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Entry version 163 (12 Aug 2020)
Sequence version 1 (01 Oct 2000)
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Protein

Gamma-1-syntrophin

Gene

SNTG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity). May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9NSN8

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9NSN8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gamma-1-syntrophin
Short name:
G1SYN
Alternative name(s):
Syntrophin-4
Short name:
SYN4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SNTG1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000147481.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13740, SNTG1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608714, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NSN8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54212

Open Targets

More...
OpenTargetsi
ENSG00000147481

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37806

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NSN8, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SNTG1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
23822220

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001840131 – 517Gamma-1-syntrophinAdd BLAST517

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NSN8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NSN8

PeptideAtlas

More...
PeptideAtlasi
Q9NSN8

PRoteomics IDEntifications database

More...
PRIDEi
Q9NSN8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82570 [Q9NSN8-1]
82571 [Q9NSN8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NSN8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NSN8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain specific. In CNS, it is expressed in the perikaryon and proximal portion of the neuronal processes. Strong expression in the hippocampus, neuron-rich dendate granule cells, and pyramidal cell layers. Highly expressed in neurons of the cerebral cortex. Also expressed in the cerebellar cortex, deep cerebellar nuclei, thalamus, and basal ganglia. No expression in muscle cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000147481, Expressed in frontal cortex and 102 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NSN8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NSN8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000147481, Group enriched (brain, lymphoid tissue, pituitary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 1, but not isoform 2, interacts with the dystrophin protein DMD and related proteins DTNA and DTNB.

Interacts with DGKZ.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
119928, 5 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9NSN8

Protein interaction database and analysis system

More...
IntActi
Q9NSN8, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000429842

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9NSN8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NSN8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini57 – 140PDZPROSITE-ProRule annotationAdd BLAST84
Domaini283 – 390PHPROSITE-ProRule annotationAdd BLAST108

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PDZ domain binds to the last three or four amino acids of DGKZ. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the syntrophin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3549, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00950000182863

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_039445_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NSN8

KEGG Orthology (KO)

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KOi
K24065

Identification of Orthologs from Complete Genome Data

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OMAi
AIVWQYK

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NSN8

TreeFam database of animal gene trees

More...
TreeFami
TF317932

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001478, PDZ
IPR036034, PDZ_sf
IPR001849, PH_domain
IPR015482, Syntrophin
IPR015483, Syntrophin_gamma

The PANTHER Classification System

More...
PANTHERi
PTHR10554, PTHR10554, 1 hit
PTHR10554:SF2, PTHR10554:SF2, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00595, PDZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00228, PDZ, 1 hit
SM00233, PH, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106, PDZ, 1 hit
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 17 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NSN8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDFRTACEET KTGICLLQDG NQEPFKVRLH LAKDILMIQE QDVICVSGEP
60 70 80 90 100
FYSGERTVTI RRQTVGGFGL SIKGGAEHNI PVVVSKISKE QRAELSGLLF
110 120 130 140 150
IGDAILQING INVRKCRHEE VVQVLRNAGE EVTLTVSFLK RAPAFLKLPL
160 170 180 190 200
NEDCACAPSD QSSGTSSPLC DSGLHLNYHP NNTDTLSCSS WPTSPGLRWE
210 220 230 240 250
KRWCDLRLIP LLHSRFSQYV PGTDLSRQNA FQVIAVDGVC TGIIQCLSAE
260 270 280 290 300
DCVDWLQAIA TNISNLTKHN IKKINRNFPV NQQIVYMGWC EAREQDPLQD
310 320 330 340 350
RVYSPTFLAL RGSCLYKFLA PPVTTWDWTR AEKTFSVYEI MCKILKDSDL
360 370 380 390 400
LDRRKQCFTV QSESGEDLYF SVELESDLAQ WERAFQTATF LEVERIQCKT
410 420 430 440 450
YACVLESHLM GLTIDFSTGF ICFDAATKAV LWRYKFSQLK GSSDDGKSKI
460 470 480 490 500
KFLFQNPDTK QIEAKELEFS NLFAVLHCIH SFFAAKVACL DPLFLGNQAT
510
ASTAASSATT SKAKYTT
Length:517
Mass (Da):57,969
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB0C87AB18CB5D79
GO
Isoform 2 (identifier: Q9NSN8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     428-464: Missing.

Show »
Length:480
Mass (Da):53,684
Checksum:i6DC6FF96D40EC447
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RHN6E5RHN6_HUMAN
Gamma-1-syntrophin
SNTG1
348Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y5T2A0A2R8Y5T2_HUMAN
Gamma-1-syntrophin
SNTG1
435Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y631A0A2R8Y631_HUMAN
Gamma-1-syntrophin
SNTG1
472Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y5G8A0A2R8Y5G8_HUMAN
Gamma-1-syntrophin
SNTG1
398Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y6P6A0A2R8Y6P6_HUMAN
Gamma-1-syntrophin
SNTG1
416Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7J9A0A2R8Y7J9_HUMAN
Gamma-1-syntrophin
SNTG1
441Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YF28A0A2R8YF28_HUMAN
Gamma-1-syntrophin
SNTG1
368Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YGL5A0A2R8YGL5_HUMAN
Gamma-1-syntrophin
SNTG1
402Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7L6A0A2R8Y7L6_HUMAN
Gamma-1-syntrophin
SNTG1
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7Z5A0A2R8Y7Z5_HUMAN
Gamma-1-syntrophin
SNTG1
236Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_006360428 – 464Missing in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ003030 mRNA Translation: CAB92968.1
AL161971 mRNA Translation: CAB82311.1
BC075072 mRNA Translation: AAH75072.1
BC104829 mRNA Translation: AAI04830.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6147.1 [Q9NSN8-1]
CCDS75737.1 [Q9NSN8-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
T47134

NCBI Reference Sequences

More...
RefSeqi
NP_001274742.1, NM_001287813.2 [Q9NSN8-1]
NP_001274743.1, NM_001287814.2 [Q9NSN8-2]
NP_001308702.1, NM_001321773.1 [Q9NSN8-1]
NP_001308705.1, NM_001321776.1
NP_001308706.1, NM_001321777.1
NP_061840.1, NM_018967.4 [Q9NSN8-1]
XP_016869068.1, XM_017013579.1 [Q9NSN8-1]
XP_016869069.1, XM_017013580.1 [Q9NSN8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000517473; ENSP00000431123; ENSG00000147481 [Q9NSN8-2]
ENST00000518864; ENSP00000429276; ENSG00000147481 [Q9NSN8-1]
ENST00000642720; ENSP00000493900; ENSG00000147481 [Q9NSN8-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54212

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:54212

UCSC genome browser

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UCSCi
uc003xqs.3, human [Q9NSN8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ003030 mRNA Translation: CAB92968.1
AL161971 mRNA Translation: CAB82311.1
BC075072 mRNA Translation: AAH75072.1
BC104829 mRNA Translation: AAI04830.1
CCDSiCCDS6147.1 [Q9NSN8-1]
CCDS75737.1 [Q9NSN8-2]
PIRiT47134
RefSeqiNP_001274742.1, NM_001287813.2 [Q9NSN8-1]
NP_001274743.1, NM_001287814.2 [Q9NSN8-2]
NP_001308702.1, NM_001321773.1 [Q9NSN8-1]
NP_001308705.1, NM_001321776.1
NP_001308706.1, NM_001321777.1
NP_061840.1, NM_018967.4 [Q9NSN8-1]
XP_016869068.1, XM_017013579.1 [Q9NSN8-1]
XP_016869069.1, XM_017013580.1 [Q9NSN8-1]

3D structure databases

SMRiQ9NSN8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119928, 5 interactors
CORUMiQ9NSN8
IntActiQ9NSN8, 2 interactors
STRINGi9606.ENSP00000429842

PTM databases

iPTMnetiQ9NSN8
PhosphoSitePlusiQ9NSN8

Polymorphism and mutation databases

BioMutaiSNTG1
DMDMi23822220

Proteomic databases

MassIVEiQ9NSN8
PaxDbiQ9NSN8
PeptideAtlasiQ9NSN8
PRIDEiQ9NSN8
ProteomicsDBi82570 [Q9NSN8-1]
82571 [Q9NSN8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
24371, 115 antibodies

The DNASU plasmid repository

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DNASUi
54212

Genome annotation databases

EnsembliENST00000517473; ENSP00000431123; ENSG00000147481 [Q9NSN8-2]
ENST00000518864; ENSP00000429276; ENSG00000147481 [Q9NSN8-1]
ENST00000642720; ENSP00000493900; ENSG00000147481 [Q9NSN8-1]
GeneIDi54212
KEGGihsa:54212
UCSCiuc003xqs.3, human [Q9NSN8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54212
DisGeNETi54212
EuPathDBiHostDB:ENSG00000147481.13

GeneCards: human genes, protein and diseases

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GeneCardsi
SNTG1
HGNCiHGNC:13740, SNTG1
HPAiENSG00000147481, Group enriched (brain, lymphoid tissue, pituitary gland)
MIMi608714, gene
neXtProtiNX_Q9NSN8
OpenTargetsiENSG00000147481
PharmGKBiPA37806

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3549, Eukaryota
GeneTreeiENSGT00950000182863
HOGENOMiCLU_039445_0_0_1
InParanoidiQ9NSN8
KOiK24065
OMAiAIVWQYK
PhylomeDBiQ9NSN8
TreeFamiTF317932

Enzyme and pathway databases

PathwayCommonsiQ9NSN8
SIGNORiQ9NSN8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
54212, 0 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SNTG1, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SNTG1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54212
PharosiQ9NSN8, Tbio

Protein Ontology

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PROi
PR:Q9NSN8
RNActiQ9NSN8, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000147481, Expressed in frontal cortex and 102 other tissues
ExpressionAtlasiQ9NSN8, baseline and differential
GenevisibleiQ9NSN8, HS

Family and domain databases

Gene3Di2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR001478, PDZ
IPR036034, PDZ_sf
IPR001849, PH_domain
IPR015482, Syntrophin
IPR015483, Syntrophin_gamma
PANTHERiPTHR10554, PTHR10554, 1 hit
PTHR10554:SF2, PTHR10554:SF2, 1 hit
PfamiView protein in Pfam
PF00595, PDZ, 1 hit
SMARTiView protein in SMART
SM00228, PDZ, 1 hit
SM00233, PH, 2 hits
SUPFAMiSSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106, PDZ, 1 hit
PS50003, PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSNTG1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NSN8
Secondary accession number(s): Q2M3Q0, Q9NY98
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 1, 2000
Last modified: August 12, 2020
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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