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Entry version 182 (13 Nov 2019)
Sequence version 3 (18 May 2010)
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Protein

Phenylalanine--tRNA ligase beta subunit

Gene

FARSB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
6.1.1.20 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-379716 Cytosolic tRNA aminoacylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phenylalanine--tRNA ligase beta subunit (EC:6.1.1.201 Publication)
Alternative name(s):
Phenylalanyl-tRNA synthetase beta subunit
Short name:
PheRS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FARSB
Synonyms:FARSLB, FRSB
ORF Names:HSPC173
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17800 FARSB

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609690 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NSD9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Rajab interstitial lung disease with brain calcifications (RILDBC)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive, lethal neurodevelopmental disorder characterized by multiple clinical manifestations including intrauterine growth restriction, failure to thrive, developmental delay, hypotonia, interstitial lung disease, and liver dysfunction. Brain imaging shows abnormal periventricular white matter, basal ganglia echogenicity, cerebral volume loss, incomplete closure of the Sylvian fissures, and normal myelination.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08105476C → R in RILDBC. 1 PublicationCorresponds to variant dbSNP:rs1419129874EnsemblClinVar.1
Natural variantiVAR_081055252F → S in RILDBC. 1 PublicationCorresponds to variant dbSNP:rs1466642025EnsemblClinVar.1
Natural variantiVAR_081056256T → M in RILDBC. 1 PublicationCorresponds to variant dbSNP:rs753710639EnsemblClinVar.1
Natural variantiVAR_081057262K → E in RILDBC. 1 PublicationCorresponds to variant dbSNP:rs1553554543EnsemblClinVar.1
Natural variantiVAR_081058285E → K in RILDBC. 1 PublicationCorresponds to variant dbSNP:rs767956337EnsemblClinVar.1
Natural variantiVAR_081059305R → Q in RILDBC; has no defect in protein synthesis. 1 PublicationCorresponds to variant dbSNP:rs773579570EnsemblClinVar.1
Natural variantiVAR_081060401R → Q in RILDBC. 1 PublicationCorresponds to variant dbSNP:rs1553553086EnsemblClinVar.1
Natural variantiVAR_081061461T → P in RILDBC. 1 PublicationCorresponds to variant dbSNP:rs1396171148EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Mental retardation, Neurodegeneration

Organism-specific databases

MalaCards human disease database

More...
MalaCardsi
FARSB
MIMi613658 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000116120

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
178506 Brain calcification, Rajab type

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162388068

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9NSD9

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4105969

Drug and drug target database

More...
DrugBanki
DB00120 L-Phenylalanine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FARSB

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452943

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001270161 – 589Phenylalanine--tRNA ligase beta subunitAdd BLAST589

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9NSD9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NSD9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9NSD9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9NSD9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9NSD9

PeptideAtlas

More...
PeptideAtlasi
Q9NSD9

PRoteomics IDEntifications database

More...
PRIDEi
Q9NSD9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
82538 [Q9NSD9-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NSD9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NSD9

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9NSD9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000116120 Expressed in 210 organ(s), highest expression level in epithelium of mammary gland

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9NSD9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036677
HPA036678
HPA061398

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer; dimer of two heterodimers formed by FARSA and FARSB.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q9Y2856EBI-353803,EBI-725361

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115367, 64 interactors

Database of interacting proteins

More...
DIPi
DIP-32869N

Protein interaction database and analysis system

More...
IntActi
Q9NSD9, 26 interactors

Molecular INTeraction database

More...
MINTi
Q9NSD9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000281828

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1589
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9NSD9

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini302 – 379B5PROSITE-ProRule annotationAdd BLAST78

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2472 Eukaryota
COG0072 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063489

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000105095

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9NSD9

KEGG Orthology (KO)

More...
KOi
K01890

Identification of Orthologs from Complete Genome Data

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OMAi
TIGVKRD

Database of Orthologous Groups

More...
OrthoDBi
378921at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9NSD9

TreeFam database of animal gene trees

More...
TreeFami
TF105681

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00769 PheRS_beta_core, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.50.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005146 B3/B4_tRNA-bd
IPR009061 DNA-bd_dom_put_sf
IPR004531 Phe-tRNA-synth_IIc_bsu_arc
IPR020825 Phe-tRNA_synthase_B3/B4
IPR041616 PheRS_beta_core
IPR040659 PhetRS_B1
IPR005147 tRNA_synthase_B5-dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03483 B3_4, 1 hit
PF03484 B5, 1 hit
PF18262 PhetRS_B1, 1 hit
PF17759 tRNA_synthFbeta, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00873 B3_4, 1 hit
SM00874 B5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46955 SSF46955, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00471 pheT_arch, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51483 B5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9NSD9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPTVSVKRDL LFQALGRTYT DEEFDELCFE FGLELDEITS EKEIISKEQG
60 70 80 90 100
NVKAAGASDV VLYKIDVPAN RYDLLCLEGL VRGLQVFKER IKAPVYKRVM
110 120 130 140 150
PDGKIQKLII TEETAKIRPF AVAAVLRNIK FTKDRYDSFI ELQEKLHQNI
160 170 180 190 200
CRKRALVAIG THDLDTLSGP FTYTAKRPSD IKFKPLNKTK EYTACELMNI
210 220 230 240 250
YKTDNHLKHY LHIIENKPLY PVIYDSNGVV LSMPPIINGD HSRITVNTRN
260 270 280 290 300
IFIECTGTDF TKAKIVLDII VTMFSEYCEN QFTVEAAEVV FPNGKSHTFP
310 320 330 340 350
ELAYRKEMVR ADLINKKVGI RETPENLAKL LTRMYLKSEV IGDGNQIEIE
360 370 380 390 400
IPPTRADIIH ACDIVEDAAI AYGYNNIQMT LPKTYTIANQ FPLNKLTELL
410 420 430 440 450
RHDMAAAGFT EALTFALCSQ EDIADKLGVD ISATKAVHIS NPKTAEFQVA
460 470 480 490 500
RTTLLPGLLK TIAANRKMPL PLKLFEISDI VIKDSNTDVG AKNYRHLCAV
510 520 530 540 550
YYNKNPGFEI IHGLLDRIMQ LLDVPPGEDK GGYVIKASEG PAFFPGRCAE
560 570 580
IFARGQSVGK LGVLHPDVIT KFELTMPCSS LEINVGPFL
Length:589
Mass (Da):66,116
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6425BA46D124BC08
GO
Isoform 2 (identifier: Q9NSD9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-99: Missing.

Note: No experimental confirmation available.
Show »
Length:490
Mass (Da):54,861
Checksum:iEB9B48047A2AF094
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti281Q → R in AAF29136 (PubMed:11042152).Curated1
Sequence conflicti555G → V in BAA95608 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08105476C → R in RILDBC. 1 PublicationCorresponds to variant dbSNP:rs1419129874EnsemblClinVar.1
Natural variantiVAR_081055252F → S in RILDBC. 1 PublicationCorresponds to variant dbSNP:rs1466642025EnsemblClinVar.1
Natural variantiVAR_081056256T → M in RILDBC. 1 PublicationCorresponds to variant dbSNP:rs753710639EnsemblClinVar.1
Natural variantiVAR_081057262K → E in RILDBC. 1 PublicationCorresponds to variant dbSNP:rs1553554543EnsemblClinVar.1
Natural variantiVAR_081058285E → K in RILDBC. 1 PublicationCorresponds to variant dbSNP:rs767956337EnsemblClinVar.1
Natural variantiVAR_081059305R → Q in RILDBC; has no defect in protein synthesis. 1 PublicationCorresponds to variant dbSNP:rs773579570EnsemblClinVar.1
Natural variantiVAR_081060401R → Q in RILDBC. 1 PublicationCorresponds to variant dbSNP:rs1553553086EnsemblClinVar.1
Natural variantiVAR_081061461T → P in RILDBC. 1 PublicationCorresponds to variant dbSNP:rs1396171148EnsemblClinVar.1
Natural variantiVAR_071245585V → I6 PublicationsCorresponds to variant dbSNP:rs7185Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0568661 – 99Missing in isoform 2. 1 PublicationAdd BLAST99

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D84430 mRNA Translation: BAA95608.1
AF042346 mRNA Translation: AAD02220.1
AF161521 mRNA Translation: AAF29136.1
AK294158 mRNA Translation: BAG57481.1
AC097461 Genomic DNA Translation: AAX88958.1
AC104772 Genomic DNA Translation: AAX81986.1
CH471063 Genomic DNA Translation: EAW70804.1
BC017783 mRNA Translation: AAH17783.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS2454.1 [Q9NSD9-1]

NCBI Reference Sequences

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RefSeqi
NP_005678.3, NM_005687.4 [Q9NSD9-1]
XP_006712232.1, XM_006712169.2 [Q9NSD9-2]
XP_011508768.1, XM_011510466.2 [Q9NSD9-2]
XP_016858599.1, XM_017003110.1 [Q9NSD9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000281828; ENSP00000281828; ENSG00000116120 [Q9NSD9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10056

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10056

UCSC genome browser

More...
UCSCi
uc002vne.2 human [Q9NSD9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84430 mRNA Translation: BAA95608.1
AF042346 mRNA Translation: AAD02220.1
AF161521 mRNA Translation: AAF29136.1
AK294158 mRNA Translation: BAG57481.1
AC097461 Genomic DNA Translation: AAX88958.1
AC104772 Genomic DNA Translation: AAX81986.1
CH471063 Genomic DNA Translation: EAW70804.1
BC017783 mRNA Translation: AAH17783.1
CCDSiCCDS2454.1 [Q9NSD9-1]
RefSeqiNP_005678.3, NM_005687.4 [Q9NSD9-1]
XP_006712232.1, XM_006712169.2 [Q9NSD9-2]
XP_011508768.1, XM_011510466.2 [Q9NSD9-2]
XP_016858599.1, XM_017003110.1 [Q9NSD9-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3L4GX-ray3.30B/D/F/H/J/L/N/P1-589[»]
SMRiQ9NSD9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi115367, 64 interactors
DIPiDIP-32869N
IntActiQ9NSD9, 26 interactors
MINTiQ9NSD9
STRINGi9606.ENSP00000281828

Chemistry databases

ChEMBLiCHEMBL4105969
DrugBankiDB00120 L-Phenylalanine

PTM databases

iPTMnetiQ9NSD9
PhosphoSitePlusiQ9NSD9
SwissPalmiQ9NSD9

Polymorphism and mutation databases

BioMutaiFARSB
DMDMi296452943

Proteomic databases

EPDiQ9NSD9
jPOSTiQ9NSD9
MassIVEiQ9NSD9
MaxQBiQ9NSD9
PaxDbiQ9NSD9
PeptideAtlasiQ9NSD9
PRIDEiQ9NSD9
ProteomicsDBi82538 [Q9NSD9-1]

Genome annotation databases

EnsembliENST00000281828; ENSP00000281828; ENSG00000116120 [Q9NSD9-1]
GeneIDi10056
KEGGihsa:10056
UCSCiuc002vne.2 human [Q9NSD9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10056

GeneCards: human genes, protein and diseases

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GeneCardsi
FARSB
HGNCiHGNC:17800 FARSB
HPAiHPA036677
HPA036678
HPA061398
MalaCardsiFARSB
MIMi609690 gene
613658 phenotype
neXtProtiNX_Q9NSD9
OpenTargetsiENSG00000116120
Orphaneti178506 Brain calcification, Rajab type
PharmGKBiPA162388068

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2472 Eukaryota
COG0072 LUCA
GeneTreeiENSGT00530000063489
HOGENOMiHOG000105095
InParanoidiQ9NSD9
KOiK01890
OMAiTIGVKRD
OrthoDBi378921at2759
PhylomeDBiQ9NSD9
TreeFamiTF105681

Enzyme and pathway databases

BRENDAi6.1.1.20 2681
ReactomeiR-HSA-379716 Cytosolic tRNA aminoacylation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FARSB human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
FARSB

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10056
PharosiQ9NSD9

Protein Ontology

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PROi
PR:Q9NSD9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000116120 Expressed in 210 organ(s), highest expression level in epithelium of mammary gland
GenevisibleiQ9NSD9 HS

Family and domain databases

CDDicd00769 PheRS_beta_core, 1 hit
Gene3Di3.50.40.10, 1 hit
InterProiView protein in InterPro
IPR005146 B3/B4_tRNA-bd
IPR009061 DNA-bd_dom_put_sf
IPR004531 Phe-tRNA-synth_IIc_bsu_arc
IPR020825 Phe-tRNA_synthase_B3/B4
IPR041616 PheRS_beta_core
IPR040659 PhetRS_B1
IPR005147 tRNA_synthase_B5-dom
PfamiView protein in Pfam
PF03483 B3_4, 1 hit
PF03484 B5, 1 hit
PF18262 PhetRS_B1, 1 hit
PF17759 tRNA_synthFbeta, 1 hit
SMARTiView protein in SMART
SM00873 B3_4, 1 hit
SM00874 B5, 1 hit
SUPFAMiSSF46955 SSF46955, 2 hits
TIGRFAMsiTIGR00471 pheT_arch, 1 hit
PROSITEiView protein in PROSITE
PS51483 B5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYFB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NSD9
Secondary accession number(s): B4DFM0
, O95708, Q4ZFX1, Q57ZJ5, Q9NZZ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: May 18, 2010
Last modified: November 13, 2019
This is version 182 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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