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Protein

Bromodomain and WD repeat-containing protein 1

Gene

BRWD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • chromatin organization Source: Reactome
  • cytoskeleton organization Source: UniProtKB
  • interleukin-7-mediated signaling pathway Source: Reactome
  • regulation of cell shape Source: UniProtKB
  • regulation of transcription by RNA polymerase II Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1266695 Interleukin-7 signaling
R-HSA-3247509 Chromatin modifying enzymes

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9NSI6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bromodomain and WD repeat-containing protein 1
Alternative name(s):
WD repeat-containing protein 9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BRWD1
Synonyms:C21orf107, WDR9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000185658.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12760 BRWD1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617824 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NSI6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54014

Open Targets

More...
OpenTargetsi
ENSG00000185658

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134906879

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3351192

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BRWD1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104296

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000508881 – 2320Bromodomain and WD repeat-containing protein 1Add BLAST2320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei687PhosphothreonineBy similarity1
Modified residuei696PhosphoserineCombined sources1
Modified residuei701PhosphoserineCombined sources1
Modified residuei710PhosphoserineCombined sources1
Modified residuei1289PhosphoserineCombined sources1
Modified residuei1475PhosphoserineCombined sources1
Modified residuei1477PhosphothreonineCombined sources1
Modified residuei1479PhosphoserineCombined sources1
Modified residuei1605PhosphoserineCombined sources1
Modified residuei1607PhosphoserineCombined sources1
Modified residuei1678PhosphoserineCombined sources1
Modified residuei1683PhosphoserineCombined sources1
Modified residuei1686PhosphoserineCombined sources1
Modified residuei1755PhosphoserineBy similarity1
Modified residuei1756PhosphoserineBy similarity1
Modified residuei1786PhosphoserineBy similarity1
Modified residuei1788PhosphoserineBy similarity1
Modified residuei1793PhosphoserineBy similarity1
Modified residuei1820PhosphoserineBy similarity1
Modified residuei1867PhosphothreonineBy similarity1
Modified residuei1871PhosphoserineBy similarity1
Modified residuei1904PhosphoserineCombined sources1
Modified residuei1905PhosphoserineCombined sources1
Modified residuei1907PhosphoserineCombined sources1
Modified residuei1910PhosphoserineCombined sources1
Modified residuei1943PhosphoserineCombined sources1
Modified residuei1955PhosphothreonineBy similarity1
Modified residuei2018PhosphoserineCombined sources1
Modified residuei2020PhosphoserineCombined sources1
Modified residuei2052PhosphoserineBy similarity1
Modified residuei2164PhosphothreonineBy similarity1
Modified residuei2166PhosphoserineBy similarity1
Isoform B (identifier: Q9NSI6-2)
Modified residuei2214PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9NSI6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NSI6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NSI6

PeptideAtlas

More...
PeptideAtlasi
Q9NSI6

PRoteomics IDEntifications database

More...
PRIDEi
Q9NSI6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82555
82556 [Q9NSI6-2]
82557 [Q9NSI6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NSI6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NSI6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185658 Expressed in 209 organ(s), highest expression level in caudate nucleus

CleanEx database of gene expression profiles

More...
CleanExi
HS_BRWD1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9NSI6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NSI6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB034184
HPA030943
HPA030944
HPA030945

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SMARCA4.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
119828, 19 interactors

Protein interaction database and analysis system

More...
IntActi
Q9NSI6, 17 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000330753

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9NSI6

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12320
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9NSI6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9NSI6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9NSI6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati184 – 223WD 1Add BLAST40
Repeati226 – 265WD 2Add BLAST40
Repeati268 – 311WD 3Add BLAST44
Repeati322 – 365WD 4Add BLAST44
Repeati366 – 405WD 5Add BLAST40
Repeati424 – 463WD 6Add BLAST40
Repeati466 – 506WD 7Add BLAST41
Repeati514 – 553WD 8Add BLAST40
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1177 – 1247Bromo 1PROSITE-ProRule annotationAdd BLAST71
Domaini1330 – 1400Bromo 2PROSITE-ProRule annotationAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi661 – 668Poly-Gln8
Compositional biasi821 – 824Poly-Ser4
Compositional biasi1539 – 1548Poly-Ser10
Compositional biasi1687 – 1692Poly-Glu6

Keywords - Domaini

Bromodomain, Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IRXQ Eukaryota
COG5076 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154754

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG080933

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NSI6

KEGG Orthology (KO)

More...
KOi
K11798

Identification of Orthologs from Complete Genome Data

More...
OMAi
RRRVHDW

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00HZ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NSI6

TreeFam database of animal gene trees

More...
TreeFami
TF324197

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.920.10, 2 hits
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00439 Bromodomain, 2 hits
PF00400 WD40, 5 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503 BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297 BROMO, 2 hits
SM00320 WD40, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370 SSF47370, 2 hits
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 2 hits
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q9NSI6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEPSSARRP VPLIESELYF LIARYLSAGP CRRAAQVLVQ ELEQYQLLPK
60 70 80 90 100
RLDWEGNEHN RSYEELVLSN KHVAPDHLLQ ICQRIGPMLD KEIPPSISRV
110 120 130 140 150
TSLLGAGRQS LLRTAKDCRH TVWKGSAFAA LHRGRPPEMP VNYGSPPNLV
160 170 180 190 200
EIHRGKQLTG CSTFSTAFPG TMYQHIKMHR RILGHLSAVY CVAFDRTGHR
210 220 230 240 250
IFTGSDDCLV KIWSTHNGRL LSTLRGHSAE ISDMAVNYEN TMIAAGSCDK
260 270 280 290 300
IIRVWCLRTC APVAVLQGHT GSITSLQFSP MAKGSQRYMV STGADGTVCF
310 320 330 340 350
WQWDLESLKF SPRPLKFTEK PRPGVQMLCS SFSVGGMFLA TGSTDHVIRM
360 370 380 390 400
YFLGFEAPEK IAELESHTDK VDSIQFCNNG DRFLSGSRDG TARIWRFEQL
410 420 430 440 450
EWRSILLDMA TRISGDLSSE EERFMKPKVT MIAWNQNDSI VVTAVNDHVL
460 470 480 490 500
KVWNSYTGQL LHNLMGHADE VFVLETHPFD SRIMLSAGHD GSIFIWDITK
510 520 530 540 550
GTKMKHYFNM IEGQGHGAVF DCKFSQDGQH FACTDSHGHL LIFGFGCSKP
560 570 580 590 600
YEKIPDQMFF HTDYRPLIRD SNNYVLDEQT QQAPHLMPPP FLVDVDGNPH
610 620 630 640 650
PTKYQRLVPG RENSADEHLI PQLGYVATSD GEVIEQIISL QTNDNDERSP
660 670 680 690 700
ESSILDGMIR QLQQQQDQRM GADQDTIPRG LSNGEETPRR GFRRLSLDIQ
710 720 730 740 750
SPPNIGLRRS GQVEGVRQMH QNAPRSQIAT ERDLQAWKRR VVVPEVPLGI
760 770 780 790 800
FRKLEDFRLE KGEEERNLYI IGRKRKTLQL SHKSDSVVLV SQSRQRTCRR
810 820 830 840 850
KYPNYGRRNR SWRELSSGNE SSSSVRHETS CDQSEGSGSS EEDEWRSDRK
860 870 880 890 900
SESYSESSSD SSSRYSDWTA DAGINLQPPL RTSCRRRITR FCSSSEDEIS
910 920 930 940 950
TENLSPPKRR RKRKKENKPK KENLRRMTPA ELANMEHLYE FHPPVWITDT
960 970 980 990 1000
TLRKSPFVPQ MGDEVIYFRQ GHEAYIEAVR RNNIYELNPN KEPWRKMDLR
1010 1020 1030 1040 1050
DQELVKIVGI RYEVGPPTLC CLKLAFIDPA TGKLMDKSFS IRYHDMPDVI
1060 1070 1080 1090 1100
DFLVLRQFYD EARQRNWQSC DRFRSIIDDA WWFGTVLSQE PYQPQYPDSH
1110 1120 1130 1140 1150
FQCYIVRWDN TEIEKLSPWD MEPIPDNVDP PEELGASISV TTDELEKLLY
1160 1170 1180 1190 1200
KPQAGEWGQK SRDEECDRII SGIDQLLNLD IAAAFAGPVD LCTYPKYCTV
1210 1220 1230 1240 1250
VAYPTDLYTI RMRLVNRFYR RLSALVWEVR YIEHNARTFN EPESVIARSA
1260 1270 1280 1290 1300
KKITDQLLKF IKNQHCTNIS ELSNTSENDE QNAEDLDDSD LPKTSSGRRR
1310 1320 1330 1340 1350
VHDGKKSIRA TNYVESNWKK QCKELVNLIF QCEDSEPFRQ PVDLVEYPDY
1360 1370 1380 1390 1400
RDIIDTPMDF GTVRETLDAG NYDSPLEFCK DIRLIFSNAK AYTPNKRSKI
1410 1420 1430 1440 1450
YSMTLRLSAL FEEKMKKISS DFKIGQKFNE KLRRSQRFKQ RQNCKGDSQP
1460 1470 1480 1490 1500
NKSIRNLKPK RLKSQTKIIP ELVGSPTQST SSRTAYLGTH KTSAGISSGV
1510 1520 1530 1540 1550
TSGDSSDSAE SSERRKRNRP ITNGSTLSES EVEDSLATSL SSSASSSSEE
1560 1570 1580 1590 1600
SKESSRARES SSRSGLSRSS NLRVTRTRAA QRKTGPVSLA NGCGRKATRK
1610 1620 1630 1640 1650
RVYLSDSDNN SLETGEILKA RAGNNRKVLR KCAAVAANKI KLMSDVEENS
1660 1670 1680 1690 1700
SSESVCSGRK LPHRNASAVA RKKLLHNSED EQSLKSEIEE EELKDENQLL
1710 1720 1730 1740 1750
PVSSSHTAQS NVDESENRDS ESESDLRVAR KNWHANGYKS HTPAPSKTKF
1760 1770 1780 1790 1800
LKIESSEEDS KSHDSDHACN RTAGPSTSVQ KLKAESISEE ADSEPGRSGG
1810 1820 1830 1840 1850
RKYNTFHKNA SFFKKTKILS DSEDSESEEQ DREDGKCHKM EMNPISGNLN
1860 1870 1880 1890 1900
CDPIAMSQCS SDHGCETDLD SDDDKIEKPN NFMKDSASQD NGLSRKISRK
1910 1920 1930 1940 1950
RVCSSDSDSS LQVVKKSSKA RTGLLRITRR CAATAANKIK LMSDVEDVSL
1960 1970 1980 1990 2000
ENVHTRSKNG RKKPLHLACT TAKKKLSDCE GSVHCEVPSE QYACEGKPPD
2010 2020 2030 2040 2050
PDSEGSTKVL SQALNGDSDS EDMLNSEHKH RHTNIHKIDA PSKRKSSSVT
2060 2070 2080 2090 2100
SSGEDSKSHI PGSETDRTFS SESTLAQKAT AENNFEVELN YGLRRWNGRR
2110 2120 2130 2140 2150
LRTYGKAPFS KTKVIHDSQE TAEKEVKRKR SHPELENVKI SETTGNSKFR
2160 2170 2180 2190 2200
PDTSSKSSDL GSVTESDIDC TDNTKTKRRK TKGKAKVVRK EFVPRDREPN
2210 2220 2230 2240 2250
TKVRTCMHNQ KDAVQMPSET LKAKMVPEKV PRRCATVAAN KIKIMSNLKE
2260 2270 2280 2290 2300
TISGPENVWI RKSSRKLPHR NASAAAKKKL LNVYKEDDTT INSESEKELE
2310 2320
DINRKMLFLR GFRSWKENAQ
Length:2,320
Mass (Da):262,936
Last modified:November 30, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i109714D79B9057E9
GO
Isoform B (identifier: Q9NSI6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2191-2320: EFVPRDREPN...GFRSWKENAQ → GKTFTANISK...NVLDFNGCTL

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Length:2,269
Mass (Da):257,238
Checksum:iEF2D6F3B745BB4EE
GO
Isoform C (identifier: Q9NSI6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2191-2285: EFVPRDREPN...AKKKLLNVYK → DKTFSPVYL
     2286-2320: Missing.

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Length:2,199
Mass (Da):248,953
Checksum:iD0B8757ED0AF6E32
GO
Isoform D (identifier: Q9NSI6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-120: DCRH → GTLI
     121-2320: Missing.

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Length:120
Mass (Da):13,558
Checksum:iF31E4C9728C92359
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y4A7H0Y4A7_HUMAN
Bromodomain and WD repeat-containin...
BRWD1
235Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4R9H0Y4R9_HUMAN
Bromodomain and WD repeat-containin...
BRWD1
266Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y500H0Y500_HUMAN
Bromodomain and WD repeat-containin...
BRWD1
409Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5I9H0Y5I9_HUMAN
Bromodomain and WD repeat-containin...
BRWD1
467Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C409H7C409_HUMAN
Bromodomain and WD repeat-containin...
BRWD1
452Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y463H0Y463_HUMAN
Bromodomain and WD repeat-containin...
BRWD1
548Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZR9H7BZR9_HUMAN
Bromodomain and WD repeat-containin...
BRWD1
640Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA10896 differs from that shown. Reason: Frameshift at positions 1762 and 1770.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1560 – 1562SSS → GTR in CAA10896 (PubMed:9480850).Curated3
Sequence conflicti1840M → V in AK002177 (PubMed:14702039).Curated1
Sequence conflicti2134E → G in AK002177 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02643583Q → E1 PublicationCorresponds to variant dbSNP:rs2056844Ensembl.1
Natural variantiVAR_0264361511S → P1 PublicationCorresponds to variant dbSNP:rs2183573Ensembl.1
Natural variantiVAR_0264371699L → P5 PublicationsCorresponds to variant dbSNP:rs1041439Ensembl.1
Natural variantiVAR_0575842156K → R. Corresponds to variant dbSNP:rs2234548Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_044245117 – 120DCRH → GTLI in isoform D. 1 Publication4
Alternative sequenceiVSP_044246121 – 2320Missing in isoform D. 1 PublicationAdd BLAST2200
Alternative sequenceiVSP_0185262191 – 2320EFVPR…KENAQ → GKTFTANISKTVRRQRQSKR PRLSVDDNDWEDLDYAKSKR VLRRSKIKTRNQGRRTVRYH DGDDDRSLENVLDFNGCTL in isoform B. 4 PublicationsAdd BLAST130
Alternative sequenceiVSP_0185272191 – 2285EFVPR…LNVYK → DKTFSPVYL in isoform C. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_0185282286 – 2320Missing in isoform C. 1 PublicationAdd BLAST35

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ238214 mRNA Translation: CAC37033.2
AJ292465 mRNA Translation: CAC44371.1
AJ292466 mRNA Translation: CAC44372.1
AB080586 mRNA Translation: BAD74071.1
AB080587 mRNA Translation: BAD74072.1
AF064861 Genomic DNA No translation available.
AF129408 Genomic DNA No translation available.
BC064602 mRNA Translation: AAH64602.1
AL163279 Genomic DNA Translation: CAB90452.1
AJ222636 mRNA Translation: CAA10896.1 Frameshift.
AK002177 mRNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS13662.1 [Q9NSI6-1]
CCDS13663.1 [Q9NSI6-2]
CCDS33557.1 [Q9NSI6-4]

NCBI Reference Sequences

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RefSeqi
NP_001007247.1, NM_001007246.2 [Q9NSI6-4]
NP_061836.2, NM_018963.4 [Q9NSI6-1]
NP_387505.1, NM_033656.3 [Q9NSI6-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.627139
Hs.654740

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000333229; ENSP00000330753; ENSG00000185658 [Q9NSI6-1]
ENST00000341322; ENSP00000342106; ENSG00000185658 [Q9NSI6-4]
ENST00000342449; ENSP00000344333; ENSG00000185658 [Q9NSI6-2]
ENST00000380800; ENSP00000370178; ENSG00000185658 [Q9NSI6-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
54014

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:54014

UCSC genome browser

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UCSCi
uc002yxk.3 human [Q9NSI6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238214 mRNA Translation: CAC37033.2
AJ292465 mRNA Translation: CAC44371.1
AJ292466 mRNA Translation: CAC44372.1
AB080586 mRNA Translation: BAD74071.1
AB080587 mRNA Translation: BAD74072.1
AF064861 Genomic DNA No translation available.
AF129408 Genomic DNA No translation available.
BC064602 mRNA Translation: AAH64602.1
AL163279 Genomic DNA Translation: CAB90452.1
AJ222636 mRNA Translation: CAA10896.1 Frameshift.
AK002177 mRNA No translation available.
CCDSiCCDS13662.1 [Q9NSI6-1]
CCDS13663.1 [Q9NSI6-2]
CCDS33557.1 [Q9NSI6-4]
RefSeqiNP_001007247.1, NM_001007246.2 [Q9NSI6-4]
NP_061836.2, NM_018963.4 [Q9NSI6-1]
NP_387505.1, NM_033656.3 [Q9NSI6-2]
UniGeneiHs.627139
Hs.654740

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3Q2EX-ray1.74A1310-1430[»]
ProteinModelPortaliQ9NSI6
SMRiQ9NSI6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119828, 19 interactors
IntActiQ9NSI6, 17 interactors
STRINGi9606.ENSP00000330753

Chemistry databases

BindingDBiQ9NSI6
ChEMBLiCHEMBL3351192

PTM databases

iPTMnetiQ9NSI6
PhosphoSitePlusiQ9NSI6

Polymorphism and mutation databases

BioMutaiBRWD1
DMDMi313104296

Proteomic databases

EPDiQ9NSI6
MaxQBiQ9NSI6
PaxDbiQ9NSI6
PeptideAtlasiQ9NSI6
PRIDEiQ9NSI6
ProteomicsDBi82555
82556 [Q9NSI6-2]
82557 [Q9NSI6-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333229; ENSP00000330753; ENSG00000185658 [Q9NSI6-1]
ENST00000341322; ENSP00000342106; ENSG00000185658 [Q9NSI6-4]
ENST00000342449; ENSP00000344333; ENSG00000185658 [Q9NSI6-2]
ENST00000380800; ENSP00000370178; ENSG00000185658 [Q9NSI6-3]
GeneIDi54014
KEGGihsa:54014
UCSCiuc002yxk.3 human [Q9NSI6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54014
DisGeNETi54014
EuPathDBiHostDB:ENSG00000185658.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
BRWD1
HGNCiHGNC:12760 BRWD1
HPAiCAB034184
HPA030943
HPA030944
HPA030945
MIMi617824 gene
neXtProtiNX_Q9NSI6
OpenTargetsiENSG00000185658
PharmGKBiPA134906879

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IRXQ Eukaryota
COG5076 LUCA
GeneTreeiENSGT00940000154754
HOVERGENiHBG080933
InParanoidiQ9NSI6
KOiK11798
OMAiRRRVHDW
OrthoDBiEOG091G00HZ
PhylomeDBiQ9NSI6
TreeFamiTF324197

Enzyme and pathway databases

ReactomeiR-HSA-1266695 Interleukin-7 signaling
R-HSA-3247509 Chromatin modifying enzymes
SignaLinkiQ9NSI6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
BRWD1 human
EvolutionaryTraceiQ9NSI6

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
BRWD1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54014

Protein Ontology

More...
PROi
PR:Q9NSI6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000185658 Expressed in 209 organ(s), highest expression level in caudate nucleus
CleanExiHS_BRWD1
ExpressionAtlasiQ9NSI6 baseline and differential
GenevisibleiQ9NSI6 HS

Family and domain databases

Gene3Di1.20.920.10, 2 hits
2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00439 Bromodomain, 2 hits
PF00400 WD40, 5 hits
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 2 hits
SM00320 WD40, 8 hits
SUPFAMiSSF47370 SSF47370, 2 hits
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 2 hits
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBRWD1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NSI6
Secondary accession number(s): C9JK25
, O43721, Q5R2V0, Q5R2V1, Q6P2D1, Q8TCV3, Q96QG9, Q96QH0, Q9NUK1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 30, 2010
Last modified: December 5, 2018
This is version 180 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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