UniProtKB - Q9NSV4 (DIAP3_HUMAN)

BLAST

>sp|Q9NSV4|DIAP3_HUMAN Protein diaphanous homolog 3 OS=Homo sapiens OX=9606 GN=DIAPH3 PE=1 SV=4
MERHQPRLHHPAQGSAAGTPYPSSASLRGCRESKMPRRKGPQHPPPPSGPEEPGEKRPKF
HLNIRTLTDDMLDKFASIRIPGSKKERPPLPNLKTAFASSDCSAAPLEMMENFPKPLSEN
ELLELFEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQYINTASKTGSLKRSRQISPQEFI
HELKMGSADERLVTCLESLRVSLTSNPVSWVESFGHEGLGLLLDILEKLISGKIQEKVVK
KNQHKVIQCLKALMNTQYGLERIMSEERSLSLLAKAVDPRHPNMMTDVVKLLSAVCIVGE
ESILEEVLEALTSAGEEKKIDRFFCIVEGLRHNSVQLQVACMQLINALVTSPDDLDFRLH
IRNEFMRCGLKEILPNLKCIKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDV
YNMVWSTVKETRAEGYFISILQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFT
YRKRLDLDLTQFVDICIDQAKLEEFEEKASELYKKFEKEFTDHQETQAELQKKEAKINEL
QAELQAFKSQFGALPADCNIPLPPSKEGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLP
GMRMPFSGPVPPPPPLGFLGGQNSPPLPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMT
ENCFWIKVNENKYENVDLLCKLENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIA
QNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNL
CEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLL
ELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNF
VDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISA
KEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKRE
AEEKEKRVRIAKELAERERLERQQKKKRLLEMKTEGDETGVMDNLLEALQSGAAFRDRRK
RTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNL
DTHTSTGRIKAAEKKEACNVESNRKKETELLGSFSKNESVPEVEALLARLRAL

Align

Format
Add to basket Added to basket
History
Entry version 174 (12 Sep 2018)
Sequence version 4 (11 Sep 2007)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Protein diaphanous homolog 3

Gene

DIAPH3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Binds to GTP-bound form of Rho and to profilin. Acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. It is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity).By similarity

GO - Molecular functionⁱ

actin binding Source: InterPro
cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
Rho GTPase binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin cytoskeleton organization Source: InterPro
spermatogenesis Source: Ensembl

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5663220 RHO GTPases Activate Formins

Reactomeⁱ

R-HSA-5663220 RHO GTPases Activate Formins

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein diaphanous homolog 3 Alternative name(s): Diaphanous-related formin-3 Short name: DRF3 MDia2
Gene namesⁱ	Name:DIAPH3 Synonyms:DIAP3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000139734.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15480 DIAPH3
MIMⁱ	614567 gene
neXtProtⁱ	NX_Q9NSV4

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Auditory neuropathy, autosomal dominant, 1 (AUNA1)1 Publication

The disease is caused by mutations affecting the gene represented in this entry. A disease-causing mutation in the conserved 5'-UTR leads to increased protein expression (PubMed:20624953).1 Publication

Disease descriptionA form of sensorineural hearing loss with absent or severely abnormal auditory brainstem response, in the presence of normal cochlear outer hair cell function and normal otoacoustic emissions. Auditory neuropathies result from a lesion in the area including the inner hair cells, connections between the inner hair cells and the cochlear branch of the auditory nerve, the auditory nerve itself and auditory pathways of the brainstem.

Keywords - Diseaseⁱ

Deafness, Neuropathy, Non-syndromic deafness

Organism-specific databases

DisGeNET More...DisGeNETⁱ	81624
MalaCards human disease database More...MalaCardsⁱ	DIAPH3
MIMⁱ	609129 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000139734
Orphanetⁱ	90635 Autosomal dominant non-syndromic sensorineural deafness type DFNA
PharmGKBⁱ	PA27335

Polymorphism and mutation databases

BioMutaⁱ	DIAPH3
DMDMⁱ	158520000

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000194897	1 – 1193	Protein diaphanous homolog 3Add BLAST		1193

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	26	PhosphoserineCombined sources	1
Modified residueⁱ	68	PhosphothreonineCombined sources	1
Modified residueⁱ	77	PhosphoserineCombined sources	1
Modified residueⁱ	175	PhosphoserineCombined sources	1
Modified residueⁱ	624	PhosphoserineCombined sources	1
Modified residueⁱ	1093	PhosphoserineCombined sources	1
Modified residueⁱ	1179	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Ubiquitinated.1 Publication

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q9NSV4
PaxDbⁱ	Q9NSV4
PeptideAtlas More...PeptideAtlasⁱ	Q9NSV4
PRIDEⁱ	Q9NSV4
ProteomicsDBⁱ	82583 82584 [Q9NSV4-1] 82585 [Q9NSV4-2] 82586 [Q9NSV4-4] 82587 [Q9NSV4-5] 82588 [Q9NSV4-6] 82589 [Q9NSV4-7]

PTM databases

iPTMnetⁱ	Q9NSV4
PhosphoSitePlusⁱ	Q9NSV4

Expressionⁱ

Developmental stageⁱ

Increased expression in S phase and mitotic cells; levels decrease as cells enter in G0/G1 phase due to proteasomal degradation (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000139734 Expressed in 135 organ(s), highest expression level in testis
CleanExⁱ	HS_DIAPH3
Genevisibleⁱ	Q9NSV4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA032151

HPAⁱ

HPA032151

Interactionⁱ

GO - Molecular functionⁱ

actin binding Source: InterPro
cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
Rho GTPase binding Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	123559, 34 interactors
IntActⁱ	Q9NSV4, 13 interactors
Molecular INTeraction database More...MINTⁱ	Q9NSV4
STRINGⁱ	9606.ENSP00000383178

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	1184 – 1191	Combined sources		8

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9NSV4
SMRⁱ	Q9NSV4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	114 – 476	GBD/FH3PROSITE-ProRule annotationAdd BLAST	363
Domainⁱ	561 – 631	FH1Add BLAST	71
Domainⁱ	636 – 1034	FH2PROSITE-ProRule annotationAdd BLAST	399
Domainⁱ	1057 – 1087	DADPROSITE-ProRule annotationAdd BLAST	31

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	497 – 554	Sequence analysisAdd BLAST		58
Coiled coilⁱ	1013 – 1056	Sequence analysisAdd BLAST		44

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	561 – 636	Pro-richAdd BLAST		76

Domainⁱ

The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).By similarity

Sequence similaritiesⁱ

Belongs to the formin homology family. Diaphanous subfamily.Curated

Keywords - Domainⁱ

Coiled coil, Repeat

Phylogenomic databases

eggNOGⁱ	KOG1924 Eukaryota ENOG410Y29H LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118986
HOVERGENⁱ	HBG051357
InParanoidⁱ	Q9NSV4
KEGG Orthology (KO) More...KOⁱ	K05745
OMAⁱ	KQMGRQL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JR0
PhylomeDBⁱ	Q9NSV4
TreeFamⁱ	TF315383

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR014767 DAD_dom IPR010465 Drf_DAD IPR015425 FH2_Formin IPR010472 FH3_dom IPR027654 Formin_DIAPH3 IPR014768 GBD/FH3_dom IPR010473 GTPase-bd
PANTHERⁱ	PTHR23213:SF198 PTHR23213:SF198, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06345 Drf_DAD, 1 hit PF06367 Drf_FH3, 1 hit PF06371 Drf_GBD, 1 hit PF02181 FH2, 1 hit
SMARTⁱ	View protein in SMART SM01139 Drf_FH3, 1 hit SM01140 Drf_GBD, 1 hit SM00498 FH2, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit
PROSITEⁱ	View protein in PROSITE PS51231 DAD, 1 hit PS51444 FH2, 1 hit PS51232 GBD_FH3, 1 hit

Sequences (7)ⁱ

Sequence statusⁱ: Complete.

This entry describes 7 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 3 (identifier: Q9NSV4-3) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERHQPRLHH PAQGSAAGTP YPSSASLRGC RESKMPRRKG PQHPPPPSGP 
        60         70         80         90        100
EEPGEKRPKF HLNIRTLTDD MLDKFASIRI PGSKKERPPL PNLKTAFASS 
       110        120        130        140        150
DCSAAPLEMM ENFPKPLSEN ELLELFEKMM EDMNLNEDKK APLREKDFSI 
       160        170        180        190        200
KKEMVMQYIN TASKTGSLKR SRQISPQEFI HELKMGSADE RLVTCLESLR 
       210        220        230        240        250
VSLTSNPVSW VESFGHEGLG LLLDILEKLI SGKIQEKVVK KNQHKVIQCL 
       260        270        280        290        300
KALMNTQYGL ERIMSEERSL SLLAKAVDPR HPNMMTDVVK LLSAVCIVGE 
       310        320        330        340        350
ESILEEVLEA LTSAGEEKKI DRFFCIVEGL RHNSVQLQVA CMQLINALVT 
       360        370        380        390        400
SPDDLDFRLH IRNEFMRCGL KEILPNLKCI KNDGLDIQLK VFDEHKEEDL 
       410        420        430        440        450
FELSHRLEDI RAELDEAYDV YNMVWSTVKE TRAEGYFISI LQHLLLIRND 
       460        470        480        490        500
YFIRQQYFKL IDECVSQIVL HRDGMDPDFT YRKRLDLDLT QFVDICIDQA 
       510        520        530        540        550
KLEEFEEKAS ELYKKFEKEF TDHQETQAEL QKKEAKINEL QAELQAFKSQ 
       560        570        580        590        600
FGALPADCNI PLPPSKEGGT GHSALPPPPP LPSGGGVPPP PPPPPPPPLP 
       610        620        630        640        650
GMRMPFSGPV PPPPPLGFLG GQNSPPLPIL PFGLKPKKEF KPEISMRRLN 
       660        670        680        690        700
WLKIRPHEMT ENCFWIKVNE NKYENVDLLC KLENTFCCQQ KERREEEDIE 
       710        720        730        740        750
EKKSIKKKIK ELKFLDSKIA QNLSIFLSSF RVPYEEIRMM ILEVDETRLA 
       760        770        780        790        800
ESMIQNLIKH LPDQEQLNSL SQFKSEYSNL CEPEQFVVVM SNVKRLRPRL 
       810        820        830        840        850
SAILFKLQFE EQVNNIKPDI MAVSTACEEI KKSKSFSKLL ELVLLMGNYM 
       860        870        880        890        900
NAGSRNAQTF GFNLSSLCKL KDTKSADQKT TLLHFLVEIC EEKYPDILNF 
       910        920        930        940        950
VDDLEPLDKA SKVSVETLEK NLRQMGRQLQ QLEKELETFP PPEDLHDKFV 
       960        970        980        990       1000
TKMSRFVISA KEQYETLSKL HENMEKLYQS IIGYYAIDVK KVSVEDFLTD 
      1010       1020       1030       1040       1050
LNNFRTTFMQ AIKENIKKRE AEEKEKRVRI AKELAERERL ERQQKKKRLL 
      1060       1070       1080       1090       1100
EMKTEGDETG VMDNLLEALQ SGAAFRDRRK RTPMPKDVRQ SLSPMSQRPV 
      1110       1120       1130       1140       1150
LKVCNHENQK VQLTEGSRSH YNINCNSTRT PVAKELNYNL DTHTSTGRIK 
      1160       1170       1180       1190 
AAEKKEACNV ESNRKKETEL LGSFSKNESV PEVEALLARL RAL

Length:1,193

Mass (Da):136,926

Last modified:September 11, 2007 - v4

Checksum:ⁱABCA4E859873F9E7

Isoform 1 (identifier: Q9NSV4-1) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-263: Missing.
     1107-1112: ENQKVQ → GNKPYL
     1113-1193: Missing.

« Hide

        10         20         30         40         50
MSEERSLSLL AKAVDPRHPN MMTDVVKLLS AVCIVGEESI LEEVLEALTS 
        60         70         80         90        100
AGEEKKIDRF FCIVEGLRHN SVQLQVACMQ LINALVTSPD DLDFRLHIRN 
       110        120        130        140        150
EFMRCGLKEI LPNLKCIKND GLDIQLKVFD EHKEEDLFEL SHRLEDIRAE 
       160        170        180        190        200
LDEAYDVYNM VWSTVKETRA EGYFISILQH LLLIRNDYFI RQQYFKLIDE 
       210        220        230        240        250
CVSQIVLHRD GMDPDFTYRK RLDLDLTQFV DICIDQAKLE EFEEKASELY 
       260        270        280        290        300
KKFEKEFTDH QETQAELQKK EAKINELQAE LQAFKSQFGA LPADCNIPLP 
       310        320        330        340        350
PSKEGGTGHS ALPPPPPLPS GGGVPPPPPP PPPPPLPGMR MPFSGPVPPP 
       360        370        380        390        400
PPLGFLGGQN SPPLPILPFG LKPKKEFKPE ISMRRLNWLK IRPHEMTENC 
       410        420        430        440        450
FWIKVNENKY ENVDLLCKLE NTFCCQQKER REEEDIEEKK SIKKKIKELK 
       460        470        480        490        500
FLDSKIAQNL SIFLSSFRVP YEEIRMMILE VDETRLAESM IQNLIKHLPD 
       510        520        530        540        550
QEQLNSLSQF KSEYSNLCEP EQFVVVMSNV KRLRPRLSAI LFKLQFEEQV 
       560        570        580        590        600
NNIKPDIMAV STACEEIKKS KSFSKLLELV LLMGNYMNAG SRNAQTFGFN 
       610        620        630        640        650
LSSLCKLKDT KSADQKTTLL HFLVEICEEK YPDILNFVDD LEPLDKASKV 
       660        670        680        690        700
SVETLEKNLR QMGRQLQQLE KELETFPPPE DLHDKFVTKM SRFVISAKEQ 
       710        720        730        740        750
YETLSKLHEN MEKLYQSIIG YYAIDVKKVS VEDFLTDLNN FRTTFMQAIK 
       760        770        780        790        800
ENIKKREAEE KEKRVRIAKE LAERERLERQ QKKKRLLEMK TEGDETGVMD 
       810        820        830        840 
NLLEALQSGA AFRDRRKRTP MPKDVRQSLS PMSQRPVLKV CNHGNKPYL

Show »

Length:849

Mass (Da):98,140

Checksum:ⁱ5CE99DEE93AC833C

Isoform 2 (identifier: Q9NSV4-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-263: Missing.
     913-956: VSVETLEKNL...DKFVTKMSRF → GLCLFKKHFM...HSVFIPNISF
     957-1193: Missing.

« Hide

        10         20         30         40         50
MSEERSLSLL AKAVDPRHPN MMTDVVKLLS AVCIVGEESI LEEVLEALTS 
        60         70         80         90        100
AGEEKKIDRF FCIVEGLRHN SVQLQVACMQ LINALVTSPD DLDFRLHIRN 
       110        120        130        140        150
EFMRCGLKEI LPNLKCIKND GLDIQLKVFD EHKEEDLFEL SHRLEDIRAE 
       160        170        180        190        200
LDEAYDVYNM VWSTVKETRA EGYFISILQH LLLIRNDYFI RQQYFKLIDE 
       210        220        230        240        250
CVSQIVLHRD GMDPDFTYRK RLDLDLTQFV DICIDQAKLE EFEEKASELY 
       260        270        280        290        300
KKFEKEFTDH QETQAELQKK EAKINELQAE LQAFKSQFGA LPADCNIPLP 
       310        320        330        340        350
PSKEGGTGHS ALPPPPPLPS GGGVPPPPPP PPPPPLPGMR MPFSGPVPPP 
       360        370        380        390        400
PPLGFLGGQN SPPLPILPFG LKPKKEFKPE ISMRRLNWLK IRPHEMTENC 
       410        420        430        440        450
FWIKVNENKY ENVDLLCKLE NTFCCQQKER REEEDIEEKK SIKKKIKELK 
       460        470        480        490        500
FLDSKIAQNL SIFLSSFRVP YEEIRMMILE VDETRLAESM IQNLIKHLPD 
       510        520        530        540        550
QEQLNSLSQF KSEYSNLCEP EQFVVVMSNV KRLRPRLSAI LFKLQFEEQV 
       560        570        580        590        600
NNIKPDIMAV STACEEIKKS KSFSKLLELV LLMGNYMNAG SRNAQTFGFN 
       610        620        630        640        650
LSSLCKLKDT KSADQKTTLL HFLVEICEEK YPDILNFVDD LEPLDKASKG 
       660        670        680        690 
LCLFKKHFMA LIFSAKRLKI IPFICMYFPL SHSVFIPNIS F

Show »

Length:691

Mass (Da):79,445

Checksum:ⁱCDFF84D86D4B66DF

Isoform 4 (identifier: Q9NSV4-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
61-71: Missing.

« Hide

        10         20         30         40         50
MERHQPRLHH PAQGSAAGTP YPSSASLRGC RESKMPRRKG PQHPPPPSGP 
        60         70         80         90        100
EEPGEKRPKF LDKFASIRIP GSKKERPPLP NLKTAFASSD CSAAPLEMME 
       110        120        130        140        150
NFPKPLSENE LLELFEKMME DMNLNEDKKA PLREKDFSIK KEMVMQYINT 
       160        170        180        190        200
ASKTGSLKRS RQISPQEFIH ELKMGSADER LVTCLESLRV SLTSNPVSWV 
       210        220        230        240        250
ESFGHEGLGL LLDILEKLIS GKIQEKVVKK NQHKVIQCLK ALMNTQYGLE 
       260        270        280        290        300
RIMSEERSLS LLAKAVDPRH PNMMTDVVKL LSAVCIVGEE SILEEVLEAL 
       310        320        330        340        350
TSAGEEKKID RFFCIVEGLR HNSVQLQVAC MQLINALVTS PDDLDFRLHI 
       360        370        380        390        400
RNEFMRCGLK EILPNLKCIK NDGLDIQLKV FDEHKEEDLF ELSHRLEDIR 
       410        420        430        440        450
AELDEAYDVY NMVWSTVKET RAEGYFISIL QHLLLIRNDY FIRQQYFKLI 
       460        470        480        490        500
DECVSQIVLH RDGMDPDFTY RKRLDLDLTQ FVDICIDQAK LEEFEEKASE 
       510        520        530        540        550
LYKKFEKEFT DHQETQAELQ KKEAKINELQ AELQAFKSQF GALPADCNIP 
       560        570        580        590        600
LPPSKEGGTG HSALPPPPPL PSGGGVPPPP PPPPPPPLPG MRMPFSGPVP 
       610        620        630        640        650
PPPPLGFLGG QNSPPLPILP FGLKPKKEFK PEISMRRLNW LKIRPHEMTE 
       660        670        680        690        700
NCFWIKVNEN KYENVDLLCK LENTFCCQQK ERREEEDIEE KKSIKKKIKE 
       710        720        730        740        750
LKFLDSKIAQ NLSIFLSSFR VPYEEIRMMI LEVDETRLAE SMIQNLIKHL 
       760        770        780        790        800
PDQEQLNSLS QFKSEYSNLC EPEQFVVVMS NVKRLRPRLS AILFKLQFEE 
       810        820        830        840        850
QVNNIKPDIM AVSTACEEIK KSKSFSKLLE LVLLMGNYMN AGSRNAQTFG 
       860        870        880        890        900
FNLSSLCKLK DTKSADQKTT LLHFLVEICE EKYPDILNFV DDLEPLDKAS 
       910        920        930        940        950
KVSVETLEKN LRQMGRQLQQ LEKELETFPP PEDLHDKFVT KMSRFVISAK 
       960        970        980        990       1000
EQYETLSKLH ENMEKLYQSI IGYYAIDVKK VSVEDFLTDL NNFRTTFMQA 
      1010       1020       1030       1040       1050
IKENIKKREA EEKEKRVRIA KELAERERLE RQQKKKRLLE MKTEGDETGV 
      1060       1070       1080       1090       1100
MDNLLEALQS GAAFRDRRKR TPMPKDVRQS LSPMSQRPVL KVCNHENQKV 
      1110       1120       1130       1140       1150
QLTEGSRSHY NINCNSTRTP VAKELNYNLD THTSTGRIKA AEKKEACNVE 
      1160       1170       1180 
SNRKKETELL GSFSKNESVP EVEALLARLR AL

Show »

Length:1,182

Mass (Da):135,615

Checksum:ⁱ9169ACD33B8FB00D

Isoform 5 (identifier: Q9NSV4-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
61-71: Missing.
131-165: Missing.

« Hide

        10         20         30         40         50
MERHQPRLHH PAQGSAAGTP YPSSASLRGC RESKMPRRKG PQHPPPPSGP 
        60         70         80         90        100
EEPGEKRPKF LDKFASIRIP GSKKERPPLP NLKTAFASSD CSAAPLEMME 
       110        120        130        140        150
NFPKPLSENE LLELFEKMMG SLKRSRQISP QEFIHELKMG SADERLVTCL 
       160        170        180        190        200
ESLRVSLTSN PVSWVESFGH EGLGLLLDIL EKLISGKIQE KVVKKNQHKV 
       210        220        230        240        250
IQCLKALMNT QYGLERIMSE ERSLSLLAKA VDPRHPNMMT DVVKLLSAVC 
       260        270        280        290        300
IVGEESILEE VLEALTSAGE EKKIDRFFCI VEGLRHNSVQ LQVACMQLIN 
       310        320        330        340        350
ALVTSPDDLD FRLHIRNEFM RCGLKEILPN LKCIKNDGLD IQLKVFDEHK 
       360        370        380        390        400
EEDLFELSHR LEDIRAELDE AYDVYNMVWS TVKETRAEGY FISILQHLLL 
       410        420        430        440        450
IRNDYFIRQQ YFKLIDECVS QIVLHRDGMD PDFTYRKRLD LDLTQFVDIC 
       460        470        480        490        500
IDQAKLEEFE EKASELYKKF EKEFTDHQET QAELQKKEAK INELQAELQA 
       510        520        530        540        550
FKSQFGALPA DCNIPLPPSK EGGTGHSALP PPPPLPSGGG VPPPPPPPPP 
       560        570        580        590        600
PPLPGMRMPF SGPVPPPPPL GFLGGQNSPP LPILPFGLKP KKEFKPEISM 
       610        620        630        640        650
RRLNWLKIRP HEMTENCFWI KVNENKYENV DLLCKLENTF CCQQKERREE 
       660        670        680        690        700
EDIEEKKSIK KKIKELKFLD SKIAQNLSIF LSSFRVPYEE IRMMILEVDE 
       710        720        730        740        750
TRLAESMIQN LIKHLPDQEQ LNSLSQFKSE YSNLCEPEQF VVVMSNVKRL 
       760        770        780        790        800
RPRLSAILFK LQFEEQVNNI KPDIMAVSTA CEEIKKSKSF SKLLELVLLM 
       810        820        830        840        850
GNYMNAGSRN AQTFGFNLSS LCKLKDTKSA DQKTTLLHFL VEICEEKYPD 
       860        870        880        890        900
ILNFVDDLEP LDKASKVSVE TLEKNLRQMG RQLQQLEKEL ETFPPPEDLH 
       910        920        930        940        950
DKFVTKMSRF VISAKEQYET LSKLHENMEK LYQSIIGYYA IDVKKVSVED 
       960        970        980        990       1000
FLTDLNNFRT TFMQAIKENI KKREAEEKEK RVRIAKELAE RERLERQQKK 
      1010       1020       1030       1040       1050
KRLLEMKTEG DETGVMDNLL EALQSGAAFR DRRKRTPMPK DVRQSLSPMS 
      1060       1070       1080       1090       1100
QRPVLKVCNH ENQKVQLTEG SRSHYNINCN STRTPVAKEL NYNLDTHTST 
      1110       1120       1130       1140 
GRIKAAEKKE ACNVESNRKK ETELLGSFSK NESVPEVEAL LARLRAL

Show »

Length:1,147

Mass (Da):131,487

Checksum:ⁱ4286EEB6F00A3F01

Isoform 6 (identifier: Q9NSV4-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
61-71: Missing.
72-130: Missing.

« Hide

        10         20         30         40         50
MERHQPRLHH PAQGSAAGTP YPSSASLRGC RESKMPRRKG PQHPPPPSGP 
        60         70         80         90        100
EEPGEKRPKF EDMNLNEDKK APLREKDFSI KKEMVMQYIN TASKTGSLKR 
       110        120        130        140        150
SRQISPQEFI HELKMGSADE RLVTCLESLR VSLTSNPVSW VESFGHEGLG 
       160        170        180        190        200
LLLDILEKLI SGKIQEKVVK KNQHKVIQCL KALMNTQYGL ERIMSEERSL 
       210        220        230        240        250
SLLAKAVDPR HPNMMTDVVK LLSAVCIVGE ESILEEVLEA LTSAGEEKKI 
       260        270        280        290        300
DRFFCIVEGL RHNSVQLQVA CMQLINALVT SPDDLDFRLH IRNEFMRCGL 
       310        320        330        340        350
KEILPNLKCI KNDGLDIQLK VFDEHKEEDL FELSHRLEDI RAELDEAYDV 
       360        370        380        390        400
YNMVWSTVKE TRAEGYFISI LQHLLLIRND YFIRQQYFKL IDECVSQIVL 
       410        420        430        440        450
HRDGMDPDFT YRKRLDLDLT QFVDICIDQA KLEEFEEKAS ELYKKFEKEF 
       460        470        480        490        500
TDHQETQAEL QKKEAKINEL QAELQAFKSQ FGALPADCNI PLPPSKEGGT 
       510        520        530        540        550
GHSALPPPPP LPSGGGVPPP PPPPPPPPLP GMRMPFSGPV PPPPPLGFLG 
       560        570        580        590        600
GQNSPPLPIL PFGLKPKKEF KPEISMRRLN WLKIRPHEMT ENCFWIKVNE 
       610        620        630        640        650
NKYENVDLLC KLENTFCCQQ KERREEEDIE EKKSIKKKIK ELKFLDSKIA 
       660        670        680        690        700
QNLSIFLSSF RVPYEEIRMM ILEVDETRLA ESMIQNLIKH LPDQEQLNSL 
       710        720        730        740        750
SQFKSEYSNL CEPEQFVVVM SNVKRLRPRL SAILFKLQFE EQVNNIKPDI 
       760        770        780        790        800
MAVSTACEEI KKSKSFSKLL ELVLLMGNYM NAGSRNAQTF GFNLSSLCKL 
       810        820        830        840        850
KDTKSADQKT TLLHFLVEIC EEKYPDILNF VDDLEPLDKA SKVSVETLEK 
       860        870        880        890        900
NLRQMGRQLQ QLEKELETFP PPEDLHDKFV TKMSRFVISA KEQYETLSKL 
       910        920        930        940        950
HENMEKLYQS IIGYYAIDVK KVSVEDFLTD LNNFRTTFMQ AIKENIKKRE 
       960        970        980        990       1000
AEEKEKRVRI AKELAERERL ERQQKKKRLL EMKTEGDETG VMDNLLEALQ 
      1010       1020       1030       1040       1050
SGAAFRDRRK RTPMPKDVRQ SLSPMSQRPV LKVCNHENQK VQLTEGSRSH 
      1060       1070       1080       1090       1100
YNINCNSTRT PVAKELNYNL DTHTSTGRIK AAEKKEACNV ESNRKKETEL 
      1110       1120 
LGSFSKNESV PEVEALLARL RAL

Show »

Length:1,123

Mass (Da):128,994

Checksum:ⁱ4623CCC9C5D433C6

Isoform 7 (identifier: Q9NSV4-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1107-1112: ENQKVQ → GNKPYL
1113-1193: Missing.

« Hide

        10         20         30         40         50
MERHQPRLHH PAQGSAAGTP YPSSASLRGC RESKMPRRKG PQHPPPPSGP 
        60         70         80         90        100
EEPGEKRPKF HLNIRTLTDD MLDKFASIRI PGSKKERPPL PNLKTAFASS 
       110        120        130        140        150
DCSAAPLEMM ENFPKPLSEN ELLELFEKMM EDMNLNEDKK APLREKDFSI 
       160        170        180        190        200
KKEMVMQYIN TASKTGSLKR SRQISPQEFI HELKMGSADE RLVTCLESLR 
       210        220        230        240        250
VSLTSNPVSW VESFGHEGLG LLLDILEKLI SGKIQEKVVK KNQHKVIQCL 
       260        270        280        290        300
KALMNTQYGL ERIMSEERSL SLLAKAVDPR HPNMMTDVVK LLSAVCIVGE 
       310        320        330        340        350
ESILEEVLEA LTSAGEEKKI DRFFCIVEGL RHNSVQLQVA CMQLINALVT 
       360        370        380        390        400
SPDDLDFRLH IRNEFMRCGL KEILPNLKCI KNDGLDIQLK VFDEHKEEDL 
       410        420        430        440        450
FELSHRLEDI RAELDEAYDV YNMVWSTVKE TRAEGYFISI LQHLLLIRND 
       460        470        480        490        500
YFIRQQYFKL IDECVSQIVL HRDGMDPDFT YRKRLDLDLT QFVDICIDQA 
       510        520        530        540        550
KLEEFEEKAS ELYKKFEKEF TDHQETQAEL QKKEAKINEL QAELQAFKSQ 
       560        570        580        590        600
FGALPADCNI PLPPSKEGGT GHSALPPPPP LPSGGGVPPP PPPPPPPPLP 
       610        620        630        640        650
GMRMPFSGPV PPPPPLGFLG GQNSPPLPIL PFGLKPKKEF KPEISMRRLN 
       660        670        680        690        700
WLKIRPHEMT ENCFWIKVNE NKYENVDLLC KLENTFCCQQ KERREEEDIE 
       710        720        730        740        750
EKKSIKKKIK ELKFLDSKIA QNLSIFLSSF RVPYEEIRMM ILEVDETRLA 
       760        770        780        790        800
ESMIQNLIKH LPDQEQLNSL SQFKSEYSNL CEPEQFVVVM SNVKRLRPRL 
       810        820        830        840        850
SAILFKLQFE EQVNNIKPDI MAVSTACEEI KKSKSFSKLL ELVLLMGNYM 
       860        870        880        890        900
NAGSRNAQTF GFNLSSLCKL KDTKSADQKT TLLHFLVEIC EEKYPDILNF 
       910        920        930        940        950
VDDLEPLDKA SKVSVETLEK NLRQMGRQLQ QLEKELETFP PPEDLHDKFV 
       960        970        980        990       1000
TKMSRFVISA KEQYETLSKL HENMEKLYQS IIGYYAIDVK KVSVEDFLTD 
      1010       1020       1030       1040       1050
LNNFRTTFMQ AIKENIKKRE AEEKEKRVRI AKELAERERL ERQQKKKRLL 
      1060       1070       1080       1090       1100
EMKTEGDETG VMDNLLEALQ SGAAFRDRRK RTPMPKDVRQ SLSPMSQRPV 
      1110 
LKVCNHGNKP YL

Show »

Length:1,112

Mass (Da):127,856

Checksum:ⁱDCB5192396280A30

Sequence cautionⁱ

The sequence AAW73254 differs from that shown. Reason: Frameshift at position 1147.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	55	E → G in BAE96352 (Ref. 3) Curated	1
Sequence conflictⁱ	128	K → R in BAC03793 (PubMed:14702039).Curated	1
Sequence conflictⁱ	274	A → V in AAH34952 (PubMed:15489334).Curated	1
Sequence conflictⁱ	330	L → P in BAE96351 (Ref. 3) Curated	1
Sequence conflictⁱ	588	P → L in BAC03793 (PubMed:14702039).Curated	1
Sequence conflictⁱ	613	P → L in BAE96351 (Ref. 3) Curated	1
Sequence conflictⁱ	669	N → K in CAE46204 (PubMed:17974005).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_049097	363	N → S. Corresponds to variant dbSNP:rs36084898EnsemblClinVar.	1
Natural variantⁱVAR_049098	773	F → L. Corresponds to variant dbSNP:rs35579086EnsemblClinVar.	1
Natural variantⁱVAR_049099	1041	E → G. Corresponds to variant dbSNP:rs7491389Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_015958	1 – 263	Missing in isoform 1 and isoform 2. 2 PublicationsAdd BLAST	263
Alternative sequenceⁱVSP_027774	61 – 71	Missing in isoform 4, isoform 5 and isoform 6. 1 PublicationAdd BLAST	11
Alternative sequenceⁱVSP_027775	72 – 130	Missing in isoform 6. 1 PublicationAdd BLAST	59
Alternative sequenceⁱVSP_027776	131 – 165	Missing in isoform 5. 1 PublicationAdd BLAST	35
Alternative sequenceⁱVSP_001574	913 – 956	VSVET…KMSRF → GLCLFKKHFMALIFSAKRLK IIPFICMYFPLSHSVFIPNI SF in isoform 2. 1 PublicationAdd BLAST	44
Alternative sequenceⁱVSP_001575	957 – 1193	Missing in isoform 2. 1 PublicationAdd BLAST	237
Alternative sequenceⁱVSP_027777	1107 – 1112	ENQKVQ → GNKPYL in isoform 7 and isoform 1. 2 Publications	6
Alternative sequenceⁱVSP_027778	1113 – 1193	Missing in isoform 7 and isoform 1. 2 PublicationsAdd BLAST	81

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY750055 mRNA Translation: AAW73254.1 Frameshift. AY818645 mRNA Translation: AAW78862.1 AB244756 mRNA Translation: BAE96350.1 AB244757 mRNA Translation: BAE96351.1 AB244758 mRNA Translation: BAE96352.1 AL137718 mRNA Translation: CAB70890.1 BX649186 mRNA Translation: CAE46204.1 AL354829 Genomic DNA No translation available. AL356502 Genomic DNA No translation available. AL359266 Genomic DNA No translation available. AL390878 Genomic DNA No translation available. BC034952 mRNA Translation: AAH34952.1 BC048963 mRNA Translation: AAH48963.1 BC068504 mRNA Translation: AAH68504.1 AK092024 mRNA Translation: BAC03793.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41898.1 [Q9NSV4-3] CCDS58294.1 [Q9NSV4-6] CCDS58295.1 [Q9NSV4-5] CCDS58296.1 [Q9NSV4-4] CCDS58297.1 [Q9NSV4-7] CCDS73579.1 [Q9NSV4-2] CCDS73580.1 [Q9NSV4-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001035982.1, NM_001042517.1 [Q9NSV4-3] NP_001245295.1, NM_001258366.1 [Q9NSV4-4] NP_001245296.1, NM_001258367.1 [Q9NSV4-5] NP_001245297.1, NM_001258368.1 [Q9NSV4-6] NP_001245298.1, NM_001258369.1 [Q9NSV4-7] NP_001245299.1, NM_001258370.1 [Q9NSV4-2] NP_112194.2, NM_030932.3 [Q9NSV4-1]
UniGeneⁱ	Hs.283127

Genome annotation databases

Ensemblⁱ	ENST00000267215; ENSP00000267215; ENSG00000139734 [Q9NSV4-7] ENST00000377908; ENSP00000367141; ENSG00000139734 [Q9NSV4-4] ENST00000400319; ENSP00000383173; ENSG00000139734 [Q9NSV4-6] ENST00000400320; ENSP00000383174; ENSG00000139734 [Q9NSV4-5] ENST00000400324; ENSP00000383178; ENSG00000139734 [Q9NSV4-3] ENST00000465066; ENSP00000478137; ENSG00000139734 [Q9NSV4-1] ENST00000498416; ENSP00000479091; ENSG00000139734 [Q9NSV4-2]
GeneIDⁱ	81624
KEGGⁱ	hsa:81624
UCSC genome browser More...UCSCⁱ	uc001vht.6 human [Q9NSV4-3]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9NSV4	DIAPH3 isoform 1		PANTR		1193	UniRef90_Q9NSV4
Diaphanous related formin 3		SAIBB		1193
Diaphanous related formin 3		Cebus capucinus imitator		1193
DIAPH3 isoform 1		PONAB		1193
Diaphanous related formin 3		PAPAN		1193
+95
Q9NSV4-2	DIAPH3 isoform 9		PANTR		691	UniRef90_Q9NSV4-2
Diaphanous related formin 3		Cebus capucinus imitator		688
DIAPH3 isoform 7		PONAB		662
Q9NSV4-5	DIAPH3 isoform 3		PANTR		1147	UniRef90_Q9NSV4-5
Diaphanous related formin 3		SAIBB		1147
Diaphanous related formin 3		Cebus capucinus imitator		1147
DIAPH3 isoform 3		PONAB		1147
Diaphanous related formin 3		PAPAN		1147
+14
Q9NSV4-6	DIAPH3 isoform 4		PANTR		1123	UniRef90_Q9NSV4-6
Diaphanous related formin 3		SAIBB		1123
Diaphanous related formin 3		Cebus capucinus imitator		1123
DIAPH3 isoform 4		PONAB		1123
Diaphanous related formin 3		PAPAN		1123
+17

Protein	Similar proteins		Species	Score	Length	Source
Q9NSV4	Diaphanous related formin 3		Cebus capucinus imitator		1193	UniRef50_Q9NSV4
Diaphanous-related formin-3		MACFA		1193
Diaphanous related formin 3		PAPAN		1193
Diaphanous related formin 3		MACNE		1193
Diaphanous related formin 3		MANLE		1193
+147
Q9NSV4-2	DIAPH3 isoform 9		PANTR		691	UniRef50_Q9NSV4-2
Diaphanous related formin 3		Cebus capucinus imitator		688
DIAPH3 isoform 7		PONAB		662
Uncharacterized protein		RAT		706
Protein diaphanous 3 (Fragment)		TYTAL		819
+3
Q9NSV4-6	Protein diaphanous homolog 2		HUMAN		1101	UniRef50_O60879
protein diaphanous homolog 2 isoform X1		PHYCD		1137
protein diaphanous homolog 2 isoform X1		DELLE		1131
protein diaphanous homolog 2 isoform X1		TURTR		1130
protein diaphanous homolog 2 isoform X1		Enhydra lutris kenyoni		1110
+364

Entry informationⁱ

Entry nameⁱ	DIAP3_HUMAN
Accessionⁱ	Q9NSV4Primary (citable) accession number: Q9NSV4 Secondary accession number(s): A2A3B8 Q8NAV4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	September 11, 2007
	Last modified:	September 12, 2018
	This is version 174 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9NSV4 (DIAP3_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Protein diaphanous homolog 3

DIAPH3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Cytosol

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ