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Entry version 108 (29 Sep 2021)
Sequence version 2 (25 Oct 2004)
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Protein
Submitted name:

Uncharacterized protein DKFZp566E044

Gene

DKFZp566E044

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1125 – 1186UBP-typePROSITE-ProRule annotationAdd BLAST62

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized protein DKFZp566E044Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DKFZp566E044Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q9NSW6

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q9NSW6, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1125 – 1186UBP-typeInterPro annotationAdd BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 44DisorderedSequence analysisAdd BLAST44
Regioni439 – 458DisorderedSequence analysisAdd BLAST20
Regioni836 – 860DisorderedSequence analysisAdd BLAST25
Regioni988 – 1041DisorderedSequence analysisAdd BLAST54

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 34Polar residuesSequence analysisAdd BLAST34
Compositional biasi443 – 457Acidic residuesSequence analysisAdd BLAST15

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1125 – 1186UBP-typePROSITE-ProRule annotationAdd BLAST62

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
HEASGHP

Database of Orthologous Groups

More...
OrthoDBi
1484694at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit
3.40.800.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000286, His_deacetylse
IPR023801, His_deacetylse_dom
IPR037138, His_deacetylse_dom_sf
IPR023696, Ureohydrolase_dom_sf
IPR013083, Znf_RING/FYVE/PHD
IPR001607, Znf_UBP

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00850, Hist_deacetyl, 2 hits
PF02148, zf-UBP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01270, HDASUPER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00290, ZnF_UBP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52768, SSF52768, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50271, ZF_UBP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9NSW6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSTGQDSTT TRQRRSRQNP QSPPQDSSVT SKRNIKKGAV PRSIPNLAEV
60 70 80 90 100
KKKGKMKKLG QAMEEDLIVG LQGMDLNLEA EALAGTGLVL DEQLNEFHCL
110 120 130 140 150
WDDSFPEGPE RLHAIKEQLI QEGLLDRCVS FQARFAEKEE LMLVHRMETT
160 170 180 190 200
QYMNEGELRV LADTYDSVYL HPNSYSCACL ASGSVLRLVD AVLGAEIRNG
210 220 230 240 250
MAIIRPPGHH AQHSLMDGYC MFNHVAVAAR YAQQKHRIRR VLIVDWDVHH
260 270 280 290 300
GQGTQFTFDQ DPSVLYFSIH RYEQGRFWPH LKASNWSTTG FGQGQGYTIN
310 320 330 340 350
VPWNQVGMRD ADYIAAFLHV LLPVALEFQP QLVLVAAGFD ALQGDPKGEM
360 370 380 390 400
AATPAGFAQL THLLMGLAGG KLILSLEGGY NLRALAEGVS ASLHTLLGDP
410 420 430 440 450
CPMLESPGAP CRSAQTSVSC ALEALEPFWE VLVRSTETVE RDNMEEDNVE
460 470 480 490 500
ESEEEGPWEP PVLPILTWPV LQSRTGLVYD QNMMNHCNLW DSHHPEVPQR
510 520 530 540 550
ILRIMCRLEE LGLAGRCLTL TPRPATEAEL LTCHSAEYVG HLRATEKMKT
560 570 580 590 600
RELHRESSNF DSIYICPSTF ACAQLATGAA CRLVEAVLSG EVLNGAAVVR
610 620 630 640 650
PPGHHAEQDA ACGFCFFNSV AVAARHAQTI SGHALRILIV DWDVHHGNGT
660 670 680 690 700
QHMFEDDPSV LYVSLHRYDH GTFFPMGDEG ASSQIGRAAG TGFTVNVAWN
710 720 730 740 750
GPRMGDADYL AAWHRLVLPI AYEFNPELVL VSAGFDAARG DPLGGCQVSP
760 770 780 790 800
EGYAHLTHLL MGLASGRIIL ILEGGYNLTS ISESMAACTR SLLGDPPPLL
810 820 830 840 850
TLPRPPLSGA LASITETIQV HRRYWRCLRV MKVEDREGPS SSKLDTKKAP
860 870 880 890 900
QPAKPRLAER MTTREKKVLE AGMGKVTSAS FGEESTPGQT NSETAVVALT
910 920 930 940 950
QDQPSEAATG GATLAQTISE AAIGGAMLGQ TTSEEAVGGA TPDQTTSEET
960 970 980 990 1000
VGGAILDQTT SEDAVGGATL GQTTSEEAVG GATLAQTTSE AAMEGATLDQ
1010 1020 1030 1040 1050
TTSEEAPGGT ELIQTPLASS TDHQTPPTSP VQGTTPQISP STLIGSLRTL
1060 1070 1080 1090 1100
ELGSESQGAS ESQAPGEENL LGEAAGGQDM ADSMLMQGSR GLTDQAIFYA
1110 1120 1130 1140 1150
VTPLPWCPHL VAVCPIPAAG LDVTQPCGDC GTIQENWVCL SCYQVYCGRY
1160 1170 1180 1190 1200
INGHMLQHHG NSGHPLVLSY IDLSAWCYYC QAYVHHQALL DVKNIAHQNK

FGEDMPHPH
Length:1,209
Mass (Da):130,804
Last modified:October 25, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA2BD1739B3EFACE0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL137696 mRNA Translation: CAB70878.2

Protein sequence database of the Protein Information Resource

More...
PIRi
T46284

NCBI Reference Sequences

More...
RefSeqi
NP_001308154.1, NM_001321225.1
NP_006035.2, NM_006044.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10013

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137696 mRNA Translation: CAB70878.2
PIRiT46284
RefSeqiNP_001308154.1, NM_001321225.1
NP_006035.2, NM_006044.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9NSW6, 1 interactor

Proteomic databases

PeptideAtlasiQ9NSW6

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10013

Genome annotation databases

GeneIDi10013

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10013

Phylogenomic databases

OMAiHEASGHP
OrthoDBi1484694at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
10013, 10 hits in 654 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10013

Family and domain databases

Gene3Di3.30.40.10, 1 hit
3.40.800.20, 2 hits
InterProiView protein in InterPro
IPR000286, His_deacetylse
IPR023801, His_deacetylse_dom
IPR037138, His_deacetylse_dom_sf
IPR023696, Ureohydrolase_dom_sf
IPR013083, Znf_RING/FYVE/PHD
IPR001607, Znf_UBP
PfamiView protein in Pfam
PF00850, Hist_deacetyl, 2 hits
PF02148, zf-UBP, 1 hit
PRINTSiPR01270, HDASUPER
SMARTiView protein in SMART
SM00290, ZnF_UBP, 1 hit
SUPFAMiSSF52768, SSF52768, 2 hits
PROSITEiView protein in PROSITE
PS50271, ZF_UBP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9NSW6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NSW6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 25, 2004
Last modified: September 29, 2021
This is version 108 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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