Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1

Gene

ST6GALNAC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-((2->6)-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity Source: GO_Central
  • sialyltransferase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:HS00998-MONOMER
BRENDAi2.4.99.3 2681
ReactomeiR-HSA-4085001 Sialic acid metabolism
UniPathwayi
UPA00378

Protein family/group databases

CAZyiGT29 Glycosyltransferase Family 29

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC:2.4.99.3)
Alternative name(s):
GalNAc alpha-2,6-sialyltransferase I
ST6GalNAc I
Short name:
ST6GalNAcI
Sialyltransferase 7A
Short name:
SIAT7-A
Gene namesi
Name:ST6GALNAC1
Synonyms:SIAT7A
ORF Names:UNQ543/PRO848
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000070526.14
HGNCiHGNC:23614 ST6GALNAC1
MIMi610138 gene
neXtProtiNX_Q9NSC7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
Transmembranei15 – 35Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini36 – 600LumenalSequence analysisAdd BLAST565

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55808
OpenTargetsiENSG00000070526
PharmGKBiPA134935906

Polymorphism and mutation databases

BioMutaiST6GALNAC1
DMDMi21759444

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001492691 – 600Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1Add BLAST600

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi311N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi331N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi365 ↔ 533By similarity
Glycosylationi375N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi460N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9NSC7
MaxQBiQ9NSC7
PaxDbiQ9NSC7
PeptideAtlasiQ9NSC7
PRIDEiQ9NSC7
ProteomicsDBi82533

PTM databases

iPTMnetiQ9NSC7
PhosphoSitePlusiQ9NSC7

Expressioni

Gene expression databases

BgeeiENSG00000070526 Expressed in 150 organ(s), highest expression level in mucosa of sigmoid colon
CleanExiHS_ST6GALNAC1
ExpressionAtlasiQ9NSC7 baseline and differential
GenevisibleiQ9NSC7 HS

Organism-specific databases

HPAiHPA014975

Interactioni

Protein-protein interaction databases

BioGridi120918, 3 interactors
IntActiQ9NSC7, 1 interactor
STRINGi9606.ENSP00000156626

Structurei

3D structure databases

ProteinModelPortaliQ9NSC7
SMRiQ9NSC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2692 Eukaryota
ENOG410XT8P LUCA
GeneTreeiENSGT00760000119095
HOGENOMiHOG000231097
HOVERGENiHBG073351
InParanoidiQ9NSC7
KOiK03479
OMAiLYQRPGP
OrthoDBiEOG091G07XX
PhylomeDBiQ9NSC7
TreeFamiTF354325

Family and domain databases

Gene3Di3.90.1480.20, 1 hit
InterProiView protein in InterPro
IPR001675 Glyco_trans_29
IPR038578 GT29-like_sf
PfamiView protein in Pfam
PF00777 Glyco_transf_29, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q9NSC7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRSCLWRCRH LSQGVQWSLL LAVLVFFLFA LPSFIKEPQT KPSRHQRTEN
60 70 80 90 100
IKERSLQSLA KPKSQAPTRA RRTTIYAEPV PENNALNTQT QPKAHTTGDR
110 120 130 140 150
GKEANQAPPE EQDKVPHTAQ RAAWKSPEKE KTMVNTLSPR GQDAGMASGR
160 170 180 190 200
TEAQSWKSQD TKTTQGNGGQ TRKLTASRTV SEKHQGKAAT TAKTLIPKSQ
210 220 230 240 250
HRMLAPTGAV STRTRQKGVT TAVIPPKEKK PQATPPPAPF QSPTTQRNQR
260 270 280 290 300
LKAANFKSEP RWDFEEKYSF EIGGLQTTCP DSVKIKASKS LWLQKLFLPN
310 320 330 340 350
LTLFLDSRHF NQSEWDRLEH FAPPFGFMEL NYSLVQKVVT RFPPVPQQQL
360 370 380 390 400
LLASLPAGSL RCITCAVVGN GGILNNSHMG QEIDSHDYVF RLSGALIKGY
410 420 430 440 450
EQDVGTRTSF YGFTAFSLTQ SLLILGNRGF KNVPLGKDVR YLHFLEGTRD
460 470 480 490 500
YEWLEALLMN QTVMSKNLFW FRHRPQEAFR EALHMDRYLL LHPDFLRYMK
510 520 530 540 550
NRFLRSKTLD GAHWRIYRPT TGALLLLTAL QLCDQVSAYG FITEGHERFS
560 570 580 590 600
DHYYDTSWKR LIFYINHDFK LEREVWKRLH DEGIIRLYQR PGPGTAKAKN
Length:600
Mass (Da):68,564
Last modified:October 1, 2000 - v1
Checksum:i9A28399A3DC8AB30
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EMB6K7EMB6_HUMAN
Alpha-N-acetylgalactosaminide alpha...
ST6GALNAC1
152Annotation score:
G3XAD9G3XAD9_HUMAN
Alpha-N-acetylgalactosaminide alpha...
ST6GALNAC1 hCG_1640683
471Annotation score:
K7EJC9K7EJC9_HUMAN
Alpha-N-acetylgalactosaminide alpha...
ST6GALNAC1
47Annotation score:
K7EJA8K7EJA8_HUMAN
Alpha-N-acetylgalactosaminide alpha...
ST6GALNAC1
63Annotation score:
K7ELU9K7ELU9_HUMAN
Alpha-N-acetylgalactosaminide alpha...
ST6GALNAC1
59Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02151480V → A1 PublicationCorresponds to variant dbSNP:rs8077382Ensembl.1
Natural variantiVAR_049226424I → V. Corresponds to variant dbSNP:rs35948039Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11339 mRNA Translation: CAA72179.2
Y11340 Genomic DNA Translation: CAA72180.1
AY096001 mRNA Translation: AAM22800.1
AY358918 mRNA Translation: AAQ89277.1
CCDSiCCDS11748.1
RefSeqiNP_060884.1, NM_018414.4
UniGeneiHs.105352

Genome annotation databases

EnsembliENST00000156626; ENSP00000156626; ENSG00000070526
GeneIDi55808
KEGGihsa:55808
UCSCiuc002jsh.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Functional Glycomics Gateway - GTase

ST6GalNAc I

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11339 mRNA Translation: CAA72179.2
Y11340 Genomic DNA Translation: CAA72180.1
AY096001 mRNA Translation: AAM22800.1
AY358918 mRNA Translation: AAQ89277.1
CCDSiCCDS11748.1
RefSeqiNP_060884.1, NM_018414.4
UniGeneiHs.105352

3D structure databases

ProteinModelPortaliQ9NSC7
SMRiQ9NSC7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120918, 3 interactors
IntActiQ9NSC7, 1 interactor
STRINGi9606.ENSP00000156626

Protein family/group databases

CAZyiGT29 Glycosyltransferase Family 29

PTM databases

iPTMnetiQ9NSC7
PhosphoSitePlusiQ9NSC7

Polymorphism and mutation databases

BioMutaiST6GALNAC1
DMDMi21759444

Proteomic databases

EPDiQ9NSC7
MaxQBiQ9NSC7
PaxDbiQ9NSC7
PeptideAtlasiQ9NSC7
PRIDEiQ9NSC7
ProteomicsDBi82533

Protocols and materials databases

DNASUi55808
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000156626; ENSP00000156626; ENSG00000070526
GeneIDi55808
KEGGihsa:55808
UCSCiuc002jsh.5 human

Organism-specific databases

CTDi55808
DisGeNETi55808
EuPathDBiHostDB:ENSG00000070526.14
GeneCardsiST6GALNAC1
HGNCiHGNC:23614 ST6GALNAC1
HPAiHPA014975
MIMi610138 gene
neXtProtiNX_Q9NSC7
OpenTargetsiENSG00000070526
PharmGKBiPA134935906
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2692 Eukaryota
ENOG410XT8P LUCA
GeneTreeiENSGT00760000119095
HOGENOMiHOG000231097
HOVERGENiHBG073351
InParanoidiQ9NSC7
KOiK03479
OMAiLYQRPGP
OrthoDBiEOG091G07XX
PhylomeDBiQ9NSC7
TreeFamiTF354325

Enzyme and pathway databases

UniPathwayi
UPA00378

BioCyciMetaCyc:HS00998-MONOMER
BRENDAi2.4.99.3 2681
ReactomeiR-HSA-4085001 Sialic acid metabolism

Miscellaneous databases

ChiTaRSiST6GALNAC1 human
GeneWikiiST6GALNAC1
GenomeRNAii55808
PROiPR:Q9NSC7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000070526 Expressed in 150 organ(s), highest expression level in mucosa of sigmoid colon
CleanExiHS_ST6GALNAC1
ExpressionAtlasiQ9NSC7 baseline and differential
GenevisibleiQ9NSC7 HS

Family and domain databases

Gene3Di3.90.1480.20, 1 hit
InterProiView protein in InterPro
IPR001675 Glyco_trans_29
IPR038578 GT29-like_sf
PfamiView protein in Pfam
PF00777 Glyco_transf_29, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSIA7A_HUMAN
AccessioniPrimary (citable) accession number: Q9NSC7
Secondary accession number(s): Q6UW90, Q9NSC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again