UniProtKB - Q9NSY0 (NRBP2_HUMAN)

BLAST

>sp|Q9NSY0|NRBP2_HUMAN Nuclear receptor-binding protein 2 OS=Homo sapiens OX=9606 GN=NRBP2 PE=1 SV=2
MAAPEPAPRRAREREREREDESEDESDILEESPCGRWQKRREQVNQGNMPGLQSTFLAMD
TEEGVEVVWNELHFGDRKAFAAHEEKIQTVFEQLVLVDHPNIVKLHKYWLDTSEACARVI
FITEYVSSGSLKQFLKKTKKNHKAMNARAWKRWCTQILSALSFLHACSPPIIHGNLTSDT
IFIQHNGLIKIGSVWHRIFSNALPDDLRSPIRAEREELRNLHFFPPEYGEVADGTAVDIF
SFGMCALEMAVLEIQTNGDTRVTEEAIARARHSLSDPNMREFILCCLARDPARRPSAHSL
LFHRVLFEVHSLKLLAAHCFIQHQYLMPENVVEEKTKAMDLHAVLAELPRPRRPPLQWRY
SEVSFMELDKFLEDVRNGIYPLMNFAATRPLGLPRVLAPPPEEVQKAKTPTPEPFDSETR
KVIQMQCNLERSEDKARWHLTLLLVLEDRLHRQLTYDLLPTDSAQDLASELVHYGFLHED
DRMKLAAFLESTFLKYRGTQA

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History
Entry version 140 (07 Nov 2018)
Sequence version 2 (15 Jun 2010)
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Protein

Nuclear receptor-binding protein 2

Gene

NRBP2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May regulate apoptosis of neural progenitor cells during their differentiation.By similarity

GO - Molecular functionⁱ

ATP binding Source: InterPro
protein serine/threonine kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ER to Golgi vesicle-mediated transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
intracellular signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of macroautophagy
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 22354037
negative regulation of neuron apoptotic process Source: UniProtKB
neuron differentiation Source: UniProtKB
protein phosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Neurogenesis

Biological process

Neurogenesis

Enzyme and pathway databases

SignaLinkⁱ	Q9NSY0

SignaLinkⁱ

Q9NSY0

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nuclear receptor-binding protein 2 Alternative name(s): Transformation-related gene 16 protein Short name: TRG-16
Gene namesⁱ	Name:NRBP2Imported ORF Names:PP9320, TRG16
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000185189.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19339 NRBP2
MIMⁱ	615563 gene
neXtProtⁱ	NX_Q9NSY0

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	340371
Open Targets More...OpenTargetsⁱ	ENSG00000185189
PharmGKBⁱ	PA134891143

Polymorphism and mutation databases

BioMutaⁱ	NRBP2
DMDMⁱ	298286835

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000225608	1 – 501	Nuclear receptor-binding protein 2Add BLAST		501

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	409	PhosphothreonineBy similarity		1
Modified residueⁱ	411	PhosphothreonineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9NSY0
PaxDbⁱ	Q9NSY0
PeptideAtlas More...PeptideAtlasⁱ	Q9NSY0
PRIDEⁱ	Q9NSY0
ProteomicsDBⁱ	82590 82591 [Q9NSY0-2] 82592 [Q9NSY0-4] 82593 [Q9NSY0-5]

PTM databases

iPTMnetⁱ	Q9NSY0
PhosphoSitePlusⁱ	Q9NSY0

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000185189 Expressed in 97 organ(s), highest expression level in spinal cord
CleanExⁱ	HS_NRBP2
ExpressionAtlasⁱ	Q9NSY0 baseline and differential
Genevisibleⁱ	Q9NSY0 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB020944 HPA029051 HPA029052

HPAⁱ

CAB020944
HPA029051
HPA029052

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	131044, 6 interactors
IntActⁱ	Q9NSY0, 4 interactors
STRINGⁱ	9606.ENSP00000414055

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9NSY0
SMRⁱ	Q9NSY0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	38 – 306	Protein kinasePROSITE-ProRule annotationAdd BLAST		269

Domainⁱ

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG1266 Eukaryota ENOG410XSIC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00800000124049
HOGENOMⁱ	HOG000267147
HOVERGENⁱ	HBG082057
InParanoidⁱ	Q9NSY0
KEGG Orthology (KO) More...KOⁱ	K08875
OMAⁱ	SELVHYA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G031V
PhylomeDBⁱ	Q9NSY0
TreeFamⁱ	TF315519

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9NSY0-3) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPEPAPRR ARERERERED ESEDESDILE ESPCGRWQKR REQVNQGNMP 
        60         70         80         90        100
GLQSTFLAMD TEEGVEVVWN ELHFGDRKAF AAHEEKIQTV FEQLVLVDHP 
       110        120        130        140        150
NIVKLHKYWL DTSEACARVI FITEYVSSGS LKQFLKKTKK NHKAMNARAW 
       160        170        180        190        200
KRWCTQILSA LSFLHACSPP IIHGNLTSDT IFIQHNGLIK IGSVWHRIFS 
       210        220        230        240        250
NALPDDLRSP IRAEREELRN LHFFPPEYGE VADGTAVDIF SFGMCALEMA 
       260        270        280        290        300
VLEIQTNGDT RVTEEAIARA RHSLSDPNMR EFILCCLARD PARRPSAHSL 
       310        320        330        340        350
LFHRVLFEVH SLKLLAAHCF IQHQYLMPEN VVEEKTKAMD LHAVLAELPR 
       360        370        380        390        400
PRRPPLQWRY SEVSFMELDK FLEDVRNGIY PLMNFAATRP LGLPRVLAPP 
       410        420        430        440        450
PEEVQKAKTP TPEPFDSETR KVIQMQCNLE RSEDKARWHL TLLLVLEDRL 
       460        470        480        490        500
HRQLTYDLLP TDSAQDLASE LVHYGFLHED DRMKLAAFLE STFLKYRGTQ 

A

Length:501

Mass (Da):57,803

Last modified:June 15, 2010 - v2

Checksum:ⁱB3F246DBA7E2AC6C

Isoform 22 Publications (identifier: Q9NSY0-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-243: Missing.
244-280: MCALEMAVLE...RHSLSDPNMR → MVLQSQNPAV...HHQPLLPVPQ

« Hide

        10         20         30         40         50
MVLQSQNPAV LKLRGPGPGL AAAAGTPPYG HPCMSCVSLR RDMGNSGATS 
        60         70         80         90        100
PRTAGPEQRA LAHHQPLLPV PQEFILCCLA RDPARRPSAH SLLFHRVLFE 
       110        120        130        140        150
VHSLKLLAAH CFIQHQYLMP ENVVEEKTKA MDLHAVLAEL PRPRRPPLQW 
       160        170        180        190        200
RYSEVSFMEL DKFLEDVRNG IYPLMNFAAT RPLGLPRVLA PPPEEVQKAK 
       210        220        230        240        250
TPTPEPFDSE TRKVIQMQCN LERSEDKARW HLTLLLVLED RLHRQLTYDL 
       260        270        280        290 
LPTDSAQDLA SELVHYGFLH EDDRMKLAAF LESTFLKYRG TQA

Note: No experimental confirmation available.

Show »

Length:293

Mass (Da):33,141

Checksum:ⁱB37F0F45BD8AC99B

Isoform 3 (identifier: Q9NSY0-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: Missing.
     244-280: MCALEMAVLE...RHSLSDPNMR → MVLQSQNPAV...HHQPLLPVPQ
     461-501: TDSAQDLASE...TFLKYRGTQA → SRLGRGLGRR...LPQVPWDPGL

« Hide

        10         20         30         40         50
MVLQSQNPAV LKLRGPGPGL AAAAGTPPYG HPCMSCVSLR RDMGNSGATS 
        60         70         80         90        100
PRTAGPEQRA LAHHQPLLPV PQEFILCCLA RDPARRPSAH SLLFHRVLFE 
       110        120        130        140        150
VHSLKLLAAH CFIQHQYLMP ENVVEEKTKA MDLHAVLAEL PRPRRPPLQW 
       160        170        180        190        200
RYSEVSFMEL DKFLEDVRNG IYPLMNFAAT RPLGLPRVLA PPPEEVQKAK 
       210        220        230        240        250
TPTPEPFDSE TRKVIQMQCN LERSEDKARW HLTLLLVLED RLHRQLTYDL 
       260        270        280        290        300
LPSRLGRGLG RRAVTPGGGW AAASCLALRH CLSGQRPGPR LGARALWLPP 
       310        320 
RGRPDEAGRL PGEHLPQVPW DPGL

Note: No experimental confirmation available.Curated

Show »

Length:324

Mass (Da):36,072

Checksum:ⁱ45EDFCB9AFCB5660

Isoform 4 (identifier: Q9NSY0-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     149-171: AWKRWCTQILSALSFLHACSPPI → VWGAGWGSHGDRTGLGQPRGLGW
     172-501: Missing.

« Hide

        10         20         30         40         50
MPGLQSTFLA MDTEEGVEVV WNELHFGDRK AFAAHEEKIQ TVFEQLVLVD 
        60         70         80         90        100
HPNIVKLHKY WLDTSEACAR VIFITEYVSS GSLKQFLKKT KKNHKAMNAR 
       110        120 
VWGAGWGSHG DRTGLGQPRG LGW

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:123

Mass (Da):13,910

Checksum:ⁱA24C99DA3D502C1C

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PR11	E9PR11_HUMAN	Nuclear receptor-binding protein 2 Nuclear receptor-binding protein 2	NRBP2	232	Annotation score:
H0YCB1	H0YCB1_HUMAN	Nuclear receptor-binding protein 2 Nuclear receptor-binding protein 2	NRBP2	168	Annotation score:

Sequence cautionⁱ

The sequence AAI13874 differs from that shown. Probable cloning artifact.Curated

The sequence CAB70864 differs from that shown. Wrong choice of CDS.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Isoform 3 (identifier: Q9NSY0-4)
Sequence conflictⁱ	10	V → A in AAQ18040 (Ref. 1) Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_039308	1 – 243	Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST	243
Alternative sequenceⁱVSP_039311	1 – 48	Missing in isoform 4. 1 PublicationAdd BLAST	48
Alternative sequenceⁱVSP_039312	149 – 171	AWKRW…CSPPI → VWGAGWGSHGDRTGLGQPRG LGW in isoform 4. 1 PublicationAdd BLAST	23
Alternative sequenceⁱVSP_039313	172 – 501	Missing in isoform 4. 1 PublicationAdd BLAST	330
Alternative sequenceⁱVSP_039309	244 – 280	MCALE…DPNMR → MVLQSQNPAVLKLRGPGPGL AAAAGTPPYGHPCMSCVSLR RDMGNSGATSPRTAGPEQRA LAHHQPLLPVPQ in isoform 2 and isoform 3. 2 PublicationsAdd BLAST	37
Alternative sequenceⁱVSP_039310	461 – 501	TDSAQ…RGTQA → SRLGRGLGRRAVTPGGGWAA ASCLALRHCLSGQRPGPRLG ARALWLPPRGRPDEAGRLPG EHLPQVPWDPGL in isoform 3. 1 PublicationAdd BLAST	41

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY277601 mRNA Translation: AAQ18040.1 AK293943 mRNA Translation: BAG57320.1 AF318376 mRNA Translation: AAL55883.1 AL137662 mRNA Translation: CAB70864.1 Sequence problems. AL834530 mRNA Translation: CAD39186.1 AC105049 Genomic DNA No translation available. BC113873 mRNA Translation: AAI13874.1 Sequence problems. CR457350 mRNA Translation: CAG33631.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34959.2 [Q9NSY0-3]
PIRⁱ	T46491
NCBI Reference Sequences More...RefSeqⁱ	NP_848659.2, NM_178564.3 [Q9NSY0-3]
UniGeneⁱ	Hs.521926

Genome annotation databases

Ensemblⁱ	ENST00000442628; ENSP00000414055; ENSG00000185189 [Q9NSY0-3]
GeneIDⁱ	340371
KEGGⁱ	hsa:340371
UCSC genome browser More...UCSCⁱ	uc011lkt.3 human [Q9NSY0-3]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NSY0	NRBP2 isoform 4		PANTR		501	UniRef100_Q9NSY0
Uncharacterized protein		PANPA		501

Protein	Similar proteins		Species	Score	Length	Source
Q9NSY0	NRBP2 isoform 4		PANTR		501	UniRef90_Q9NSY0
Uncharacterized protein		PANPA		501
NRBP2 isoform 3		PONAB		501
Uncharacterized protein		RHIRO		499
Uncharacterized protein		CERAT		499
+41
Q9NSY0-2	Uncharacterized protein		PONAB		251	UniRef90_Q9NSY0-2

Protein	Similar proteins		Species	Score	Length	Source
Q9NSY0	Nuclear receptor-binding protein		HUMAN		535	UniRef50_Q9UHY1
Nuclear receptor-binding protein		MACFA		535
Nuclear receptor-binding protein		PONAB		535
Nuclear receptor binding protein 1		MACMU		535
Uncharacterized protein		PROCO		535
+225
Q9NSY0-2	Isoform 3 of Nuclear receptor-binding protein 2		HUMAN		324	UniRef50_Q9NSY0-4
LOW QUALITY PROTEIN: nuclear receptor-binding protein 2		Yangtze finless porpoise		348
Uncharacterized protein		PONAB		251
Uncharacterized protein		Cebus capucinus imitator		261
Nuclear receptor binding protein 2		PANTR		257
+3
Q9NSY0-4	LOW QUALITY PROTEIN: nuclear receptor-binding protein 2		Yangtze finless porpoise		348	UniRef50_Q9NSY0-4
Uncharacterized protein		PONAB		251
Isoform 2 of Nuclear receptor-binding protein 2		HUMAN		293
Uncharacterized protein		Cebus capucinus imitator		261
Nuclear receptor binding protein 2		PANTR		257
+3

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY277601 mRNA Translation: AAQ18040.1 AK293943 mRNA Translation: BAG57320.1 AF318376 mRNA Translation: AAL55883.1 AL137662 mRNA Translation: CAB70864.1 Sequence problems. AL834530 mRNA Translation: CAD39186.1 AC105049 Genomic DNA No translation available. BC113873 mRNA Translation: AAI13874.1 Sequence problems. CR457350 mRNA Translation: CAG33631.1
CCDSⁱ	CCDS34959.2 [Q9NSY0-3]
PIRⁱ	T46491
RefSeqⁱ	NP_848659.2, NM_178564.3 [Q9NSY0-3]
UniGeneⁱ	Hs.521926

3D structure databases

ProteinModelPortalⁱ	Q9NSY0
SMRⁱ	Q9NSY0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	131044, 6 interactors
IntActⁱ	Q9NSY0, 4 interactors
STRINGⁱ	9606.ENSP00000414055

PTM databases

iPTMnetⁱ	Q9NSY0
PhosphoSitePlusⁱ	Q9NSY0

Polymorphism and mutation databases

BioMutaⁱ	NRBP2
DMDMⁱ	298286835

Proteomic databases

EPDⁱ	Q9NSY0
PaxDbⁱ	Q9NSY0
PeptideAtlasⁱ	Q9NSY0
PRIDEⁱ	Q9NSY0
ProteomicsDBⁱ	82590 82591 [Q9NSY0-2] 82592 [Q9NSY0-4] 82593 [Q9NSY0-5]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	340371
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000442628; ENSP00000414055; ENSG00000185189 [Q9NSY0-3]
GeneIDⁱ	340371
KEGGⁱ	hsa:340371
UCSCⁱ	uc011lkt.3 human [Q9NSY0-3]

Organism-specific databases

CTDⁱ	340371
DisGeNETⁱ	340371
EuPathDBⁱ	HostDB:ENSG00000185189.15
GeneCardsⁱ	NRBP2
H-InvDBⁱ	HIX0021894
HGNCⁱ	HGNC:19339 NRBP2
HPAⁱ	CAB020944 HPA029051 HPA029052
MIMⁱ	615563 gene
neXtProtⁱ	NX_Q9NSY0
OpenTargetsⁱ	ENSG00000185189
PharmGKBⁱ	PA134891143
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1266 Eukaryota ENOG410XSIC LUCA
GeneTreeⁱ	ENSGT00800000124049
HOGENOMⁱ	HOG000267147
HOVERGENⁱ	HBG082057
InParanoidⁱ	Q9NSY0
KOⁱ	K08875
OMAⁱ	SELVHYA
OrthoDBⁱ	EOG091G031V
PhylomeDBⁱ	Q9NSY0
TreeFamⁱ	TF315519

Enzyme and pathway databases

SignaLinkⁱ	Q9NSY0

SignaLinkⁱ

Q9NSY0

Miscellaneous databases

ChiTaRSⁱ	NRBP2 human
GenomeRNAiⁱ	340371
Protein Ontology More...PROⁱ	PR:Q9NSY0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000185189 Expressed in 97 organ(s), highest expression level in spinal cord
CleanExⁱ	HS_NRBP2
ExpressionAtlasⁱ	Q9NSY0 baseline and differential
Genevisibleⁱ	Q9NSY0 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50011 PROTEIN_KINASE_DOM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NRBP2_HUMAN
Accessionⁱ	Q9NSY0Primary (citable) accession number: Q9NSY0 Secondary accession number(s): B4DF59 , Q2HIX8, Q597G7, Q8NCX8, Q8WYS5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
	Last sequence update:	June 15, 2010
	Last modified:	November 7, 2018
	This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - Q9NSY0 (NRBP2_HUMAN)

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Nuclear receptor-binding protein 2

NRBP2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ