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UniProtKB - Q9NSC5 (HOME3_HUMAN)

Entry version 176 (22 Apr 2020)
Sequence version 2 (28 Nov 2003)
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Protein

Homer protein homolog 3

Gene

HOMER3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6794361 Neurexins and neuroligins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homer protein homolog 3Curated
Short name:
Homer-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HOMER3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17514 HOMER3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604800 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9NSC5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cytoplasm, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi22A → N: Does not affect interaction with NFATC2. Decreases interaction with NFATC2; when associated with 53-L--S-56. Decreases interaction with NFATC2; when associated with S-43 and 53-L--S-56. Markedly decreases interaction with NFATC2; when associated with T-30 and S-31 and 53-L--S-56. Impairs interaction with NFATC2; when associated with T-30; S-31; S-43 and 53-L--S-56. 1 Publication1
Mutagenesisi30 – 31AG → TS: Markedly decreases interaction with NFATC2; when associated with S-43 and 53-L--S-56. Markedly decreases interaction with NFATC2; when associated with N-22 and 53-L--S-56. Impairs interaction with NFATC2; when associated with N-22; S-43 and 53-L--S-56. 1 Publication2
Mutagenesisi36T → A: Does not affect interaction with NFATC2; when associated with A-38 and A-52. Attenuates inhibition by AKT; when associated with A-38 and A-52. 1 Publication1
Mutagenesisi38S → A: Does not affect interaction with NFATC2; when associated with A-36 and A-52. Attenuates inhibition by AKT; when associated with A-36 and A-52. 1 Publication1
Mutagenesisi43A → S: Does not affect interaction with NFATC2. Decreases interaction with NFATC2; when associated with N-22 and 53-L--S-56. Markedly decreases interaction with NFATC2; when associated with T-30; S-31 and 53-L--S-56. Impairs interaction with NFATC2; when associated with N-22; T-30; S-31 and 53-L--S-56. 1 Publication1
Mutagenesisi52S → A: Does not affect interaction with NFATC2; when associated with A-36 and A-38. Attenuates inhibition by AKT; when associated with A-36 and A-38. 1 Publication1
Mutagenesisi53 – 56IGGA → LDGS: Decreases interaction with NFATC2. Decreases interaction with NFATC2; when associated with N-22. Decreases interaction with NFATC2; when associated with N-22 and S-43. Markedly decreases interaction with NFATC2; when associated with T-30; S-31 and S-43. Markedly decreases interaction with NFATC2; when associated with N-22; T-30 and S-31. Impairs interaction with NFATC2; when associated with N-22; T-30, S-31 and S-43. 2 Publications4
Mutagenesisi54G → D: Decreases interaction with NFATC2. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		9454

Open Targets

More...OpenTargetsi		ENSG00000051128

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134988320

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9NSC5 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HOMER3

Domain mapping of disease mutations (DMDM)

More...DMDMi		38605068

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001910111 – 361Homer protein homolog 3Add BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei120PhosphoserineBy similarity1
Modified residuei159PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9NSC5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9NSC5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9NSC5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9NSC5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9NSC5

PeptideAtlas

More...PeptideAtlasi		Q9NSC5

PRoteomics IDEntifications database

More...PRIDEi		Q9NSC5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		19531
82529 [Q9NSC5-1]
82530 [Q9NSC5-2]
82531 [Q9NSC5-3]
82532 [Q9NSC5-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9NSC5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9NSC5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000051128 Expressed in right hemisphere of cerebellum and 217 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9NSC5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9NSC5 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000051128 Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Tetramer (PubMed:19345194). Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization.

Interacts with NFATC2; interaction is calcium independent; interaction competes with PPP3CA for NFATC2 binding; interaction is reduced by AKT activation (PubMed:18218901).

Interacts with NFATC1 and NFATC4 (PubMed:18218901).

Interacts with SHANK1; forms a high-order complex at least composed of SHANK1 and HOMER3; the complex formation is regulated by CAMK2A-mediated phosphorylation (PubMed:19345194).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9NSC5
With#Exp.IntAct
itself7EBI-748420,EBI-748420
ABI1 - isoform 5 [Q8IZP0-5]3EBI-748420,EBI-11743294
ABI2 [Q9NYB9]7EBI-748420,EBI-743598
ABI2 - isoform 2 [Q9NYB9-2]3EBI-748420,EBI-11096309
ABI3 [Q9P2A4]8EBI-748420,EBI-742038
APP - isoform APP751 [P05067-8]3EBI-748420,EBI-302661
ARL13B [Q3SXY8]3EBI-748420,EBI-11343438
C4orf17 [Q53FE4]3EBI-748420,EBI-715110
CCDC120 [Q96HB5]3EBI-748420,EBI-744556
CCDC141 [Q6ZP82]3EBI-748420,EBI-928795
CDC37 [Q16543]3EBI-748420,EBI-295634
CDK18 [Q07002]3EBI-748420,EBI-746238
CWF19L2 [Q2TBE0]3EBI-748420,EBI-5453285
DVL3 [Q92997]3EBI-748420,EBI-739789
DYNLL1 [P63167]5EBI-748420,EBI-349105
DYNLL2 [Q96FJ2]4EBI-748420,EBI-742371
EAF1 [Q96JC9]7EBI-748420,EBI-769261
EFHC1 [Q5JVL4]3EBI-748420,EBI-743105
EIF3D [O15371]8EBI-748420,EBI-353818
FAM161B [Q96MY7]3EBI-748420,EBI-7225287
FAM90A1 [Q86YD7]3EBI-748420,EBI-6658203
FAT1 [Q14517]4EBI-748420,EBI-1171918
FBXO28 [Q9NVF7]5EBI-748420,EBI-740282
FRYL - isoform 2 [O94915-2]3EBI-748420,EBI-12023420
GAS8 [O95995]3EBI-748420,EBI-1052570
GGN [Q86UU5]3EBI-748420,EBI-10259069
HOMER1 [Q86YM7]15EBI-748420,EBI-746815
HOXB5 [P09067]3EBI-748420,EBI-3893317
INCA1 [Q0VD86]3EBI-748420,EBI-6509505
KANK2 [Q63ZY3]3EBI-748420,EBI-2556193
KANK4 [Q5T7N3]3EBI-748420,EBI-9355810
KDM1A [O60341]3EBI-748420,EBI-710124
KRTAP19-7 [Q3SYF9]3EBI-748420,EBI-10241353
LHX2 [P50458]3EBI-748420,EBI-12179869
LNX1 [Q8TBB1]6EBI-748420,EBI-739832
LRRC7 [A1L1C6]3EBI-748420,EBI-10171988
LSM14B - isoform 2 [Q9BX40-2]3EBI-748420,EBI-19133880
MDM1 [Q8TC05]3EBI-748420,EBI-3951677
MEOX1 [P50221]3EBI-748420,EBI-2864512
MFAP1 [P55081]3EBI-748420,EBI-1048159
MGC50722 [Q8IVT4]3EBI-748420,EBI-14086479
MIA3 [Q5JRA6]3EBI-748420,EBI-2291868
MOS [P00540]8EBI-748420,EBI-1757866
MSS51 [Q4VC12]3EBI-748420,EBI-11599933
NEBL [O76041]3EBI-748420,EBI-2880203
OTX2 - isoform 2 [P32243-2]3EBI-748420,EBI-9087860
PALLD - isoform 2 [Q8WX93-2]3EBI-748420,EBI-12218525
PAX6 [P26367]6EBI-748420,EBI-747278
PAX7 - isoform 2 [P23759-2]3EBI-748420,EBI-12859446
PKN1 [Q16512]7EBI-748420,EBI-602382
PLAAT5 - isoform 3 [Q96KN8-3]3EBI-748420,EBI-10290304
POLI [Q9UNA4]3EBI-748420,EBI-741774
POM121 [Q96HA1]3EBI-748420,EBI-739990
POM121 - isoform 2 [Q96HA1-2]3EBI-748420,EBI-11956563
PPP1R18 [Q6NYC8]6EBI-748420,EBI-2557469
PPP1R32 - isoform 2 [Q7Z5V6-2]3EBI-748420,EBI-12000762
PRCC [A0A0S2Z470]3EBI-748420,EBI-16438356
PRCC [Q92733]3EBI-748420,EBI-4397741
PRR35 [P0CG20]3EBI-748420,EBI-11986293
PSMA1 [P25786]11EBI-748420,EBI-359352
PSORS1C2 [Q9UIG4]3EBI-748420,EBI-11974061
RBM14 [Q96PK6]3EBI-748420,EBI-954272
RBM22 [Q9NW64]3EBI-748420,EBI-2602260
RUNX1T1 - isoform MTG8A [Q06455-2]3EBI-748420,EBI-11984663
RUNX1T1 - isoform 4 [Q06455-4]3EBI-748420,EBI-10224192
SARG [Q9BW04]3EBI-748420,EBI-2320464
SAXO1 [Q8IYX7]3EBI-748420,EBI-3957636
SCNM1 [Q9BWG6]3EBI-748420,EBI-748391
SDCBP [O00560]5EBI-748420,EBI-727004
SLAIN1 [Q8ND83]3EBI-748420,EBI-10269374
SMR3B [P02814]3EBI-748420,EBI-738612
SNRPF [P62306]9EBI-748420,EBI-356900
TBC1D22B [Q9NU19]3EBI-748420,EBI-8787464
TOX2 - isoform 3 [Q96NM4-3]3EBI-748420,EBI-12815137
USP2 [O75604]6EBI-748420,EBI-743272
WBP2 [Q969T9]3EBI-748420,EBI-727055
WDYHV1 [Q96HA8]3EBI-748420,EBI-741158
WIPF1 [O43516]3EBI-748420,EBI-346356
YPO1006 [A0A384KXH8] from Yersinia pestis.2EBI-748420,EBI-20592344
yscB [Q56973] from Yersinia pestis.2EBI-748420,EBI-20592268
ZBTB4 [Q9P1Z0]3EBI-748420,EBI-2564133
ZNF19 [P17023]3EBI-748420,EBI-12884200
ZNF35 [P13682]3EBI-748420,EBI-11041653
ZNF414 [Q96IQ9]3EBI-748420,EBI-744257
ZNF655 [Q8N720]3EBI-748420,EBI-625509

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		114843, 70 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9NSC5

Protein interaction database and analysis system

More...IntActi		Q9NSC5, 121 interactors

Molecular INTeraction database

More...MINTi		Q9NSC5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000439937

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9NSC5 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1361
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9NSC5

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9NSC5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 113WH1PROSITE-ProRule annotationAdd BLAST113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 80Required for interaction with NFATC21 PublicationAdd BLAST80

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili191 – 243Sequence analysisAdd BLAST53
Coiled coili254 – 358Sequence analysisAdd BLAST105

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi206 – 211Poly-Ala6

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Homer family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IIX6 Eukaryota
ENOG41101PM LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158081

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_033940_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9NSC5

KEGG Orthology (KO)

More...KOi		K15010

Identification of Orthologs from Complete Genome Data

More...OMAi		KEGPGQS

Database of Orthologous Groups

More...OrthoDBi		1251658at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9NSC5

TreeFam database of animal gene trees

More...TreeFami		TF325627

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011993 PH-like_dom_sf
IPR000697 WH1/EVH1_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00568 WH1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00461 WH1, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50229 WH1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NSC5-1) [UniParc]FASTAAdd to basket
Also known as: 3a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTAREQPIF STRAHVFQID PATKRNWIPA GKHALTVSYF YDATRNVYRI 
        60         70         80         90        100
ISIGGAKAII NSTVTPNMTF TKTSQKFGQW ADSRANTVYG LGFASEQHLT 
       110        120        130        140        150
QFAEKFQEVK EAARLAREKS QDGGELTSPA LGLASHQVPP SPLVSANGPG 
       160        170        180        190        200
EEKLFRSQSA DAPGPTERER LKKMLSEGSV GEVQWEAEFF ALQDSNNKLA 
       210        220        230        240        250
GALREANAAA AQWRQQLEAQ RAEAERLRQR VAELEAQAAS EVTPTGEKEG 
       260        270        280        290        300
LGQGQSLEQL EALVQTKDQE IQTLKSQTGG PREALEAAER EETQQKVQDL 
       310        320        330        340        350
ETRNAELEHQ LRAMERSLEE ARAERERARA EVGRAAQLLD VSLFELSELR 
       360 
EGLARLAEAA P
Length:361
Mass (Da):39,836
Last modified:November 28, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9FCC62319FF5165A
GO
Isoform 2 (identifier: Q9NSC5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     299-301: Missing.

Show »
Length:358
Mass (Da):39,479
Checksum:i0799594DEABE399F
GO
Isoform 3 (identifier: Q9NSC5-3) [UniParc]FASTAAdd to basket
Also known as: 3c

The sequence of this isoform differs from the canonical sequence as follows:
     124-145: GELTSPALGLASHQVPPSPLVS → WGGPQSALVVGSFGAVFELLIV
     146-361: Missing.

Show »
Length:145
Mass (Da):16,032
Checksum:i4DA4F12F2893744C
GO
Isoform 4 (identifier: Q9NSC5-4) [UniParc]FASTAAdd to basket
Also known as: 3d

The sequence of this isoform differs from the canonical sequence as follows:
     118-121: EKSQ → QLQR
     122-361: Missing.

Show »
Length:121
Mass (Da):13,685
Checksum:i42C572EB13211534
GO
Isoform 5 (identifier: Q9NSC5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     101-136: Missing.

Show »
Length:325
Mass (Da):35,954
Checksum:iF51CA5A05CB92734
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R2U7M0R2U7_HUMAN
Homer protein homolog 3
HOMER3
243Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZN1M0QZN1_HUMAN
Homer protein homolog 3
HOMER3
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QYF9M0QYF9_HUMAN
Homer protein homolog 3
HOMER3
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2T8M0R2T8_HUMAN
Homer protein homolog 3
HOMER3
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB81545 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_017410342S → R4 PublicationsCorresponds to variant dbSNP:rs1059240Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_045715101 – 136Missing in isoform 5. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_009073118 – 121EKSQ → QLQR in isoform 4. 1 Publication4
Alternative sequenceiVSP_009074122 – 361Missing in isoform 4. 1 PublicationAdd BLAST240
Alternative sequenceiVSP_009075124 – 145GELTS…SPLVS → WGGPQSALVVGSFGAVFELL IV in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_009076146 – 361Missing in isoform 3. 1 PublicationAdd BLAST216
Alternative sequenceiVSP_009077299 – 301Missing in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF093265 mRNA Translation: AAC71029.1
Y17573 mRNA Translation: CAB75536.1
Y18894 mRNA Translation: CAB75543.1
Y18895 mRNA Translation: CAB75544.1
Y18896 mRNA Translation: CAB75545.1
AK124450 mRNA Translation: BAG54040.1
AK313995 mRNA Translation: BAG36707.1
AC002985 Genomic DNA Translation: AAB81545.1 Sequence problems.
CH471106 Genomic DNA Translation: EAW84763.1
BC012113 mRNA Translation: AAH12113.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12391.1 [Q9NSC5-1]
CCDS46022.1 [Q9NSC5-5]
CCDS46023.1 [Q9NSC5-2]

NCBI Reference Sequences

More...RefSeqi		NP_001139193.1, NM_001145721.1 [Q9NSC5-2]
NP_001139194.1, NM_001145722.1 [Q9NSC5-1]
NP_001139196.1, NM_001145724.1 [Q9NSC5-5]
NP_004829.3, NM_004838.3 [Q9NSC5-1]
XP_006723006.1, XM_006722943.1 [Q9NSC5-1]
XP_006723007.1, XM_006722944.1 [Q9NSC5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000221222; ENSP00000221222; ENSG00000051128 [Q9NSC5-2]
ENST00000392351; ENSP00000376162; ENSG00000051128 [Q9NSC5-1]
ENST00000433218; ENSP00000396154; ENSG00000051128 [Q9NSC5-2]
ENST00000539827; ENSP00000439937; ENSG00000051128 [Q9NSC5-1]
ENST00000542541; ENSP00000446026; ENSG00000051128 [Q9NSC5-1]
ENST00000594439; ENSP00000471835; ENSG00000051128 [Q9NSC5-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9454

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9454

UCSC genome browser

More...UCSCi		uc002nku.3 human [Q9NSC5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093265 mRNA Translation: AAC71029.1
Y17573 mRNA Translation: CAB75536.1
Y18894 mRNA Translation: CAB75543.1
Y18895 mRNA Translation: CAB75544.1
Y18896 mRNA Translation: CAB75545.1
AK124450 mRNA Translation: BAG54040.1
AK313995 mRNA Translation: BAG36707.1
AC002985 Genomic DNA Translation: AAB81545.1 Sequence problems.
CH471106 Genomic DNA Translation: EAW84763.1
BC012113 mRNA Translation: AAH12113.1
CCDSiCCDS12391.1 [Q9NSC5-1]
CCDS46022.1 [Q9NSC5-5]
CCDS46023.1 [Q9NSC5-2]
RefSeqiNP_001139193.1, NM_001145721.1 [Q9NSC5-2]
NP_001139194.1, NM_001145722.1 [Q9NSC5-1]
NP_001139196.1, NM_001145724.1 [Q9NSC5-5]
NP_004829.3, NM_004838.3 [Q9NSC5-1]
XP_006723006.1, XM_006722943.1 [Q9NSC5-1]
XP_006723007.1, XM_006722944.1 [Q9NSC5-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2P8VX-ray1.85A2-118[»]
3CVFX-ray2.90A/B/C/D287-361[»]
SMRiQ9NSC5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi114843, 70 interactors
CORUMiQ9NSC5
IntActiQ9NSC5, 121 interactors
MINTiQ9NSC5
STRINGi9606.ENSP00000439937

PTM databases

iPTMnetiQ9NSC5
PhosphoSitePlusiQ9NSC5

Polymorphism and mutation databases

BioMutaiHOMER3
DMDMi38605068

Proteomic databases

EPDiQ9NSC5
jPOSTiQ9NSC5
MassIVEiQ9NSC5
MaxQBiQ9NSC5
PaxDbiQ9NSC5
PeptideAtlasiQ9NSC5
PRIDEiQ9NSC5
ProteomicsDBi19531
82529 [Q9NSC5-1]
82530 [Q9NSC5-2]
82531 [Q9NSC5-3]
82532 [Q9NSC5-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28304 217 antibodies

The DNASU plasmid repository

More...DNASUi		9454

Genome annotation databases

EnsembliENST00000221222; ENSP00000221222; ENSG00000051128 [Q9NSC5-2]
ENST00000392351; ENSP00000376162; ENSG00000051128 [Q9NSC5-1]
ENST00000433218; ENSP00000396154; ENSG00000051128 [Q9NSC5-2]
ENST00000539827; ENSP00000439937; ENSG00000051128 [Q9NSC5-1]
ENST00000542541; ENSP00000446026; ENSG00000051128 [Q9NSC5-1]
ENST00000594439; ENSP00000471835; ENSG00000051128 [Q9NSC5-5]
GeneIDi9454
KEGGihsa:9454
UCSCiuc002nku.3 human [Q9NSC5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9454
DisGeNETi9454

GeneCards: human genes, protein and diseases

More...GeneCardsi		HOMER3
HGNCiHGNC:17514 HOMER3
HPAiENSG00000051128 Tissue enhanced (lymphoid)
MIMi604800 gene
neXtProtiNX_Q9NSC5
OpenTargetsiENSG00000051128
PharmGKBiPA134988320

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IIX6 Eukaryota
ENOG41101PM LUCA
GeneTreeiENSGT00940000158081
HOGENOMiCLU_033940_0_0_1
InParanoidiQ9NSC5
KOiK15010
OMAiKEGPGQS
OrthoDBi1251658at2759
PhylomeDBiQ9NSC5
TreeFamiTF325627

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins

Miscellaneous databases

EvolutionaryTraceiQ9NSC5

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		HOMER3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9454
PharosiQ9NSC5 Tbio

Protein Ontology

More...PROi		PR:Q9NSC5
RNActiQ9NSC5 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000051128 Expressed in right hemisphere of cerebellum and 217 other tissues
ExpressionAtlasiQ9NSC5 baseline and differential
GenevisibleiQ9NSC5 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR000697 WH1/EVH1_dom
PfamiView protein in Pfam
PF00568 WH1, 1 hit
SMARTiView protein in SMART
SM00461 WH1, 1 hit
PROSITEiView protein in PROSITE
PS50229 WH1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHOME3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NSC5
Secondary accession number(s): B2RA10
, E9PCW9, O14580, O95350, Q9NSB9, Q9NSC0, Q9NSC1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 28, 2003
Last modified: April 22, 2020
This is version 176 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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