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Entry version 157 (10 Apr 2019)
Sequence version 1 (01 Oct 2000)
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Protein

SAM domain-containing protein SAMSN-1

Gene

SAMSN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SAM domain-containing protein SAMSN-1
Alternative name(s):
Hematopoietic adaptor containing SH3 and SAM domains 1
Nash1
SAM domain, SH3 domain and nuclear localization signals protein 1
SH3-SAM adaptor protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SAMSN1
Synonyms:HACS1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000155307.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10528 SAMSN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607978 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NSI8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64092

Open Targets

More...
OpenTargetsi
ENSG00000155307

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34939

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SAMSN1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12230638

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000975741 – 373SAM domain-containing protein SAMSN-1Add BLAST373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei23PhosphoserineCombined sources1
Modified residuei34PhosphoserineCombined sources1
Modified residuei74PhosphoserineCombined sources1
Modified residuei76PhosphothreonineCombined sources1
Modified residuei90PhosphoserineCombined sources1
Modified residuei119PhosphoserineCombined sources1
Modified residuei160PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NSI8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9NSI8

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9NSI8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NSI8

PeptideAtlas

More...
PeptideAtlasi
Q9NSI8

PRoteomics IDEntifications database

More...
PRIDEi
Q9NSI8

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82558
82559 [Q9NSI8-2]
82560 [Q9NSI8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NSI8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9NSI8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in peripheral blood B-cells (at protein level). Detected in spleen, liver and peripheral blood.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in peripheral blood B-cells by IL4, IL13 and by CD40 stimulation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000155307 Expressed in 198 organ(s), highest expression level in bone marrow

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NSI8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NSI8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA010645
HPA017055

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FASLG. Interacts with phosphotyrosine containing proteins. Interacts (via SH3 domain) with CTTN. Interacts (phosphorylated at Ser-23) with YWHAB, YWHAE, YWHAG, YWHAH, YWHAZ and SFN. Interacts directly with SAP30 and HDAC1. Identified in a complex with SAP30 and HDAC1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122054, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NSI8, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000285670

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1373
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KEANMR-A162-224[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9NSI8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NSI8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9NSI8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini163 – 224SH3PROSITE-ProRule annotationAdd BLAST62
Domaini241 – 305SAMPROSITE-ProRule annotationAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi20 – 25Important for interaction with 14-3-3 proteinsBy similarity6

Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4384 Eukaryota
ENOG410ZEDF LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157806

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000049202

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000461

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NSI8

Identification of Orthologs from Complete Genome Data

More...
OMAi
LPDMVQK

Database of Orthologous Groups

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OrthoDBi
278880at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NSI8

TreeFam database of animal gene trees

More...
TreeFami
TF350709

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09561 SAM_SAMSN1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021090 rSAM/SH3_domain-containing
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR037623 SAMSN1_SAM
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07647 SAM_2, 1 hit
PF07653 SH3_2, 1 hit
PF12485 SLY, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00454 SAM, 1 hit
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50105 SAM_DOMAIN, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NSI8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLKRKPSNVS EKEKHQKPKR SSSFGNFDRF RNNSLSKPDD STEAHEGDPT
60 70 80 90 100
NGSGEQSKTS NNGGGLGKKM RAISWTMKKK VGKKYIKALS EEKDEEDGEN
110 120 130 140 150
AHPYRNSDPV IGTHTEKVSL KASDSMDSLY SGQSSSSGIT SCSDGTSNRD
160 170 180 190 200
SFRLDDDGPY SGPFCGRARV HTDFTPSPYD TDSLKIKKGD IIDIICKTPM
210 220 230 240 250
GMWTGMLNNK VGNFKFIYVD VISEEEAAPK KIKANRRSNS KKSKTLQEFL
260 270 280 290 300
ERIHLQEYTS TLLLNGYETL EDLKDIKESH LIELNIENPD DRRRLLSAAE
310 320 330 340 350
NFLEEEIIQE QENEPEPLSL SSDISLNKSQ LDDCPRDSGC YISSGNSDNG
360 370
KEDLESENLS DMVHKIIITE PSD
Length:373
Mass (Da):41,708
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i964B852ADBA2D777
GO
Isoform 2 (identifier: Q9NSI8-2) [UniParc]FASTAAdd to basket
Also known as: b

The sequence of this isoform differs from the canonical sequence as follows:
     19-186: Missing.

Show »
Length:205
Mass (Da):23,466
Checksum:i362B2FB490B972BE
GO
Isoform 3 (identifier: Q9NSI8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MLKRKPSNVSEKEKHQKPK → MEIRLDTLSA...CSDMDLLHSW

Show »
Length:441
Mass (Da):49,627
Checksum:iC2757916D880F563
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S6FRS6S6FRS6_HUMAN
SAM domain, SH3 domain and nuclear ...
SAMSN1
304Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y4K8A0A2R8Y4K8_HUMAN
SAM domain-containing protein SAMSN...
SAMSN1
669Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK07746 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti105R → G in BAG54155 (PubMed:14702039).Curated1
Isoform 3 (identifier: Q9NSI8-3)
Sequence conflicti20N → D in AAK07746 (PubMed:11536050).Curated1
Sequence conflicti64H → Y in AAK07746 (PubMed:11536050).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05133163G → A. Corresponds to variant dbSNP:rs34607574Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0081201 – 19MLKRK…HQKPK → MEIRLDTLSASLGRSSTLNN CNLEDKLAWYEGEAYMWHHW KPFPENPLWTCLDFQIAQVG PWDHCSSCIRHTRLKSSCSD MDLLHSW in isoform 3. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_00811919 – 186Missing in isoform 2. 1 PublicationAdd BLAST168

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF222927 mRNA Translation: AAG23355.1
AF218085 mRNA Translation: AAK07746.1 Different initiation.
AF519621 mRNA Translation: AAM75349.1
AK125144 mRNA Translation: BAG54155.1
AL163206 Genomic DNA Translation: CAB90391.1
AF165138 Genomic DNA No translation available.
BC029112 mRNA Translation: AAH29112.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42906.1 [Q9NSI8-1]
CCDS58786.1 [Q9NSI8-3]

NCBI Reference Sequences

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RefSeqi
NP_001243299.1, NM_001256370.1 [Q9NSI8-3]
NP_001273452.1, NM_001286523.1
NP_071419.3, NM_022136.4 [Q9NSI8-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.473341
Hs.719474

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000285670; ENSP00000285670; ENSG00000155307 [Q9NSI8-3]
ENST00000400564; ENSP00000383409; ENSG00000155307 [Q9NSI8-2]
ENST00000400566; ENSP00000383411; ENSG00000155307 [Q9NSI8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
64092

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:64092

UCSC genome browser

More...
UCSCi
uc002yju.3 human [Q9NSI8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF222927 mRNA Translation: AAG23355.1
AF218085 mRNA Translation: AAK07746.1 Different initiation.
AF519621 mRNA Translation: AAM75349.1
AK125144 mRNA Translation: BAG54155.1
AL163206 Genomic DNA Translation: CAB90391.1
AF165138 Genomic DNA No translation available.
BC029112 mRNA Translation: AAH29112.1
CCDSiCCDS42906.1 [Q9NSI8-1]
CCDS58786.1 [Q9NSI8-3]
RefSeqiNP_001243299.1, NM_001256370.1 [Q9NSI8-3]
NP_001273452.1, NM_001286523.1
NP_071419.3, NM_022136.4 [Q9NSI8-1]
UniGeneiHs.473341
Hs.719474

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KEANMR-A162-224[»]
ProteinModelPortaliQ9NSI8
SMRiQ9NSI8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122054, 12 interactors
IntActiQ9NSI8, 2 interactors
STRINGi9606.ENSP00000285670

PTM databases

iPTMnetiQ9NSI8
PhosphoSitePlusiQ9NSI8

Polymorphism and mutation databases

BioMutaiSAMSN1
DMDMi12230638

Proteomic databases

EPDiQ9NSI8
jPOSTiQ9NSI8
MaxQBiQ9NSI8
PaxDbiQ9NSI8
PeptideAtlasiQ9NSI8
PRIDEiQ9NSI8
ProteomicsDBi82558
82559 [Q9NSI8-2]
82560 [Q9NSI8-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
64092
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285670; ENSP00000285670; ENSG00000155307 [Q9NSI8-3]
ENST00000400564; ENSP00000383409; ENSG00000155307 [Q9NSI8-2]
ENST00000400566; ENSP00000383411; ENSG00000155307 [Q9NSI8-1]
GeneIDi64092
KEGGihsa:64092
UCSCiuc002yju.3 human [Q9NSI8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64092
DisGeNETi64092
EuPathDBiHostDB:ENSG00000155307.17

GeneCards: human genes, protein and diseases

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GeneCardsi
SAMSN1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0016027
HGNCiHGNC:10528 SAMSN1
HPAiHPA010645
HPA017055
MIMi607978 gene
neXtProtiNX_Q9NSI8
OpenTargetsiENSG00000155307
PharmGKBiPA34939

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4384 Eukaryota
ENOG410ZEDF LUCA
GeneTreeiENSGT00940000157806
HOGENOMiHOG000049202
HOVERGENiHBG000461
InParanoidiQ9NSI8
OMAiLPDMVQK
OrthoDBi278880at2759
PhylomeDBiQ9NSI8
TreeFamiTF350709

Miscellaneous databases

EvolutionaryTraceiQ9NSI8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64092

Protein Ontology

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PROi
PR:Q9NSI8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000155307 Expressed in 198 organ(s), highest expression level in bone marrow
ExpressionAtlasiQ9NSI8 baseline and differential
GenevisibleiQ9NSI8 HS

Family and domain databases

CDDicd09561 SAM_SAMSN1, 1 hit
InterProiView protein in InterPro
IPR021090 rSAM/SH3_domain-containing
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR037623 SAMSN1_SAM
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF07647 SAM_2, 1 hit
PF07653 SH3_2, 1 hit
PF12485 SLY, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSAMN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NSI8
Secondary accession number(s): B3KWJ3
, F8WAA1, Q8NFF7, Q9C041
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: April 10, 2019
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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