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UniProtKB - Q9NSY0 (NRBP2_HUMAN)

Entry version 160 (25 May 2022)
Sequence version 2 (15 Jun 2010)
Previous versions | rss
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Protein

Nuclear receptor-binding protein 2

Gene

NRBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May regulate apoptosis of neural progenitor cells during their differentiation.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processNeurogenesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9NSY0

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9NSY0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear receptor-binding protein 2
Alternative name(s):
Transformation-related gene 16 protein
Short name:
TRG-16
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NRBP2Imported
ORF Names:PP9320, TRG16
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19339, NRBP2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		615563, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NSY0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000185189

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		340371

Open Targets

More...OpenTargetsi		ENSG00000185189

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134891143

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NSY0, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NRBP2

Domain mapping of disease mutations (DMDM)

More...DMDMi		298286835

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002256081 – 501Nuclear receptor-binding protein 2Add BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei409PhosphothreonineBy similarity1
Modified residuei411PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NSY0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NSY0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NSY0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NSY0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NSY0

PeptideAtlas

More...PeptideAtlasi		Q9NSY0

PRoteomics IDEntifications database

More...PRIDEi		Q9NSY0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		82590 [Q9NSY0-3]
82591 [Q9NSY0-2]
82592 [Q9NSY0-4]
82593 [Q9NSY0-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NSY0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NSY0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000185189, Expressed in spinal cord and 122 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NSY0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NSY0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000185189, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		131044, 13 interactors

Protein interaction database and analysis system

More...IntActi		Q9NSY0, 60 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000414055

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NSY0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9NSY0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NSY0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini38 – 306Protein kinasePROSITE-ProRule annotationAdd BLAST269

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 33DisorderedSequence analysisAdd BLAST33

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The protein kinase domain is predicted to be catalytically inactive.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1266, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160430

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_024273_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NSY0

Identification of Orthologs from Complete Genome Data

More...OMAi		KVFKAHE

Database of Orthologous Groups

More...OrthoDBi		695382at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NSY0

TreeFam database of animal gene trees

More...TreeFami		TF315519

Family and domain databases

Conserved Domains Database

More...CDDi		cd14035, PK_MADML, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR042697, NRBP2_PK
IPR000719, Prot_kinase_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00069, Pkinase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NSY0-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPEPAPRR ARERERERED ESEDESDILE ESPCGRWQKR REQVNQGNMP 
        60         70         80         90        100
GLQSTFLAMD TEEGVEVVWN ELHFGDRKAF AAHEEKIQTV FEQLVLVDHP 
       110        120        130        140        150
NIVKLHKYWL DTSEACARVI FITEYVSSGS LKQFLKKTKK NHKAMNARAW 
       160        170        180        190        200
KRWCTQILSA LSFLHACSPP IIHGNLTSDT IFIQHNGLIK IGSVWHRIFS 
       210        220        230        240        250
NALPDDLRSP IRAEREELRN LHFFPPEYGE VADGTAVDIF SFGMCALEMA 
       260        270        280        290        300
VLEIQTNGDT RVTEEAIARA RHSLSDPNMR EFILCCLARD PARRPSAHSL 
       310        320        330        340        350
LFHRVLFEVH SLKLLAAHCF IQHQYLMPEN VVEEKTKAMD LHAVLAELPR 
       360        370        380        390        400
PRRPPLQWRY SEVSFMELDK FLEDVRNGIY PLMNFAATRP LGLPRVLAPP 
       410        420        430        440        450
PEEVQKAKTP TPEPFDSETR KVIQMQCNLE RSEDKARWHL TLLLVLEDRL 
       460        470        480        490        500
HRQLTYDLLP TDSAQDLASE LVHYGFLHED DRMKLAAFLE STFLKYRGTQ 

A
Length:501
Mass (Da):57,803
Last modified:June 15, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB3F246DBA7E2AC6C
GO
Isoform 22 Publications (identifier: Q9NSY0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: Missing.
     244-280: MCALEMAVLE...RHSLSDPNMR → MVLQSQNPAV...HHQPLLPVPQ

Show »
Length:293
Mass (Da):33,141
Checksum:iB37F0F45BD8AC99B
GO
Isoform 3 (identifier: Q9NSY0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: Missing.
     244-280: MCALEMAVLE...RHSLSDPNMR → MVLQSQNPAV...HHQPLLPVPQ
     461-501: TDSAQDLASE...TFLKYRGTQA → SRLGRGLGRR...LPQVPWDPGL

Show »
Length:324
Mass (Da):36,072
Checksum:i45EDFCB9AFCB5660
GO
Isoform 4 (identifier: Q9NSY0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     149-171: AWKRWCTQILSALSFLHACSPPI → VWGAGWGSHGDRTGLGQPRGLGW
     172-501: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:123
Mass (Da):13,910
Checksum:iA24C99DA3D502C1C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PR11E9PR11_HUMAN
Nuclear receptor-binding protein 2
NRBP2
232Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCB1H0YCB1_HUMAN
Nuclear receptor-binding protein 2
NRBP2
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI13874 differs from that shown. Probable cloning artifact.Curated
The sequence CAB70864 differs from that shown. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 3 (identifier: Q9NSY0-4)
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10V → A in AAQ18040 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0393081 – 243Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST243
Alternative sequenceiVSP_0393111 – 48Missing in isoform 4. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_039312149 – 171AWKRW…CSPPI → VWGAGWGSHGDRTGLGQPRG LGW in isoform 4. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_039313172 – 501Missing in isoform 4. 1 PublicationAdd BLAST330
Alternative sequenceiVSP_039309244 – 280MCALE…DPNMR → MVLQSQNPAVLKLRGPGPGL AAAAGTPPYGHPCMSCVSLR RDMGNSGATSPRTAGPEQRA LAHHQPLLPVPQ in isoform 2 and isoform 3. 2 PublicationsAdd BLAST37
Alternative sequenceiVSP_039310461 – 501TDSAQ…RGTQA → SRLGRGLGRRAVTPGGGWAA ASCLALRHCLSGQRPGPRLG ARALWLPPRGRPDEAGRLPG EHLPQVPWDPGL in isoform 3. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY277601 mRNA Translation: AAQ18040.1
AK293943 mRNA Translation: BAG57320.1
AF318376 mRNA Translation: AAL55883.1
AL137662 mRNA Translation: CAB70864.1 Sequence problems.
AL834530 mRNA Translation: CAD39186.1
AC105049 Genomic DNA No translation available.
BC113873 mRNA Translation: AAI13874.1 Sequence problems.
CR457350 mRNA Translation: CAG33631.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34959.2 [Q9NSY0-3]

Protein sequence database of the Protein Information Resource

More...PIRi		T46491

NCBI Reference Sequences

More...RefSeqi		NP_848659.2, NM_178564.3 [Q9NSY0-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000442628.7; ENSP00000414055.2; ENSG00000185189.18

Database of genes from NCBI RefSeq genomes

More...GeneIDi		340371

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:340371

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000442628.7; ENSP00000414055.2; NM_178564.4; NP_848659.2

UCSC genome browser

More...UCSCi		uc011lkt.3, human [Q9NSY0-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY277601 mRNA Translation: AAQ18040.1
AK293943 mRNA Translation: BAG57320.1
AF318376 mRNA Translation: AAL55883.1
AL137662 mRNA Translation: CAB70864.1 Sequence problems.
AL834530 mRNA Translation: CAD39186.1
AC105049 Genomic DNA No translation available.
BC113873 mRNA Translation: AAI13874.1 Sequence problems.
CR457350 mRNA Translation: CAG33631.1
CCDSiCCDS34959.2 [Q9NSY0-3]
PIRiT46491
RefSeqiNP_848659.2, NM_178564.3 [Q9NSY0-3]

3D structure databases

AlphaFoldDBiQ9NSY0
SMRiQ9NSY0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi131044, 13 interactors
IntActiQ9NSY0, 60 interactors
STRINGi9606.ENSP00000414055

PTM databases

iPTMnetiQ9NSY0
PhosphoSitePlusiQ9NSY0

Genetic variation databases

BioMutaiNRBP2
DMDMi298286835

Proteomic databases

EPDiQ9NSY0
jPOSTiQ9NSY0
MassIVEiQ9NSY0
MaxQBiQ9NSY0
PaxDbiQ9NSY0
PeptideAtlasiQ9NSY0
PRIDEiQ9NSY0
ProteomicsDBi82590 [Q9NSY0-3]
82591 [Q9NSY0-2]
82592 [Q9NSY0-4]
82593 [Q9NSY0-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28122, 200 antibodies from 26 providers

The DNASU plasmid repository

More...DNASUi		340371

Genome annotation databases

EnsembliENST00000442628.7; ENSP00000414055.2; ENSG00000185189.18
GeneIDi340371
KEGGihsa:340371
MANE-SelectiENST00000442628.7; ENSP00000414055.2; NM_178564.4; NP_848659.2
UCSCiuc011lkt.3, human [Q9NSY0-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		340371
DisGeNETi340371

GeneCards: human genes, protein and diseases

More...GeneCardsi		NRBP2
HGNCiHGNC:19339, NRBP2
HPAiENSG00000185189, Low tissue specificity
MIMi615563, gene
neXtProtiNX_Q9NSY0
OpenTargetsiENSG00000185189
PharmGKBiPA134891143
VEuPathDBiHostDB:ENSG00000185189

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1266, Eukaryota
GeneTreeiENSGT00940000160430
HOGENOMiCLU_024273_0_0_1
InParanoidiQ9NSY0
OMAiKVFKAHE
OrthoDBi695382at2759
PhylomeDBiQ9NSY0
TreeFamiTF315519

Enzyme and pathway databases

PathwayCommonsiQ9NSY0
SignaLinkiQ9NSY0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		340371, 15 hits in 1112 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NRBP2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		340371
PharosiQ9NSY0, Tdark

Protein Ontology

More...PROi		PR:Q9NSY0
RNActiQ9NSY0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000185189, Expressed in spinal cord and 122 other tissues
ExpressionAtlasiQ9NSY0, baseline and differential
GenevisibleiQ9NSY0, HS

Family and domain databases

CDDicd14035, PK_MADML, 1 hit
InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR042697, NRBP2_PK
IPR000719, Prot_kinase_dom
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011, PROTEIN_KINASE_DOM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRBP2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NSY0
Secondary accession number(s): B4DF59
, Q2HIX8, Q597G7, Q8NCX8, Q8WYS5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: June 15, 2010
Last modified: May 25, 2022
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
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