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Protein

Centromere protein M

Gene

CENPM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.1 Publication

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-68877 Mitotic Prometaphase

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein M
Short name:
CENP-M
Alternative name(s):
Interphase centromere complex protein 39
Proliferation-associated nuclear element protein 1
Gene namesi
Name:CENPM
Synonyms:C22orf18, ICEN39, PANE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100162.14
HGNCiHGNC:18352 CENPM
MIMi610152 gene
neXtProtiNX_Q9NSP4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Kinetochore, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100162
PharmGKBiPA25885

Polymorphism and mutation databases

BioMutaiCENPM
DMDMi47117330

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000582241 – 180Centromere protein MAdd BLAST180

Proteomic databases

EPDiQ9NSP4
MaxQBiQ9NSP4
PaxDbiQ9NSP4
PeptideAtlasiQ9NSP4
PRIDEiQ9NSP4
ProteomicsDBi82572
82573 [Q9NSP4-2]
82574 [Q9NSP4-3]

PTM databases

iPTMnetiQ9NSP4
PhosphoSitePlusiQ9NSP4

Expressioni

Tissue specificityi

Isoform 3 is highly expressed in spleen, and intermediately in heart, prostate and ovary. Isoform 3 is highly expressed in resting CD19 B-cells and B-lineage chronic lymphocytic leukemia (B-CLL) cells and weakly expressed in activated B-cells. Isoform 1 is selectively expressed in activated CD19 cells and weakly in resting CD19 B-cells.

Gene expression databases

BgeeiENSG00000100162 Expressed in 123 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_CENPM
ExpressionAtlasiQ9NSP4 baseline and differential
GenevisibleiQ9NSP4 HS

Organism-specific databases

HPAiHPA042404
HPA056500

Interactioni

Subunit structurei

Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS.1 Publication

Protein-protein interaction databases

BioGridi122488, 54 interactors
CORUMiQ9NSP4
IntActiQ9NSP4, 5 interactors
STRINGi9606.ENSP00000215980

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NSP4
SMRiQ9NSP4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IZ5U Eukaryota
ENOG4111PTI LUCA
GeneTreeiENSGT00390000017504
HOGENOMiHOG000048739
HOVERGENiHBG081086
InParanoidiQ9NSP4
KOiK11505
OMAiMLQICAG
OrthoDBiEOG091G0PZ0
PhylomeDBiQ9NSP4
TreeFamiTF328778

Family and domain databases

InterProiView protein in InterPro
IPR020987 Centromere_Cenp-M
PANTHERiPTHR34436 PTHR34436, 1 hit
PfamiView protein in Pfam
PF11111 CENP-M, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NSP4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVLRPLDKL PGLNTATILL VGTEDALLQQ LADSMLKEDC ASELKVHLAK
60 70 80 90 100
SLPLPSSVNR PRIDLIVFVV NLHSKYSLQN TEESLRHVDA SFFLGKVCFL
110 120 130 140 150
ATGAGRESHC SIHRHTVVKL AHTYQSPLLY CDLEVEGFRA TMAQRLVRVL
160 170 180
QICAGHVPGV SALNLLSLLR SSEGPSLEDL
Length:180
Mass (Da):19,737
Last modified:October 1, 2000 - v1
Checksum:i37DB044092BF63F4
GO
Isoform 2 (identifier: Q9NSP4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-132: AGRESHCSIHRHTVVKLAHTYQSPLLYCD → GKYVPRLLLPTPSQGKAGAAVGFLLRHPG
     133-180: Missing.

Note: Due to intron retention. No experimental confirmation available.
Show »
Length:132
Mass (Da):14,287
Checksum:i3A8E77D553024B38
GO
Isoform 3 (identifier: Q9NSP4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-122: Missing.
     123-134: TYQSPLLYCDLE → MGRVWDLPGVLK

Show »
Length:58
Mass (Da):6,257
Checksum:iD5B353502075D069
GO
Isoform 4 (identifier: Q9NSP4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-179: AGRESHCSIH...RSSEGPSLED → GGR

Note: No experimental confirmation available.
Show »
Length:107
Mass (Da):11,687
Checksum:i4FBAB92E26A66A1F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AHQ6B1AHQ6_HUMAN
Centromere protein M
CENPM
146Annotation score:
B1AHQ7B1AHQ7_HUMAN
Centromere protein M
CENPM
73Annotation score:
B1AHQ8B1AHQ8_HUMAN
Centromere protein M
CENPM
125Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0177261 – 122Missing in isoform 3. 1 PublicationAdd BLAST122
Alternative sequenceiVSP_046189104 – 179AGRES…PSLED → GGR in isoform 4. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_010259104 – 132AGRES…LLYCD → GKYVPRLLLPTPSQGKAGAA VGFLLRHPG in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_017725123 – 134TYQSP…YCDLE → MGRVWDLPGVLK in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_010260133 – 180Missing in isoform 2. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU035297 mRNA Translation: ABS84666.1
AL160131 mRNA Translation: CAB77147.1
AK123479 mRNA Translation: BAC85624.1
CR456399 mRNA Translation: CAG30285.1
CR457392 mRNA Translation: CAG33673.1
Z99716 Genomic DNA No translation available.
BC000705 mRNA Translation: AAH00705.1
BC007495 mRNA Translation: AAH07495.1
BU194618 mRNA No translation available.
CCDSiCCDS14025.1 [Q9NSP4-1]
CCDS46719.1 [Q9NSP4-3]
CCDS46720.1 [Q9NSP4-4]
RefSeqiNP_001002876.1, NM_001002876.2 [Q9NSP4-4]
NP_001103685.1, NM_001110215.2 [Q9NSP4-3]
NP_001291299.1, NM_001304370.1
NP_001291300.1, NM_001304371.1 [Q9NSP4-2]
NP_001291301.1, NM_001304372.1
NP_001291302.1, NM_001304373.1
NP_076958.1, NM_024053.4 [Q9NSP4-1]
UniGeneiHs.208912

Genome annotation databases

EnsembliENST00000215980; ENSP00000215980; ENSG00000100162 [Q9NSP4-1]
ENST00000407253; ENSP00000384743; ENSG00000100162 [Q9NSP4-4]
ENST00000472374; ENSP00000430624; ENSG00000100162 [Q9NSP4-3]
GeneIDi79019
KEGGihsa:79019
UCSCiuc003bbn.4 human [Q9NSP4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU035297 mRNA Translation: ABS84666.1
AL160131 mRNA Translation: CAB77147.1
AK123479 mRNA Translation: BAC85624.1
CR456399 mRNA Translation: CAG30285.1
CR457392 mRNA Translation: CAG33673.1
Z99716 Genomic DNA No translation available.
BC000705 mRNA Translation: AAH00705.1
BC007495 mRNA Translation: AAH07495.1
BU194618 mRNA No translation available.
CCDSiCCDS14025.1 [Q9NSP4-1]
CCDS46719.1 [Q9NSP4-3]
CCDS46720.1 [Q9NSP4-4]
RefSeqiNP_001002876.1, NM_001002876.2 [Q9NSP4-4]
NP_001103685.1, NM_001110215.2 [Q9NSP4-3]
NP_001291299.1, NM_001304370.1
NP_001291300.1, NM_001304371.1 [Q9NSP4-2]
NP_001291301.1, NM_001304372.1
NP_001291302.1, NM_001304373.1
NP_076958.1, NM_024053.4 [Q9NSP4-1]
UniGeneiHs.208912

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4P0TX-ray1.49A/B1-171[»]
4WAUX-ray2.20A/B1-171[»]
ProteinModelPortaliQ9NSP4
SMRiQ9NSP4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122488, 54 interactors
CORUMiQ9NSP4
IntActiQ9NSP4, 5 interactors
STRINGi9606.ENSP00000215980

PTM databases

iPTMnetiQ9NSP4
PhosphoSitePlusiQ9NSP4

Polymorphism and mutation databases

BioMutaiCENPM
DMDMi47117330

Proteomic databases

EPDiQ9NSP4
MaxQBiQ9NSP4
PaxDbiQ9NSP4
PeptideAtlasiQ9NSP4
PRIDEiQ9NSP4
ProteomicsDBi82572
82573 [Q9NSP4-2]
82574 [Q9NSP4-3]

Protocols and materials databases

DNASUi79019
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215980; ENSP00000215980; ENSG00000100162 [Q9NSP4-1]
ENST00000407253; ENSP00000384743; ENSG00000100162 [Q9NSP4-4]
ENST00000472374; ENSP00000430624; ENSG00000100162 [Q9NSP4-3]
GeneIDi79019
KEGGihsa:79019
UCSCiuc003bbn.4 human [Q9NSP4-1]

Organism-specific databases

CTDi79019
EuPathDBiHostDB:ENSG00000100162.14
GeneCardsiCENPM
HGNCiHGNC:18352 CENPM
HPAiHPA042404
HPA056500
MIMi610152 gene
neXtProtiNX_Q9NSP4
OpenTargetsiENSG00000100162
PharmGKBiPA25885
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZ5U Eukaryota
ENOG4111PTI LUCA
GeneTreeiENSGT00390000017504
HOGENOMiHOG000048739
HOVERGENiHBG081086
InParanoidiQ9NSP4
KOiK11505
OMAiMLQICAG
OrthoDBiEOG091G0PZ0
PhylomeDBiQ9NSP4
TreeFamiTF328778

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-68877 Mitotic Prometaphase

Miscellaneous databases

ChiTaRSiCENPM human
GeneWikiiCENPM
GenomeRNAii79019
PROiPR:Q9NSP4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100162 Expressed in 123 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_CENPM
ExpressionAtlasiQ9NSP4 baseline and differential
GenevisibleiQ9NSP4 HS

Family and domain databases

InterProiView protein in InterPro
IPR020987 Centromere_Cenp-M
PANTHERiPTHR34436 PTHR34436, 1 hit
PfamiView protein in Pfam
PF11111 CENP-M, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCENPM_HUMAN
AccessioniPrimary (citable) accession number: Q9NSP4
Secondary accession number(s): A7LM22, B1AHQ9, Q6I9W3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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