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Protein

Relaxin-3 receptor 1

Gene

RXFP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation.1 Publication

GO - Molecular functioni

  • galanin receptor activity Source: GO_Central
  • G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-444821 Relaxin receptors

Protein family/group databases

TCDBi9.A.14.13.21 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Relaxin-3 receptor 1
Short name:
RLN3 receptor 1
Alternative name(s):
G protein-coupled receptor SALPR
G-protein coupled receptor GPCR135
Relaxin family peptide receptor 3
Somatostatin- and angiotensin-like peptide receptor
Gene namesi
Name:RXFP3
Synonyms:RLN3R1, SALPR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000182631.6
HGNCiHGNC:24883 RXFP3
MIMi609445 gene
neXtProtiNX_Q9NSD7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 81ExtracellularSequence analysisAdd BLAST81
Transmembranei82 – 102Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini103 – 119CytoplasmicSequence analysisAdd BLAST17
Transmembranei120 – 140Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini141 – 156ExtracellularSequence analysisAdd BLAST16
Transmembranei157 – 177Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini178 – 215CytoplasmicSequence analysisAdd BLAST38
Transmembranei216 – 236Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini237 – 270ExtracellularSequence analysisAdd BLAST34
Transmembranei271 – 291Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini292 – 329CytoplasmicSequence analysisAdd BLAST38
Transmembranei330 – 350Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini351 – 356ExtracellularSequence analysis6
Transmembranei357 – 377Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini378 – 469CytoplasmicSequence analysisAdd BLAST92

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51289
OpenTargetsiENSG00000182631
PharmGKBiPA134868535

Chemistry databases

ChEMBLiCHEMBL1628472
GuidetoPHARMACOLOGYi353

Polymorphism and mutation databases

BioMutaiRXFP3
DMDMi20455271

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701041 – 469Relaxin-3 receptor 1Add BLAST469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi40N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi155 ↔ 247PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9NSD7
PRIDEiQ9NSD7
ProteomicsDBi82537

PTM databases

iPTMnetiQ9NSD7
PhosphoSitePlusiQ9NSD7

Expressioni

Tissue specificityi

Expressed predominantly in brain regions. Highest expression in substantia nigra and pituitary, followed by hippocampus, spinal cord, amygdala, caudate nucleus and corpus callosum, quite low level in cerebellum. In peripheral tissues, relatively high levels in adrenal glands, low levels in pancreas, salivary gland, placenta, mammary gland and testis.

Gene expression databases

BgeeiENSG00000182631 Expressed in 10 organ(s), highest expression level in right adrenal gland
CleanExiHS_RXFP3
GenevisibleiQ9NSD7 HS

Organism-specific databases

HPAiHPA027833

Interactioni

Protein-protein interaction databases

BioGridi119440, 2 interactors
STRINGi9606.ENSP00000328708

Chemistry databases

BindingDBiQ9NSD7

Structurei

3D structure databases

ProteinModelPortaliQ9NSD7
SMRiQ9NSD7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119055
HOGENOMiHOG000230485
HOVERGENiHBG101327
InParanoidiQ9NSD7
KOiK08397
OMAiILIKFNA
OrthoDBiEOG091G0BQS
PhylomeDBiQ9NSD7
TreeFamiTF330024

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NSD7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQMADAATIA TMNKAAGGDK LAELFSLVPD LLEAANTSGN ASLQLPDLWW
60 70 80 90 100
ELGLELPDGA PPGHPPGSGG AESADTEARV RILISVVYWV VCALGLAGNL
110 120 130 140 150
LVLYLMKSMQ GWRKSSINLF VTNLALTDFQ FVLTLPFWAV ENALDFKWPF
160 170 180 190 200
GKAMCKIVSM VTSMNMYASV FFLTAMSVTR YHSVASALKS HRTRGHGRGD
210 220 230 240 250
CCGRSLGDSC CFSAKALCVW IWALAALASL PSAIFSTTVK VMGEELCLVR
260 270 280 290 300
FPDKLLGRDR QFWLGLYHSQ KVLLGFVLPL GIIILCYLLL VRFIADRRAA
310 320 330 340 350
GTKGGAAVAG GRPTGASARR LSKVTKSVTI VVLSFFLCWL PNQALTTWSI
360 370 380 390 400
LIKFNAVPFS QEYFLCQVYA FPVSVCLAHS NSCLNPVLYC LVRREFRKAL
410 420 430 440 450
KSLLWRIASP SITSMRPFTA TTKPEHEDQG LQAPAPPHAA AEPDLLYYPP
460
GVVVYSGGRY DLLPSSSAY
Length:469
Mass (Da):51,124
Last modified:October 1, 2000 - v1
Checksum:i932E7B3001689F7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88437 mRNA Translation: BAA93001.1
AY236541 Genomic DNA Translation: AAO92063.1
AY394501 mRNA Translation: AAQ92315.1
BC113438 mRNA Translation: AAI13439.1
BC113440 mRNA Translation: AAI13441.1
CCDSiCCDS3900.1
RefSeqiNP_057652.1, NM_016568.3
UniGeneiHs.170146

Genome annotation databases

EnsembliENST00000330120; ENSP00000328708; ENSG00000182631
ENST00000616205; ENSP00000480733; ENSG00000277069
GeneIDi51289
KEGGihsa:51289
UCSCiuc003jic.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88437 mRNA Translation: BAA93001.1
AY236541 Genomic DNA Translation: AAO92063.1
AY394501 mRNA Translation: AAQ92315.1
BC113438 mRNA Translation: AAI13439.1
BC113440 mRNA Translation: AAI13441.1
CCDSiCCDS3900.1
RefSeqiNP_057652.1, NM_016568.3
UniGeneiHs.170146

3D structure databases

ProteinModelPortaliQ9NSD7
SMRiQ9NSD7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119440, 2 interactors
STRINGi9606.ENSP00000328708

Chemistry databases

BindingDBiQ9NSD7
ChEMBLiCHEMBL1628472
GuidetoPHARMACOLOGYi353

Protein family/group databases

TCDBi9.A.14.13.21 the g-protein-coupled receptor (gpcr) family
GPCRDBiSearch...

PTM databases

iPTMnetiQ9NSD7
PhosphoSitePlusiQ9NSD7

Polymorphism and mutation databases

BioMutaiRXFP3
DMDMi20455271

Proteomic databases

PaxDbiQ9NSD7
PRIDEiQ9NSD7
ProteomicsDBi82537

Protocols and materials databases

DNASUi51289
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330120; ENSP00000328708; ENSG00000182631
ENST00000616205; ENSP00000480733; ENSG00000277069
GeneIDi51289
KEGGihsa:51289
UCSCiuc003jic.3 human

Organism-specific databases

CTDi51289
DisGeNETi51289
EuPathDBiHostDB:ENSG00000182631.6
GeneCardsiRXFP3
HGNCiHGNC:24883 RXFP3
HPAiHPA027833
MIMi609445 gene
neXtProtiNX_Q9NSD7
OpenTargetsiENSG00000182631
PharmGKBiPA134868535
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119055
HOGENOMiHOG000230485
HOVERGENiHBG101327
InParanoidiQ9NSD7
KOiK08397
OMAiILIKFNA
OrthoDBiEOG091G0BQS
PhylomeDBiQ9NSD7
TreeFamiTF330024

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-444821 Relaxin receptors

Miscellaneous databases

GeneWikiiRelaxin/insulin-like_family_peptide_receptor_3
GenomeRNAii51289
PROiPR:Q9NSD7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182631 Expressed in 10 organ(s), highest expression level in right adrenal gland
CleanExiHS_RXFP3
GenevisibleiQ9NSD7 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRL3R1_HUMAN
AccessioniPrimary (citable) accession number: Q9NSD7
Secondary accession number(s): Q14DA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: October 1, 2000
Last modified: September 12, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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