Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fibroblast growth factor 21

Gene

FGF21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-HSA-189200 Cellular hexose transport
R-HSA-8963889 Assembly of active LPL and LIPC lipase complexes
SIGNORiQ9NSA1

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 21
Short name:
FGF-21
Gene namesi
Name:FGF21
ORF Names:UNQ3115/PRO10196
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105550.8
HGNCiHGNC:3678 FGF21
MIMi609436 gene
neXtProtiNX_Q9NSA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi26291
OpenTargetsiENSG00000105550
PharmGKBiPA28117

Polymorphism and mutation databases

BioMutaiFGF21
DMDMi13626703

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 281 PublicationAdd BLAST28
ChainiPRO_000000899429 – 209Fibroblast growth factor 21Add BLAST181

Proteomic databases

PaxDbiQ9NSA1
PeptideAtlasiQ9NSA1
PRIDEiQ9NSA1
ProteomicsDBi82520

Expressioni

Gene expression databases

BgeeiENSG00000105550 Expressed in 38 organ(s), highest expression level in right lobe of liver
CleanExiHS_FGF21
GenevisibleiQ9NSA1 HS

Organism-specific databases

HPAiHPA061286

Interactioni

Subunit structurei

Interacts (via C-terminus) with KLB; this interaction is direct. Interacts with FGFR4.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
KLBQ86Z142EBI-3909329,EBI-8515198

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117672, 7 interactors
CORUMiQ9NSA1
IntActiQ9NSA1, 8 interactors
MINTiQ9NSA1
STRINGi9606.ENSP00000222157

Structurei

Secondary structure

1209
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9NSA1
SMRiQ9NSA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00530000063469
HOGENOMiHOG000112572
HOVERGENiHBG051612
InParanoidiQ9NSA1
KOiK22429
OMAiYNIYHSE
OrthoDBiEOG091G0NAY
PhylomeDBiQ9NSA1
TreeFamiTF335872

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR035444 FGF15/19/21
IPR028292 FGF21
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF81 PTHR11486:SF81, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PIRSFiPIRSF037961 FGF-19_FGF-21, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NSA1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSDETGFEH SGLWVSVLAG LLLGACQAHP IPDSSPLLQF GGQVRQRYLY
60 70 80 90 100
TDDAQQTEAH LEIREDGTVG GAADQSPESL LQLKALKPGV IQILGVKTSR
110 120 130 140 150
FLCQRPDGAL YGSLHFDPEA CSFRELLLED GYNVYQSEAH GLPLHLPGNK
160 170 180 190 200
SPHRDPAPRG PARFLPLPGL PPALPEPPGI LAPQPPDVGS SDPLSMVGPS

QGRSPSYAS
Length:209
Mass (Da):22,300
Last modified:October 1, 2000 - v1
Checksum:i27925C52A0023823
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23Missing in AAQ89444 (PubMed:12975309).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055375141G → S1 PublicationCorresponds to variant dbSNP:rs41308776Ensembl.1
Natural variantiVAR_049064174L → P1 PublicationCorresponds to variant dbSNP:rs739320Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021975 mRNA Translation: BAA99415.1
AY359086 mRNA Translation: AAQ89444.1
DQ847413 Genomic DNA Translation: ABI75345.1
CH471177 Genomic DNA Translation: EAW52402.1
BC018404 mRNA Translation: AAH18404.1
CCDSiCCDS12734.1
RefSeqiNP_061986.1, NM_019113.3
UniGeneiHs.283015

Genome annotation databases

EnsembliENST00000222157; ENSP00000222157; ENSG00000105550
ENST00000593756; ENSP00000471477; ENSG00000105550
GeneIDi26291
KEGGihsa:26291
UCSCiuc002pkn.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021975 mRNA Translation: BAA99415.1
AY359086 mRNA Translation: AAQ89444.1
DQ847413 Genomic DNA Translation: ABI75345.1
CH471177 Genomic DNA Translation: EAW52402.1
BC018404 mRNA Translation: AAH18404.1
CCDSiCCDS12734.1
RefSeqiNP_061986.1, NM_019113.3
UniGeneiHs.283015

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5VAQX-ray2.61C186-209[»]
ProteinModelPortaliQ9NSA1
SMRiQ9NSA1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117672, 7 interactors
CORUMiQ9NSA1
IntActiQ9NSA1, 8 interactors
MINTiQ9NSA1
STRINGi9606.ENSP00000222157

Polymorphism and mutation databases

BioMutaiFGF21
DMDMi13626703

Proteomic databases

PaxDbiQ9NSA1
PeptideAtlasiQ9NSA1
PRIDEiQ9NSA1
ProteomicsDBi82520

Protocols and materials databases

DNASUi26291
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222157; ENSP00000222157; ENSG00000105550
ENST00000593756; ENSP00000471477; ENSG00000105550
GeneIDi26291
KEGGihsa:26291
UCSCiuc002pkn.2 human

Organism-specific databases

CTDi26291
DisGeNETi26291
EuPathDBiHostDB:ENSG00000105550.8
GeneCardsiFGF21
HGNCiHGNC:3678 FGF21
HPAiHPA061286
MIMi609436 gene
neXtProtiNX_Q9NSA1
OpenTargetsiENSG00000105550
PharmGKBiPA28117
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00530000063469
HOGENOMiHOG000112572
HOVERGENiHBG051612
InParanoidiQ9NSA1
KOiK22429
OMAiYNIYHSE
OrthoDBiEOG091G0NAY
PhylomeDBiQ9NSA1
TreeFamiTF335872

Enzyme and pathway databases

ReactomeiR-HSA-189200 Cellular hexose transport
R-HSA-8963889 Assembly of active LPL and LIPC lipase complexes
SIGNORiQ9NSA1

Miscellaneous databases

GeneWikiiFGF21
GenomeRNAii26291
PROiPR:Q9NSA1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105550 Expressed in 38 organ(s), highest expression level in right lobe of liver
CleanExiHS_FGF21
GenevisibleiQ9NSA1 HS

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR035444 FGF15/19/21
IPR028292 FGF21
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF81 PTHR11486:SF81, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PIRSFiPIRSF037961 FGF-19_FGF-21, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFGF21_HUMAN
AccessioniPrimary (citable) accession number: Q9NSA1
Secondary accession number(s): Q8N683
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: November 7, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again