UniProtKB - Q9NSA2 (KCND1_HUMAN)
Protein
Potassium voltage-gated channel subfamily D member 1
Gene
KCND1
Organism
Homo sapiens (Human)
Status
Functioni
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 104 | ZincBy similarity | 1 | |
Metal bindingi | 131 | ZincBy similarity | 1 | |
Metal bindingi | 132 | ZincBy similarity | 1 |
GO - Molecular functioni
- A-type (transient outward) potassium channel activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- voltage-gated potassium channel activity Source: GO_Central
GO - Biological processi
- cardiac conduction Source: Reactome
- potassium ion transmembrane transport Source: GO_Central
- protein homooligomerization Source: InterPro
- regulation of ion transmembrane transport Source: UniProtKB-KW
Keywordsi
Molecular function | Ion channel, Potassium channel, Voltage-gated channel |
Biological process | Ion transport, Potassium transport, Transport |
Ligand | Metal-binding, Potassium, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9NSA2 |
Reactomei | R-HSA-1296072, Voltage gated Potassium channels R-HSA-5576894, Phase 1 - inactivation of fast Na+ channels |
Protein family/group databases
TCDBi | 1.A.1.2.28, the voltage-gated ion channel (vic) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium voltage-gated channel subfamily D member 1Alternative name(s): Voltage-gated potassium channel subunit Kv4.1 |
Gene namesi | Name:KCND1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6237, KCND1 |
MIMi | 300281, gene |
neXtProti | NX_Q9NSA2 |
VEuPathDBi | HostDB:ENSG00000102057.9 |
Subcellular locationi
Other locations
- Membrane ; Multi-pass membrane protein
- dendrite By similarity
Plasma Membrane
- plasma membrane Source: Reactome
- postsynaptic membrane Source: GO_Central
- voltage-gated potassium channel complex Source: GO_Central
Other locations
- dendritic spine Source: GO_Central
- integral component of membrane Source: GO_Central
- neuronal cell body Source: Ensembl
- postsynaptic density Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 184 | CytoplasmicSequence analysisAdd BLAST | 184 | |
Transmembranei | 185 – 205 | Helical; Name=Segment S1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 227 – 247 | Helical; Name=Segment S2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 248 – 261 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 262 – 282 | Helical; Name=Segment S3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 292 – 312 | Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 313 – 325 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 326 – 346 | Helical; Name=Segment S5Sequence analysisAdd BLAST | 21 | |
Intramembranei | 365 – 385 | Pore-forming; Name=Segment H5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 387 – 407 | Helical; Name=Segment S6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 408 – 647 | CytoplasmicSequence analysisAdd BLAST | 240 |
Keywords - Cellular componenti
Cell projection, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 3750 |
OpenTargetsi | ENSG00000102057 |
PharmGKBi | PA30029 |
Miscellaneous databases
Pharosi | Q9NSA2, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2362996 |
DrugBanki | DB06637, Dalfampridine DB00228, Enflurane DB01110, Miconazole DB01069, Promethazine |
DrugCentrali | Q9NSA2 |
GuidetoPHARMACOLOGYi | 552 |
Genetic variation databases
BioMutai | KCND1 |
DMDMi | 38258256 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054061 | 1 – 647 | Potassium voltage-gated channel subfamily D member 1Add BLAST | 647 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 352 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 355 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 458 | PhosphoserineBy similarity | 1 | |
Modified residuei | 555 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | Q9NSA2 |
MassIVEi | Q9NSA2 |
PaxDbi | Q9NSA2 |
PeptideAtlasi | Q9NSA2 |
PRIDEi | Q9NSA2 |
ProteomicsDBi | 82521 [Q9NSA2-1] 980 |
PTM databases
GlyGeni | Q9NSA2, 2 sites |
iPTMneti | Q9NSA2 |
PhosphoSitePlusi | Q9NSA2 |
Expressioni
Tissue specificityi
Widely expressed. Highly expressed in brain, in particular in cerebellum and thalamus; detected at lower levels in the other parts of the brain.1 Publication
Gene expression databases
Bgeei | ENSG00000102057, Expressed in cerebellar hemisphere and 121 other tissues |
ExpressionAtlasi | Q9NSA2, baseline and differential |
Genevisiblei | Q9NSA2, HS |
Organism-specific databases
HPAi | ENSG00000102057, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Homotetramer or heterotetramer with KCND2 and/or KCND3. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4 (By similarity).
Interacts with DPP10 (Probable).
By similarityCuratedProtein-protein interaction databases
BioGRIDi | 109952, 1 interactor |
IntActi | Q9NSA2, 1 interactor |
STRINGi | 9606.ENSP00000218176 |
Miscellaneous databases
RNActi | Q9NSA2, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 20 | Interaction with KCNIP2By similarityAdd BLAST | 19 | |
Regioni | 474 – 489 | Mediates dendritic targetingBy similarityAdd BLAST | 16 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 372 – 377 | Selectivity filterBy similarity | 6 |
Domaini
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
Sequence similaritiesi
Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.1/KCND1 sub-subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4390, Eukaryota |
GeneTreei | ENSGT00940000162057 |
HOGENOMi | CLU_070236_0_0_1 |
InParanoidi | Q9NSA2 |
OMAi | EQPCGDR |
OrthoDBi | 469107at2759 |
PhylomeDBi | Q9NSA2 |
TreeFami | TF313103 |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR005821, Ion_trans_dom IPR003968, K_chnl_volt-dep_Kv IPR003975, K_chnl_volt-dep_Kv4 IPR004054, K_chnl_volt-dep_Kv4.1 IPR024587, K_chnl_volt-dep_Kv4_C IPR021645, Shal-type_N IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB IPR028325, VG_K_chnl IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR11537, PTHR11537, 1 hit |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit PF11879, DUF3399, 1 hit PF00520, Ion_trans, 1 hit PF11601, Shal-type, 1 hit |
PRINTSi | PR01516, KV41CHANNEL PR01491, KVCHANNEL PR01497, SHALCHANNEL |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9NSA2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAGLATWLP FARAAAVGWL PLAQQPLPPA PGVKASRGDE VLVVNVSGRR
60 70 80 90 100
FETWKNTLDR YPDTLLGSSE KEFFYDADSG EYFFDRDPDM FRHVLNFYRT
110 120 130 140 150
GRLHCPRQEC IQAFDEELAF YGLVPELVGD CCLEEYRDRK KENAERLAED
160 170 180 190 200
EEAEQAGDGP ALPAGSSLRQ RLWRAFENPH TSTAALVFYY VTGFFIAVSV
210 220 230 240 250
IANVVETIPC RGSARRSSRE QPCGERFPQA FFCMDTACVL IFTGEYLLRL
260 270 280 290 300
FAAPSRCRFL RSVMSLIDVV AILPYYIGLL VPKNDDVSGA FVTLRVFRVF
310 320 330 340 350
RIFKFSRHSQ GLRILGYTLK SCASELGFLL FSLTMAIIIF ATVMFYAEKG
360 370 380 390 400
TNKTNFTSIP AAFWYTIVTM TTLGYGDMVP STIAGKIFGS ICSLSGVLVI
410 420 430 440 450
ALPVPVIVSN FSRIYHQNQR ADKRRAQQKV RLARIRLAKS GTTNAFLQYK
460 470 480 490 500
QNGGLEDSGS GEEQALCVRN RSAFEQQHHH LLHCLEKTTC HEFTDELTFS
510 520 530 540 550
EALGAVSPGG RTSRSTSVSS QPVGPGSLLS SCCPRRAKRR AIRLANSTAS
560 570 580 590 600
VSRGSMQELD MLAGLRRSHA PQSRSSLNAK PHDSLDLNCD SRDFVAAIIS
610 620 630 640
IPTPPANTPD ESQPSSPGGG GRAGSTLRNS SLGTPCLFPE TVKISSL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7C3V4 | H7C3V4_HUMAN | Potassium voltage-gated channel sub... | KCND1 | 133 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 358 | S → N in BAA96454 (Ref. 2) Curated | 1 | |
Sequence conflicti | 406 | V → I in BAA96454 (Ref. 2) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_057040 | 1 – 377 | Missing in isoform 2. 1 PublicationAdd BLAST | 377 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF166003 mRNA Translation: AAF65516.1 AF166006, AF166004, AF166005 Genomic DNA Translation: AAF65617.1 AB021865 mRNA Translation: BAA96454.1 AJ005898 mRNA Translation: CAA06755.1 AK094431 mRNA Translation: BAG52865.1 AK315092 mRNA Translation: BAG37557.1 AF207550 Genomic DNA No translation available. CH471224 Genomic DNA Translation: EAW50720.1 CH471224 Genomic DNA Translation: EAW50721.1 BC045659 mRNA Translation: AAH45659.1 |
CCDSi | CCDS14314.1 [Q9NSA2-1] |
RefSeqi | NP_004970.3, NM_004979.5 [Q9NSA2-1] XP_011542212.1, XM_011543910.2 [Q9NSA2-1] |
Genome annotation databases
Ensembli | ENST00000218176; ENSP00000218176; ENSG00000102057 [Q9NSA2-1] ENST00000376477; ENSP00000365660; ENSG00000102057 [Q9NSA2-2] |
GeneIDi | 3750 |
KEGGi | hsa:3750 |
UCSCi | uc004dlw.1, human [Q9NSA2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF166003 mRNA Translation: AAF65516.1 AF166006, AF166004, AF166005 Genomic DNA Translation: AAF65617.1 AB021865 mRNA Translation: BAA96454.1 AJ005898 mRNA Translation: CAA06755.1 AK094431 mRNA Translation: BAG52865.1 AK315092 mRNA Translation: BAG37557.1 AF207550 Genomic DNA No translation available. CH471224 Genomic DNA Translation: EAW50720.1 CH471224 Genomic DNA Translation: EAW50721.1 BC045659 mRNA Translation: AAH45659.1 |
CCDSi | CCDS14314.1 [Q9NSA2-1] |
RefSeqi | NP_004970.3, NM_004979.5 [Q9NSA2-1] XP_011542212.1, XM_011543910.2 [Q9NSA2-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 109952, 1 interactor |
IntActi | Q9NSA2, 1 interactor |
STRINGi | 9606.ENSP00000218176 |
Chemistry databases
ChEMBLi | CHEMBL2362996 |
DrugBanki | DB06637, Dalfampridine DB00228, Enflurane DB01110, Miconazole DB01069, Promethazine |
DrugCentrali | Q9NSA2 |
GuidetoPHARMACOLOGYi | 552 |
Protein family/group databases
TCDBi | 1.A.1.2.28, the voltage-gated ion channel (vic) superfamily |
PTM databases
GlyGeni | Q9NSA2, 2 sites |
iPTMneti | Q9NSA2 |
PhosphoSitePlusi | Q9NSA2 |
Genetic variation databases
BioMutai | KCND1 |
DMDMi | 38258256 |
Proteomic databases
jPOSTi | Q9NSA2 |
MassIVEi | Q9NSA2 |
PaxDbi | Q9NSA2 |
PeptideAtlasi | Q9NSA2 |
PRIDEi | Q9NSA2 |
ProteomicsDBi | 82521 [Q9NSA2-1] 980 |
Protocols and materials databases
Antibodypediai | 370, 249 antibodies |
DNASUi | 3750 |
Genome annotation databases
Ensembli | ENST00000218176; ENSP00000218176; ENSG00000102057 [Q9NSA2-1] ENST00000376477; ENSP00000365660; ENSG00000102057 [Q9NSA2-2] |
GeneIDi | 3750 |
KEGGi | hsa:3750 |
UCSCi | uc004dlw.1, human [Q9NSA2-1] |
Organism-specific databases
CTDi | 3750 |
DisGeNETi | 3750 |
GeneCardsi | KCND1 |
HGNCi | HGNC:6237, KCND1 |
HPAi | ENSG00000102057, Tissue enhanced (brain) |
MIMi | 300281, gene |
neXtProti | NX_Q9NSA2 |
OpenTargetsi | ENSG00000102057 |
PharmGKBi | PA30029 |
VEuPathDBi | HostDB:ENSG00000102057.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4390, Eukaryota |
GeneTreei | ENSGT00940000162057 |
HOGENOMi | CLU_070236_0_0_1 |
InParanoidi | Q9NSA2 |
OMAi | EQPCGDR |
OrthoDBi | 469107at2759 |
PhylomeDBi | Q9NSA2 |
TreeFami | TF313103 |
Enzyme and pathway databases
PathwayCommonsi | Q9NSA2 |
Reactomei | R-HSA-1296072, Voltage gated Potassium channels R-HSA-5576894, Phase 1 - inactivation of fast Na+ channels |
Miscellaneous databases
BioGRID-ORCSi | 3750, 6 hits in 620 CRISPR screens |
ChiTaRSi | KCND1, human |
GeneWikii | KCND1 |
GenomeRNAii | 3750 |
Pharosi | Q9NSA2, Tclin |
PROi | PR:Q9NSA2 |
RNActi | Q9NSA2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000102057, Expressed in cerebellar hemisphere and 121 other tissues |
ExpressionAtlasi | Q9NSA2, baseline and differential |
Genevisiblei | Q9NSA2, HS |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit |
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR005821, Ion_trans_dom IPR003968, K_chnl_volt-dep_Kv IPR003975, K_chnl_volt-dep_Kv4 IPR004054, K_chnl_volt-dep_Kv4.1 IPR024587, K_chnl_volt-dep_Kv4_C IPR021645, Shal-type_N IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB IPR028325, VG_K_chnl IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR11537, PTHR11537, 1 hit |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit PF11879, DUF3399, 1 hit PF00520, Ion_trans, 1 hit PF11601, Shal-type, 1 hit |
PRINTSi | PR01516, KV41CHANNEL PR01491, KVCHANNEL PR01497, SHALCHANNEL |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KCND1_HUMAN | |
Accessioni | Q9NSA2Primary (citable) accession number: Q9NSA2 Secondary accession number(s): A6NEF1, B2RCG0, O75671 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 7, 2003 |
Last sequence update: | November 7, 2003 | |
Last modified: | April 7, 2021 | |
This is version 172 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families