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Entry version 140 (08 May 2019)
Sequence version 1 (01 Oct 2000)
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Protein

Solute carrier family 22 member 11

Gene

SLC22A11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-561048 Organic anion transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.19.10 the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 22 member 11
Alternative name(s):
Organic anion transporter 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC22A11
Synonyms:OAT4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18120 SLC22A11

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607097 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9NSA0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 10CytoplasmicSequence analysis10
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 142ExtracellularSequence analysisAdd BLAST111
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Topological domaini164 – 174CytoplasmicSequence analysisAdd BLAST11
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 200ExtracellularSequence analysis5
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Topological domaini222 – 231CytoplasmicSequence analysis10
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 256ExtracellularSequence analysis4
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Topological domaini278 – 346CytoplasmicSequence analysisAdd BLAST69
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21
Topological domaini368 – 378ExtracellularSequence analysisAdd BLAST11
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Topological domaini400 – 402CytoplasmicSequence analysis3
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Topological domaini424 – 430ExtracellularSequence analysis7
Transmembranei431 – 451HelicalSequence analysisAdd BLAST21
Topological domaini452 – 463CytoplasmicSequence analysisAdd BLAST12
Transmembranei464 – 484HelicalSequence analysisAdd BLAST21
Topological domaini485 – 490ExtracellularSequence analysis6
Transmembranei491 – 511HelicalSequence analysisAdd BLAST21
Topological domaini512 – 550CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi39N → Q: No visible effect on N-glycosylation. Loss of N-glycosylation and of cell surface location; when associated with Q-56; Q-63 and Q-99. 1 Publication1
Mutagenesisi47H → A: Reduced cell surface expression and estrone sulfate transport. Reduced cell surface expression and estrone sulfate transport; when associated with A-52; A-83; A-305 and A-469. 1 Publication1
Mutagenesisi52H → A: Slightly reduced estrone sulfate transport. Reduced cell surface expression and estrone sulfate transport; when associated with A-47; A-83; A-305 and A-469. 1 Publication1
Mutagenesisi56N → Q: No visible effect on N-glycosylation. Loss of N-glycosylation and of cell surface expression; when associated with Q-39; Q-63 and Q-99. 1 Publication1
Mutagenesisi63N → Q: No visible effect on N-glycosylation. Loss of N-glycosylation and of cell surface expression; when associated with Q-39; Q-56 and Q-99. 1 Publication1
Mutagenesisi83H → A: Reduced cell surface expression and estrone sulfate transport; when associated with A-47; A-52; A-305 and A-469. 1 Publication1
Mutagenesisi99N → Q: No visible effect on N-glycosylation. Loss of N-glycosylation and of cell surface expression; when associated with Q-39; Q-56 and Q-63. 1 Publication1
Mutagenesisi241G → L, S or V: Strongly reduced cell surface expression and estrone sulfate transport. 1 Publication1
Mutagenesisi305H → A: Reduced cell surface expression and estrone sulfate transport; when associated with A-47; A-52; A-83 and A-469. 1 Publication1
Mutagenesisi400G → L, S or V: Strongly reduced cell surface expression and estrone sulfate transport. 1 Publication1
Mutagenesisi469H → A: Slightly reduced estrone sulfate transport. Reduced cell surface expression and estrone sulfate transport; when associated with A-47; A-52; A-83 and A-305. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
55867

Open Targets

More...
OpenTargetsi
ENSG00000168065

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38295

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2073677

Drug and drug target database

More...
DrugBanki
DB00345 Aminohippuric acid
DB00168 Aspartame
DB01053 Benzylpenicillin
DB00887 Bumetanide
DB04519 Caprylic acid
DB00456 Cefalotin
DB01326 Cefamandole
DB01327 Cefazolin
DB01329 Cefoperazone
DB00493 Cefotaxime
DB01212 Ceftriaxone
DB00501 Cimetidine
DB00286 Conjugated Equine Estrogens
DB04133 Degraded Cephaloridine
DB00586 Diclofenac
DB01160 Dinoprost Tromethamine
DB00917 Dinoprostone
DB00254 Doxycycline
DB08846 Ellagic Acid
DB00783 Estradiol
DB00695 Furosemide
DB03553 Glutaric Acid
DB01050 Ibuprofen
DB00328 Indomethacin
DB01009 Ketoprofen
DB11560 Lesinurad
DB00563 Methotrexate
DB01017 Minocycline
DB01051 Novobiocin
DB00595 Oxytetracycline
DB00812 Phenylbutazone
DB00554 Piroxicam
DB00175 Pravastatin
DB01032 Probenecid
DB00936 Salicylic acid
DB00759 Tetracycline
DB00495 Zidovudine

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1030

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC22A11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74734337

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002344351 – 550Solute carrier family 22 member 11Add BLAST550

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated. Contains several complex-type N-glycans.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9NSA0

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9NSA0

PeptideAtlas

More...
PeptideAtlasi
Q9NSA0

PRoteomics IDEntifications database

More...
PRIDEi
Q9NSA0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
82518
82519 [Q9NSA0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9NSA0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9NSA0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in placenta and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168065 Expressed in 56 organ(s), highest expression level in adult mammalian kidney

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9NSA0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9NSA0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA026076

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120967, 3 interactors

Protein interaction database and analysis system

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IntActi
Q9NSA0, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000301891

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9NSA0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0255 Eukaryota
COG0477 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163267

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000234569

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9NSA0

KEGG Orthology (KO)

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KOi
K08207

Identification of Orthologs from Complete Genome Data

More...
OMAi
FPTPLRM

Database of Orthologous Groups

More...
OrthoDBi
464838at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9NSA0

TreeFam database of animal gene trees

More...
TreeFami
TF315847

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06174 MFS, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00083 Sugar_tr, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473 SSF103473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850 MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9NSA0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFSKLLEQA GGVGLFQTLQ VLTFILPCLM IPSQMLLENF SAAIPGHRCW
60 70 80 90 100
THMLDNGSAV STNMTPKALL TISIPPGPNQ GPHQCRRFRQ PQWQLLDPNA
110 120 130 140 150
TATSWSEADT EPCVDGWVYD RSVFTSTIVA KWDLVCSSQG LKPLSQSIFM
160 170 180 190 200
SGILVGSFIW GLLSYRFGRK PMLSWCCLQL AVAGTSTIFA PTFVIYCGLR
210 220 230 240 250
FVAAFGMAGI FLSSLTLMVE WTTTSRRAVT MTVVGCAFSA GQAALGGLAF
260 270 280 290 300
ALRDWRTLQL AASVPFFAIS LISWWLPESA RWLIIKGKPD QALQELRKVA
310 320 330 340 350
RINGHKEAKN LTIEVLMSSV KEEVASAKEP RSVLDLFCVP VLRWRSCAML
360 370 380 390 400
VVNFSLLISY YGLVFDLQSL GRDIFLLQAL FGAVDFLGRA TTALLLSFLG
410 420 430 440 450
RRTIQAGSQA MAGLAILANM LVPQDLQTLR VVFAVLGKGC FGISLTCLTI
460 470 480 490 500
YKAELFPTPV RMTADGILHT VGRLGAMMGP LILMSRQALP LLPPLLYGVI
510 520 530 540 550
SIASSLVVLF FLPETQGLPL PDTIQDLESQ KSTAAQGNRQ EAVTVESTSL
Length:550
Mass (Da):59,972
Last modified:October 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i233BE6C4A520E58A
GO
Isoform 2 (identifier: Q9NSA0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     353-461: NFSLLISYYG...KAELFPTPVR → K

Note: No experimental confirmation available.
Show »
Length:442
Mass (Da):48,301
Checksum:iF9D42F38249733FB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NCG2A6NCG2_HUMAN
Solute carrier family 22 member 11
SLC22A11
481Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0B7H7C0B7_HUMAN
Solute carrier family 22 member 11
SLC22A11
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3R9H7C3R9_HUMAN
Solute carrier family 22 member 11
SLC22A11
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC11483 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti180L → S in BAD96589 (Ref. 3) Curated1
Sequence conflicti376L → R in BAC85252 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053962155V → G. Corresponds to variant dbSNP:rs12785832Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_018319353 – 461NFSLL…PTPVR → K in isoform 2. 1 PublicationAdd BLAST109

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB026116 mRNA Translation: BAA95316.1
AK075224 mRNA Translation: BAC11483.1 Different initiation.
AK129930 mRNA Translation: BAC85252.1
AK222869 mRNA Translation: BAD96589.1
AK290791 mRNA Translation: BAF83480.1
AC044790 Genomic DNA Translation: AAK68155.1
CH471076 Genomic DNA Translation: EAW74269.1
BC034384 mRNA Translation: AAH34384.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS76425.1 [Q9NSA0-2]
CCDS8074.1 [Q9NSA0-1]

NCBI Reference Sequences

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RefSeqi
NP_001294914.1, NM_001307985.1 [Q9NSA0-2]
NP_060954.1, NM_018484.3 [Q9NSA0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000301891; ENSP00000301891; ENSG00000168065 [Q9NSA0-1]
ENST00000377585; ENSP00000366809; ENSG00000168065 [Q9NSA0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55867

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55867

UCSC genome browser

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UCSCi
uc001oai.4 human [Q9NSA0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026116 mRNA Translation: BAA95316.1
AK075224 mRNA Translation: BAC11483.1 Different initiation.
AK129930 mRNA Translation: BAC85252.1
AK222869 mRNA Translation: BAD96589.1
AK290791 mRNA Translation: BAF83480.1
AC044790 Genomic DNA Translation: AAK68155.1
CH471076 Genomic DNA Translation: EAW74269.1
BC034384 mRNA Translation: AAH34384.1
CCDSiCCDS76425.1 [Q9NSA0-2]
CCDS8074.1 [Q9NSA0-1]
RefSeqiNP_001294914.1, NM_001307985.1 [Q9NSA0-2]
NP_060954.1, NM_018484.3 [Q9NSA0-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi120967, 3 interactors
IntActiQ9NSA0, 1 interactor
STRINGi9606.ENSP00000301891

Chemistry databases

BindingDBiQ9NSA0
ChEMBLiCHEMBL2073677
DrugBankiDB00345 Aminohippuric acid
DB00168 Aspartame
DB01053 Benzylpenicillin
DB00887 Bumetanide
DB04519 Caprylic acid
DB00456 Cefalotin
DB01326 Cefamandole
DB01327 Cefazolin
DB01329 Cefoperazone
DB00493 Cefotaxime
DB01212 Ceftriaxone
DB00501 Cimetidine
DB00286 Conjugated Equine Estrogens
DB04133 Degraded Cephaloridine
DB00586 Diclofenac
DB01160 Dinoprost Tromethamine
DB00917 Dinoprostone
DB00254 Doxycycline
DB08846 Ellagic Acid
DB00783 Estradiol
DB00695 Furosemide
DB03553 Glutaric Acid
DB01050 Ibuprofen
DB00328 Indomethacin
DB01009 Ketoprofen
DB11560 Lesinurad
DB00563 Methotrexate
DB01017 Minocycline
DB01051 Novobiocin
DB00595 Oxytetracycline
DB00812 Phenylbutazone
DB00554 Piroxicam
DB00175 Pravastatin
DB01032 Probenecid
DB00936 Salicylic acid
DB00759 Tetracycline
DB00495 Zidovudine
GuidetoPHARMACOLOGYi1030

Protein family/group databases

TCDBi2.A.1.19.10 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiQ9NSA0
PhosphoSitePlusiQ9NSA0

Polymorphism and mutation databases

BioMutaiSLC22A11
DMDMi74734337

Proteomic databases

jPOSTiQ9NSA0
PaxDbiQ9NSA0
PeptideAtlasiQ9NSA0
PRIDEiQ9NSA0
ProteomicsDBi82518
82519 [Q9NSA0-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
55867
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301891; ENSP00000301891; ENSG00000168065 [Q9NSA0-1]
ENST00000377585; ENSP00000366809; ENSG00000168065 [Q9NSA0-2]
GeneIDi55867
KEGGihsa:55867
UCSCiuc001oai.4 human [Q9NSA0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55867
DisGeNETi55867

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC22A11
HGNCiHGNC:18120 SLC22A11
HPAiHPA026076
MIMi607097 gene
neXtProtiNX_Q9NSA0
OpenTargetsiENSG00000168065
PharmGKBiPA38295

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0255 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00940000163267
HOGENOMiHOG000234569
InParanoidiQ9NSA0
KOiK08207
OMAiFPTPLRM
OrthoDBi464838at2759
PhylomeDBiQ9NSA0
TreeFamiTF315847

Enzyme and pathway databases

ReactomeiR-HSA-561048 Organic anion transport

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC22A11 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC22A11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55867

Protein Ontology

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PROi
PR:Q9NSA0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000168065 Expressed in 56 organ(s), highest expression level in adult mammalian kidney
ExpressionAtlasiQ9NSA0 baseline and differential
GenevisibleiQ9NSA0 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS22AB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9NSA0
Secondary accession number(s): A8K426
, Q53GR2, Q6ZP72, Q8NBU4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 1, 2000
Last modified: May 8, 2019
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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