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UniProtKB - Q9NSV4 (DIAP3_HUMAN)

Protein

Protein diaphanous homolog 3

Gene

DIAPH3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity.By similarity

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

ReactomeiR-HSA-5663220 RHO GTPases Activate Formins

Names & Taxonomyi

Protein namesi
Recommended name:
Protein diaphanous homolog 3
Alternative name(s):
Diaphanous-related formin-3
Short name:
DRF3
MDia2
Gene namesi
Name:DIAPH3
Synonyms:DIAP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000139734.17
HGNCiHGNC:15480 DIAPH3
MIMi614567 gene
neXtProtiNX_Q9NSV4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Auditory neuropathy, autosomal dominant, 1 (AUNA1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry. A disease-causing mutation in the conserved 5'-UTR leads to increased protein expression.1 Publication
Disease descriptionA form of sensorineural hearing loss with absent or severely abnormal auditory brainstem response, in the presence of normal cochlear outer hair cell function and normal otoacoustic emissions. Auditory neuropathies result from a lesion in the area including the inner hair cells, connections between the inner hair cells and the cochlear branch of the auditory nerve, the auditory nerve itself and auditory pathways of the brainstem.
See also OMIM:609129

Keywords - Diseasei

Deafness, Neuropathy, Non-syndromic deafness

Organism-specific databases

DisGeNETi81624
MalaCardsiDIAPH3
MIMi609129 phenotype
OpenTargetsiENSG00000139734
Orphaneti90635 Autosomal dominant non-syndromic sensorineural deafness type DFNA
PharmGKBiPA27335

Polymorphism and mutation databases

BioMutaiDIAPH3
DMDMi158520000

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001948971 – 1193Protein diaphanous homolog 3Add BLAST1193

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26PhosphoserineCombined sources1
Modified residuei68PhosphothreonineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei175PhosphoserineCombined sources1
Modified residuei624PhosphoserineCombined sources1
Modified residuei1093PhosphoserineCombined sources1
Modified residuei1179PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9NSV4
PaxDbiQ9NSV4
PeptideAtlasiQ9NSV4
PRIDEiQ9NSV4
ProteomicsDBi82583
82584 [Q9NSV4-1]
82585 [Q9NSV4-2]
82586 [Q9NSV4-4]
82587 [Q9NSV4-5]
82588 [Q9NSV4-6]
82589 [Q9NSV4-7]

PTM databases

iPTMnetiQ9NSV4
PhosphoSitePlusiQ9NSV4

Expressioni

Developmental stagei

Increased expression in S phase and mitotic cells; levels decrease as cells enter in G0/G1 phase due to proteasomal degradation (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000139734 Expressed in 135 organ(s), highest expression level in testis
CleanExiHS_DIAPH3
GenevisibleiQ9NSV4 HS

Organism-specific databases

HPAiHPA032151

Interactioni

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi123559, 34 interactors
IntActiQ9NSV4, 13 interactors
MINTiQ9NSV4
STRINGi9606.ENSP00000383178

Structurei

Secondary structure

11193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NSV4
SMRiQ9NSV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini114 – 476GBD/FH3PROSITE-ProRule annotationAdd BLAST363
Domaini561 – 631FH1Add BLAST71
Domaini636 – 1034FH2PROSITE-ProRule annotationAdd BLAST399
Domaini1057 – 1087DADPROSITE-ProRule annotationAdd BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili497 – 554Sequence analysisAdd BLAST58
Coiled coili1013 – 1056Sequence analysisAdd BLAST44

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 60Nuclear localization signalBy similarityAdd BLAST25
Motifi1184 – 1193Nuclear export signalBy similarity10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi561 – 636Pro-richAdd BLAST76

Domaini

The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments.By similarity

Sequence similaritiesi

Belongs to the formin homology family. Diaphanous subfamily.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1924 Eukaryota
ENOG410Y29H LUCA
GeneTreeiENSGT00760000118986
HOVERGENiHBG051357
InParanoidiQ9NSV4
KOiK05745
OMAiKQMGRQL
OrthoDBiEOG091G0JR0
PhylomeDBiQ9NSV4
TreeFamiTF315383

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR014767 DAD_dom
IPR010465 Drf_DAD
IPR015425 FH2_Formin
IPR010472 FH3_dom
IPR027654 Formin_DIAPH3
IPR014768 GBD/FH3_dom
IPR010473 GTPase-bd
PANTHERiPTHR23213:SF198 PTHR23213:SF198, 1 hit
PfamiView protein in Pfam
PF06345 Drf_DAD, 1 hit
PF06367 Drf_FH3, 1 hit
PF06371 Drf_GBD, 1 hit
PF02181 FH2, 1 hit
SMARTiView protein in SMART
SM01139 Drf_FH3, 1 hit
SM01140 Drf_GBD, 1 hit
SM00498 FH2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51231 DAD, 1 hit
PS51444 FH2, 1 hit
PS51232 GBD_FH3, 1 hit

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 3 (identifier: Q9NSV4-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERHQPRLHH PAQGSAAGTP YPSSASLRGC RESKMPRRKG PQHPPPPSGP 
        60         70         80         90        100
EEPGEKRPKF HLNIRTLTDD MLDKFASIRI PGSKKERPPL PNLKTAFASS 
       110        120        130        140        150
DCSAAPLEMM ENFPKPLSEN ELLELFEKMM EDMNLNEDKK APLREKDFSI 
       160        170        180        190        200
KKEMVMQYIN TASKTGSLKR SRQISPQEFI HELKMGSADE RLVTCLESLR 
       210        220        230        240        250
VSLTSNPVSW VESFGHEGLG LLLDILEKLI SGKIQEKVVK KNQHKVIQCL 
       260        270        280        290        300
KALMNTQYGL ERIMSEERSL SLLAKAVDPR HPNMMTDVVK LLSAVCIVGE 
       310        320        330        340        350
ESILEEVLEA LTSAGEEKKI DRFFCIVEGL RHNSVQLQVA CMQLINALVT 
       360        370        380        390        400
SPDDLDFRLH IRNEFMRCGL KEILPNLKCI KNDGLDIQLK VFDEHKEEDL 
       410        420        430        440        450
FELSHRLEDI RAELDEAYDV YNMVWSTVKE TRAEGYFISI LQHLLLIRND 
       460        470        480        490        500
YFIRQQYFKL IDECVSQIVL HRDGMDPDFT YRKRLDLDLT QFVDICIDQA 
       510        520        530        540        550
KLEEFEEKAS ELYKKFEKEF TDHQETQAEL QKKEAKINEL QAELQAFKSQ 
       560        570        580        590        600
FGALPADCNI PLPPSKEGGT GHSALPPPPP LPSGGGVPPP PPPPPPPPLP 
       610        620        630        640        650
GMRMPFSGPV PPPPPLGFLG GQNSPPLPIL PFGLKPKKEF KPEISMRRLN 
       660        670        680        690        700
WLKIRPHEMT ENCFWIKVNE NKYENVDLLC KLENTFCCQQ KERREEEDIE 
       710        720        730        740        750
EKKSIKKKIK ELKFLDSKIA QNLSIFLSSF RVPYEEIRMM ILEVDETRLA 
       760        770        780        790        800
ESMIQNLIKH LPDQEQLNSL SQFKSEYSNL CEPEQFVVVM SNVKRLRPRL 
       810        820        830        840        850
SAILFKLQFE EQVNNIKPDI MAVSTACEEI KKSKSFSKLL ELVLLMGNYM 
       860        870        880        890        900
NAGSRNAQTF GFNLSSLCKL KDTKSADQKT TLLHFLVEIC EEKYPDILNF 
       910        920        930        940        950
VDDLEPLDKA SKVSVETLEK NLRQMGRQLQ QLEKELETFP PPEDLHDKFV 
       960        970        980        990       1000
TKMSRFVISA KEQYETLSKL HENMEKLYQS IIGYYAIDVK KVSVEDFLTD 
      1010       1020       1030       1040       1050
LNNFRTTFMQ AIKENIKKRE AEEKEKRVRI AKELAERERL ERQQKKKRLL 
      1060       1070       1080       1090       1100
EMKTEGDETG VMDNLLEALQ SGAAFRDRRK RTPMPKDVRQ SLSPMSQRPV 
      1110       1120       1130       1140       1150
LKVCNHENQK VQLTEGSRSH YNINCNSTRT PVAKELNYNL DTHTSTGRIK 
      1160       1170       1180       1190 
AAEKKEACNV ESNRKKETEL LGSFSKNESV PEVEALLARL RAL
Length:1,193
Mass (Da):136,926
Last modified:September 11, 2007 - v4
Checksum:iABCA4E859873F9E7
GO
Isoform 1 (identifier: Q9NSV4-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-263: Missing.
     1107-1112: ENQKVQ → GNKPYL
     1113-1193: Missing.

Show »
Length:849
Mass (Da):98,140
Checksum:i5CE99DEE93AC833C
GO
Isoform 2 (identifier: Q9NSV4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-263: Missing.
     913-956: VSVETLEKNL...DKFVTKMSRF → GLCLFKKHFM...HSVFIPNISF
     957-1193: Missing.

Show »
Length:691
Mass (Da):79,445
Checksum:iCDFF84D86D4B66DF
GO
Isoform 4 (identifier: Q9NSV4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-71: Missing.

Show »
Length:1,182
Mass (Da):135,615
Checksum:i9169ACD33B8FB00D
GO
Isoform 5 (identifier: Q9NSV4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-71: Missing.
     131-165: Missing.

Show »
Length:1,147
Mass (Da):131,487
Checksum:i4286EEB6F00A3F01
GO
Isoform 6 (identifier: Q9NSV4-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-71: Missing.
     72-130: Missing.

Show »
Length:1,123
Mass (Da):128,994
Checksum:i4623CCC9C5D433C6
GO
Isoform 7 (identifier: Q9NSV4-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1107-1112: ENQKVQ → GNKPYL
     1113-1193: Missing.

Show »
Length:1,112
Mass (Da):127,856
Checksum:iDCB5192396280A30
GO

Sequence cautioni

The sequence AAW73254 differs from that shown. Reason: Frameshift at position 1147.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55E → G in BAE96352 (Ref. 3) Curated1
Sequence conflicti128K → R in BAC03793 (PubMed:14702039).Curated1
Sequence conflicti274A → V in AAH34952 (PubMed:15489334).Curated1
Sequence conflicti330L → P in BAE96351 (Ref. 3) Curated1
Sequence conflicti588P → L in BAC03793 (PubMed:14702039).Curated1
Sequence conflicti613P → L in BAE96351 (Ref. 3) Curated1
Sequence conflicti669N → K in CAE46204 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049097363N → S. Corresponds to variant dbSNP:rs36084898EnsemblClinVar.1
Natural variantiVAR_049098773F → L. Corresponds to variant dbSNP:rs35579086EnsemblClinVar.1
Natural variantiVAR_0490991041E → G. Corresponds to variant dbSNP:rs7491389Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0159581 – 263Missing in isoform 1 and isoform 2. 2 PublicationsAdd BLAST263
Alternative sequenceiVSP_02777461 – 71Missing in isoform 4, isoform 5 and isoform 6. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_02777572 – 130Missing in isoform 6. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_027776131 – 165Missing in isoform 5. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_001574913 – 956VSVET…KMSRF → GLCLFKKHFMALIFSAKRLK IIPFICMYFPLSHSVFIPNI SF in isoform 2. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_001575957 – 1193Missing in isoform 2. 1 PublicationAdd BLAST237
Alternative sequenceiVSP_0277771107 – 1112ENQKVQ → GNKPYL in isoform 7 and isoform 1. 2 Publications6
Alternative sequenceiVSP_0277781113 – 1193Missing in isoform 7 and isoform 1. 2 PublicationsAdd BLAST81

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY750055 mRNA Translation: AAW73254.1 Frameshift.
AY818645 mRNA Translation: AAW78862.1
AB244756 mRNA Translation: BAE96350.1
AB244757 mRNA Translation: BAE96351.1
AB244758 mRNA Translation: BAE96352.1
AL137718 mRNA Translation: CAB70890.1
BX649186 mRNA Translation: CAE46204.1
AL354829 Genomic DNA No translation available.
AL356502 Genomic DNA No translation available.
AL359266 Genomic DNA No translation available.
AL390878 Genomic DNA No translation available.
BC034952 mRNA Translation: AAH34952.1
BC048963 mRNA Translation: AAH48963.1
BC068504 mRNA Translation: AAH68504.1
AK092024 mRNA Translation: BAC03793.1
CCDSiCCDS41898.1 [Q9NSV4-3]
CCDS58294.1 [Q9NSV4-6]
CCDS58295.1 [Q9NSV4-5]
CCDS58296.1 [Q9NSV4-4]
CCDS58297.1 [Q9NSV4-7]
CCDS73579.1 [Q9NSV4-2]
CCDS73580.1 [Q9NSV4-1]
RefSeqiNP_001035982.1, NM_001042517.1 [Q9NSV4-3]
NP_001245295.1, NM_001258366.1 [Q9NSV4-4]
NP_001245296.1, NM_001258367.1 [Q9NSV4-5]
NP_001245297.1, NM_001258368.1 [Q9NSV4-6]
NP_001245298.1, NM_001258369.1 [Q9NSV4-7]
NP_001245299.1, NM_001258370.1 [Q9NSV4-2]
NP_112194.2, NM_030932.3 [Q9NSV4-1]
UniGeneiHs.283127

Genome annotation databases

EnsembliENST00000267215; ENSP00000267215; ENSG00000139734 [Q9NSV4-7]
ENST00000377908; ENSP00000367141; ENSG00000139734 [Q9NSV4-4]
ENST00000400319; ENSP00000383173; ENSG00000139734 [Q9NSV4-6]
ENST00000400320; ENSP00000383174; ENSG00000139734 [Q9NSV4-5]
ENST00000400324; ENSP00000383178; ENSG00000139734 [Q9NSV4-3]
ENST00000465066; ENSP00000478137; ENSG00000139734 [Q9NSV4-1]
ENST00000498416; ENSP00000479091; ENSG00000139734 [Q9NSV4-2]
GeneIDi81624
KEGGihsa:81624
UCSCiuc001vht.6 human [Q9NSV4-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY750055 mRNA Translation: AAW73254.1 Frameshift.
AY818645 mRNA Translation: AAW78862.1
AB244756 mRNA Translation: BAE96350.1
AB244757 mRNA Translation: BAE96351.1
AB244758 mRNA Translation: BAE96352.1
AL137718 mRNA Translation: CAB70890.1
BX649186 mRNA Translation: CAE46204.1
AL354829 Genomic DNA No translation available.
AL356502 Genomic DNA No translation available.
AL359266 Genomic DNA No translation available.
AL390878 Genomic DNA No translation available.
BC034952 mRNA Translation: AAH34952.1
BC048963 mRNA Translation: AAH48963.1
BC068504 mRNA Translation: AAH68504.1
AK092024 mRNA Translation: BAC03793.1
CCDSiCCDS41898.1 [Q9NSV4-3]
CCDS58294.1 [Q9NSV4-6]
CCDS58295.1 [Q9NSV4-5]
CCDS58296.1 [Q9NSV4-4]
CCDS58297.1 [Q9NSV4-7]
CCDS73579.1 [Q9NSV4-2]
CCDS73580.1 [Q9NSV4-1]
RefSeqiNP_001035982.1, NM_001042517.1 [Q9NSV4-3]
NP_001245295.1, NM_001258366.1 [Q9NSV4-4]
NP_001245296.1, NM_001258367.1 [Q9NSV4-5]
NP_001245297.1, NM_001258368.1 [Q9NSV4-6]
NP_001245298.1, NM_001258369.1 [Q9NSV4-7]
NP_001245299.1, NM_001258370.1 [Q9NSV4-2]
NP_112194.2, NM_030932.3 [Q9NSV4-1]
UniGeneiHs.283127

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5UWPX-ray2.05D1179-1193[»]
ProteinModelPortaliQ9NSV4
SMRiQ9NSV4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123559, 34 interactors
IntActiQ9NSV4, 13 interactors
MINTiQ9NSV4
STRINGi9606.ENSP00000383178

PTM databases

iPTMnetiQ9NSV4
PhosphoSitePlusiQ9NSV4

Polymorphism and mutation databases

BioMutaiDIAPH3
DMDMi158520000

Proteomic databases

EPDiQ9NSV4
PaxDbiQ9NSV4
PeptideAtlasiQ9NSV4
PRIDEiQ9NSV4
ProteomicsDBi82583
82584 [Q9NSV4-1]
82585 [Q9NSV4-2]
82586 [Q9NSV4-4]
82587 [Q9NSV4-5]
82588 [Q9NSV4-6]
82589 [Q9NSV4-7]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267215; ENSP00000267215; ENSG00000139734 [Q9NSV4-7]
ENST00000377908; ENSP00000367141; ENSG00000139734 [Q9NSV4-4]
ENST00000400319; ENSP00000383173; ENSG00000139734 [Q9NSV4-6]
ENST00000400320; ENSP00000383174; ENSG00000139734 [Q9NSV4-5]
ENST00000400324; ENSP00000383178; ENSG00000139734 [Q9NSV4-3]
ENST00000465066; ENSP00000478137; ENSG00000139734 [Q9NSV4-1]
ENST00000498416; ENSP00000479091; ENSG00000139734 [Q9NSV4-2]
GeneIDi81624
KEGGihsa:81624
UCSCiuc001vht.6 human [Q9NSV4-3]

Organism-specific databases

CTDi81624
DisGeNETi81624
EuPathDBiHostDB:ENSG00000139734.17
GeneCardsiDIAPH3
H-InvDBiHIX0037336
HGNCiHGNC:15480 DIAPH3
HPAiHPA032151
MalaCardsiDIAPH3
MIMi609129 phenotype
614567 gene
neXtProtiNX_Q9NSV4
OpenTargetsiENSG00000139734
Orphaneti90635 Autosomal dominant non-syndromic sensorineural deafness type DFNA
PharmGKBiPA27335
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1924 Eukaryota
ENOG410Y29H LUCA
GeneTreeiENSGT00760000118986
HOVERGENiHBG051357
InParanoidiQ9NSV4
KOiK05745
OMAiKQMGRQL
OrthoDBiEOG091G0JR0
PhylomeDBiQ9NSV4
TreeFamiTF315383

Enzyme and pathway databases

ReactomeiR-HSA-5663220 RHO GTPases Activate Formins

Miscellaneous databases

ChiTaRSiDIAPH3 human
GenomeRNAii81624
PROiPR:Q9NSV4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139734 Expressed in 135 organ(s), highest expression level in testis
CleanExiHS_DIAPH3
GenevisibleiQ9NSV4 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR014767 DAD_dom
IPR010465 Drf_DAD
IPR015425 FH2_Formin
IPR010472 FH3_dom
IPR027654 Formin_DIAPH3
IPR014768 GBD/FH3_dom
IPR010473 GTPase-bd
PANTHERiPTHR23213:SF198 PTHR23213:SF198, 1 hit
PfamiView protein in Pfam
PF06345 Drf_DAD, 1 hit
PF06367 Drf_FH3, 1 hit
PF06371 Drf_GBD, 1 hit
PF02181 FH2, 1 hit
SMARTiView protein in SMART
SM01139 Drf_FH3, 1 hit
SM01140 Drf_GBD, 1 hit
SM00498 FH2, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51231 DAD, 1 hit
PS51444 FH2, 1 hit
PS51232 GBD_FH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDIAP3_HUMAN
AccessioniPrimary (citable) accession number: Q9NSV4
Secondary accession number(s): A2A3B8
, A2A3B9, A2A3C0, Q18P99, Q18PA0, Q18PA1, Q2KPB6, Q3ZK23, Q5JTP8, Q5T2S7, Q5XKF6, Q6MZF0, Q6NUP0, Q86VS4, Q8NAV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: September 11, 2007
Last modified: October 10, 2018
This is version 175 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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