs12507099Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008093330 – 340NSSIPSALPEP → KCCKQLLRHGALLTEILLFL QLFLNR in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_008091651 – 662NRLEE…SSDKN → SKGHLKAYFASQ in isoform 2 and isoform 3. 4 PublicationsAdd BLAST12
Alternative sequenceiVSP_008092663 – 1161Missing in isoform 2 and isoform 3. 4 PublicationsAdd BLAST499

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK075278 mRNA Translation: BAC11515.1
AK292147 mRNA Translation: BAF84836.1
AL137275 mRNA Translation: CAB70673.1
AL137661 mRNA Translation: CAB70863.1
AC098818 Genomic DNA Translation: AAY40926.1
BC036021 mRNA Translation: AAH36021.1
AF527532 mRNA Translation: AAM88867.1
AB015331 mRNA Translation: BAA34790.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34019.1 [Q9NSY1-2]
CCDS47083.1 [Q9NSY1-1]

Protein sequence database of the Protein Information Resource

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PIRi
T46347
T46364

NCBI Reference Sequences

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RefSeqi
NP_060063.2, NM_017593.3 [Q9NSY1-2]
NP_942595.1, NM_198892.1 [Q9NSY1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000335016; ENSP00000334836; ENSG00000138756 [Q9NSY1-1]
ENST00000502871; ENSP00000421768; ENSG00000138756 [Q9NSY1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55589

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55589

UCSC genome browser

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UCSCi
uc003hlj.4 human [Q9NSY1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075278 mRNA Translation: BAC11515.1
AK292147 mRNA Translation: BAF84836.1
AL137275 mRNA Translation: CAB70673.1
AL137661 mRNA Translation: CAB70863.1
AC098818 Genomic DNA Translation: AAY40926.1
BC036021 mRNA Translation: AAH36021.1
AF527532 mRNA Translation: AAM88867.1
AB015331 mRNA Translation: BAA34790.1
CCDSiCCDS34019.1 [Q9NSY1-2]
CCDS47083.1 [Q9NSY1-1]
PIRiT46347
T46364
RefSeqiNP_060063.2, NM_017593.3 [Q9NSY1-2]
NP_942595.1, NM_198892.1 [Q9NSY1-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4W9WX-ray1.72A39-344[»]
4W9XX-ray2.14A38-345[»]
5I3OX-ray2.40A/B42-343[»]
5I3RX-ray2.40A/B42-343[»]
5IKWX-ray2.41A38-345[»]
SMRiQ9NSY1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120735, 64 interactors
IntActiQ9NSY1, 55 interactors
MINTiQ9NSY1
STRINGi9606.ENSP00000334836

Chemistry databases

BindingDBiQ9NSY1
ChEMBLiCHEMBL4522
DrugBankiDB12010 Fostamatinib
DrugCentraliQ9NSY1
GuidetoPHARMACOLOGYi1941

PTM databases

iPTMnetiQ9NSY1
PhosphoSitePlusiQ9NSY1

Polymorphism and mutation databases

BioMutaiBMP2K
DMDMi34222653

Proteomic databases

EPDiQ9NSY1
jPOSTiQ9NSY1
MassIVEiQ9NSY1
MaxQBiQ9NSY1
PaxDbiQ9NSY1
PeptideAtlasiQ9NSY1
PRIDEiQ9NSY1
ProteomicsDBi82594 [Q9NSY1-1]
82595 [Q9NSY1-2]
82596 [Q9NSY1-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
24948 187 antibodies

The DNASU plasmid repository

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DNASUi
55589

Genome annotation databases

EnsembliENST00000335016; ENSP00000334836; ENSG00000138756 [Q9NSY1-1]
ENST00000502871; ENSP00000421768; ENSG00000138756 [Q9NSY1-2]
GeneIDi55589
KEGGihsa:55589
UCSCiuc003hlj.4 human [Q9NSY1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55589
DisGeNETi55589
EuPathDBiHostDB:ENSG00000138756.17

GeneCards: human genes, protein and diseases

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GeneCardsi
BMP2K
HGNCiHGNC:18041 BMP2K
HPAiENSG00000138756 Low tissue specificity
MIMi617648 gene
neXtProtiNX_Q9NSY1
OpenTargetsiENSG00000138756
PharmGKBiPA134992822

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1989 Eukaryota
ENOG410Y515 LUCA
GeneTreeiENSGT00940000157548
HOGENOMiCLU_000288_109_5_1
InParanoidiQ9NSY1
KOiK08854
OMAiPTMMPQY
OrthoDBi826336at2759
PhylomeDBiQ9NSY1
TreeFamiTF335936

Enzyme and pathway databases

SignaLinkiQ9NSY1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
55589 9 hits in 816 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BMP2K human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
BMP2K

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55589
PharosiQ9NSY1 Tchem

Protein Ontology

More...
PROi
PR:Q9NSY1
RNActiQ9NSY1 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138756 Expressed in intestine and 230 other tissues
ExpressionAtlasiQ9NSY1 baseline and differential
GenevisibleiQ9NSY1 HS

Family and domain databases

InterProiView protein in InterPro
IPR026105 BMP-2-ind_kinase
IPR028182 BMP2K_C
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR22967:SF10 PTHR22967:SF10, 1 hit
PfamiView protein in Pfam
PF15282 BMP2K_C, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBMP2K_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NSY1
Secondary accession number(s): O94791
, Q4W5H2, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: August 22, 2003
Last modified: June 17, 2020
This is version 178 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  7. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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