UniProtKB - Q9NSN8 (SNTG1_HUMAN)
Protein
Gamma-1-syntrophin
Gene
SNTG1
Organism
Homo sapiens (Human)
Status
Functioni
Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity). May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation.By similarity
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- protein C-terminus binding Source: UniProtKB
- structural molecule activity Source: InterPro
GO - Biological processi
- cell communication Source: ProtInc
Keywordsi
Molecular function | Actin-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9NSN8 |
SIGNORi | Q9NSN8 |
Names & Taxonomyi
Protein namesi | Recommended name: Gamma-1-syntrophinShort name: G1SYN Alternative name(s): Syntrophin-4 Short name: SYN4 |
Gene namesi | Name:SNTG1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13740, SNTG1 |
MIMi | 608714, gene |
neXtProti | NX_Q9NSN8 |
VEuPathDBi | HostDB:ENSG00000147481.13 |
Subcellular locationi
Cytoskeleton
Nucleus
Note: Mainly cytoplasmic and weakly nuclear.
Cytoskeleton
- cytoskeleton Source: LIFEdb
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- dystrophin-associated glycoprotein complex Source: GO_Central
- ruffle membrane Source: UniProtKB
- syntrophin complex Source: ProtInc
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 54212 |
OpenTargetsi | ENSG00000147481 |
PharmGKBi | PA37806 |
Miscellaneous databases
Pharosi | Q9NSN8, Tbio |
Genetic variation databases
BioMutai | SNTG1 |
DMDMi | 23822220 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000184013 | 1 – 517 | Gamma-1-syntrophinAdd BLAST | 517 |
Proteomic databases
MassIVEi | Q9NSN8 |
PaxDbi | Q9NSN8 |
PeptideAtlasi | Q9NSN8 |
PRIDEi | Q9NSN8 |
ProteomicsDBi | 82570 [Q9NSN8-1] 82571 [Q9NSN8-2] |
PTM databases
iPTMneti | Q9NSN8 |
PhosphoSitePlusi | Q9NSN8 |
Expressioni
Tissue specificityi
Brain specific. In CNS, it is expressed in the perikaryon and proximal portion of the neuronal processes. Strong expression in the hippocampus, neuron-rich dendate granule cells, and pyramidal cell layers. Highly expressed in neurons of the cerebral cortex. Also expressed in the cerebellar cortex, deep cerebellar nuclei, thalamus, and basal ganglia. No expression in muscle cells.1 Publication
Gene expression databases
Bgeei | ENSG00000147481, Expressed in frontal cortex and 102 other tissues |
ExpressionAtlasi | Q9NSN8, baseline and differential |
Genevisiblei | Q9NSN8, HS |
Organism-specific databases
HPAi | ENSG00000147481, Group enriched (brain, lymphoid tissue, pituitary gland) |
Interactioni
Subunit structurei
Isoform 1, but not isoform 2, interacts with the dystrophin protein DMD and related proteins DTNA and DTNB.
Interacts with DGKZ.
2 PublicationsBinary interactionsi
Hide detailsGO - Molecular functioni
- actin binding Source: UniProtKB-KW
- protein C-terminus binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 119928, 11 interactors |
CORUMi | Q9NSN8 |
IntActi | Q9NSN8, 2 interactors |
STRINGi | 9606.ENSP00000429842 |
Miscellaneous databases
RNActi | Q9NSN8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 57 – 140 | PDZPROSITE-ProRule annotationAdd BLAST | 84 | |
Domaini | 283 – 390 | PHPROSITE-ProRule annotationAdd BLAST | 108 |
Domaini
The PDZ domain binds to the last three or four amino acids of DGKZ. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane.
Sequence similaritiesi
Belongs to the syntrophin family.Curated
Phylogenomic databases
eggNOGi | KOG3549, Eukaryota |
GeneTreei | ENSGT00950000182863 |
HOGENOMi | CLU_039445_0_0_1 |
InParanoidi | Q9NSN8 |
OMAi | AIVWQYK |
PhylomeDBi | Q9NSN8 |
TreeFami | TF317932 |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf IPR001849, PH_domain IPR015482, Syntrophin IPR015483, Syntrophin_gamma |
PANTHERi | PTHR10554, PTHR10554, 1 hit PTHR10554:SF2, PTHR10554:SF2, 1 hit |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit SM00233, PH, 2 hits |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50106, PDZ, 1 hit PS50003, PH_DOMAIN, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 17 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NSN8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDFRTACEET KTGICLLQDG NQEPFKVRLH LAKDILMIQE QDVICVSGEP
60 70 80 90 100
FYSGERTVTI RRQTVGGFGL SIKGGAEHNI PVVVSKISKE QRAELSGLLF
110 120 130 140 150
IGDAILQING INVRKCRHEE VVQVLRNAGE EVTLTVSFLK RAPAFLKLPL
160 170 180 190 200
NEDCACAPSD QSSGTSSPLC DSGLHLNYHP NNTDTLSCSS WPTSPGLRWE
210 220 230 240 250
KRWCDLRLIP LLHSRFSQYV PGTDLSRQNA FQVIAVDGVC TGIIQCLSAE
260 270 280 290 300
DCVDWLQAIA TNISNLTKHN IKKINRNFPV NQQIVYMGWC EAREQDPLQD
310 320 330 340 350
RVYSPTFLAL RGSCLYKFLA PPVTTWDWTR AEKTFSVYEI MCKILKDSDL
360 370 380 390 400
LDRRKQCFTV QSESGEDLYF SVELESDLAQ WERAFQTATF LEVERIQCKT
410 420 430 440 450
YACVLESHLM GLTIDFSTGF ICFDAATKAV LWRYKFSQLK GSSDDGKSKI
460 470 480 490 500
KFLFQNPDTK QIEAKELEFS NLFAVLHCIH SFFAAKVACL DPLFLGNQAT
510
ASTAASSATT SKAKYTT
Computationally mapped potential isoform sequencesi
There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RHN6 | E5RHN6_HUMAN | Gamma-1-syntrophin | SNTG1 | 348 | Annotation score: | ||
A0A2R8Y5T2 | A0A2R8Y5T2_HUMAN | Gamma-1-syntrophin | SNTG1 | 435 | Annotation score: | ||
A0A2R8Y631 | A0A2R8Y631_HUMAN | Gamma-1-syntrophin | SNTG1 | 472 | Annotation score: | ||
A0A2R8Y5G8 | A0A2R8Y5G8_HUMAN | Gamma-1-syntrophin | SNTG1 | 398 | Annotation score: | ||
A0A2R8Y6P6 | A0A2R8Y6P6_HUMAN | Gamma-1-syntrophin | SNTG1 | 416 | Annotation score: | ||
A0A2R8Y7J9 | A0A2R8Y7J9_HUMAN | Gamma-1-syntrophin | SNTG1 | 441 | Annotation score: | ||
A0A2R8YF28 | A0A2R8YF28_HUMAN | Gamma-1-syntrophin | SNTG1 | 368 | Annotation score: | ||
A0A2R8YGL5 | A0A2R8YGL5_HUMAN | Gamma-1-syntrophin | SNTG1 | 402 | Annotation score: | ||
A0A2R8Y7L6 | A0A2R8Y7L6_HUMAN | Gamma-1-syntrophin | SNTG1 | 155 | Annotation score: | ||
A0A2R8Y7Z5 | A0A2R8Y7Z5_HUMAN | Gamma-1-syntrophin | SNTG1 | 236 | Annotation score: | ||
There are more potential isoformsShow all |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006360 | 428 – 464 | Missing in isoform 2. 1 PublicationAdd BLAST | 37 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ003030 mRNA Translation: CAB92968.1 AL161971 mRNA Translation: CAB82311.1 BC075072 mRNA Translation: AAH75072.1 BC104829 mRNA Translation: AAI04830.1 |
CCDSi | CCDS6147.1 [Q9NSN8-1] CCDS75737.1 [Q9NSN8-2] |
PIRi | T47134 |
RefSeqi | NP_001274742.1, NM_001287813.2 [Q9NSN8-1] NP_001274743.1, NM_001287814.2 [Q9NSN8-2] NP_001308702.1, NM_001321773.1 [Q9NSN8-1] NP_001308705.1, NM_001321776.1 NP_001308706.1, NM_001321777.1 NP_061840.1, NM_018967.4 [Q9NSN8-1] XP_016869068.1, XM_017013579.1 [Q9NSN8-1] XP_016869069.1, XM_017013580.1 [Q9NSN8-1] |
Genome annotation databases
Ensembli | ENST00000517473; ENSP00000431123; ENSG00000147481 [Q9NSN8-2] ENST00000518864; ENSP00000429276; ENSG00000147481 [Q9NSN8-1] ENST00000642720; ENSP00000493900; ENSG00000147481 [Q9NSN8-1] |
GeneIDi | 54212 |
KEGGi | hsa:54212 |
UCSCi | uc003xqs.3, human [Q9NSN8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ003030 mRNA Translation: CAB92968.1 AL161971 mRNA Translation: CAB82311.1 BC075072 mRNA Translation: AAH75072.1 BC104829 mRNA Translation: AAI04830.1 |
CCDSi | CCDS6147.1 [Q9NSN8-1] CCDS75737.1 [Q9NSN8-2] |
PIRi | T47134 |
RefSeqi | NP_001274742.1, NM_001287813.2 [Q9NSN8-1] NP_001274743.1, NM_001287814.2 [Q9NSN8-2] NP_001308702.1, NM_001321773.1 [Q9NSN8-1] NP_001308705.1, NM_001321776.1 NP_001308706.1, NM_001321777.1 NP_061840.1, NM_018967.4 [Q9NSN8-1] XP_016869068.1, XM_017013579.1 [Q9NSN8-1] XP_016869069.1, XM_017013580.1 [Q9NSN8-1] |
3D structure databases
SMRi | Q9NSN8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119928, 11 interactors |
CORUMi | Q9NSN8 |
IntActi | Q9NSN8, 2 interactors |
STRINGi | 9606.ENSP00000429842 |
PTM databases
iPTMneti | Q9NSN8 |
PhosphoSitePlusi | Q9NSN8 |
Genetic variation databases
BioMutai | SNTG1 |
DMDMi | 23822220 |
Proteomic databases
MassIVEi | Q9NSN8 |
PaxDbi | Q9NSN8 |
PeptideAtlasi | Q9NSN8 |
PRIDEi | Q9NSN8 |
ProteomicsDBi | 82570 [Q9NSN8-1] 82571 [Q9NSN8-2] |
Protocols and materials databases
Antibodypediai | 24371, 115 antibodies |
DNASUi | 54212 |
Genome annotation databases
Ensembli | ENST00000517473; ENSP00000431123; ENSG00000147481 [Q9NSN8-2] ENST00000518864; ENSP00000429276; ENSG00000147481 [Q9NSN8-1] ENST00000642720; ENSP00000493900; ENSG00000147481 [Q9NSN8-1] |
GeneIDi | 54212 |
KEGGi | hsa:54212 |
UCSCi | uc003xqs.3, human [Q9NSN8-1] |
Organism-specific databases
CTDi | 54212 |
DisGeNETi | 54212 |
GeneCardsi | SNTG1 |
HGNCi | HGNC:13740, SNTG1 |
HPAi | ENSG00000147481, Group enriched (brain, lymphoid tissue, pituitary gland) |
MIMi | 608714, gene |
neXtProti | NX_Q9NSN8 |
OpenTargetsi | ENSG00000147481 |
PharmGKBi | PA37806 |
VEuPathDBi | HostDB:ENSG00000147481.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3549, Eukaryota |
GeneTreei | ENSGT00950000182863 |
HOGENOMi | CLU_039445_0_0_1 |
InParanoidi | Q9NSN8 |
OMAi | AIVWQYK |
PhylomeDBi | Q9NSN8 |
TreeFami | TF317932 |
Enzyme and pathway databases
PathwayCommonsi | Q9NSN8 |
SIGNORi | Q9NSN8 |
Miscellaneous databases
BioGRID-ORCSi | 54212, 0 hits in 878 CRISPR screens |
ChiTaRSi | SNTG1, human |
GeneWikii | SNTG1 |
GenomeRNAii | 54212 |
Pharosi | Q9NSN8, Tbio |
PROi | PR:Q9NSN8 |
RNActi | Q9NSN8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000147481, Expressed in frontal cortex and 102 other tissues |
ExpressionAtlasi | Q9NSN8, baseline and differential |
Genevisiblei | Q9NSN8, HS |
Family and domain databases
Gene3Di | 2.30.42.10, 1 hit |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf IPR001849, PH_domain IPR015482, Syntrophin IPR015483, Syntrophin_gamma |
PANTHERi | PTHR10554, PTHR10554, 1 hit PTHR10554:SF2, PTHR10554:SF2, 1 hit |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 1 hit SM00233, PH, 2 hits |
SUPFAMi | SSF50156, SSF50156, 1 hit |
PROSITEi | View protein in PROSITE PS50106, PDZ, 1 hit PS50003, PH_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SNTG1_HUMAN | |
Accessioni | Q9NSN8Primary (citable) accession number: Q9NSN8 Secondary accession number(s): Q2M3Q0, Q9NY98 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2002 |
Last sequence update: | October 1, 2000 | |
Last modified: | February 10, 2021 | |
This is version 166 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families