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Entry version 178 (12 Aug 2020)
Sequence version 3 (17 Oct 2006)
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Protein

Kinesin light chain 4

Gene

KLC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9NSK0

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2132295, MHC class II antigen presentation
R-HSA-5625970, RHO GTPases activate KTN1
R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189, Kinesins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinesin light chain 4
Short name:
KLC 4
Alternative name(s):
Kinesin-like protein 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KLC4
Synonyms:KNSL8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000137171.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21624, KLC4

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NSK0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
89953

Open Targets

More...
OpenTargetsi
ENSG00000137171

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134934134

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NSK0, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KLC4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
116242607

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002150972 – 619Kinesin light chain 4Add BLAST618

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei174PhosphoserineBy similarity1
Modified residuei460PhosphoserineCombined sources1
Modified residuei519PhosphoserineBy similarity1
Modified residuei565PhosphoserineBy similarity1
Modified residuei566PhosphoserineCombined sources1
Modified residuei590PhosphoserineCombined sources1
Modified residuei612PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NSK0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NSK0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NSK0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NSK0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NSK0

PeptideAtlas

More...
PeptideAtlasi
Q9NSK0

PRoteomics IDEntifications database

More...
PRIDEi
Q9NSK0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
4604
82562 [Q9NSK0-1]
82563 [Q9NSK0-2]
82564 [Q9NSK0-3]
82565 [Q9NSK0-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NSK0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NSK0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137171, Expressed in right lobe of liver and 205 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NSK0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NSK0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000137171, Tissue enhanced (intestine)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Oligomeric complex composed of two heavy chains and two light chains.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NSK0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati55 – 88TPR 1Add BLAST34
Repeati211 – 244TPR 2Add BLAST34
Repeati253 – 286TPR 3Add BLAST34
Repeati295 – 328TPR 4Add BLAST34
Repeati337 – 370TPR 5Add BLAST34
Repeati379 – 412TPR 6Add BLAST34
Repeati464 – 497TPR 7Add BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili32 – 150Sequence analysisAdd BLAST119

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the kinesin light chain family.Curated

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1840, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161323

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_1926883_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NSK0

KEGG Orthology (KO)

More...
KOi
K10407

Identification of Orthologs from Complete Genome Data

More...
OMAi
GTPYTEY

Database of Orthologous Groups

More...
OrthoDBi
511880at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NSK0

TreeFam database of animal gene trees

More...
TreeFami
TF314010

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002151, Kinesin_light
IPR015792, Kinesin_light_repeat
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00381, KINESINLIGHT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028, TPR, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01160, KINESIN_LIGHT, 3 hits
PS50005, TPR, 6 hits
PS50293, TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NSK0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGLVLGQRD EPAGHRLSQE EILGSTRLVS QGLEALRSEH QAVLQSLSQT
60 70 80 90 100
IECLQQGGHE EGLVHEKARQ LRRSMENIEL GLSEAQVMLA LASHLSTVES
110 120 130 140 150
EKQKLRAQVR RLCQENQWLR DELAGTQQRL QRSEQAVAQL EEEKKHLEFL
160 170 180 190 200
GQLRQYDEDG HTSEEKEGDA TKDSLDDLFP NEEEEDPSNG LSRGQGATAA
210 220 230 240 250
QQGGYEIPAR LRTLHNLVIQ YAAQGRYEVA VPLCKQALED LERTSGRGHP
260 270 280 290 300
DVATMLNILA LVYRDQNKYK EAAHLLNDAL SIRESTLGPD HPAVAATLNN
310 320 330 340 350
LAVLYGKRGK YKEAEPLCQR ALEIREKVLG TNHPDVAKQL NNLALLCQNQ
360 370 380 390 400
GKYEAVERYY QRALAIYEGQ LGPDNPNVAR TKNNLASCYL KQGKYAEAET
410 420 430 440 450
LYKEILTRAH VQEFGSVDDD HKPIWMHAEE REEMSKSRHH EGGTPYAEYG
460 470 480 490 500
GWYKACKVSS PTVNTTLRNL GALYRRQGKL EAAETLEECA LRSRRQGTDP
510 520 530 540 550
ISQTKVAELL GESDGRRTSQ EGPGDSVKFE GGEDASVAVE WSGDGSGTLQ
560 570 580 590 600
RSGSLGKIRD VLRRSSELLV RKLQGTEPRP SSSNMKRAAS LNYLNQPSAA
610
PLQVSRGLSA STMDLSSSS
Length:619
Mass (Da):68,640
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i32DFC2A9A91B5574
GO
Isoform 2 (identifier: Q9NSK0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-131: VMLALASHLS...ELAGTQQRLQ → NLELRGCAHL...AMPGEPVAAG
     132-619: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:131
Mass (Da):13,682
Checksum:i18DB578896960243
GO
Isoform 3 (identifier: Q9NSK0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MEVTGFGVTRPGKVPQARM

Show »
Length:637
Mass (Da):70,552
Checksum:iCAA62901967C6918
GO
Isoform 4 (identifier: Q9NSK0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     295-315: AATLNNLAVLYGKRGKYKEAE → SIPCPPHPTPRTPHHCCFGLS
     316-619: Missing.

Show »
Length:315
Mass (Da):35,102
Checksum:iB2F27C231C949391
GO
Isoform 5 (identifier: Q9NSK0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-163: Missing.

Show »
Length:542
Mass (Da):59,640
Checksum:i85687792E15F896D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J8T5C9J8T5_HUMAN
Kinesin light chain
KLC4
271Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4M1H7C4M1_HUMAN
Kinesin light chain
KLC4
159Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZE5C9JZE5_HUMAN
Kinesin light chain
KLC4
162Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQU1C9JQU1_HUMAN
Kinesin light chain 4
KLC4
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JXT5C9JXT5_HUMAN
Kinesin light chain 4
KLC4
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9K0D5C9K0D5_HUMAN
Kinesin light chain 4
KLC4
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCA4F8WCA4_HUMAN
Kinesin light chain 4
KLC4
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC86788 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti54L → LQTIECL in BAC87179 (PubMed:14702039).Curated1
Sequence conflicti286T → S in BAG51695 (PubMed:14702039).Curated1
Sequence conflicti366I → T in BAG51695 (PubMed:14702039).Curated1
Sequence conflicti434M → L in BAG52815 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04970872R → H1 PublicationCorresponds to variant dbSNP:rs11558979Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0380831M → MEVTGFGVTRPGKVPQARM in isoform 3. 1 Publication1
Alternative sequenceiVSP_05723187 – 163Missing in isoform 5. 1 PublicationAdd BLAST77
Alternative sequenceiVSP_03787587 – 131VMLAL…QQRLQ → NLELRGCAHLGDAGSSQPPE HSGVGETEAAGSGAAAMPGE PVAAG in isoform 2. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_037876132 – 619Missing in isoform 2. 1 PublicationAdd BLAST488
Alternative sequenceiVSP_043324295 – 315AATLN…YKEAE → SIPCPPHPTPRTPHHCCFGL S in isoform 4. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_043325316 – 619Missing in isoform 4. 1 PublicationAdd BLAST304

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK055293 mRNA Translation: BAG51496.1
AK056393 mRNA Translation: BAG51695.1
AK094102 mRNA Translation: BAG52815.1
AK127018 mRNA Translation: BAC86788.1 Sequence problems.
AK127894 mRNA Translation: BAC87179.1
AK297433 mRNA Translation: BAG59861.1
AL162078 mRNA Translation: CAB82411.1
AL136304 Genomic DNA No translation available.
AL355385 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04149.1
BC012357 mRNA Translation: AAH12357.1
BC080637 mRNA Translation: AAH80637.1
BC103727 mRNA Translation: AAI03728.1
BX640717 mRNA Translation: CAE45836.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47429.1 [Q9NSK0-4]
CCDS4882.1 [Q9NSK0-3]
CCDS4883.1 [Q9NSK0-1]
CCDS75459.1 [Q9NSK0-5]

Protein sequence database of the Protein Information Resource

More...
PIRi
T47147

NCBI Reference Sequences

More...
RefSeqi
NP_001275963.1, NM_001289034.1 [Q9NSK0-1]
NP_001275964.1, NM_001289035.1 [Q9NSK0-5]
NP_612352.1, NM_138343.3 [Q9NSK0-4]
NP_958929.1, NM_201521.2 [Q9NSK0-1]
NP_958930.1, NM_201522.2 [Q9NSK0-1]
NP_958931.1, NM_201523.2 [Q9NSK0-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000259708; ENSP00000259708; ENSG00000137171 [Q9NSK0-3]
ENST00000347162; ENSP00000340221; ENSG00000137171 [Q9NSK0-1]
ENST00000394056; ENSP00000377620; ENSG00000137171 [Q9NSK0-1]
ENST00000453940; ENSP00000395806; ENSG00000137171 [Q9NSK0-5]
ENST00000458460; ENSP00000410358; ENSG00000137171 [Q9NSK0-4]
ENST00000467906; ENSP00000418759; ENSG00000137171 [Q9NSK0-2]
ENST00000479388; ENSP00000418031; ENSG00000137171 [Q9NSK0-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
89953

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:89953

UCSC genome browser

More...
UCSCi
uc003otu.4, human [Q9NSK0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055293 mRNA Translation: BAG51496.1
AK056393 mRNA Translation: BAG51695.1
AK094102 mRNA Translation: BAG52815.1
AK127018 mRNA Translation: BAC86788.1 Sequence problems.
AK127894 mRNA Translation: BAC87179.1
AK297433 mRNA Translation: BAG59861.1
AL162078 mRNA Translation: CAB82411.1
AL136304 Genomic DNA No translation available.
AL355385 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04149.1
BC012357 mRNA Translation: AAH12357.1
BC080637 mRNA Translation: AAH80637.1
BC103727 mRNA Translation: AAI03728.1
BX640717 mRNA Translation: CAE45836.1
CCDSiCCDS47429.1 [Q9NSK0-4]
CCDS4882.1 [Q9NSK0-3]
CCDS4883.1 [Q9NSK0-1]
CCDS75459.1 [Q9NSK0-5]
PIRiT47147
RefSeqiNP_001275963.1, NM_001289034.1 [Q9NSK0-1]
NP_001275964.1, NM_001289035.1 [Q9NSK0-5]
NP_612352.1, NM_138343.3 [Q9NSK0-4]
NP_958929.1, NM_201521.2 [Q9NSK0-1]
NP_958930.1, NM_201522.2 [Q9NSK0-1]
NP_958931.1, NM_201523.2 [Q9NSK0-3]

3D structure databases

SMRiQ9NSK0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124648, 84 interactors
IntActiQ9NSK0, 60 interactors
MINTiQ9NSK0
STRINGi9606.ENSP00000259708

PTM databases

iPTMnetiQ9NSK0
PhosphoSitePlusiQ9NSK0

Polymorphism and mutation databases

BioMutaiKLC4
DMDMi116242607

Proteomic databases

EPDiQ9NSK0
jPOSTiQ9NSK0
MassIVEiQ9NSK0
MaxQBiQ9NSK0
PaxDbiQ9NSK0
PeptideAtlasiQ9NSK0
PRIDEiQ9NSK0
ProteomicsDBi4604
82562 [Q9NSK0-1]
82563 [Q9NSK0-2]
82564 [Q9NSK0-3]
82565 [Q9NSK0-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
30259, 70 antibodies

The DNASU plasmid repository

More...
DNASUi
89953

Genome annotation databases

EnsembliENST00000259708; ENSP00000259708; ENSG00000137171 [Q9NSK0-3]
ENST00000347162; ENSP00000340221; ENSG00000137171 [Q9NSK0-1]
ENST00000394056; ENSP00000377620; ENSG00000137171 [Q9NSK0-1]
ENST00000453940; ENSP00000395806; ENSG00000137171 [Q9NSK0-5]
ENST00000458460; ENSP00000410358; ENSG00000137171 [Q9NSK0-4]
ENST00000467906; ENSP00000418759; ENSG00000137171 [Q9NSK0-2]
ENST00000479388; ENSP00000418031; ENSG00000137171 [Q9NSK0-1]
GeneIDi89953
KEGGihsa:89953
UCSCiuc003otu.4, human [Q9NSK0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
89953
DisGeNETi89953
EuPathDBiHostDB:ENSG00000137171.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KLC4
HGNCiHGNC:21624, KLC4
HPAiENSG00000137171, Tissue enhanced (intestine)
neXtProtiNX_Q9NSK0
OpenTargetsiENSG00000137171
PharmGKBiPA134934134

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1840, Eukaryota
GeneTreeiENSGT00940000161323
HOGENOMiCLU_1926883_0_0_1
InParanoidiQ9NSK0
KOiK10407
OMAiGTPYTEY
OrthoDBi511880at2759
PhylomeDBiQ9NSK0
TreeFamiTF314010

Enzyme and pathway databases

PathwayCommonsiQ9NSK0
ReactomeiR-HSA-2132295, MHC class II antigen presentation
R-HSA-5625970, RHO GTPases activate KTN1
R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983189, Kinesins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
89953, 9 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KLC4, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
KLC4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
89953
PharosiQ9NSK0, Tdark

Protein Ontology

More...
PROi
PR:Q9NSK0
RNActiQ9NSK0, protein

Gene expression databases

BgeeiENSG00000137171, Expressed in right lobe of liver and 205 other tissues
ExpressionAtlasiQ9NSK0, baseline and differential
GenevisibleiQ9NSK0, HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR002151, Kinesin_light
IPR015792, Kinesin_light_repeat
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
PRINTSiPR00381, KINESINLIGHT
SMARTiView protein in SMART
SM00028, TPR, 5 hits
SUPFAMiSSF48452, SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS01160, KINESIN_LIGHT, 3 hits
PS50005, TPR, 6 hits
PS50293, TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKLC4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NSK0
Secondary accession number(s): B3KNY4
, B3KPI3, B3KSQ3, B4DME9, Q66K28, Q96EG6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 17, 2006
Last modified: August 12, 2020
This is version 178 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
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