UniProtKB - Q9NSY0 (NRBP2_HUMAN)
Nuclear receptor-binding protein 2
NRBP2
Functioni
May regulate apoptosis of neural progenitor cells during their differentiation.
By similarityGO - Molecular functioni
- ATP binding Source: InterPro
- protein serine/threonine kinase activity Source: GO_Central
GO - Biological processi
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: GO_Central
- intracellular signal transduction Source: GO_Central
- negative regulation of macroautophagy Source: BHF-UCL
- negative regulation of neuron apoptotic process Source: UniProtKB
- neuron differentiation Source: UniProtKB
- protein phosphorylation Source: GO_Central
Keywordsi
Biological process | Neurogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q9NSY0 |
SignaLinki | Q9NSY0 |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear receptor-binding protein 2Alternative name(s): Transformation-related gene 16 protein Short name: TRG-16 |
Gene namesi | Name:NRBP2Imported ORF Names:PP9320, TRG16 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19339, NRBP2 |
MIMi | 615563, gene |
neXtProti | NX_Q9NSY0 |
VEuPathDBi | HostDB:ENSG00000185189 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: UniProtKB
- endomembrane system Source: GO_Central
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 340371 |
OpenTargetsi | ENSG00000185189 |
PharmGKBi | PA134891143 |
Miscellaneous databases
Pharosi | Q9NSY0, Tdark |
Genetic variation databases
BioMutai | NRBP2 |
DMDMi | 298286835 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000225608 | 1 – 501 | Nuclear receptor-binding protein 2Add BLAST | 501 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 409 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 411 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9NSY0 |
jPOSTi | Q9NSY0 |
MassIVEi | Q9NSY0 |
MaxQBi | Q9NSY0 |
PaxDbi | Q9NSY0 |
PeptideAtlasi | Q9NSY0 |
PRIDEi | Q9NSY0 |
ProteomicsDBi | 82590 [Q9NSY0-3] 82591 [Q9NSY0-2] 82592 [Q9NSY0-4] 82593 [Q9NSY0-5] |
PTM databases
iPTMneti | Q9NSY0 |
PhosphoSitePlusi | Q9NSY0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000185189, Expressed in spinal cord and 122 other tissues |
ExpressionAtlasi | Q9NSY0, baseline and differential |
Genevisiblei | Q9NSY0, HS |
Organism-specific databases
HPAi | ENSG00000185189, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 131044, 13 interactors |
IntActi | Q9NSY0, 60 interactors |
STRINGi | 9606.ENSP00000414055 |
Miscellaneous databases
RNActi | Q9NSY0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 306 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 269 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 33 | DisorderedSequence analysisAdd BLAST | 33 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1266, Eukaryota |
GeneTreei | ENSGT00940000160430 |
HOGENOMi | CLU_024273_0_0_1 |
InParanoidi | Q9NSY0 |
OMAi | KVFKAHE |
OrthoDBi | 695382at2759 |
PhylomeDBi | Q9NSY0 |
TreeFami | TF315519 |
Family and domain databases
CDDi | cd14035, PK_MADML, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR042697, NRBP2_PK IPR000719, Prot_kinase_dom |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAPEPAPRR ARERERERED ESEDESDILE ESPCGRWQKR REQVNQGNMP
60 70 80 90 100
GLQSTFLAMD TEEGVEVVWN ELHFGDRKAF AAHEEKIQTV FEQLVLVDHP
110 120 130 140 150
NIVKLHKYWL DTSEACARVI FITEYVSSGS LKQFLKKTKK NHKAMNARAW
160 170 180 190 200
KRWCTQILSA LSFLHACSPP IIHGNLTSDT IFIQHNGLIK IGSVWHRIFS
210 220 230 240 250
NALPDDLRSP IRAEREELRN LHFFPPEYGE VADGTAVDIF SFGMCALEMA
260 270 280 290 300
VLEIQTNGDT RVTEEAIARA RHSLSDPNMR EFILCCLARD PARRPSAHSL
310 320 330 340 350
LFHRVLFEVH SLKLLAAHCF IQHQYLMPEN VVEEKTKAMD LHAVLAELPR
360 370 380 390 400
PRRPPLQWRY SEVSFMELDK FLEDVRNGIY PLMNFAATRP LGLPRVLAPP
410 420 430 440 450
PEEVQKAKTP TPEPFDSETR KVIQMQCNLE RSEDKARWHL TLLLVLEDRL
460 470 480 490 500
HRQLTYDLLP TDSAQDLASE LVHYGFLHED DRMKLAAFLE STFLKYRGTQ
A
The sequence of this isoform differs from the canonical sequence as follows:
1-48: Missing.
149-171: AWKRWCTQILSALSFLHACSPPI → VWGAGWGSHGDRTGLGQPRGLGW
172-501: Missing.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PR11 | E9PR11_HUMAN | Nuclear receptor-binding protein 2 | NRBP2 | 232 | Annotation score: | ||
H0YCB1 | H0YCB1_HUMAN | Nuclear receptor-binding protein 2 | NRBP2 | 168 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 3 (identifier: Q9NSY0-4) | |||||
Sequence conflicti | 10 | V → A in AAQ18040 (Ref. 1) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_039308 | 1 – 243 | Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 243 | |
Alternative sequenceiVSP_039311 | 1 – 48 | Missing in isoform 4. 1 PublicationAdd BLAST | 48 | |
Alternative sequenceiVSP_039312 | 149 – 171 | AWKRW…CSPPI → VWGAGWGSHGDRTGLGQPRG LGW in isoform 4. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_039313 | 172 – 501 | Missing in isoform 4. 1 PublicationAdd BLAST | 330 | |
Alternative sequenceiVSP_039309 | 244 – 280 | MCALE…DPNMR → MVLQSQNPAVLKLRGPGPGL AAAAGTPPYGHPCMSCVSLR RDMGNSGATSPRTAGPEQRA LAHHQPLLPVPQ in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 37 | |
Alternative sequenceiVSP_039310 | 461 – 501 | TDSAQ…RGTQA → SRLGRGLGRRAVTPGGGWAA ASCLALRHCLSGQRPGPRLG ARALWLPPRGRPDEAGRLPG EHLPQVPWDPGL in isoform 3. 1 PublicationAdd BLAST | 41 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY277601 mRNA Translation: AAQ18040.1 AK293943 mRNA Translation: BAG57320.1 AF318376 mRNA Translation: AAL55883.1 AL137662 mRNA Translation: CAB70864.1 Sequence problems. AL834530 mRNA Translation: CAD39186.1 AC105049 Genomic DNA No translation available. BC113873 mRNA Translation: AAI13874.1 Sequence problems. CR457350 mRNA Translation: CAG33631.1 |
CCDSi | CCDS34959.2 [Q9NSY0-3] |
PIRi | T46491 |
RefSeqi | NP_848659.2, NM_178564.3 [Q9NSY0-3] |
Genome annotation databases
Ensembli | ENST00000442628.7; ENSP00000414055.2; ENSG00000185189.18 |
GeneIDi | 340371 |
KEGGi | hsa:340371 |
MANE-Selecti | ENST00000442628.7; ENSP00000414055.2; NM_178564.4; NP_848659.2 |
UCSCi | uc011lkt.3, human [Q9NSY0-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY277601 mRNA Translation: AAQ18040.1 AK293943 mRNA Translation: BAG57320.1 AF318376 mRNA Translation: AAL55883.1 AL137662 mRNA Translation: CAB70864.1 Sequence problems. AL834530 mRNA Translation: CAD39186.1 AC105049 Genomic DNA No translation available. BC113873 mRNA Translation: AAI13874.1 Sequence problems. CR457350 mRNA Translation: CAG33631.1 |
CCDSi | CCDS34959.2 [Q9NSY0-3] |
PIRi | T46491 |
RefSeqi | NP_848659.2, NM_178564.3 [Q9NSY0-3] |
3D structure databases
AlphaFoldDBi | Q9NSY0 |
SMRi | Q9NSY0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 131044, 13 interactors |
IntActi | Q9NSY0, 60 interactors |
STRINGi | 9606.ENSP00000414055 |
PTM databases
iPTMneti | Q9NSY0 |
PhosphoSitePlusi | Q9NSY0 |
Genetic variation databases
BioMutai | NRBP2 |
DMDMi | 298286835 |
Proteomic databases
EPDi | Q9NSY0 |
jPOSTi | Q9NSY0 |
MassIVEi | Q9NSY0 |
MaxQBi | Q9NSY0 |
PaxDbi | Q9NSY0 |
PeptideAtlasi | Q9NSY0 |
PRIDEi | Q9NSY0 |
ProteomicsDBi | 82590 [Q9NSY0-3] 82591 [Q9NSY0-2] 82592 [Q9NSY0-4] 82593 [Q9NSY0-5] |
Protocols and materials databases
Antibodypediai | 28122, 200 antibodies from 26 providers |
DNASUi | 340371 |
Genome annotation databases
Ensembli | ENST00000442628.7; ENSP00000414055.2; ENSG00000185189.18 |
GeneIDi | 340371 |
KEGGi | hsa:340371 |
MANE-Selecti | ENST00000442628.7; ENSP00000414055.2; NM_178564.4; NP_848659.2 |
UCSCi | uc011lkt.3, human [Q9NSY0-3] |
Organism-specific databases
CTDi | 340371 |
DisGeNETi | 340371 |
GeneCardsi | NRBP2 |
HGNCi | HGNC:19339, NRBP2 |
HPAi | ENSG00000185189, Low tissue specificity |
MIMi | 615563, gene |
neXtProti | NX_Q9NSY0 |
OpenTargetsi | ENSG00000185189 |
PharmGKBi | PA134891143 |
VEuPathDBi | HostDB:ENSG00000185189 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1266, Eukaryota |
GeneTreei | ENSGT00940000160430 |
HOGENOMi | CLU_024273_0_0_1 |
InParanoidi | Q9NSY0 |
OMAi | KVFKAHE |
OrthoDBi | 695382at2759 |
PhylomeDBi | Q9NSY0 |
TreeFami | TF315519 |
Enzyme and pathway databases
PathwayCommonsi | Q9NSY0 |
SignaLinki | Q9NSY0 |
Miscellaneous databases
BioGRID-ORCSi | 340371, 15 hits in 1112 CRISPR screens |
ChiTaRSi | NRBP2, human |
GenomeRNAii | 340371 |
Pharosi | Q9NSY0, Tdark |
PROi | PR:Q9NSY0 |
RNActi | Q9NSY0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000185189, Expressed in spinal cord and 122 other tissues |
ExpressionAtlasi | Q9NSY0, baseline and differential |
Genevisiblei | Q9NSY0, HS |
Family and domain databases
CDDi | cd14035, PK_MADML, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR042697, NRBP2_PK IPR000719, Prot_kinase_dom |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50011, PROTEIN_KINASE_DOM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NRBP2_HUMAN | |
Accessioni | Q9NSY0Primary (citable) accession number: Q9NSY0 Secondary accession number(s): B4DF59 Q8WYS5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 7, 2006 |
Last sequence update: | June 15, 2010 | |
Last modified: | May 25, 2022 | |
This is version 160 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families